CY1121944T1 - Σταθεροποιημενες πρωτεϊνες για ανοσοποιηση εναντι staphylococcus aureus - Google Patents
Σταθεροποιημενες πρωτεϊνες για ανοσοποιηση εναντι staphylococcus aureusInfo
- Publication number
- CY1121944T1 CY1121944T1 CY20191100727T CY191100727T CY1121944T1 CY 1121944 T1 CY1121944 T1 CY 1121944T1 CY 20191100727 T CY20191100727 T CY 20191100727T CY 191100727 T CY191100727 T CY 191100727T CY 1121944 T1 CY1121944 T1 CY 1121944T1
- Authority
- CY
- Cyprus
- Prior art keywords
- staphylococcus aureus
- immunization against
- against staphylococcus
- stabilized proteins
- cysteine
- Prior art date
Links
- 241000191967 Staphylococcus aureus Species 0.000 title 1
- 230000003053 immunization Effects 0.000 title 1
- 238000002649 immunization Methods 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 2
- 235000018417 cysteine Nutrition 0.000 abstract 2
- 238000006664 bond formation reaction Methods 0.000 abstract 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
- C07K14/31—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F) from Staphylococcus (G)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Abstract
Εξάλειψη σχηματισμού δεσμού δισουλφιδίου αντιγόνων S.aureus που περιέχουν κυστεΐνη ενισχύει σταθερότητα αντιγόνου. Η εφεύρεση παρέχει παραλλακτικές μορφές περιέχοντος κυστεΐνη αντιγόνου S.aureus με μετάλλαξη σημείου που αντικαθιστά, απαλείφει ή τροποποιεί το υπόλειμμα κυστεΐνης.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261695723P | 2012-08-31 | 2012-08-31 | |
PCT/EP2013/067853 WO2014033190A1 (en) | 2012-08-31 | 2013-08-29 | Stabilised proteins for immunising against staphylococcus aureus |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1121944T1 true CY1121944T1 (el) | 2020-10-14 |
Family
ID=49036594
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20191100727T CY1121944T1 (el) | 2012-08-31 | 2019-07-10 | Σταθεροποιημενες πρωτεϊνες για ανοσοποιηση εναντι staphylococcus aureus |
Country Status (15)
Country | Link |
---|---|
US (1) | US9926344B2 (el) |
EP (1) | EP2890394B1 (el) |
JP (1) | JP6435261B2 (el) |
CN (2) | CN110563818A (el) |
CY (1) | CY1121944T1 (el) |
DK (1) | DK2890394T3 (el) |
ES (1) | ES2737024T3 (el) |
HR (1) | HRP20191166T1 (el) |
HU (1) | HUE044211T2 (el) |
LT (1) | LT2890394T (el) |
PL (1) | PL2890394T3 (el) |
PT (1) | PT2890394T (el) |
SI (1) | SI2890394T1 (el) |
TR (1) | TR201910573T4 (el) |
WO (1) | WO2014033190A1 (el) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20140066212A (ko) * | 2011-09-01 | 2014-05-30 | 노파르티스 아게 | 스타필로코쿠스 아우레우스 항원의 보조제 첨가된 조제물 |
CA2942450A1 (en) | 2014-03-26 | 2015-10-01 | Glaxosmithkline Biologicals S.A. | Mutant staphylococcal antigens |
WO2018089932A1 (en) | 2016-11-14 | 2018-05-17 | Lilac Solutions, Inc. | Lithium extraction with coated ion exchange particles |
JP6916042B2 (ja) * | 2017-06-09 | 2021-08-11 | 株式会社明治 | 抗原特異的インターフェロンγ産生促進用組成物 |
AR112663A1 (es) | 2017-08-02 | 2019-11-27 | Lilac Solutions Inc | Extracción de litio con perlas porosas de intercambio iónico |
JP7427598B2 (ja) | 2018-02-28 | 2024-02-05 | ライラック ソリューションズ,インク. | リチウム抽出用の粒子トラップを備えたイオン交換反応器 |
CA3166921A1 (en) | 2020-01-09 | 2021-07-15 | Lilac Solutions, Inc. | Process for separating undesirable metals |
CN111595658B (zh) * | 2020-06-06 | 2023-11-14 | 宾傲 | 一种提取细胞中蛋白的裂解液及其制备方法 |
JP2023529444A (ja) | 2020-06-09 | 2023-07-10 | ライラック ソリューションズ,インク. | スケール物質存在下におけるリチウム抽出 |
CA3199218A1 (en) | 2020-11-20 | 2022-05-27 | David Henry SNYDACKER | Lithium production with volatile acid |
AR125722A1 (es) | 2021-04-23 | 2023-08-09 | Lilac Solutions Inc | Dispositivos de intercambio iónico para la extracción de litio |
Family Cites Families (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS624300A (ja) * | 1985-06-28 | 1987-01-10 | Dai Ichi Seiyaku Co Ltd | 改良型ヒトガンマインタ−フエロンおよびその製造方法 |
DE68929273T2 (de) * | 1988-08-24 | 2001-07-05 | American Cyanamid Co | Stabilisierung von Somatotropinen durch Modifikation von Cystein-Resten durch orts-spezifische Mutagenese oder chemische Derivatisierung |
JPH0832638B2 (ja) | 1989-05-25 | 1996-03-29 | カイロン コーポレイション | サブミクロン油滴乳剤を含んで成るアジュバント製剤 |
US5874238A (en) * | 1993-02-26 | 1999-02-23 | Immtech International Inc. | Mutant protein and methods and materials for making and using it |
AU5543294A (en) | 1993-10-29 | 1995-05-22 | Pharmos Corp. | Submicron emulsions as vaccine adjuvants |
US6080725A (en) | 1997-05-20 | 2000-06-27 | Galenica Pharmaceuticals, Inc. | Immunostimulating and vaccine compositions employing saponin analog adjuvants and uses thereof |
CN1306438A (zh) | 1998-05-07 | 2001-08-01 | 科里克萨有限公司 | 佐剂组合物及其使用方法 |
EP1126876B1 (en) | 1998-10-16 | 2007-03-21 | GlaxoSmithKline Biologicals S.A. | Adjuvant systems and vaccines |
GB9825421D0 (en) * | 1998-11-19 | 1999-01-13 | Isis Innovation | Process for oxidising terpenes |
DK1150918T3 (da) | 1999-02-03 | 2004-12-20 | Biosante Pharmaceuticals Inc | Fremgangsmåde til fremstilling af terapeutiske calciumphosphatpartikler |
KR100382239B1 (ko) * | 2000-02-17 | 2003-04-26 | 주식회사 엘지생명과학 | 황색 포도상 구균의 변이 독소 에스이씨-에스이알, 그것의발현벡터 및 숙주세포, 그 생산방법 및 백신제조방법 |
DE60129432T2 (de) | 2000-05-16 | 2008-04-17 | Bolder Biotechnology, Inc., Louisville | Verfahren zur rückfaltung von proteinen mit freien cysteinresten |
GB0107661D0 (en) | 2001-03-27 | 2001-05-16 | Chiron Spa | Staphylococcus aureus |
NZ550152A (en) | 2004-04-05 | 2009-04-30 | Pfizer Prod Inc | Microfluidized oil-in-water emulsions and vaccine compositions |
US20060228369A1 (en) | 2005-04-11 | 2006-10-12 | Program For Appropriate Technology In Health | Stabilization and preservation of temperature-sensitive vaccines |
US7691368B2 (en) | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
US8703095B2 (en) | 2005-07-07 | 2014-04-22 | Sanofi Pasteur S.A. | Immuno-adjuvant emulsion |
EP2471550A1 (en) * | 2005-10-07 | 2012-07-04 | Health Protection Agency | Proteins with improved solubility and methods for producing and using same |
FR2896162B1 (fr) | 2006-01-13 | 2008-02-15 | Sanofi Pasteur Sa | Emulsion huile dans eau thermoreversible |
CA2637598A1 (en) | 2006-01-18 | 2007-02-14 | University Of Chicago | Compositions and methods related to staphylococcal bacterium proteins |
WO2008043774A1 (en) | 2006-10-12 | 2008-04-17 | Glaxosmithkline Biologicals S.A. | Vaccine comprising an oil in water emulsion adjuvant |
UY31930A (es) * | 2008-06-25 | 2010-01-29 | Boheringer Ingelheim Pharma Kg | Pestivirus atenuados recombinantes, en particular a csfv, bvdv o bdv atenuado recombinante |
EP2510947B1 (en) * | 2009-04-14 | 2016-02-10 | GlaxoSmithKline Biologicals SA | Compositions for immunising against Staphylococcus aureus |
MX2012002723A (es) | 2009-09-02 | 2012-04-11 | Novartis Ag | Composiciones inmunogenicas que incluyen moduladores de la actividad de receptores tipo toll. |
AU2010352695B2 (en) * | 2009-09-30 | 2014-08-21 | Glaxosmithkline Biologicals S.A. | Conjugation of Staphylococcus aureus type 5 and type 8 capsular polysaccharides |
BR122019005883A8 (pt) * | 2009-10-30 | 2022-10-04 | Novartis Ag | Método para liberação de polissacarídeo capsular, processo de purificação de sacarídeos capsulares tipo 5 e tipo 8 de staphylococcus aureus e composição |
JP2011212008A (ja) * | 2010-03-16 | 2011-10-27 | Olympus Corp | 蛍光タンパク質およびpH測定方法 |
KR20140066212A (ko) * | 2011-09-01 | 2014-05-30 | 노파르티스 아게 | 스타필로코쿠스 아우레우스 항원의 보조제 첨가된 조제물 |
JP2015500864A (ja) | 2011-12-23 | 2015-01-08 | ノバルティス アーゲー | 黄色ブドウ球菌(Staphylococcusaureus)に対して免疫するための安定な組成物 |
-
2013
- 2013-08-29 JP JP2015529011A patent/JP6435261B2/ja active Active
- 2013-08-29 ES ES13753327T patent/ES2737024T3/es active Active
- 2013-08-29 PT PT13753327T patent/PT2890394T/pt unknown
- 2013-08-29 LT LTEP13753327.9T patent/LT2890394T/lt unknown
- 2013-08-29 EP EP13753327.9A patent/EP2890394B1/en active Active
- 2013-08-29 DK DK13753327.9T patent/DK2890394T3/da active
- 2013-08-29 CN CN201910909421.9A patent/CN110563818A/zh active Pending
- 2013-08-29 US US14/420,831 patent/US9926344B2/en active Active
- 2013-08-29 CN CN201380042881.7A patent/CN104619336A/zh active Pending
- 2013-08-29 SI SI201331461T patent/SI2890394T1/sl unknown
- 2013-08-29 HU HUE13753327 patent/HUE044211T2/hu unknown
- 2013-08-29 PL PL13753327T patent/PL2890394T3/pl unknown
- 2013-08-29 TR TR2019/10573T patent/TR201910573T4/tr unknown
- 2013-08-29 WO PCT/EP2013/067853 patent/WO2014033190A1/en active Application Filing
-
2019
- 2019-06-27 HR HRP20191166TT patent/HRP20191166T1/hr unknown
- 2019-07-10 CY CY20191100727T patent/CY1121944T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2737024T3 (es) | 2020-01-09 |
EP2890394B1 (en) | 2019-05-01 |
HUE044211T2 (hu) | 2019-10-28 |
EP2890394A1 (en) | 2015-07-08 |
DK2890394T3 (da) | 2019-07-15 |
US20150203542A1 (en) | 2015-07-23 |
PL2890394T3 (pl) | 2019-12-31 |
CN104619336A (zh) | 2015-05-13 |
JP2015528455A (ja) | 2015-09-28 |
US9926344B2 (en) | 2018-03-27 |
SI2890394T1 (sl) | 2019-06-28 |
CN110563818A (zh) | 2019-12-13 |
LT2890394T (lt) | 2019-07-25 |
JP6435261B2 (ja) | 2018-12-05 |
WO2014033190A1 (en) | 2014-03-06 |
HRP20191166T1 (hr) | 2019-10-04 |
TR201910573T4 (tr) | 2019-08-21 |
PT2890394T (pt) | 2019-07-15 |
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