CY1122658T1 - Αντισωματα συνδεσης ανθρωπινου cgrp υποδοχεα - Google Patents

Αντισωματα συνδεσης ανθρωπινου cgrp υποδοχεα

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Publication number
CY1122658T1
CY1122658T1 CY20191100989T CY191100989T CY1122658T1 CY 1122658 T1 CY1122658 T1 CY 1122658T1 CY 20191100989 T CY20191100989 T CY 20191100989T CY 191100989 T CY191100989 T CY 191100989T CY 1122658 T1 CY1122658 T1 CY 1122658T1
Authority
CY
Cyprus
Prior art keywords
cgrp
receptor binding
cgrp receptor
binding antibodies
human cgrp
Prior art date
Application number
CY20191100989T
Other languages
English (en)
Inventor
David W. Brankow
Jr. Colin V. Gegg
Shaw-Fen Sylvia Hu
Chadwick T. King
Hsieng Sen Lu
Licheng Shi
Cen XU
Thomas Charles Boone
Original Assignee
Amgen Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc. filed Critical Amgen Inc.
Publication of CY1122658T1 publication Critical patent/CY1122658T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/32—Immunoglobulins specific features characterized by aspects of specificity or valency specific for a neo-epitope on a complex, e.g. antibody-antigen or ligand-receptor
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

Abstract

Παρέχονται πρωτεΐνες σύνδεσης-αντιγόνου που συνδέονται προς ανθρώπινο CGRP υποδοχέα (CGRP R). Παρέχονται επίσης νουκλεϊνικά οξέα, τα οποία κωδικοποιούν την πρωτεΐνη σύνδεσης αντιγόνου, τους φορείς και τα κύτταρα που τα κωδικοποιούν. Οι πρωτεΐνες σύνδεσης-αντιγόνου μπορεί να αναστέλλουν τη σύνδεση του CGRP R προς CGRP και είναι χρήσιμες σε έναν αριθμό σχετικών με CGRP R διαταραχών, που συμπεριλαμβάνουν τη θεραπεία και/ή την πρόληψη κεφαλαλγιών ημικρανίας.
CY20191100989T 2008-12-23 2019-09-19 Αντισωματα συνδεσης ανθρωπινου cgrp υποδοχεα CY1122658T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US20356908P 2008-12-23 2008-12-23
US26462209P 2009-11-25 2009-11-25
EP09775072.3A EP2379594B8 (en) 2008-12-23 2009-12-18 Human cgrp receptor binding antibodies
PCT/US2009/068858 WO2010075238A1 (en) 2008-12-23 2009-12-18 Human cgrp receptor binding proteins

Publications (1)

Publication Number Publication Date
CY1122658T1 true CY1122658T1 (el) 2021-03-12

Family

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CY20171100901T CY1119465T1 (el) 2008-12-23 2017-08-28 Αντισωματα συνδεσης ανθρωπινου cgrp υποδοχεα
CY2018032C CY2018032I1 (el) 2008-12-23 2018-12-04 Αντισωματα συνδεσης ανθρωπινου cgrp υποδοχεα
CY20191100989T CY1122658T1 (el) 2008-12-23 2019-09-19 Αντισωματα συνδεσης ανθρωπινου cgrp υποδοχεα

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CY20171100901T CY1119465T1 (el) 2008-12-23 2017-08-28 Αντισωματα συνδεσης ανθρωπινου cgrp υποδοχεα
CY2018032C CY2018032I1 (el) 2008-12-23 2018-12-04 Αντισωματα συνδεσης ανθρωπινου cgrp υποδοχεα

Country Status (40)

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US (6) US9102731B2 (el)
EP (3) EP3569620A1 (el)
JP (6) JP5761805B2 (el)
KR (4) KR101740615B1 (el)
CN (2) CN102348722B (el)
AR (1) AR074857A1 (el)
AU (2) AU2009330175C1 (el)
BR (2) BR122020010360B1 (el)
CA (1) CA2746858C (el)
CL (1) CL2011001578A1 (el)
CO (1) CO6400232A2 (el)
CR (1) CR20110400A (el)
CY (3) CY1119465T1 (el)
DK (2) DK3184546T3 (el)
EA (2) EA201891500A3 (el)
ES (2) ES2746571T3 (el)
HR (2) HRP20171690T1 (el)
HU (3) HUE034506T2 (el)
IL (2) IL213429A (el)
JO (2) JO3382B1 (el)
LT (3) LT2379594T (el)
LU (1) LUC00095I2 (el)
MA (1) MA32982B1 (el)
ME (1) ME03601B (el)
MX (1) MX2011006804A (el)
MY (1) MY180564A (el)
NL (1) NL300961I2 (el)
NO (2) NO2379594T3 (el)
NZ (2) NZ606090A (el)
PE (1) PE20120427A1 (el)
PL (2) PL2379594T3 (el)
PT (2) PT3184546T (el)
RS (2) RS56567B1 (el)
SG (2) SG172307A1 (el)
SI (2) SI2379594T1 (el)
TN (1) TN2011000283A1 (el)
TW (4) TW202241950A (el)
UA (1) UA108066C2 (el)
WO (1) WO2010075238A1 (el)
ZA (1) ZA201105418B (el)

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