HRP20182078T1 - Derivati cis-tetrahidro-spiro(cikloheksan-1,1’-pirido[3,4-b]indol)-4-amina - Google Patents

Derivati cis-tetrahidro-spiro(cikloheksan-1,1’-pirido[3,4-b]indol)-4-amina

Info

Publication number
HRP20182078T1
HRP20182078T1 HRP20182078TT HRP20182078T HRP20182078T1 HR P20182078 T1 HRP20182078 T1 HR P20182078T1 HR P20182078T T HRP20182078T T HR P20182078TT HR P20182078 T HRP20182078 T HR P20182078T HR P20182078 T1 HRP20182078 T1 HR P20182078T1
Authority
HR
Croatia
Prior art keywords
cyclohexan
amin
derivate
pyrido
indol
Prior art date
Application number
HRP20182078TT
Other languages
English (en)
Inventor
Klaus Linz
Saskia Zemolka
Bert Nolte
Stefan Schunk
Hans Schick
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=44315152&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HRP20182078(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of HRP20182078T1 publication Critical patent/HRP20182078T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HRP20182078TT 2010-07-28 2018-12-10 Derivati cis-tetrahidro-spiro(cikloheksan-1,1’-pirido[3,4-b]indol)-4-amina HRP20182078T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10007822 2010-07-28
EP14000496.1A EP2740476B1 (de) 2010-07-28 2011-07-27 Cis-Tetrahydro-Spiro(Cyclohexan-1,1'-Pyrido[3,4-b]Indol)-4-Amin-Derivate

Publications (1)

Publication Number Publication Date
HRP20182078T1 true HRP20182078T1 (hr) 2019-02-08

Family

ID=44315152

Family Applications (2)

Application Number Title Priority Date Filing Date
HRP20140569AT HRP20140569T1 (hr) 2010-07-28 2014-06-17 Derivati cis-tetrahidro-spiro(cikloheksan-1,1'-pirido[3,4-b]indol)-4-amina
HRP20182078TT HRP20182078T1 (hr) 2010-07-28 2018-12-10 Derivati cis-tetrahidro-spiro(cikloheksan-1,1’-pirido[3,4-b]indol)-4-amina

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HRP20140569AT HRP20140569T1 (hr) 2010-07-28 2014-06-17 Derivati cis-tetrahidro-spiro(cikloheksan-1,1'-pirido[3,4-b]indol)-4-amina

Country Status (32)

Country Link
US (3) US20120029006A1 (hr)
EP (2) EP2598503B1 (hr)
JP (1) JP5898193B2 (hr)
KR (1) KR101927054B1 (hr)
CN (1) CN103025732B (hr)
AR (1) AR082393A1 (hr)
AU (1) AU2011285217B8 (hr)
BR (1) BR112013003642A2 (hr)
CA (1) CA2806633C (hr)
CL (1) CL2013000266A1 (hr)
CO (1) CO6650378A2 (hr)
CY (2) CY1115186T1 (hr)
DK (2) DK2598503T3 (hr)
EC (1) ECSP13012409A (hr)
ES (2) ES2474644T3 (hr)
HK (1) HK1183660A1 (hr)
HR (2) HRP20140569T1 (hr)
HU (1) HUE042732T2 (hr)
IL (1) IL223756A (hr)
LT (1) LT2740476T (hr)
MX (1) MX2013000751A (hr)
NZ (1) NZ607529A (hr)
PE (1) PE20130808A1 (hr)
PL (2) PL2598503T3 (hr)
PT (2) PT2598503E (hr)
RS (2) RS53341B (hr)
RU (1) RU2592283C2 (hr)
SI (2) SI2740476T1 (hr)
TR (1) TR201821273T4 (hr)
TW (1) TWI582092B (hr)
WO (1) WO2012013343A1 (hr)
ZA (1) ZA201301505B (hr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9296749B2 (en) 2013-03-15 2016-03-29 Gruenenthal Gmbh Crystalline cis-(E)-4-(3-fluorophenyl)-2′,3′,4′,9′-tetrahydro-N,N-dimethyl-2′-(1-oxo-3-phenyl-2-propenyl)-spiro[cyclohexane-1,1′[1H]
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
US9907786B2 (en) 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
RS60315B1 (sr) 2016-01-13 2020-07-31 Gruenenthal Gmbh Derivati 3-((hetero-)aril)-alkil-8-amino-2-okso-1,3-diaza-spiro-[4.5]-dekana
CA3011182A1 (en) 2016-01-13 2017-07-20 Grunenthal Gmbh 8-amino-2-oxo-1,3-diaza-spiro-[4.5]-decane derivatives
BR112018014305B1 (pt) 2016-01-13 2023-10-17 Grünenthal GmbH Derivados de 3-((hetero-)aril)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano
AR107361A1 (es) 2016-01-13 2018-04-25 Gruenenthal Gmbh Derivados de 3-(carboxietil)-8-amino-2-oxo-1,3-diaza-espiro-[4.5]-decano
SI3402785T1 (sl) * 2016-01-13 2020-07-31 Gruenenthal Gmbh Derivati 3-(karboksimetil)-8-amino-2-okso-1,3-diaza-spiro-(4.5)-dekana
HUE053737T2 (hu) 2016-01-26 2021-07-28 Intra Cellular Therapies Inc Piridopirrolokinoxalin vegyületek, készítményeik és alkalmazásaik
TW201832765A (zh) 2017-02-24 2018-09-16 德商歌林達有限公司 膀胱內投藥用於治療膀胱痛之組合物
TW201908295A (zh) 2017-07-12 2019-03-01 德商歌林達有限公司 １，３－二氮雜－螺－［３．４］－辛烷衍生物
JP2019073493A (ja) * 2017-10-17 2019-05-16 グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング ヴルヴォディニアの治療
WO2020030777A1 (en) 2018-08-10 2020-02-13 Grünenthal GmbH Composition for treating urinary frequency and/or urinary urgency
US20220184072A1 (en) * 2019-04-04 2022-06-16 Intra-Cellular Therapies, Inc. Methods of treating neuropathic pain
WO2021134086A1 (en) 2019-12-26 2021-07-01 Gilgamesh Pharmaceuticals, Inc. Arylcyclohexylamine derivatives and their use in the treatment of psychiatric disorders
RU2725197C1 (ru) * 2020-02-12 2020-06-30 федеральное государственное бюджетное образовательное учреждение высшего образования «Ижевская государственная медицинская академия» Министерства здравоохранения Российской Федерации Метод оценки висцеральной гиперчувствительности
CN117503759A (zh) 2020-02-18 2024-02-06 吉尔伽美什制药公司 用于治疗情绪障碍的特定色胺

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10252667A1 (de) * 2002-11-11 2004-05-27 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10323172A1 (de) 2003-05-22 2004-12-09 Ina-Schaeffler Kg Treiberstufe für ein Solenoidventil
DE10360792A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE10360793A1 (de) * 2003-12-23 2005-07-28 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102004019502A1 (de) 2004-04-22 2005-11-17 Rheinmetall Landsysteme Gmbh Munitionsmagazin
DE102004039382A1 (de) 2004-08-13 2006-02-23 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
US8425881B2 (en) 2005-03-18 2013-04-23 Colgate-Palmolive Company Antibacterial 3′,5-disubstituted 2,4′-dihydroxybiphenyl compounds, derivatives and related methods
DE102005016460A1 (de) * 2005-04-11 2006-10-19 Grünenthal GmbH Spriocyclische Cyclohexanderivate zur Behandlung von Substanzabhängigkeit
EP1869344A2 (en) 2005-04-12 2007-12-26 The Ohio State University All wheel drive electrically-variable transmission
EP1996722A4 (en) 2006-03-30 2009-09-09 Innovative Dairy Products Pty CHROMOSOMAL BLOCKS AS A MARKER FOR PROPERTIES
WO2007117173A1 (en) 2006-04-07 2007-10-18 Closed Joint Stock Company 'biocad' Fluid dispensing system, methods and products
DE102006019597A1 (de) * 2006-04-27 2007-10-31 Grünenthal GmbH Spirocyclische Cyclohexan-Derivate
DE102006033114A1 (de) 2006-07-18 2008-01-24 Grünenthal GmbH Spirocyclische Azaindol-Derivate
DE102006046745A1 (de) * 2006-09-29 2008-04-03 Grünenthal GmbH Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz
US20080201095A1 (en) 2007-02-12 2008-08-21 Yip Ping F Method for Calibrating an Analytical Instrument
CN102046633B (zh) * 2008-03-27 2015-03-25 格吕伦塔尔有限公司 取代的螺环状环己烷衍生物
US9296749B2 (en) * 2013-03-15 2016-03-29 Gruenenthal Gmbh Crystalline cis-(E)-4-(3-fluorophenyl)-2′,3′,4′,9′-tetrahydro-N,N-dimethyl-2′-(1-oxo-3-phenyl-2-propenyl)-spiro[cyclohexane-1,1′[1H]

Also Published As

Publication number Publication date
CY1115186T1 (el) 2017-01-04
US20160159787A1 (en) 2016-06-09
ES2708930T3 (es) 2019-04-12
HK1183660A1 (en) 2014-01-03
EP2598503B1 (de) 2014-03-26
CY1120993T1 (el) 2019-12-11
ZA201301505B (en) 2014-08-27
ECSP13012409A (es) 2013-06-28
KR101927054B1 (ko) 2018-12-10
SI2740476T1 (sl) 2019-02-28
ES2474644T3 (es) 2014-07-09
JP2013532669A (ja) 2013-08-19
US20170313703A1 (en) 2017-11-02
MX2013000751A (es) 2013-01-29
SI2598503T1 (sl) 2014-05-30
CN103025732B (zh) 2016-06-01
AU2011285217A8 (en) 2014-04-24
CA2806633C (en) 2019-08-20
JP5898193B2 (ja) 2016-04-06
LT2740476T (lt) 2018-12-27
DK2598503T3 (da) 2014-04-14
PL2740476T3 (pl) 2019-06-28
EP2740476A1 (de) 2014-06-11
RU2013108696A (ru) 2014-09-10
HUE042732T2 (hu) 2019-07-29
CL2013000266A1 (es) 2013-05-24
CN103025732A (zh) 2013-04-03
AU2011285217A1 (en) 2013-03-14
TR201821273T4 (tr) 2019-01-21
HRP20140569T1 (hr) 2014-08-15
TWI582092B (zh) 2017-05-11
PE20130808A1 (es) 2013-07-06
KR20130098315A (ko) 2013-09-04
RU2592283C2 (ru) 2016-07-20
EP2598503A1 (de) 2013-06-05
BR112013003642A2 (pt) 2016-09-06
DK2740476T3 (en) 2019-01-14
PT2598503E (pt) 2014-05-06
TW201204724A (en) 2012-02-01
US20120029006A1 (en) 2012-02-02
AU2011285217B2 (en) 2014-04-10
WO2012013343A1 (de) 2012-02-02
CA2806633A1 (en) 2012-02-02
RS53341B (en) 2014-10-31
AU2011285217B8 (en) 2014-04-24
IL223756A (en) 2015-06-30
PL2598503T3 (pl) 2014-08-29
CO6650378A2 (es) 2013-04-15
EP2740476B1 (de) 2018-12-05
RS58036B1 (sr) 2019-02-28
NZ607529A (en) 2014-05-30
PT2740476T (pt) 2019-03-18
AR082393A1 (es) 2012-12-05

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