CY1120993T1 - ΠΑΡΑΓΩΓΑ CIS-ΤΕΤΡΑΫΔΡΟ-ΣΠΕΙΡΟ(ΚΥΚΛΟΕΞΑΝ-1,1'-ΠΥΡΙΔΟ[3,4-b]ΙΝΔΟΛ)-4-ΑΜΙΝΗΣ - Google Patents

ΠΑΡΑΓΩΓΑ CIS-ΤΕΤΡΑΫΔΡΟ-ΣΠΕΙΡΟ(ΚΥΚΛΟΕΞΑΝ-1,1'-ΠΥΡΙΔΟ[3,4-b]ΙΝΔΟΛ)-4-ΑΜΙΝΗΣ

Info

Publication number
CY1120993T1
CY1120993T1 CY181101335T CY181101335T CY1120993T1 CY 1120993 T1 CY1120993 T1 CY 1120993T1 CY 181101335 T CY181101335 T CY 181101335T CY 181101335 T CY181101335 T CY 181101335T CY 1120993 T1 CY1120993 T1 CY 1120993T1
Authority
CY
Cyprus
Prior art keywords
pain
pyrido
tetrahydro
cis
amine
Prior art date
Application number
CY181101335T
Other languages
English (en)
Inventor
Klaus Linz
Saskia Zemolka
Bert Nolte
Stefan Schunk
Hans Schick
Original Assignee
Gruenenthal Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44315152&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1120993(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gruenenthal Gmbh filed Critical Gruenenthal Gmbh
Publication of CY1120993T1 publication Critical patent/CY1120993T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Η εφεύρεση αφορά παράγωγα cis-τετραϋδρο-σπειρο(κυκλοεξαν-1,1'-πυριδο[3,4-ο]ινδολ)-4-αμίνης για τη χρήση στην αγωγή νευροπαθητικού και/ή χρόνιου πόνου, τα οποία επιδρούν στο σύστημα υποδοχέα νοσισεπτίνης/ORL-1, καθώς επίσης στο σύστημα υποδοχέα μ-οπιοειδούς και χαρακτηρίζονται ειδικότερα από μία εκλεκτική δραστικότητα κατά την αγωγή του χρόνιου πόνου (μεταξύ άλλων πόνου φλεγμονής, σπλαχνικού πόνου, πόνου όγκου, κατά προτίμηση νευροπαθητικού πόνου), χωρίς συγχρόνως να αναπτύσσουν μία έντονη δραστικότητα στον οξύ αλγαισθητικό πόνο.
CY181101335T 2010-07-28 2018-12-12 ΠΑΡΑΓΩΓΑ CIS-ΤΕΤΡΑΫΔΡΟ-ΣΠΕΙΡΟ(ΚΥΚΛΟΕΞΑΝ-1,1'-ΠΥΡΙΔΟ[3,4-b]ΙΝΔΟΛ)-4-ΑΜΙΝΗΣ CY1120993T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10007822 2010-07-28
PCT/EP2011/003771 WO2012013343A1 (de) 2010-07-28 2011-07-27 Cis-tetrahydro-spiro(cyclohexan-1,1'-pyrido[3,4-b]indol)-4-amin-derivate
EP11737904.0A EP2598503B1 (de) 2010-07-28 2011-07-27 Cis-tetrahydro-spiro(cyclohexan-1,1'-pyrido[3,4-b]indol)-4-amin-derivate

Publications (1)

Publication Number Publication Date
CY1120993T1 true CY1120993T1 (el) 2019-12-11

Family

ID=44315152

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20141100338T CY1115186T1 (el) 2010-07-28 2014-05-13 Παραγωγα cis-τετραϋδρο-σπειρο(κυκλοεξανο-1,1'-πυριδο[3,4-b]ινδολ)-4-αμινης
CY181101335T CY1120993T1 (el) 2010-07-28 2018-12-12 ΠΑΡΑΓΩΓΑ CIS-ΤΕΤΡΑΫΔΡΟ-ΣΠΕΙΡΟ(ΚΥΚΛΟΕΞΑΝ-1,1'-ΠΥΡΙΔΟ[3,4-b]ΙΝΔΟΛ)-4-ΑΜΙΝΗΣ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20141100338T CY1115186T1 (el) 2010-07-28 2014-05-13 Παραγωγα cis-τετραϋδρο-σπειρο(κυκλοεξανο-1,1'-πυριδο[3,4-b]ινδολ)-4-αμινης

Country Status (32)

Country Link
US (3) US20120029006A1 (el)
EP (2) EP2598503B1 (el)
JP (1) JP5898193B2 (el)
KR (1) KR101927054B1 (el)
CN (1) CN103025732B (el)
AR (1) AR082393A1 (el)
AU (1) AU2011285217B8 (el)
BR (1) BR112013003642A2 (el)
CA (1) CA2806633C (el)
CL (1) CL2013000266A1 (el)
CO (1) CO6650378A2 (el)
CY (2) CY1115186T1 (el)
DK (2) DK2740476T3 (el)
EC (1) ECSP13012409A (el)
ES (2) ES2474644T3 (el)
HK (1) HK1183660A1 (el)
HR (2) HRP20140569T1 (el)
HU (1) HUE042732T2 (el)
IL (1) IL223756A (el)
LT (1) LT2740476T (el)
MX (1) MX2013000751A (el)
NZ (1) NZ607529A (el)
PE (1) PE20130808A1 (el)
PL (2) PL2740476T3 (el)
PT (2) PT2598503E (el)
RS (2) RS53341B (el)
RU (1) RU2592283C2 (el)
SI (2) SI2740476T1 (el)
TR (1) TR201821273T4 (el)
TW (1) TWI582092B (el)
WO (1) WO2012013343A1 (el)
ZA (1) ZA201301505B (el)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX360290B (es) 2013-03-15 2018-10-29 Gruenenthal Gmbh Cis-(e)-4-(3-fluorofenil)-2',3',4,9'-tetrahidro-n,n-dimetil-2'-(1 -oxo-3-fenil-2-propenil)-espiro[ciclohexan-1,1'[1h]-pirido[3,4-b] indol]-4-amina cristalina.
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
US9907786B2 (en) 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
RS60855B1 (sr) 2016-01-13 2020-10-30 Gruenenthal Gmbh Derivati 8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana
RS60307B1 (sr) 2016-01-13 2020-07-31 Gruenenthal Gmbh Derivati 3-((hetero-)aril)-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana
DK3402783T3 (da) 2016-01-13 2020-05-04 Gruenenthal Gmbh 3-(carboxyethyl)-8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decan-derivater
AR107358A1 (es) * 2016-01-13 2018-04-25 Gruenenthal Gmbh Derivados de 3-(carboximetil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano
ES2797904T3 (es) 2016-01-13 2020-12-04 Gruenenthal Gmbh Derivados de 3-((hetero)aril)alquil-8-amino-2-oxo-1,3-diazaespiro-[4.5]-decano
PL3407888T3 (pl) 2016-01-26 2021-08-30 Intra-Cellular Therapies, Inc. Związki pirydopirolochinoksaliny, ich kompozycje i zastosowania
TW201832765A (zh) * 2017-02-24 2018-09-16 德商歌林達有限公司 膀胱內投藥用於治療膀胱痛之組合物
TW201908295A (zh) 2017-07-12 2019-03-01 德商歌林達有限公司 １，３－二氮雜－螺－［３．４］－辛烷衍生物
JP2019073493A (ja) 2017-10-17 2019-05-16 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ヴルヴォディニアの治療
WO2020030777A1 (en) 2018-08-10 2020-02-13 Grünenthal GmbH Composition for treating urinary frequency and/or urinary urgency
US20220184072A1 (en) * 2019-04-04 2022-06-16 Intra-Cellular Therapies, Inc. Methods of treating neuropathic pain
JP2023508469A (ja) 2019-12-26 2023-03-02 ギルガメッシュ・ファーマシューティカルズ・インコーポレイテッド アリールシクロヘキシルアミン誘導体及び精神障害の処置におけるそれらの使用
RU2725197C1 (ru) * 2020-02-12 2020-06-30 федеральное государственное бюджетное образовательное учреждение высшего образования «Ижевская государственная медицинская академия» Министерства здравоохранения Российской Федерации Метод оценки висцеральной гиперчувствительности
MX2022010082A (es) 2020-02-18 2022-11-14 Gilgamesh Pharmaceuticals Inc Triptaminas especificas para usarse en el tratamiento de trastornos de estado de animo.

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10323172A1 (de) 2003-05-22 2004-12-09 Ina-Schaeffler Kg Treiberstufe für ein Solenoidventil
DE10360792A1 (de) 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360793A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102004019502A1 (de) 2004-04-22 2005-11-17 Rheinmetall Landsysteme Gmbh Munitionsmagazin
DE102004039382A1 (de) 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
US8425881B2 (en) 2005-03-18 2013-04-23 Colgate-Palmolive Company Antibacterial 3′,5-disubstituted 2,4′-dihydroxybiphenyl compounds, derivatives and related methods
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
EP1869344A2 (en) 2005-04-12 2007-12-26 The Ohio State University All wheel drive electrically-variable transmission
US20090246774A1 (en) 2006-03-30 2009-10-01 Mehar Singh Khatkar Chromosomal Blocks as Markers for Traits
WO2007117173A1 (en) 2006-04-07 2007-10-18 Closed Joint Stock Company 'biocad' Fluid dispensing system, methods and products
DE102006019597A1 (de) 2006-04-27 2007-10-31 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006033114A1 (de) 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
WO2008100941A2 (en) 2007-02-12 2008-08-21 Correlogic Systems Inc. A method for calibrating an analytical instrument
MX2010009955A (es) * 2008-03-27 2010-09-30 Gruenenthal Gmbh Derivados de ciclohexano espirociclicos sustituidos.
MX360290B (es) * 2013-03-15 2018-10-29 Gruenenthal Gmbh Cis-(e)-4-(3-fluorofenil)-2',3',4,9'-tetrahidro-n,n-dimetil-2'-(1 -oxo-3-fenil-2-propenil)-espiro[ciclohexan-1,1'[1h]-pirido[3,4-b] indol]-4-amina cristalina.

Also Published As

Publication number Publication date
US20120029006A1 (en) 2012-02-02
KR20130098315A (ko) 2013-09-04
ECSP13012409A (es) 2013-06-28
PE20130808A1 (es) 2013-07-06
LT2740476T (lt) 2018-12-27
CL2013000266A1 (es) 2013-05-24
EP2598503B1 (de) 2014-03-26
HRP20182078T1 (hr) 2019-02-08
HRP20140569T1 (hr) 2014-08-15
JP5898193B2 (ja) 2016-04-06
HK1183660A1 (en) 2014-01-03
PL2740476T3 (pl) 2019-06-28
TR201821273T4 (tr) 2019-01-21
CN103025732B (zh) 2016-06-01
CA2806633C (en) 2019-08-20
IL223756A (en) 2015-06-30
CN103025732A (zh) 2013-04-03
BR112013003642A2 (pt) 2016-09-06
CO6650378A2 (es) 2013-04-15
PT2740476T (pt) 2019-03-18
ES2708930T3 (es) 2019-04-12
RS58036B1 (sr) 2019-02-28
ZA201301505B (en) 2014-08-27
ES2474644T3 (es) 2014-07-09
JP2013532669A (ja) 2013-08-19
RS53341B (en) 2014-10-31
NZ607529A (en) 2014-05-30
PL2598503T3 (pl) 2014-08-29
SI2740476T1 (sl) 2019-02-28
AU2011285217B8 (en) 2014-04-24
WO2012013343A1 (de) 2012-02-02
CY1115186T1 (el) 2017-01-04
KR101927054B1 (ko) 2018-12-10
AU2011285217A8 (en) 2014-04-24
US20160159787A1 (en) 2016-06-09
EP2740476A1 (de) 2014-06-11
CA2806633A1 (en) 2012-02-02
DK2598503T3 (da) 2014-04-14
SI2598503T1 (sl) 2014-05-30
AU2011285217B2 (en) 2014-04-10
RU2013108696A (ru) 2014-09-10
EP2740476B1 (de) 2018-12-05
MX2013000751A (es) 2013-01-29
DK2740476T3 (en) 2019-01-14
TWI582092B (zh) 2017-05-11
HUE042732T2 (hu) 2019-07-29
TW201204724A (en) 2012-02-01
RU2592283C2 (ru) 2016-07-20
US20170313703A1 (en) 2017-11-02
EP2598503A1 (de) 2013-06-05
AU2011285217A1 (en) 2013-03-14
AR082393A1 (es) 2012-12-05
PT2598503E (pt) 2014-05-06

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