CY1124612T1 - Συντηγμενοι δικυκλικοι sgc διεγερτες - Google Patents
Συντηγμενοι δικυκλικοι sgc διεγερτεςInfo
- Publication number
- CY1124612T1 CY1124612T1 CY20211100756T CY211100756T CY1124612T1 CY 1124612 T1 CY1124612 T1 CY 1124612T1 CY 20211100756 T CY20211100756 T CY 20211100756T CY 211100756 T CY211100756 T CY 211100756T CY 1124612 T1 CY1124612 T1 CY 1124612T1
- Authority
- CY
- Cyprus
- Prior art keywords
- sgc
- exciters
- fused bicyclic
- concentration
- increase
- Prior art date
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 abstract 2
- 102000007637 Soluble Guanylyl Cyclase Human genes 0.000 abstract 2
- 108010007205 Soluble Guanylyl Cyclase Proteins 0.000 abstract 2
- ZOOGRGPOEVQQDX-KHLHZJAASA-N cyclic guanosine monophosphate Chemical compound C([C@H]1O2)O[P@](O)(=O)O[C@@H]1[C@H](O)[C@H]2N1C(N=C(NC2=O)N)=C2N=C1 ZOOGRGPOEVQQDX-KHLHZJAASA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000037361 pathway Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003827 upregulation Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
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Abstract
Η παρούσα δημοσίευση σχετίζεται με διεγέρτες διαλυτής γουανυλικής κυκλάσης (sGC), φαρμακευτικές συνθέσεις που τους περιέχουν και τις χρήσεις τους, μόνες ή σε συνδυασμό με έναν ή περισσότερους πρόσθετους παράγοντες, για τη θεραπεία διαφόρων νόσων, όπου η αύξηση της συγκέντρωσης του νιτρικού οξειδίου (NO) ή η αύξηση της συγκέντρωσης της κυκλικής, μονοφωσφορικής γουανοσίνης (cGMP) ή και των δύο, ή μια αυξορρύθμιση της οδού του NO είναι επιθυμητή. Οι ενώσεις είναι του Τύπου Ι:
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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US201662382942P | 2016-09-02 | 2016-09-02 | |
US201662423445P | 2016-11-17 | 2016-11-17 | |
US201762468598P | 2017-03-08 | 2017-03-08 | |
US201762482486P | 2017-04-06 | 2017-04-06 | |
PCT/US2017/049834 WO2018045276A1 (en) | 2016-09-02 | 2017-09-01 | Fused bicyclic sgc stimulators |
Publications (1)
Publication Number | Publication Date |
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CY1124612T1 true CY1124612T1 (el) | 2022-07-22 |
Family
ID=59887396
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CY20211100756T CY1124612T1 (el) | 2016-09-02 | 2021-08-24 | Συντηγμενοι δικυκλικοι sgc διεγερτες |
Country Status (29)
Country | Link |
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US (4) | US10472363B2 (el) |
EP (2) | EP3872080B1 (el) |
JP (2) | JP7050759B2 (el) |
KR (2) | KR20230124760A (el) |
CN (2) | CN117105939A (el) |
AU (2) | AU2017321810B2 (el) |
BR (1) | BR112019004468A2 (el) |
CA (1) | CA3035210A1 (el) |
CL (1) | CL2019000486A1 (el) |
CO (1) | CO2019001760A2 (el) |
CR (2) | CR20190101A (el) |
CY (1) | CY1124612T1 (el) |
DK (1) | DK3507291T3 (el) |
ES (2) | ES2957159T3 (el) |
HR (1) | HRP20211355T1 (el) |
HU (1) | HUE056051T2 (el) |
IL (2) | IL292968A (el) |
LT (1) | LT3507291T (el) |
MA (1) | MA53999A (el) |
MX (3) | MX2021007580A (el) |
PE (1) | PE20190607A1 (el) |
PH (1) | PH12019500461A1 (el) |
PL (1) | PL3507291T3 (el) |
PT (1) | PT3507291T (el) |
RS (1) | RS62256B1 (el) |
SG (1) | SG11201901729YA (el) |
SI (1) | SI3507291T1 (el) |
TW (2) | TWI813078B (el) |
WO (1) | WO2018045276A1 (el) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6133637A (en) * | 1997-01-24 | 2000-10-17 | Rohm Co., Ltd. | Semiconductor device having a plurality of semiconductor chips |
JP2017527604A (ja) * | 2014-09-17 | 2017-09-21 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | sGC刺激剤 |
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