CY1118157T1 - Εκλεκτικοι αναστολεις γλυκοσιδασης και χρησεις αυτων - Google Patents

Εκλεκτικοι αναστολεις γλυκοσιδασης και χρησεις αυτων

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Publication number
CY1118157T1
CY1118157T1 CY20161100886T CY161100886T CY1118157T1 CY 1118157 T1 CY1118157 T1 CY 1118157T1 CY 20161100886 T CY20161100886 T CY 20161100886T CY 161100886 T CY161100886 T CY 161100886T CY 1118157 T1 CY1118157 T1 CY 1118157T1
Authority
CY
Cyprus
Prior art keywords
compounds
inspectors
extensive
glucose residues
prodrugs
Prior art date
Application number
CY20161100886T
Other languages
English (en)
Inventor
Ramesh Kaul
Ernest J Mceachern
Changwei Mu
Harold G Selnick
David J Vocadlo
Yaode Wang
Zhongyong Wei
Yuanxi Zhou
Yongbao Zhu
Original Assignee
Alectos Therapeutics Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CN2011/074569 external-priority patent/WO2012159262A1/en
Application filed by Alectos Therapeutics Inc. filed Critical Alectos Therapeutics Inc.
Publication of CY1118157T1 publication Critical patent/CY1118157T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/06—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing nitrogen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
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    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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Abstract

Η εφεύρεση παρέχει ενώσεις με ενισχυμένη διαπερατότητα για εκλεκτική αναστολή γλυκοσιδασών, προφάρμακα των ενώσεων και φαρμακευτικές συνθέσεις που περιλαμβάνουν τις ενώσεις ή προφάρμακα των ενώσεων. Η εφεύρεση επίσης παρέχει μεθόδους θεραπείας ασθενειών και διαταραχών που σχετίζονται με ανεπάρκεια ή υπερέκφραση O-GlcNAcάσης, συσσώρευση ή ανεπάρκεια GlcNAc.
CY20161100886T 2010-12-23 2016-09-07 Εκλεκτικοι αναστολεις γλυκοσιδασης και χρησεις αυτων CY1118157T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201061426773P 2010-12-23 2010-12-23
PCT/CN2011/074569 WO2012159262A1 (en) 2011-05-24 2011-05-24 Selective glycosidase inhibitors and uses thereof
US201161507684P 2011-07-14 2011-07-14
PCT/CA2011/001397 WO2012083435A1 (en) 2010-12-23 2011-12-21 Selective glycosidase inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
CY1118157T1 true CY1118157T1 (el) 2017-06-28

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CY20161100886T CY1118157T1 (el) 2010-12-23 2016-09-07 Εκλεκτικοι αναστολεις γλυκοσιδασης και χρησεις αυτων

Country Status (27)

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US (2) US9243020B2 (el)
EP (1) EP2655388B1 (el)
JP (2) JP5861194B2 (el)
KR (1) KR101979036B1 (el)
CN (1) CN103339138B (el)
AR (1) AR085004A1 (el)
AU (1) AU2011349021B2 (el)
BR (1) BR112013016179A2 (el)
CA (1) CA2822493C (el)
CO (1) CO6821931A2 (el)
CY (1) CY1118157T1 (el)
DK (1) DK2655388T3 (el)
ES (1) ES2589164T3 (el)
HK (1) HK1191016A1 (el)
HR (1) HRP20161079T1 (el)
HU (1) HUE030624T2 (el)
IL (1) IL227055A (el)
LT (1) LT2655388T (el)
MX (1) MX343822B (el)
MY (1) MY165728A (el)
NZ (1) NZ612703A (el)
PL (1) PL2655388T3 (el)
PT (1) PT2655388T (el)
RU (1) RU2609210C2 (el)
TW (1) TWI572609B (el)
WO (1) WO2012083435A1 (el)
ZA (1) ZA201305531B (el)

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WO2008025170A1 (en) 2006-08-31 2008-03-06 Simon Fraser University Selective glycosidase inhibitors and uses thereof
US9079868B2 (en) * 2008-08-01 2015-07-14 Simon Fraser University Selective glycosidase inhibitors and uses thereof
WO2011140640A1 (en) 2010-05-11 2011-11-17 Simon Fraser University Selective glycosidase inhibitors and uses thereof
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JP5861194B2 (ja) * 2010-12-23 2016-02-16 アレクトス・セラピューティクス・インコーポレイテッド 選択的グルコシダーゼインヒビターおよびその使用
US8927507B2 (en) 2011-03-24 2015-01-06 Ernest J. McEachern Selective glycosidase inhibitors and uses thereof
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CN111956656B (zh) * 2020-08-28 2021-10-15 河北大学 Oga抑制剂在制备抗肿瘤药物中的应用
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KR101979036B1 (ko) 2019-05-15
AU2011349021B2 (en) 2016-12-22
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