CY1124916T1 - Υγρο σκευασμα νευροτοξινης σταθεροποιημενο με τρυπτοφανη ή τυροσινη - Google Patents
Υγρο σκευασμα νευροτοξινης σταθεροποιημενο με τρυπτοφανη ή τυροσινηInfo
- Publication number
- CY1124916T1 CY1124916T1 CY20221100057T CY221100057T CY1124916T1 CY 1124916 T1 CY1124916 T1 CY 1124916T1 CY 20221100057 T CY20221100057 T CY 20221100057T CY 221100057 T CY221100057 T CY 221100057T CY 1124916 T1 CY1124916 T1 CY 1124916T1
- Authority
- CY
- Cyprus
- Prior art keywords
- tyrosine
- neurotoxin
- tryptophane
- liquid preparation
- tryptophan
- Prior art date
Links
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 title abstract 3
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 title abstract 3
- 101710138657 Neurotoxin Proteins 0.000 title abstract 3
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 title abstract 3
- 239000007788 liquid Substances 0.000 title abstract 3
- 239000002581 neurotoxin Substances 0.000 title abstract 3
- 231100000618 neurotoxin Toxicity 0.000 title abstract 3
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000006035 Tryptophane Substances 0.000 title 1
- 229960004799 tryptophan Drugs 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 abstract 1
- 235000021120 animal protein Nutrition 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 229910052708 sodium Inorganic materials 0.000 abstract 1
- 239000011734 sodium Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
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- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
- A61K38/4893—Botulinum neurotoxin (3.4.24.69)
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- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
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- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
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- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
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- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
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- Gerontology & Geriatric Medicine (AREA)
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- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Ophthalmology & Optometry (AREA)
- Neurosurgery (AREA)
- Toxicology (AREA)
- Medicinal Preparation (AREA)
Abstract
Η εφεύρεση αφορά σε σταθερά υγρά σκευάσματα νευροτοξίνης που είναι άνευ ζωικών πρωτεϊνών, που περιλαμβάνουν επιφανειοδραστικό, αμινοξύ που επιλέγεται από τρυπτοφάνη και τυροσίνη, ρυθμιστικό που περιλαμβάνει νατρίου, χλωριούχου και φωσφορικού ιόντα, που έχει pΗ μεταξύ 5,5 και 8, και που είναι σταθερά για 2 μήνες. Αυτές οι συνθέσεις είναι κατάλληλες για χρήση στη θεραπεία και ιδιαιτέρως για χορήγηση σε έναν ασθενή για να επιτευχθεί επιθυμητό θεραπευτικό ή αισθητικό αποτέλεσμα. Η εφεύρεση επίσης αφορά στη χρήση ενός αμινοξέος που επιλέγεται από τρυπτοφάνη και τυροσίνη για να προστατεύει πρωτεϊνώδη νευροτοξίνη από αποικοδόμηση σε υγρή σύνθεση η οποία είναι ελεύθερη ζωικά λαμβανόμενων πρωτεϊνών.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP2016062085 | 2016-05-27 | ||
EP20152386.7A EP3679946B1 (en) | 2016-05-27 | 2017-05-26 | Liquid neurotoxin formulation stabilized with tryptophan or tyrosine |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124916T1 true CY1124916T1 (el) | 2023-01-05 |
Family
ID=56289455
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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CY20211100001T CY1124237T1 (el) | 2016-05-27 | 2021-01-05 | Υγρο σκευασμα νευροτοξινης σταθεροποιημενο με τρυπτοφανη ή τυροσινη |
CY20221100057T CY1124916T1 (el) | 2016-05-27 | 2022-01-25 | Υγρο σκευασμα νευροτοξινης σταθεροποιημενο με τρυπτοφανη ή τυροσινη |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
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CY20211100001T CY1124237T1 (el) | 2016-05-27 | 2021-01-05 | Υγρο σκευασμα νευροτοξινης σταθεροποιημενο με τρυπτοφανη ή τυροσινη |
Country Status (30)
Country | Link |
---|---|
US (4) | US20190183988A1 (el) |
EP (3) | EP3463432B1 (el) |
JP (1) | JP7053498B2 (el) |
KR (2) | KR102399451B1 (el) |
CN (2) | CN109562148A (el) |
AR (1) | AR108631A1 (el) |
AU (1) | AU2017270359B2 (el) |
BR (1) | BR112018074311A2 (el) |
CA (1) | CA3025437A1 (el) |
CY (2) | CY1124237T1 (el) |
DK (2) | DK3679946T3 (el) |
EA (1) | EA038124B1 (el) |
ES (2) | ES2846350T3 (el) |
GE (1) | GEP20207139B (el) |
HR (2) | HRP20220024T1 (el) |
HU (2) | HUE052023T2 (el) |
IL (2) | IL285190B (el) |
LT (2) | LT3679946T (el) |
MX (1) | MX2018014631A (el) |
PL (2) | PL3463432T3 (el) |
PT (2) | PT3463432T (el) |
RS (2) | RS61340B1 (el) |
RU (1) | RU2741497C9 (el) |
SA (1) | SA518400513B1 (el) |
SG (1) | SG11201810561YA (el) |
SI (2) | SI3679946T1 (el) |
TW (1) | TWI777955B (el) |
UA (1) | UA123679C2 (el) |
WO (1) | WO2017203038A1 (el) |
ZA (1) | ZA201807904B (el) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8168206B1 (en) | 2005-10-06 | 2012-05-01 | Allergan, Inc. | Animal protein-free pharmaceutical compositions |
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