CY1118628T1 - Προσκολλητινες μηνιγγιοκοκκου - Google Patents

Προσκολλητινες μηνιγγιοκοκκου

Info

Publication number
CY1118628T1
CY1118628T1 CY20171100197T CY171100197T CY1118628T1 CY 1118628 T1 CY1118628 T1 CY 1118628T1 CY 20171100197 T CY20171100197 T CY 20171100197T CY 171100197 T CY171100197 T CY 171100197T CY 1118628 T1 CY1118628 T1 CY 1118628T1
Authority
CY
Cyprus
Prior art keywords
disclosed
app
nada
proteins
cycle clocks
Prior art date
Application number
CY20171100197T
Other languages
English (en)
Inventor
Maria Arico
Maurizio Comanducci
Original Assignee
Glaxosmithkline Biologicals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0118401A external-priority patent/GB0118401D0/en
Priority claimed from GBGB0121591.2A external-priority patent/GB0121591D0/en
Priority claimed from GB0211025A external-priority patent/GB0211025D0/en
Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Publication of CY1118628T1 publication Critical patent/CY1118628T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Compounds Of Unknown Constitution (AREA)

Abstract

Τα NadA, Αpp και ORF40 λειτουργούν ως προσκολλητίνες στο Ν. meningitidis. Η προσκόλληση μπορεί να τροποποιηθεί με στόχευση αυτών των τριών πρωτεϊνών. Αλληλόμορφες παραλλαγές NadA αποκαλύπτονται. Αυτοπρωτεολυτική απόσπαση του Αpp αποκαλύπτεται, όπως επίσης κι απομάκρυνση της δραστικότητας με μεταλλαξιγένεση. Το Αpp υποβάλλεται σε επεξεργασία κι εκκρίνεται στο μέσο καλλιέργειας όταν εκφράζεται σε Ε. coli. Ώριμες πρωτεΐνες Αpp αποκαλύπτονται. Μεταλλάγματα με αφαίρεση γονιδίου (knockout) αποκαλύπτονται. Κυστίδια από ξενιστές που δεν είναι Neisseria με ετερόλογη έκφραση προσκολλητίνης αποκαλύπτονται.
CY20171100197T 2001-07-27 2017-02-14 Προσκολλητινες μηνιγγιοκοκκου CY1118628T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB0118401A GB0118401D0 (en) 2001-07-27 2001-07-27 Meningococcus data
GBGB0121591.2A GB0121591D0 (en) 2001-09-06 2001-09-06 Hybrid and tandem expression of neisserial proteins
GB0211025A GB0211025D0 (en) 2002-05-14 2002-05-14 Meningococcus adhesins
EP02790218A EP1412381B1 (en) 2001-07-27 2002-07-26 Antibodies against meningococcal adhesin app

Publications (1)

Publication Number Publication Date
CY1118628T1 true CY1118628T1 (el) 2017-07-12

Family

ID=27256234

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20101100776T CY1111715T1 (el) 2001-07-27 2010-08-20 Αντισωματα κατα της επικολλωμενης app του μηνιγγιτιδοκοκκου
CY20171100197T CY1118628T1 (el) 2001-07-27 2017-02-14 Προσκολλητινες μηνιγγιοκοκκου

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20101100776T CY1111715T1 (el) 2001-07-27 2010-08-20 Αντισωματα κατα της επικολλωμενης app του μηνιγγιτιδοκοκκου

Country Status (14)

Country Link
US (3) US20050232936A1 (el)
EP (2) EP1412381B1 (el)
JP (3) JP4592284B2 (el)
AT (1) ATE469915T1 (el)
AU (1) AU2002355197A1 (el)
BR (1) BR0211494A (el)
CA (1) CA2452836C (el)
CY (2) CY1111715T1 (el)
DE (1) DE60236596D1 (el)
DK (1) DK2248822T3 (el)
ES (1) ES2615362T3 (el)
MX (1) MXPA04000653A (el)
PT (1) PT2248822T (el)
WO (1) WO2003010194A2 (el)

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GB0118249D0 (en) 2001-07-26 2001-09-19 Chiron Spa Histidine vaccines
DE60236596D1 (de) 2001-07-27 2010-07-15 Novartis Vaccines & Diagnostic Antikörper gegen das meningokokken adhäsin app
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BR112013005626B1 (pt) * 2010-09-10 2022-07-26 Glaxosmithkline Biologicals Sa Meningococo, processo para a preparação de uma cepa meningocócica, vesículas de membrana externa, composição farmacêutica imunogênica, e, uso de uma composição
CA2876138C (en) 2012-06-14 2023-09-19 Novartis Ag Vaccines for serogroup x meningococcus
US10000545B2 (en) 2012-07-27 2018-06-19 Institut National De La Sante Et De La Recherche Medicale CD147 as receptor for pilus-mediated adhesion of Meningococci to vascular endothelia
TW201620927A (zh) * 2014-02-24 2016-06-16 葛蘭素史密斯克藍生物品公司 Ｕｓｐａ２蛋白質構築體及其用途
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PT2351579T (pt) 2002-10-11 2016-12-22 Novartis Vaccines And Diagnostics S R L Vacinas polipeptídicas para proteção ampla contra linhagens meningocócicas hipervirulentas
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ES2397923T3 (es) * 2003-10-02 2013-03-12 Novartis Ag Vacunas líquidas para múltiples serogrupos meningocócicos

Also Published As

Publication number Publication date
ATE469915T1 (de) 2010-06-15
US9249197B2 (en) 2016-02-02
ES2615362T3 (es) 2017-06-06
CA2452836A1 (en) 2003-02-06
DK2248822T3 (en) 2017-02-13
US20140294884A1 (en) 2014-10-02
CA2452836C (en) 2012-11-27
CY1111715T1 (el) 2015-10-07
EP2248822A2 (en) 2010-11-10
JP4902678B2 (ja) 2012-03-21
JP4592284B2 (ja) 2010-12-01
BR0211494A (pt) 2004-08-17
JP2005503785A (ja) 2005-02-10
EP1412381A2 (en) 2004-04-28
EP2248822A3 (en) 2011-04-13
JP2009148279A (ja) 2009-07-09
US20050232936A1 (en) 2005-10-20
EP2248822B1 (en) 2016-11-23
WO2003010194A3 (en) 2003-10-02
DE60236596D1 (de) 2010-07-15
JP2010268801A (ja) 2010-12-02
EP1412381B1 (en) 2010-06-02
MXPA04000653A (es) 2004-11-22
US20100221256A1 (en) 2010-09-02
AU2002355197A1 (en) 2003-02-17
WO2003010194A2 (en) 2003-02-06
PT2248822T (pt) 2017-02-14

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