CY1115633T1 - Παραγωγα πυραζολο πυριδινης ως αναστολεις της nadph οξειδασης - Google Patents
Παραγωγα πυραζολο πυριδινης ως αναστολεις της nadph οξειδασηςInfo
- Publication number
- CY1115633T1 CY1115633T1 CY20141100820T CY141100820T CY1115633T1 CY 1115633 T1 CY1115633 T1 CY 1115633T1 CY 20141100820 T CY20141100820 T CY 20141100820T CY 141100820 T CY141100820 T CY 141100820T CY 1115633 T1 CY1115633 T1 CY 1115633T1
- Authority
- CY
- Cyprus
- Prior art keywords
- pyrozine
- pyridene
- producers
- oxidation inhibitors
- nadph oxidation
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Pain & Pain Management (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Gynecology & Obstetrics (AREA)
- Communicable Diseases (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε παράγωγα πυραζολο πυριδίνης του Τύπου (Ι), σε φαρμακευτική σύνθεση αυτών και στη χρήση τους για τη θεραπευτική αγωγή ή/και προφύλαξη από διαταραχές ή καταστάσεις που σχετίζονται με ανηγμένη μορφή του φωσφορικού νικοτιναμιδο αδενινο δινουκλεοτιδίου-οξειδάση (NADPH Οξειδάση).
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US89628407P | 2007-03-22 | 2007-03-22 | |
EP07109555A EP2002835A1 (en) | 2007-06-04 | 2007-06-04 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
EP12187254.3A EP2545918B1 (en) | 2007-03-22 | 2008-03-20 | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1115633T1 true CY1115633T1 (el) | 2017-01-04 |
Family
ID=38653574
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20131100067T CY1113556T1 (el) | 2007-03-22 | 2013-01-23 | Παραγωγα πυραζολο πυριδινης ως αναστολεις της nadph οξειδασης |
CY20141100820T CY1115633T1 (el) | 2007-03-22 | 2014-10-09 | Παραγωγα πυραζολο πυριδινης ως αναστολεις της nadph οξειδασης |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20131100067T CY1113556T1 (el) | 2007-03-22 | 2013-01-23 | Παραγωγα πυραζολο πυριδινης ως αναστολεις της nadph οξειδασης |
Country Status (18)
Country | Link |
---|---|
US (2) | US8389518B2 (el) |
EP (3) | EP2002835A1 (el) |
JP (2) | JP5715340B2 (el) |
CN (2) | CN105061422B (el) |
AU (1) | AU2008228186C1 (el) |
BR (1) | BRPI0808824B8 (el) |
CA (1) | CA2676954C (el) |
CY (2) | CY1113556T1 (el) |
DK (2) | DK2139477T3 (el) |
ES (2) | ES2398994T3 (el) |
HK (2) | HK1141734A1 (el) |
HR (2) | HRP20130143T1 (el) |
IL (1) | IL201009A (el) |
PL (2) | PL2139477T3 (el) |
PT (2) | PT2545918E (el) |
RS (2) | RS52640B (el) |
SI (2) | SI2139477T1 (el) |
WO (1) | WO2008113856A1 (el) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2002835A1 (en) * | 2007-06-04 | 2008-12-17 | GenKyo Tex | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
EP2000176A1 (en) | 2007-06-04 | 2008-12-10 | GenKyo Tex | Tetrahydroindole derivatives as NADPH Oxidase inhibitors |
EP2166010A1 (en) * | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
EP2166008A1 (en) | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
EP2166009A1 (en) * | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as nadph oxidase inhibitors |
EP2165707A1 (en) * | 2008-09-23 | 2010-03-24 | Genkyo Tex Sa | Pyrazolo pyridine derivatives as NADPH oxidase inhibitors |
US20120141461A1 (en) * | 2009-07-17 | 2012-06-07 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating fibrotic disorders |
EP2305679A1 (en) * | 2009-09-28 | 2011-04-06 | GenKyoTex SA | Pyrazoline dione derivatives as nadph oxidase inhibitors |
WO2011075559A1 (en) * | 2009-12-18 | 2011-06-23 | Glaxo Wellcome Manufacturing Pte Ltd. | Novel compounds |
EP2361912A1 (en) * | 2010-02-18 | 2011-08-31 | GenKyoTex SA | Pyrazolo piperidine derivatives as NADPH oxidase inhibitors |
EP2361911A1 (en) * | 2010-02-18 | 2011-08-31 | GenKyoTex SA | Pyrazolo piperidine derivatives as NADPH oxidase inhibitors |
WO2012173952A1 (en) | 2011-06-13 | 2012-12-20 | Emory University | Piperazine derivatives, compositions, and uses related thereto |
GB2494679A (en) * | 2011-09-15 | 2013-03-20 | Univ Jw Goethe Frankfurt Main | Treatment of neuropathic pain and nerve injury by Nox4 inhibition |
EP2591782A1 (en) * | 2011-11-11 | 2013-05-15 | Johann Wolfgang Goethe-Universität | Nadph oxidase 4 inhibitors and use thereof |
WO2014153227A1 (en) * | 2013-03-14 | 2014-09-25 | Eastern Virginia Medical School | Methods of preserving and protecting pancreatic beta cells and treating or preventing diabetes by inhibiting nox-1 |
EP2857399A1 (en) | 2013-10-03 | 2015-04-08 | GenKyoTex SA | Compounds useful for the treatment of PDE5 inhibitor-poorly responsive erectile dysfunction |
EP3098220A1 (en) | 2015-05-28 | 2016-11-30 | GenKyoTex SA | Process for the preparation of a nadph oxidase inhibitor and its polymorphs and uses thereof |
TW201713650A (en) | 2015-06-22 | 2017-04-16 | Actelion Pharmaceuticals Ltd | NADPH oxidase 4 inhibitors |
WO2017196970A1 (en) | 2016-05-10 | 2017-11-16 | Georgia State University Research Foundation, Inc. | Heterocyclic derivatives for the thratment of rsv |
EP3454897A4 (en) * | 2016-05-10 | 2020-01-15 | Georgia State University Research Foundation, Inc. | BICYCLIC CONDENSED PYRAZOLE DERIVATIVES FOR THE TREATMENT OF RSV |
AR109595A1 (es) | 2016-09-09 | 2018-12-26 | Incyte Corp | Compuestos de pirazolopirimidina y usos de estos como inhibidores de hpk1 |
AR109596A1 (es) | 2016-09-09 | 2018-12-26 | Incyte Corp | Compuestos pirazolopiridina y sus usos |
US20180072718A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
WO2018049191A1 (en) | 2016-09-09 | 2018-03-15 | Incyte Corporation | Pyrazolopyridone derivatives as hpk1 modulators and uses thereof for the treatment of cancer |
US20180228786A1 (en) | 2017-02-15 | 2018-08-16 | Incyte Corporation | Pyrazolopyridine compounds and uses thereof |
PE20191789A1 (es) | 2017-05-04 | 2019-12-24 | Glenmark Pharmaceuticals Sa | Compuestos heterociclicos biciclicos sustituidos como inhibidores de la nadph oxidasa |
US11236053B2 (en) | 2017-07-26 | 2022-02-01 | Emory University | NADPH oxidase inhibitors and uses thereof |
WO2019051199A1 (en) | 2017-09-08 | 2019-03-14 | Incyte Corporation | 6-CYANO-INDAZOLE COMPOUNDS AS HEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) MODULATORS |
EP3479843A1 (en) | 2017-11-01 | 2019-05-08 | GenKyoTex Suisse SA | Use of nox inhibitors for treatment of cancer |
US10745388B2 (en) | 2018-02-20 | 2020-08-18 | Incyte Corporation | Indazole compounds and uses thereof |
SI3755703T1 (sl) | 2018-02-20 | 2022-11-30 | Incyte Corporation | N-(fenil)-2-(fenil)pirimidin-4-karboksamidni derivati in sorodne spojine kot zaviralci HPK1 za zravljenje raka |
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