CY1119824T1 - Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθopo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και μελοξικαμη - Google Patents
Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθopo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και μελοξικαμηInfo
- Publication number
- CY1119824T1 CY1119824T1 CY20181100090T CY181100090T CY1119824T1 CY 1119824 T1 CY1119824 T1 CY 1119824T1 CY 20181100090 T CY20181100090 T CY 20181100090T CY 181100090 T CY181100090 T CY 181100090T CY 1119824 T1 CY1119824 T1 CY 1119824T1
- Authority
- CY
- Cyprus
- Prior art keywords
- meloxicam
- dihydro
- fluoro
- dimethyl
- amine
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Η εφεύρεση αφορά σε φαρμακευτική σύνθεση που περιλαμβάνει πρώτο φαρμακολογικώς δραστικό συστατικό, το οποίο επιλέγεται από (1r,4r)-6'-φθορο-Ν,Ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3’H-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,b]ινδολ]-4-αμίνη και τα φυσιολογικώς αποδεκτά άλατα αυτής και δεύτερο φαρμακολογικώς δραστικό συστατικό το οποίο είναι οξικάμη που επιλέγεται από την ομάδα που αποτελείται από μελοξικάμη, πιροξικάμη, τενοξικάμη, λονοξικάμη, δροξικάμη και τα φυσιολογικώς αποδεκτά άλατα αυτών.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12003896 | 2012-05-18 | ||
PCT/EP2013/001469 WO2013170970A1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and an oxicam |
EP13724168.3A EP2849746B1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and meloxicam |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1119824T1 true CY1119824T1 (el) | 2018-06-27 |
Family
ID=48470899
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100090T CY1119824T1 (el) | 2012-05-18 | 2018-01-24 | Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθopo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και μελοξικαμη |
Country Status (23)
Country | Link |
---|---|
US (1) | US9308196B2 (el) |
EP (1) | EP2849746B1 (el) |
JP (1) | JP6116677B2 (el) |
CN (2) | CN108451956A (el) |
AU (1) | AU2013262076B2 (el) |
BR (1) | BR112014028569A2 (el) |
CA (1) | CA2873863A1 (el) |
CY (1) | CY1119824T1 (el) |
DK (1) | DK2849746T3 (el) |
EA (1) | EA026719B1 (el) |
ES (1) | ES2659948T3 (el) |
HK (1) | HK1204939A1 (el) |
HR (1) | HRP20171843T1 (el) |
HU (1) | HUE035122T2 (el) |
IL (1) | IL235652B (el) |
LT (1) | LT2849746T (el) |
MX (1) | MX354685B (el) |
NO (1) | NO2849746T3 (el) |
PL (1) | PL2849746T3 (el) |
PT (1) | PT2849746T (el) |
RS (1) | RS56830B1 (el) |
SI (1) | SI2849746T1 (el) |
WO (1) | WO2013170970A1 (el) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6673924B2 (ja) | 2015-01-23 | 2020-03-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 肝機能障害および/または腎機能障害を有する対象における疼痛を治療するためのセブラノパドール |
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DE3273329D1 (en) | 1981-06-26 | 1986-10-23 | Upjohn Co | Analgesic process and composition |
US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
DK0473655T3 (da) | 1989-05-22 | 1997-02-10 | Biochemical Veterinary Res | Divalente metalsalte af indomethacin |
US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
US5914129A (en) | 1996-07-23 | 1999-06-22 | Mauskop; Alexander | Analgesic composition for treatment of migraine headaches |
RS49982B (sr) * | 1997-09-17 | 2008-09-29 | Euro-Celtique S.A., | Sinergistička analgetička kombinacija analgetičkog opijata i inhibitora ciklooksigenaze-2 |
DE69905380T2 (de) * | 1998-09-10 | 2003-11-27 | Nycomed Danmark A/S, Roskilde | Pharmazeutische zusammensetzungen mit schneller freisetzung von wirkstoffen |
ATE279920T1 (de) | 2000-12-28 | 2004-11-15 | Fresenius Kabi Austria Gmbh | Stabile infusionslösung von diclofenac-salzen, deren herstellung und verwendung |
ES2286177T3 (es) | 2002-06-17 | 2007-12-01 | Chiesi Farmaceutici S.P.A. | Procedimiento para la preparacion de piroxicam: compuestos de inclusion de betaciclodextrina. |
TWI323265B (en) * | 2002-08-06 | 2010-04-11 | Glaxo Group Ltd | Antibodies |
DE10252667A1 (de) * | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE10257824B4 (de) | 2002-12-10 | 2004-11-11 | Kochem, Hans-Günter, Dr. | Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen |
US20100297252A1 (en) | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
US7132452B2 (en) | 2003-03-10 | 2006-11-07 | Fang-Yu Lee | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection |
DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
WO2006134486A2 (en) | 2005-06-17 | 2006-12-21 | Pfizer Japan Inc. | Alpha-(aryl-or heteroaryl-methyl)-beta piperidino propanamide compounds as orl1-receptor antagonists |
NZ571939A (en) * | 2006-04-28 | 2011-10-28 | Gruenenthal Chemie | Pharmaceutical combination comprising 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol and an NSAID |
CN101147735A (zh) | 2006-09-19 | 2008-03-26 | 沈阳华泰药物研究有限公司 | 注射用药物组合物及其药盒 |
DE102006046745A1 (de) * | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
DE102006056458A1 (de) | 2006-11-28 | 2008-05-29 | Grünenthal GmbH | Arzneimittelzubereitung von Tramadol und Acetaminophen |
CN100560061C (zh) | 2008-06-20 | 2009-11-18 | 海南锦瑞制药股份有限公司 | 一种氯诺昔康冻干粉针剂及其制备方法 |
TR201904388T4 (tr) * | 2008-09-05 | 2019-05-21 | Gruenenthal Gmbh | Pregabalin veya gabapentin ve 3-(3-dimetilamino-1-etil-2-metil-propil)-fenolün farmasötik kombinasyonu. |
PE20110305A1 (es) * | 2008-09-05 | 2011-06-15 | Gruenenthal Chemie | Combinacion farmaceutica que contiene el 6-dimetilaminometil-1-(3-metoxi-fenil)-ciclohexano-1,3-diol y un nsaid |
DK2600851T3 (en) * | 2010-08-04 | 2018-06-25 | Gruenenthal Gmbh | PHARMACEUTICAL DOSAGE FORM CONTAINING 6'-FLUORO- (N-METHYL OR N, N-DIMETHYL -) - 4-PHENYL-4 ', 9'-DIHYDRO-3'H-SPIRO [CYCLOHEXAN-1,1'-PYRANO [3,4, B] INDOL] -4-AMINE FOR TREATMENT OF NEUROPATHIC PAIN |
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-
2013
- 2013-05-13 US US13/892,362 patent/US9308196B2/en active Active
- 2013-05-16 NO NO13724168A patent/NO2849746T3/no unknown
- 2013-05-16 PL PL13724168T patent/PL2849746T3/pl unknown
- 2013-05-16 WO PCT/EP2013/001469 patent/WO2013170970A1/en active Application Filing
- 2013-05-16 CA CA2873863A patent/CA2873863A1/en not_active Abandoned
- 2013-05-16 JP JP2015511956A patent/JP6116677B2/ja active Active
- 2013-05-16 EA EA201401265A patent/EA026719B1/ru not_active IP Right Cessation
- 2013-05-16 RS RS20180128A patent/RS56830B1/sr unknown
- 2013-05-16 CN CN201810667716.5A patent/CN108451956A/zh active Pending
- 2013-05-16 DK DK13724168.3T patent/DK2849746T3/en active
- 2013-05-16 LT LTEP13724168.3T patent/LT2849746T/lt unknown
- 2013-05-16 ES ES13724168.3T patent/ES2659948T3/es active Active
- 2013-05-16 EP EP13724168.3A patent/EP2849746B1/en active Active
- 2013-05-16 CN CN201380025679.3A patent/CN104302288A/zh active Pending
- 2013-05-16 MX MX2014012862A patent/MX354685B/es active IP Right Grant
- 2013-05-16 BR BR112014028569A patent/BR112014028569A2/pt not_active IP Right Cessation
- 2013-05-16 HU HUE13724168A patent/HUE035122T2/en unknown
- 2013-05-16 PT PT137241683T patent/PT2849746T/pt unknown
- 2013-05-16 AU AU2013262076A patent/AU2013262076B2/en not_active Ceased
- 2013-05-16 SI SI201330919T patent/SI2849746T1/en unknown
-
2014
- 2014-11-12 IL IL235652A patent/IL235652B/en active IP Right Grant
-
2015
- 2015-06-11 HK HK15105570.0A patent/HK1204939A1/xx not_active IP Right Cessation
-
2017
- 2017-11-27 HR HRP20171843TT patent/HRP20171843T1/hr unknown
-
2018
- 2018-01-24 CY CY20181100090T patent/CY1119824T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU2013262076B2 (en) | 2017-10-26 |
EA026719B1 (ru) | 2017-05-31 |
PT2849746T (pt) | 2018-02-22 |
EP2849746A1 (en) | 2015-03-25 |
RS56830B1 (sr) | 2018-04-30 |
MX2014012862A (es) | 2015-01-19 |
IL235652B (en) | 2018-08-30 |
EP2849746B1 (en) | 2017-11-15 |
CN108451956A (zh) | 2018-08-28 |
PL2849746T3 (pl) | 2018-04-30 |
CN104302288A (zh) | 2015-01-21 |
US9308196B2 (en) | 2016-04-12 |
IL235652A0 (en) | 2015-01-29 |
JP6116677B2 (ja) | 2017-04-19 |
NO2849746T3 (el) | 2018-04-14 |
ES2659948T3 (es) | 2018-03-20 |
JP2015516450A (ja) | 2015-06-11 |
LT2849746T (lt) | 2018-02-12 |
HRP20171843T1 (hr) | 2018-01-12 |
BR112014028569A2 (pt) | 2017-06-27 |
MX354685B (es) | 2018-03-15 |
HUE035122T2 (en) | 2018-05-02 |
US20130310371A1 (en) | 2013-11-21 |
AU2013262076A1 (en) | 2015-01-22 |
DK2849746T3 (en) | 2017-12-04 |
CA2873863A1 (en) | 2013-11-21 |
SI2849746T1 (en) | 2018-02-28 |
EA201401265A1 (ru) | 2015-05-29 |
HK1204939A1 (en) | 2015-12-11 |
WO2013170970A1 (en) | 2013-11-21 |
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