CY1119781T1 - Φαρμακευτικη συνθεση που περιλαμβανει (1r,4r)-6'-φθοpo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο-[3,4,β]ινδολ]-4-αμινη και ιμπουπροφενη - Google Patents

Φαρμακευτικη συνθεση που περιλαμβανει (1r,4r)-6'-φθοpo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο-[3,4,β]ινδολ]-4-αμινη και ιμπουπροφενη

Info

Publication number
CY1119781T1
CY1119781T1 CY20181100051T CY181100051T CY1119781T1 CY 1119781 T1 CY1119781 T1 CY 1119781T1 CY 20181100051 T CY20181100051 T CY 20181100051T CY 181100051 T CY181100051 T CY 181100051T CY 1119781 T1 CY1119781 T1 CY 1119781T1
Authority
CY
Cyprus
Prior art keywords
dimethyl
amine
phenyl
pharmaceutical composition
acid
Prior art date
Application number
CY20181100051T
Other languages
English (en)
Inventor
Stefanie Frosch
Klaus Linz
Klaus Schiene
Original Assignee
Grünenthal GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Grünenthal GmbH filed Critical Grünenthal GmbH
Publication of CY1119781T1 publication Critical patent/CY1119781T1/el

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Η εφεύρεση αφορά σε φαρμακευτική σύνθεση περιλαμβάνουσα ένα πρώτο φαρμακολογικώς δραστικό συστατικό που επιλέγεται από (1r,4r)-6'-φθορο-Ν,Ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'Η-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,b]ινδολ]-4-αμίνη και τα φυσιολογικώς αποδεκτά άλατα αυτής και ένα δεύτερο φαρμακολογικώς δραστικό συστατικό το οποίο είναι μη στεροειδές αντιρρευματικό φάρμακο που επιλέγεται από την ομάδα που αποτελείται από ινδομεθακίνη, δικολφενάκη, σουλιντάκη, τολμετίνη, ζομεπιράκη, ακλοφενάκη, μπουμαδιζόνη, ετοδολάκη, λοναζολάκη, φεντιαζάκη, ακεμετακίνη, διφενπιραμίδη, οξαμετακίνη, προγλουμετακίνη, κετορολάκη, ακεκλοφενάκη, μπουφεξαμάκη, μεφεναμικό οξύ, τολφεναμικό οξύ, φλουφεναμικό οξύ, μεκλοφεναμικό οξύ και τα φυσιολογικώς αποδεκτά άλατα αυτών.
CY20181100051T 2012-05-18 2018-01-16 Φαρμακευτικη συνθεση που περιλαμβανει (1r,4r)-6'-φθοpo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο-[3,4,β]ινδολ]-4-αμινη και ιμπουπροφενη CY1119781T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12003895 2012-05-18
EP13725072.6A EP2849747B1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and a nsar
PCT/EP2013/001470 WO2013170971A1 (en) 2012-05-18 2013-05-16 Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and a nsar

Publications (1)

Publication Number Publication Date
CY1119781T1 true CY1119781T1 (el) 2018-06-27

Family

ID=48520892

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20181100051T CY1119781T1 (el) 2012-05-18 2018-01-16 Φαρμακευτικη συνθεση που περιλαμβανει (1r,4r)-6'-φθοpo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο-[3,4,β]ινδολ]-4-αμινη και ιμπουπροφενη

Country Status (23)

Country Link
US (1) US8912226B2 (el)
EP (1) EP2849747B1 (el)
JP (1) JP6116678B2 (el)
CN (1) CN104284660A (el)
AU (1) AU2013262077B2 (el)
BR (1) BR112014028566A2 (el)
CA (1) CA2873867A1 (el)
CY (1) CY1119781T1 (el)
DK (1) DK2849747T3 (el)
EA (1) EA027145B1 (el)
ES (1) ES2658217T3 (el)
HK (1) HK1204938A1 (el)
HR (1) HRP20171725T1 (el)
HU (1) HUE034658T2 (el)
IL (1) IL235653B (el)
LT (1) LT2849747T (el)
MX (1) MX356493B (el)
NO (1) NO2849747T3 (el)
PL (1) PL2849747T3 (el)
PT (1) PT2849747T (el)
RS (1) RS56788B1 (el)
SI (1) SI2849747T1 (el)
WO (1) WO2013170971A1 (el)

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WO2016168388A2 (en) 2015-04-14 2016-10-20 Palatin Technologies, Inc. Therapies for obesity, diabetes and related indications

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Also Published As

Publication number Publication date
US8912226B2 (en) 2014-12-16
IL235653A0 (en) 2015-01-29
AU2013262077B2 (en) 2017-10-26
PL2849747T3 (pl) 2018-03-30
PT2849747T (pt) 2018-02-07
MX2014013028A (es) 2015-02-04
IL235653B (en) 2018-08-30
EP2849747B1 (en) 2017-11-01
HUE034658T2 (hu) 2018-02-28
CA2873867A1 (en) 2013-11-21
EA201401270A1 (ru) 2016-05-31
MX356493B (es) 2018-05-31
JP6116678B2 (ja) 2017-04-19
BR112014028566A2 (pt) 2017-06-27
US20130317075A1 (en) 2013-11-28
EP2849747A1 (en) 2015-03-25
NO2849747T3 (el) 2018-03-31
DK2849747T3 (en) 2017-12-04
CN104284660A (zh) 2015-01-14
JP2015516451A (ja) 2015-06-11
RS56788B1 (sr) 2018-04-30
AU2013262077A1 (en) 2015-01-22
ES2658217T3 (es) 2018-03-08
LT2849747T (lt) 2018-01-25
HK1204938A1 (en) 2015-12-11
WO2013170971A1 (en) 2013-11-21
EA027145B1 (ru) 2017-06-30
SI2849747T1 (en) 2018-04-30
HRP20171725T1 (hr) 2017-12-29

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