CY1119781T1 - Φαρμακευτικη συνθεση που περιλαμβανει (1r,4r)-6'-φθοpo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο-[3,4,β]ινδολ]-4-αμινη και ιμπουπροφενη - Google Patents
Φαρμακευτικη συνθεση που περιλαμβανει (1r,4r)-6'-φθοpo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο-[3,4,β]ινδολ]-4-αμινη και ιμπουπροφενηInfo
- Publication number
- CY1119781T1 CY1119781T1 CY20181100051T CY181100051T CY1119781T1 CY 1119781 T1 CY1119781 T1 CY 1119781T1 CY 20181100051 T CY20181100051 T CY 20181100051T CY 181100051 T CY181100051 T CY 181100051T CY 1119781 T1 CY1119781 T1 CY 1119781T1
- Authority
- CY
- Cyprus
- Prior art keywords
- dimethyl
- amine
- phenyl
- pharmaceutical composition
- acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/405—Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η εφεύρεση αφορά σε φαρμακευτική σύνθεση περιλαμβάνουσα ένα πρώτο φαρμακολογικώς δραστικό συστατικό που επιλέγεται από (1r,4r)-6'-φθορο-Ν,Ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'Η-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,b]ινδολ]-4-αμίνη και τα φυσιολογικώς αποδεκτά άλατα αυτής και ένα δεύτερο φαρμακολογικώς δραστικό συστατικό το οποίο είναι μη στεροειδές αντιρρευματικό φάρμακο που επιλέγεται από την ομάδα που αποτελείται από ινδομεθακίνη, δικολφενάκη, σουλιντάκη, τολμετίνη, ζομεπιράκη, ακλοφενάκη, μπουμαδιζόνη, ετοδολάκη, λοναζολάκη, φεντιαζάκη, ακεμετακίνη, διφενπιραμίδη, οξαμετακίνη, προγλουμετακίνη, κετορολάκη, ακεκλοφενάκη, μπουφεξαμάκη, μεφεναμικό οξύ, τολφεναμικό οξύ, φλουφεναμικό οξύ, μεκλοφεναμικό οξύ και τα φυσιολογικώς αποδεκτά άλατα αυτών.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP12003895 | 2012-05-18 | ||
EP13725072.6A EP2849747B1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and a nsar |
PCT/EP2013/001470 WO2013170971A1 (en) | 2012-05-18 | 2013-05-16 | Pharmaceutical composition comprising (1r,4r)-6'-fluoro-n,n-dimethyl-4-phenyl-4',9'-dihydro-3'h-spiro[cyclohexane-1,1'-pyrano [3,4,b]indol]-4-amine and a nsar |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1119781T1 true CY1119781T1 (el) | 2018-06-27 |
Family
ID=48520892
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20181100051T CY1119781T1 (el) | 2012-05-18 | 2018-01-16 | Φαρμακευτικη συνθεση που περιλαμβανει (1r,4r)-6'-φθοpo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο-[3,4,β]ινδολ]-4-αμινη και ιμπουπροφενη |
Country Status (23)
Country | Link |
---|---|
US (1) | US8912226B2 (el) |
EP (1) | EP2849747B1 (el) |
JP (1) | JP6116678B2 (el) |
CN (1) | CN104284660A (el) |
AU (1) | AU2013262077B2 (el) |
BR (1) | BR112014028566A2 (el) |
CA (1) | CA2873867A1 (el) |
CY (1) | CY1119781T1 (el) |
DK (1) | DK2849747T3 (el) |
EA (1) | EA027145B1 (el) |
ES (1) | ES2658217T3 (el) |
HK (1) | HK1204938A1 (el) |
HR (1) | HRP20171725T1 (el) |
HU (1) | HUE034658T2 (el) |
IL (1) | IL235653B (el) |
LT (1) | LT2849747T (el) |
MX (1) | MX356493B (el) |
NO (1) | NO2849747T3 (el) |
PL (1) | PL2849747T3 (el) |
PT (1) | PT2849747T (el) |
RS (1) | RS56788B1 (el) |
SI (1) | SI2849747T1 (el) |
WO (1) | WO2013170971A1 (el) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6673924B2 (ja) | 2015-01-23 | 2020-03-25 | グリュネンタール・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | 肝機能障害および/または腎機能障害を有する対象における疼痛を治療するためのセブラノパドール |
WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
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DE3273329D1 (en) | 1981-06-26 | 1986-10-23 | Upjohn Co | Analgesic process and composition |
US4389393A (en) | 1982-03-26 | 1983-06-21 | Forest Laboratories, Inc. | Sustained release therapeutic compositions based on high molecular weight hydroxypropylmethylcellulose |
US4404208A (en) * | 1982-06-30 | 1983-09-13 | E. I. Du Pont De Nemours And Company | Analgesic mixture of nalbuphine and tiflamizole |
US4765989A (en) | 1983-05-11 | 1988-08-23 | Alza Corporation | Osmotic device for administering certain drugs |
US4783337A (en) | 1983-05-11 | 1988-11-08 | Alza Corporation | Osmotic system comprising plurality of members for dispensing drug |
US4612008A (en) | 1983-05-11 | 1986-09-16 | Alza Corporation | Osmotic device with dual thermodynamic activity |
DK0473655T3 (da) | 1989-05-22 | 1997-02-10 | Biochemical Veterinary Res | Divalente metalsalte af indomethacin |
US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
US5330761A (en) | 1993-01-29 | 1994-07-19 | Edward Mendell Co. Inc. | Bioadhesive tablet for non-systemic use products |
US5455046A (en) | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
US5399362A (en) | 1994-04-25 | 1995-03-21 | Edward Mendell Co., Inc. | Once-a-day metoprolol oral dosage form |
US5914129A (en) | 1996-07-23 | 1999-06-22 | Mauskop; Alexander | Analgesic composition for treatment of migraine headaches |
ATE279920T1 (de) | 2000-12-28 | 2004-11-15 | Fresenius Kabi Austria Gmbh | Stabile infusionslösung von diclofenac-salzen, deren herstellung und verwendung |
ES2286177T3 (es) | 2002-06-17 | 2007-12-01 | Chiesi Farmaceutici S.P.A. | Procedimiento para la preparacion de piroxicam: compuestos de inclusion de betaciclodextrina. |
DE10252667A1 (de) | 2002-11-11 | 2004-05-27 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
DE10257824B4 (de) | 2002-12-10 | 2004-11-11 | Kochem, Hans-Günter, Dr. | Zusammensetzung zur Schmerzbehandlung, insbesondere zur Behandlung von Gelenkschmerzen |
US20100297252A1 (en) | 2003-03-03 | 2010-11-25 | Elan Pharma International Ltd. | Nanoparticulate meloxicam formulations |
US7132452B2 (en) | 2003-03-10 | 2006-11-07 | Fang-Yu Lee | Topical formulation having effects on alleviating pain/inflammation caused by herpes virus infection |
DE10360792A1 (de) | 2003-12-23 | 2005-07-28 | Grünenthal GmbH | Spirocyclische Cyclohexan-Derivate |
WO2006134486A2 (en) * | 2005-06-17 | 2006-12-21 | Pfizer Japan Inc. | Alpha-(aryl-or heteroaryl-methyl)-beta piperidino propanamide compounds as orl1-receptor antagonists |
NZ571939A (en) * | 2006-04-28 | 2011-10-28 | Gruenenthal Chemie | Pharmaceutical combination comprising 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol and an NSAID |
CN101147735A (zh) | 2006-09-19 | 2008-03-26 | 沈阳华泰药物研究有限公司 | 注射用药物组合物及其药盒 |
DE102006046745A1 (de) | 2006-09-29 | 2008-04-03 | Grünenthal GmbH | Gemischte ORL1/µ-Agonisten zur Behandlung von Schmerz |
DE102006056458A1 (de) | 2006-11-28 | 2008-05-29 | Grünenthal GmbH | Arzneimittelzubereitung von Tramadol und Acetaminophen |
AU2008310114B2 (en) * | 2007-10-09 | 2014-01-16 | Merck Patent Gmbh | Pharmaceutical compositions containing benfotiamine and one or more pharmaceutically active agents for the treatment of pain conditions of neuropathic origin |
CN100560061C (zh) | 2008-06-20 | 2009-11-18 | 海南锦瑞制药股份有限公司 | 一种氯诺昔康冻干粉针剂及其制备方法 |
TR201904388T4 (tr) * | 2008-09-05 | 2019-05-21 | Gruenenthal Gmbh | Pregabalin veya gabapentin ve 3-(3-dimetilamino-1-etil-2-metil-propil)-fenolün farmasötik kombinasyonu. |
PE20110305A1 (es) * | 2008-09-05 | 2011-06-15 | Gruenenthal Chemie | Combinacion farmaceutica que contiene el 6-dimetilaminometil-1-(3-metoxi-fenil)-ciclohexano-1,3-diol y un nsaid |
DK2600851T3 (en) * | 2010-08-04 | 2018-06-25 | Gruenenthal Gmbh | PHARMACEUTICAL DOSAGE FORM CONTAINING 6'-FLUORO- (N-METHYL OR N, N-DIMETHYL -) - 4-PHENYL-4 ', 9'-DIHYDRO-3'H-SPIRO [CYCLOHEXAN-1,1'-PYRANO [3,4, B] INDOL] -4-AMINE FOR TREATMENT OF NEUROPATHIC PAIN |
HUE028436T2 (hu) * | 2010-08-04 | 2016-12-28 | Gruenenthal Gmbh | Gyógyszerészeti adagolási forma, amely tartalmaz-6'-fluor-(N-metil- vagy N,N-dimetil)-4-fenil-4',9'-dihidro-3'H-spiro[ciklohexán-1,1'-pirano[3,4B]indol]-4-amint |
SI2600838T1 (sl) * | 2010-08-04 | 2015-12-31 | Gruenenthal Gmbh | Farmacevtska odmerna oblika, ki obsega 6'-fluoro-(N-metil- ali N,N-dimetil-)-4-fenil-4',9'-dihidro-3'H-spiro(cikloheksan-1,1'-pirano (3,4,b)indol)-4-amin |
-
2013
- 2013-05-13 US US13/892,732 patent/US8912226B2/en active Active
- 2013-05-16 DK DK13725072.6T patent/DK2849747T3/en active
- 2013-05-16 ES ES13725072.6T patent/ES2658217T3/es active Active
- 2013-05-16 LT LTEP13725072.6T patent/LT2849747T/lt unknown
- 2013-05-16 SI SI201330926T patent/SI2849747T1/en unknown
- 2013-05-16 EP EP13725072.6A patent/EP2849747B1/en active Active
- 2013-05-16 MX MX2014013028A patent/MX356493B/es active IP Right Grant
- 2013-05-16 CA CA2873867A patent/CA2873867A1/en not_active Abandoned
- 2013-05-16 RS RS20180063A patent/RS56788B1/sr unknown
- 2013-05-16 BR BR112014028566A patent/BR112014028566A2/pt active Search and Examination
- 2013-05-16 CN CN201380025645.4A patent/CN104284660A/zh active Pending
- 2013-05-16 AU AU2013262077A patent/AU2013262077B2/en not_active Ceased
- 2013-05-16 NO NO13725072A patent/NO2849747T3/no unknown
- 2013-05-16 JP JP2015511957A patent/JP6116678B2/ja active Active
- 2013-05-16 EA EA201401270A patent/EA027145B1/ru not_active IP Right Cessation
- 2013-05-16 PT PT137250726T patent/PT2849747T/pt unknown
- 2013-05-16 HU HUE13725072A patent/HUE034658T2/hu unknown
- 2013-05-16 WO PCT/EP2013/001470 patent/WO2013170971A1/en active Application Filing
- 2013-05-16 PL PL13725072T patent/PL2849747T3/pl unknown
-
2014
- 2014-11-12 IL IL235653A patent/IL235653B/en active IP Right Grant
-
2015
- 2015-06-11 HK HK15105569.3A patent/HK1204938A1/xx not_active IP Right Cessation
-
2017
- 2017-11-10 HR HRP20171725TT patent/HRP20171725T1/hr unknown
-
2018
- 2018-01-16 CY CY20181100051T patent/CY1119781T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US8912226B2 (en) | 2014-12-16 |
IL235653A0 (en) | 2015-01-29 |
AU2013262077B2 (en) | 2017-10-26 |
PL2849747T3 (pl) | 2018-03-30 |
PT2849747T (pt) | 2018-02-07 |
MX2014013028A (es) | 2015-02-04 |
IL235653B (en) | 2018-08-30 |
EP2849747B1 (en) | 2017-11-01 |
HUE034658T2 (hu) | 2018-02-28 |
CA2873867A1 (en) | 2013-11-21 |
EA201401270A1 (ru) | 2016-05-31 |
MX356493B (es) | 2018-05-31 |
JP6116678B2 (ja) | 2017-04-19 |
BR112014028566A2 (pt) | 2017-06-27 |
US20130317075A1 (en) | 2013-11-28 |
EP2849747A1 (en) | 2015-03-25 |
NO2849747T3 (el) | 2018-03-31 |
DK2849747T3 (en) | 2017-12-04 |
CN104284660A (zh) | 2015-01-14 |
JP2015516451A (ja) | 2015-06-11 |
RS56788B1 (sr) | 2018-04-30 |
AU2013262077A1 (en) | 2015-01-22 |
ES2658217T3 (es) | 2018-03-08 |
LT2849747T (lt) | 2018-01-25 |
HK1204938A1 (en) | 2015-12-11 |
WO2013170971A1 (en) | 2013-11-21 |
EA027145B1 (ru) | 2017-06-30 |
SI2849747T1 (en) | 2018-04-30 |
HRP20171725T1 (hr) | 2017-12-29 |
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CY1119887T1 (el) | ΦΑΡΜΑΚΕΥΤΙΚΗ ΜΟΡΦΗ ΔΟΣΟΛΟΓΙΑΣ ΠΟΥ ΠΕΡΙΛΑΜΒΑΝΕΙ 6'-ΦΘΟΡΟ-(Ν-ΜΕΘΥΛΟ- Ή Ν,Ν-ΔΙΜΕΘΥΛΟ-)-4-ΦΑΙΝΥΛΟ-4',9'-ΔΙΥΔΡΟ-3'Η-ΣΠΕΙΡΟ [ΚΥΚΛΟΕΞΑΝΟ-1,1'-ΠΥΡΑΝΟ[3,4,b] ΙΝΔΟΛ]-4-ΑΜΙΝΗ | |
CY1119825T1 (el) | Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθopo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και ντουλοξετινη | |
CY1118132T1 (el) | ΣΤΕΡΕΕΣ ΜΟΡΦΕΣ ΤΗΣ ΥΔΡΟΧΛΩΡΙΚΗΣ (1R,4R)-6'-ΦΘΟΡΟ-Ν,Ν-ΔΙΜΕΘΥΛ-4-ΦΑΙΝΥΛ-4',9'-ΔΙΥΔΡΟ-3´H-ΣΠΕΙΡΟ-[ΚΥΚΛΟΕΞΑΝΟ-1,1'-ΠΥΡΑΝΟ[3,4,b]ΙΝΔΟΛ]-4-ΑΜΙΝΗΣ | |
CY1119824T1 (el) | Φαρμακευτικη συνθεση περιλαμβανουσα (1r,4r)-6'-φθopo-n,n-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη και μελοξικαμη | |
CY1119610T1 (el) | Φαρμακευτικη συνθεση που περιλαμβανει (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3'h-σπιρο[κυκλοεξαν-1,1'-πυρανο'[3,4,b]ινδολ]-4-αμινη παρακεταμολη ή προπακεταμολη | |
CY1119692T1 (el) | Φαρμακευτικη συνθεση η οποια περιλαμβανει (1r,4r)-6'-φθορο-ν,ν-διμεθυλ-4-φαινυλ-4',9'-διυδρο-3ή-σπιρο [κυκλο-εξανο-1,1'-πυρανο-(3,4,b)ινδολ)-αμινη και ακετυλο-σαλικυλικο οξυ | |
BR112014014168A2 (pt) | processo para a preparação de (1r,4r)-6'-fluoro-(n,n-dimetil e n-metil)-4-fenil-4',9'-dihidro-3'h-espiro[ciclohexano-1,1'-pirano-[3,4,b]indol]-4-amina | |
CY1118799T1 (el) | (1r,4r)-6’-φθopo-(n-meθyλ- ή ν,ν-διμεθυλ-)-4-φαινυλ-4’,9’-διϋδρο-3’h-σπειρο-[κυκλοεξανο-1,1’πυρανο[3,4,β]ινδολ]-4-αμινη για θεραπεια ινομυαλγιας και συνδρομου χρονιας κοπωσεως | |
CY1116996T1 (el) | Φαρμακευτικη δοσολογικη μορφη που περιεχει 6'-φθορο-(ν-μεθυλο- ή ν,ν-διμεθυλο-)-4-φαινυλο-4',9',-διυδρο-3'η-σπιρο[κυκλοεξαν-1,1'-πυρανο[3,4-β]ινδολ]-4-αμινη | |
CY1117385T1 (el) | Φαρμακευτικη μορφη δοσολογιας περιλαμβανουσα 6'-φθορο-(ν-μεθυλ-ή ν,ν-διμεθυλ-)-4-φαινυλ-4΄,9'-διϋδρο-3ή-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη | |
CY1120616T1 (el) | Φαρμακευτικη μορφη δοσολογιας η οποια περιλαμβανει 6'-φθορο-(ν-μεθυλ- ή ν,ν-διμεθυλ-)-4-φαινυλ-4',9'-διυδρο-3'η-σπειρο[κυκλοεξανο-1,1'-πυρανο[3,4,β]ινδολ]-4-αμινη για την αγωγη του νευροπαθητικου πονου | |
CU23681B7 (es) | Derivados de triazolopirazina |