CY1124129T1 - Ενωσεις υποκατεστημενης τετραϋδροκινολινης ως ρυθμιστες του ror γαμμα - Google Patents

Ενωσεις υποκατεστημενης τετραϋδροκινολινης ως ρυθμιστες του ror γαμμα

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Publication number
CY1124129T1
CY1124129T1 CY20211100415T CY211100415T CY1124129T1 CY 1124129 T1 CY1124129 T1 CY 1124129T1 CY 20211100415 T CY20211100415 T CY 20211100415T CY 211100415 T CY211100415 T CY 211100415T CY 1124129 T1 CY1124129 T1 CY 1124129T1
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CY
Cyprus
Prior art keywords
compounds
substituted tetrahydroquinoline
regulators
ror gamma
tetrahydroquinoline compounds
Prior art date
Application number
CY20211100415T
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English (en)
Inventor
Ravi KOTRABASAIAH UJJINAMATADA
Chetan Pandit
Original Assignee
Aurigene Discovery Technologies Limited
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Publication date
Application filed by Aurigene Discovery Technologies Limited filed Critical Aurigene Discovery Technologies Limited
Publication of CY1124129T1 publication Critical patent/CY1124129T1/el

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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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Abstract

Η παρούσα εφεύρεση παρέχει υποκατεστημένη τετραϋδροκινολίνη και σχετικές ενώσεις του τύπου (Ι), που έχουν θεραπευτική χρήση ως ρυθμιστές των ορφανών υποδοχέων που σχετίζονται με τους υποδοχείς ρετινοϊκού οξέος (ROR), πιο συγκεκριμένα ως ρυθμιστές του RORγ. Οι ενώσεις αυτές είναι χρήσιμες στη θεραπεία και την πρόληψη νόσων ή/και διαταραχών, ειδικότερα η χρήση τους σε νόσους ή/και διαταραχές που μεσολαβούνται από τον υποδοχέα RORγ. Η παρούσα εφεύρεση παρέχει επίσης την παρασκευή των ενώσεων και των φαρμακευτικών σκευασμάτων που περιέχουν τουλάχιστον ένα από τα εξής: υποκατεστημένη τετραϋδροκινολίνη ή σχετικές ενώσεις του τύπου (Ι), μαζί με έναν φαρμακευτικά αποδεκτό φορέα, διαλύτη ή έκδοχο αυτού.
CY20211100415T 2015-05-15 2021-05-14 Ενωσεις υποκατεστημενης τετραϋδροκινολινης ως ρυθμιστες του ror γαμμα CY1124129T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN2448CH2015 2015-05-15
PCT/IB2016/052773 WO2016185342A1 (en) 2015-05-15 2016-05-13 Substituted tetrahydroquinolinone compounds as ror gamma modulators

Publications (1)

Publication Number Publication Date
CY1124129T1 true CY1124129T1 (el) 2022-05-27

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US (3) US20180200247A1 (el)
EP (2) EP3294713B1 (el)
JP (2) JP6684516B2 (el)
KR (1) KR20180029971A (el)
CN (2) CN113121497A (el)
AU (2) AU2016262969C1 (el)
BR (1) BR112017024517A2 (el)
CA (1) CA2985547C (el)
CU (1) CU24487B1 (el)
CY (1) CY1124129T1 (el)
DK (1) DK3294713T5 (el)
EA (1) EA036679B1 (el)
ES (1) ES2868175T3 (el)
HK (1) HK1255229A1 (el)
HR (1) HRP20210745T1 (el)
HU (1) HUE054009T2 (el)
IL (2) IL255522B (el)
LT (1) LT3294713T (el)
MX (2) MX2021009561A (el)
MY (1) MY189194A (el)
PH (1) PH12017502052A1 (el)
PL (1) PL3294713T3 (el)
PT (1) PT3294713T (el)
RS (1) RS62016B1 (el)
SI (1) SI3294713T1 (el)
WO (1) WO2016185342A1 (el)

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