CY1119961T1 - Ενδοφθαλμια εμφυτευματα που περιεχουν προσταμιδιο και μεθοδοι χρησης αυτων - Google Patents
Ενδοφθαλμια εμφυτευματα που περιεχουν προσταμιδιο και μεθοδοι χρησης αυτωνInfo
- Publication number
- CY1119961T1 CY1119961T1 CY20181100242T CY181100242T CY1119961T1 CY 1119961 T1 CY1119961 T1 CY 1119961T1 CY 20181100242 T CY20181100242 T CY 20181100242T CY 181100242 T CY181100242 T CY 181100242T CY 1119961 T1 CY1119961 T1 CY 1119961T1
- Authority
- CY
- Cyprus
- Prior art keywords
- methods
- eye
- implants
- prostamide
- intraocular implants
- Prior art date
Links
- 239000007943 implant Substances 0.000 title abstract 4
- AQOKCDNYWBIDND-FTOWTWDKSA-N bimatoprost Chemical compound CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCC1=CC=CC=C1 AQOKCDNYWBIDND-FTOWTWDKSA-N 0.000 title abstract 3
- 229960002470 bimatoprost Drugs 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 230000004410 intraocular pressure Effects 0.000 abstract 2
- 206010030043 Ocular hypertension Diseases 0.000 abstract 1
- 210000002159 anterior chamber Anatomy 0.000 abstract 1
- 229920002988 biodegradable polymer Polymers 0.000 abstract 1
- 239000004621 biodegradable polymer Substances 0.000 abstract 1
- 238000007918 intramuscular administration Methods 0.000 abstract 1
- 229920000747 poly(lactic acid) Polymers 0.000 abstract 1
- 229920001606 poly(lactic acid-co-glycolic acid) Polymers 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
- A61K31/5575—Eicosanoids, e.g. leukotrienes or prostaglandins having a cyclopentane, e.g. prostaglandin E2, prostaglandin F2-alpha
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/14—Eye parts, e.g. lenses, corneal implants; Implanting instruments specially adapted therefor; Artificial eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Inorganic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Cardiology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
- Polyesters Or Polycarbonates (AREA)
Abstract
Ενδοφθάλμια εμφυτεύματα που περιέχουν προσταμίδιο τα οποία αποικοδομούνται εντός του οφθαλμού και τα οποία είναι αποτελεσματικά για τη μείωση της ενδοφθάλμιας πίεσης σε έναν οφθαλμό για μία παρατεταμένη περίοδο. Τα εμφυτεύματα γενικά περιέχουν ένα προσταμίδιο όπως βιματοπρόστη και τουλάχιστον τρία διακριτά βιοαποικοδομήσιμα πολυμερή που επιλέγονται από πολυμερή πολυλακτιδίου και πολυ(λακτιδίου-συν-γλυκολιδίου) και είναι βελτιστοποιημένα για τοποθέτηση εντός και σε συμβατότητα με τον πρόσθιο θάλαμο του οφθαλμού, συγκεκριμένα τη γωνία του προσθίου θαλάμου. Περιγράφονται μέθοδοι για τη δημιουργία και χρήση των εμφυτευμάτων ώστε να μειώνεται η οφθαλμική υπέρταση και η ενδοφθάλμια πίεση σε έναν ασθενή.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361898241P | 2013-10-31 | 2013-10-31 | |
PCT/US2014/063569 WO2015066548A1 (en) | 2013-10-31 | 2014-10-31 | Prostamide-containing intraocular implants and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1119961T1 true CY1119961T1 (el) | 2018-12-12 |
Family
ID=51982758
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100242T CY1119961T1 (el) | 2013-10-31 | 2018-02-27 | Ενδοφθαλμια εμφυτευματα που περιεχουν προσταμιδιο και μεθοδοι χρησης αυτων |
CY20201100577T CY1123077T1 (el) | 2013-10-31 | 2020-06-25 | Ενδοφθαλμια εμφυτευματα που περιεχουν προσταμιδιο και μεθοδοι χρησης αυτων |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20201100577T CY1123077T1 (el) | 2013-10-31 | 2020-06-25 | Ενδοφθαλμια εμφυτευματα που περιεχουν προσταμιδιο και μεθοδοι χρησης αυτων |
Country Status (29)
Country | Link |
---|---|
US (6) | US9492316B2 (el) |
EP (5) | EP3669865A1 (el) |
JP (2) | JP6482547B2 (el) |
KR (1) | KR102307281B1 (el) |
CN (2) | CN110302138B (el) |
AU (3) | AU2014342017B2 (el) |
BR (1) | BR112016009575B1 (el) |
CA (1) | CA2926515C (el) |
CL (1) | CL2016001041A1 (el) |
CY (2) | CY1119961T1 (el) |
DK (2) | DK3062775T3 (el) |
ES (2) | ES2805880T3 (el) |
HK (1) | HK1258014A1 (el) |
HU (2) | HUE050902T2 (el) |
IL (2) | IL244859B (el) |
MX (2) | MX2016005508A (el) |
MY (1) | MY177958A (el) |
NO (1) | NO3102476T3 (el) |
PH (1) | PH12016500767B1 (el) |
PL (2) | PL3062775T3 (el) |
PT (2) | PT3351239T (el) |
RU (1) | RU2650614C2 (el) |
SA (1) | SA516371022B1 (el) |
SG (2) | SG10201800978UA (el) |
SI (2) | SI3351239T1 (el) |
TR (1) | TR201802759T4 (el) |
UA (1) | UA119853C2 (el) |
WO (1) | WO2015066548A1 (el) |
ZA (1) | ZA201602556B (el) |
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US10245178B1 (en) | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
EP3669865A1 (en) * | 2013-10-31 | 2020-06-24 | Allergan, Inc. | Prostamide-containing intraocular implants and methods of use thereof |
MX2016007345A (es) * | 2013-12-06 | 2016-12-09 | Envisia Therapeutics Inc | Implante intracameral para el tratamiento de una condicion ocular. |
JP6655610B2 (ja) | 2014-05-29 | 2020-02-26 | グローコス コーポレーション | 制御された薬物送達機能を備えるインプラント及びそれを使用する方法 |
AU2016230026B2 (en) | 2015-03-06 | 2020-07-09 | Envisia Therapeutics, Inc. | Implant applicators and methods of administering implants |
US10624904B2 (en) | 2015-07-23 | 2020-04-21 | Aerie Pharmaceuticals, Inc. | Intravitreal drug delivery systems for the treatment of ocular conditions |
EP3324890A4 (en) * | 2015-07-23 | 2019-06-19 | Allergan, Inc. | GLACO-TREATMENT VIA INTRAKAMERAL EYE IMPLANTS |
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US11564833B2 (en) | 2015-09-25 | 2023-01-31 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
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