BR112019004468A2 - estimulantes de sgc - Google Patents

estimulantes de sgc

Info

Publication number
BR112019004468A2
BR112019004468A2 BR112019004468A BR112019004468A BR112019004468A2 BR 112019004468 A2 BR112019004468 A2 BR 112019004468A2 BR 112019004468 A BR112019004468 A BR 112019004468A BR 112019004468 A BR112019004468 A BR 112019004468A BR 112019004468 A2 BR112019004468 A2 BR 112019004468A2
Authority
BR
Brazil
Prior art keywords
formula
increase
sgc
stimulants
sgc stimulants
Prior art date
Application number
BR112019004468A
Other languages
English (en)
Inventor
Timothy Claude Barden
Peter Germano
G-Yoon Jamie Im
Rajesh R Iyengar
Karthik Iyer
Lei Jia
Joon Jung
Thomas Wai-Ho Lee
Ara Mermerian
Takashi Nakai
Paul Allan Renhowe
Glen Robert Rennie
Kim Tang
Original Assignee
Ironwood Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ironwood Pharmaceuticals Inc filed Critical Ironwood Pharmaceuticals Inc
Publication of BR112019004468A2 publication Critical patent/BR112019004468A2/pt

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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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Abstract

o presente relatório refere-se a estimulantes da guanilato ciclase solúvel (sgc), formulações farmacêuticas os compreendendo e seus usos, separadamente ou em combinação com um ou mais outros agentes, para o tratamento de várias doenças, em que um aumento na concentração de óxido nítrico (no) ou um aumento na concentração de guanosino monofosfato cíclico (cgmp), ou ambos, ou uma sobrerregulação da rota de no é desejável. os compostos apresentam a fórmula i: fórmula i.
BR112019004468A 2016-09-02 2017-09-01 estimulantes de sgc BR112019004468A2 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662382942P 2016-09-02 2016-09-02
US201662423445P 2016-11-17 2016-11-17
US201762468598P 2017-03-08 2017-03-08
US201762482486P 2017-04-06 2017-04-06
PCT/US2017/049834 WO2018045276A1 (en) 2016-09-02 2017-09-01 Fused bicyclic sgc stimulators

Publications (1)

Publication Number Publication Date
BR112019004468A2 true BR112019004468A2 (pt) 2019-05-28

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BR112019004468A BR112019004468A2 (pt) 2016-09-02 2017-09-01 estimulantes de sgc

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