ATE543873T1 - Herstellung von 3-hydroxypropionsäure mittels beta-alanine-pyruvat-aminotrransferase - Google Patents
Herstellung von 3-hydroxypropionsäure mittels beta-alanine-pyruvat-aminotrransferaseInfo
- Publication number
- ATE543873T1 ATE543873T1 AT04821820T AT04821820T ATE543873T1 AT E543873 T1 ATE543873 T1 AT E543873T1 AT 04821820 T AT04821820 T AT 04821820T AT 04821820 T AT04821820 T AT 04821820T AT E543873 T1 ATE543873 T1 AT E543873T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- hydroxypropionic acid
- production
- pyruvate aminotransferase
- alanine
- Prior art date
Links
- ALRHLSYJTWAHJZ-UHFFFAOYSA-N 3-hydroxypropionic acid Chemical compound OCCC(O)=O ALRHLSYJTWAHJZ-UHFFFAOYSA-N 0.000 title abstract 4
- 102100026790 Alanine-glyoxylate aminotransferase 2, mitochondrial Human genes 0.000 title 1
- 108010010560 Beta-alanine-pyruvate transaminase Proteins 0.000 title 1
- UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 abstract 4
- 229940000635 beta-alanine Drugs 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 108010025593 phenylalanine (histidine) aminotransferase Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/18—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic polyhydric
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
- C12P7/42—Hydroxy-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/62—Carboxylic acid esters
- C12P7/625—Polyesters of hydroxy carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y206/00—Transferases transferring nitrogenous groups (2.6)
- C12Y206/01—Transaminases (2.6.1)
- C12Y206/01018—Beta-alanine-pyruvate transaminase (2.6.1.18)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US52735703P | 2003-12-04 | 2003-12-04 | |
| PCT/US2004/040827 WO2005118719A2 (en) | 2003-12-04 | 2004-12-06 | Production of 3-hydroxypropionic acid using beta-alanine/pyruvate aminotransferase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE543873T1 true ATE543873T1 (de) | 2012-02-15 |
Family
ID=35463438
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04821820T ATE543873T1 (de) | 2003-12-04 | 2004-12-06 | Herstellung von 3-hydroxypropionsäure mittels beta-alanine-pyruvat-aminotrransferase |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US7700319B2 (de) |
| EP (1) | EP1706457B1 (de) |
| AT (1) | ATE543873T1 (de) |
| BR (1) | BRPI0416546A (de) |
| DK (1) | DK1706457T3 (de) |
| WO (1) | WO2005118719A2 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MXPA03004324A (es) * | 2000-11-20 | 2004-01-26 | Cargill Inc | Acido 3-hidroxipropionico y otros compuestos organicos. |
| JP4532116B2 (ja) * | 2002-01-18 | 2010-08-25 | ノボザイムズ エー／エス | アラニン２，３−アミノムターゼ |
| JP2008507970A (ja) * | 2004-07-30 | 2008-03-21 | カーギル インコーポレイテッド | アラニン２，３アミノムターゼ |
| AR051466A1 (es) | 2004-10-25 | 2007-01-17 | Codexis | 2,3 -aminomutasas de alanina mejoradas y polinucleotidos relacionados |
| WO2007047773A2 (en) | 2005-10-14 | 2007-04-26 | Codexis, Inc. | Alanine 2,3-aminomutases and related polynucleotides |
| US20070203323A1 (en) | 2006-02-10 | 2007-08-30 | Gyorgyi Fenyvesi | Food compositions comprising biologically-based biodegradable 1,3-propanediol esters |
| EP2586313B1 (de) | 2006-03-13 | 2017-02-22 | Cargill, Incorporated | Fermentationsverfahren unter Verwendung von Hefezellen mit unterbrochenem Weg von Dihydroxyacetonphosphat zu Glycerin |
| BRPI0716212A2 (pt) * | 2006-08-30 | 2013-10-15 | Cargill Inc | Beta-alanina/alfa-cetoglutarato aminotransferase para produção de ácido 3-hidroxipropiônico |
| AU2008206403A1 (en) * | 2007-01-12 | 2008-07-24 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for enhancing tolerance for the production of organic chemicals produced by microorganisms |
| US8048624B1 (en) | 2007-12-04 | 2011-11-01 | Opx Biotechnologies, Inc. | Compositions and methods for 3-hydroxypropionate bio-production from biomass |
| DE102008020688B3 (de) | 2008-04-24 | 2009-11-05 | Evonik Stockhausen Gmbh | Verfahren zur Herstellung und Aufreinigung wässriger Phasen |
| AU2009273953B2 (en) * | 2008-07-23 | 2013-08-29 | Opx Biotechnologies, Inc | Methods, systems and compositions for increased microorganism tolerance to and production of 3-hydroxypropionic acid (3-HP) |
| US20130189787A1 (en) * | 2008-09-15 | 2013-07-25 | Opx Biotechnologies ,Inc. | Methods, Systems And Compositions Related To Reduction Of Conversions Of Microbially Produced 3-Hydroxyproplonic Acid (3-HP) To Aldehyde Metabolites |
| AU2010298004B2 (en) | 2009-09-27 | 2016-02-25 | Opx Biotechnologies, Inc. | Method for producing 3-hydroxypropionic acid and other products |
| US8809027B1 (en) * | 2009-09-27 | 2014-08-19 | Opx Biotechnologies, Inc. | Genetically modified organisms for increased microbial production of 3-hydroxypropionic acid involving an oxaloacetate alpha-decarboxylase |
| US20110125118A1 (en) * | 2009-11-20 | 2011-05-26 | Opx Biotechnologies, Inc. | Production of an Organic Acid and/or Related Chemicals |
| US20130122541A1 (en) * | 2010-01-27 | 2013-05-16 | The Regents Of The University Of Colorado | Microorganism production of high-value chemical products, and related compositions, methods and systems |
| RU2012132908A (ru) | 2010-02-11 | 2014-03-20 | Метаболикс, Инк. | Способ получения производных химических соединений |
| US8911978B2 (en) | 2010-07-02 | 2014-12-16 | Metabolic Explorer | Method for the preparation of hydroxy acids |
| WO2012074818A2 (en) | 2010-11-22 | 2012-06-07 | Novozymes, Inc. | Compositions and methods for 3-hydroxypropionic acid production |
| CA2849303C (en) | 2011-09-30 | 2019-09-17 | Novozymes, Inc. | Dehydrogenase variants and polynucleotides encoding same |
| CN104321427A (zh) * | 2012-03-20 | 2015-01-28 | 梅塔玻利克斯公司 | 用于生产聚-4-羟基丁酸酯的遗传工程微生物 |
| WO2013173711A1 (en) | 2012-05-18 | 2013-11-21 | Novozymes A/S | Bacterial mutants with improved transformation efficiency |
| WO2013185009A1 (en) | 2012-06-08 | 2013-12-12 | Metabolix, Inc. | Renewable acrylic acid production and products made therefrom |
| SG11201501013PA (en) | 2012-08-10 | 2015-04-29 | Opx Biotechnologies Inc | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| WO2014052630A1 (en) | 2012-09-27 | 2014-04-03 | Novozymes, Inc. | Bacterial mutants with improved transformation efficiency |
| BR112015008111A2 (pt) * | 2012-10-11 | 2017-11-28 | Univ Denmark Tech Dtu | célula de levedura geneticamente modificada, e , método para a produção de 3hp. |
| WO2014085330A1 (en) | 2012-11-30 | 2014-06-05 | Novozymes, Inc. | 3-hydroxypropionic acid production by recombinant yeasts |
| WO2014145096A1 (en) | 2013-03-15 | 2014-09-18 | Cindy Hoppe | Flash evaporation for production purification and recovery |
| EP2970085B1 (de) | 2013-03-15 | 2018-11-07 | Cargill, Incorporated | Rückgewinnung von 3-hydroxypropionsäure |
| US20150119601A1 (en) | 2013-03-15 | 2015-04-30 | Opx Biotechnologies, Inc. | Monofunctional mcr + 3-hp dehydrogenase |
| JP2016520325A (ja) * | 2013-06-05 | 2016-07-14 | ランザテク・ニュージーランド・リミテッド | 発酵経路を通る流束の増加を示す、組換え微生物 |
| EP3008179A1 (de) | 2013-06-14 | 2016-04-20 | Technical University of Denmark | 3hp-toleranz |
| WO2015010103A2 (en) | 2013-07-19 | 2015-01-22 | Opx Biotechnologies, Inc. | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| EP2993228B1 (de) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Herstellung von fettsäureestern |
| KR101730035B1 (ko) | 2015-03-20 | 2017-04-26 | 한국과학기술원 | L-아스파르트산 유도체를 생산하는 변이미생물 및 이를 이용한 l-아스파르트산 유도체의 제조방법 |
| JP2020506702A (ja) | 2017-02-02 | 2020-03-05 | カーギル インコーポレイテッド | Ｃ６−ｃ１０脂肪酸誘導体を生成する遺伝子組み換え細胞 |
| WO2018190398A1 (ja) * | 2017-04-13 | 2018-10-18 | 協和発酵バイオ株式会社 | テアニンの製造方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001016346A1 (en) | 1999-08-30 | 2001-03-08 | Wisconsin Alumni Research Foundation | Production of 3-hydroxypropionic acid in recombinant organisms |
| MXPA03004324A (es) * | 2000-11-20 | 2004-01-26 | Cargill Inc | Acido 3-hidroxipropionico y otros compuestos organicos. |
| JP4532116B2 (ja) | 2002-01-18 | 2010-08-25 | ノボザイムズ エー／エス | アラニン２，３−アミノムターゼ |
| JP2008507970A (ja) | 2004-07-30 | 2008-03-21 | カーギル インコーポレイテッド | アラニン２，３アミノムターゼ |
-
2004
- 2004-12-06 EP EP04821820A patent/EP1706457B1/de not_active Not-in-force
- 2004-12-06 BR BRPI0416546-2A patent/BRPI0416546A/pt not_active Application Discontinuation
- 2004-12-06 AT AT04821820T patent/ATE543873T1/de active
- 2004-12-06 US US10/581,570 patent/US7700319B2/en not_active Expired - Fee Related
- 2004-12-06 DK DK04821820.0T patent/DK1706457T3/da active
- 2004-12-06 WO PCT/US2004/040827 patent/WO2005118719A2/en active Search and Examination
-
2010
- 2010-02-03 US US12/699,715 patent/US7785837B2/en not_active Expired - Fee Related
- 2010-06-29 US US12/826,401 patent/US8124388B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005118719A2 (en) | 2005-12-15 |
| US8124388B2 (en) | 2012-02-28 |
| US7700319B2 (en) | 2010-04-20 |
| BRPI0416546A (pt) | 2007-01-09 |
| EP1706457A2 (de) | 2006-10-04 |
| DK1706457T3 (da) | 2012-05-21 |
| US20100267115A1 (en) | 2010-10-21 |
| US20100136638A1 (en) | 2010-06-03 |
| EP1706457B1 (de) | 2012-02-01 |
| US7785837B2 (en) | 2010-08-31 |
| WO2005118719A3 (en) | 2006-09-21 |
| US20070107080A1 (en) | 2007-05-10 |
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