CY1115227T1 - Νεοι καταστολεις φωσφοδιεστερασης (phosphodiesterase) - Google Patents
Νεοι καταστολεις φωσφοδιεστερασης (phosphodiesterase)Info
- Publication number
- CY1115227T1 CY1115227T1 CY20141100437T CY141100437T CY1115227T1 CY 1115227 T1 CY1115227 T1 CY 1115227T1 CY 20141100437 T CY20141100437 T CY 20141100437T CY 141100437 T CY141100437 T CY 141100437T CY 1115227 T1 CY1115227 T1 CY 1115227T1
- Authority
- CY
- Cyprus
- Prior art keywords
- representatives
- compounds
- new phosphodiesterase
- phosphodiesterase
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/357—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
- A61K31/36—Compounds containing methylenedioxyphenyl groups, e.g. sesamin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/08—Antiseborrheics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
Abstract
Η παρούσα εφεύρεση σχετίζεται με μία ένωση σύμφωνα με τον τύπο I, όπου τα Χ, A, G, Ε, R1, R2, R3 είναι όπως φαίνεται στην παρούσα και φαρμακευτικά αποδεκτά άλατα, ένυδρα, Ν-οξείδια ή διαλυτώματα αυτών. Η εφεύρεση σχετίζεται περαιτέρω με τις εν λόγω ενώσεις, με μεθόδους θεραπείας ασθενειών, π.χ. δερματικών ασθενειών, με τις εν λόγω ενώσεις, και την χρήση των εν λόγω ενώσεων στην κατασκευή φαρμάκων.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90384907P | 2007-02-28 | 2007-02-28 | |
US94684907P | 2007-06-28 | 2007-06-28 | |
EP08706922.5A EP2114951B9 (en) | 2007-02-28 | 2008-02-26 | Novel phosphodiesterase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1115227T1 true CY1115227T1 (el) | 2017-01-04 |
Family
ID=39415336
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20141100437T CY1115227T1 (el) | 2007-02-28 | 2014-06-17 | Νεοι καταστολεις φωσφοδιεστερασης (phosphodiesterase) |
Country Status (22)
Country | Link |
---|---|
US (1) | US8338431B2 (el) |
EP (1) | EP2114951B9 (el) |
JP (1) | JP5501770B2 (el) |
KR (1) | KR101571654B1 (el) |
AU (1) | AU2008221121B2 (el) |
BR (1) | BRPI0807749B8 (el) |
CA (1) | CA2676933C (el) |
CY (1) | CY1115227T1 (el) |
DK (1) | DK2114951T3 (el) |
ES (1) | ES2478670T3 (el) |
HK (1) | HK1138262A1 (el) |
HR (1) | HRP20140585T1 (el) |
IL (1) | IL200153A (el) |
MX (1) | MX2009009238A (el) |
MY (1) | MY150075A (el) |
NZ (1) | NZ578804A (el) |
PL (1) | PL2114951T3 (el) |
PT (1) | PT2114951E (el) |
RS (1) | RS53407B (el) |
RU (1) | RU2495043C2 (el) |
SI (1) | SI2114951T1 (el) |
WO (1) | WO2008104175A2 (el) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2560677C2 (ru) | 2009-12-22 | 2015-08-20 | Лео Фарма А/С | Кожная композиция, включающая аналог витамина d и смесь растворителя и поверхностно-активных веществ |
MX2012007234A (es) | 2009-12-22 | 2012-07-30 | Leo Pharma As | Nanocristales de monohidrato de calciprotiol. |
ES2452872T3 (es) | 2009-12-22 | 2014-04-03 | Leo Pharma A/S | Composición farmacéutica que comprende una mezcla solvente y un derivado o análogo de vitamina D |
PT2585469T (pt) | 2010-06-24 | 2016-08-29 | Leo Pharma As | Compostos heterocíclicos de benzodioxolo ou benzodioxepina como inibidores da fosfodiesterase |
WO2013122855A1 (en) * | 2012-02-14 | 2013-08-22 | University Of Rochester | Methods of increasing lymphatic transport |
RU2637945C2 (ru) * | 2012-06-04 | 2017-12-08 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Производные 1-фенил-2-пиридинил-алкиловых спиртов в качестве ингибиторов фосфодиэстеразы |
RU2663448C2 (ru) * | 2012-11-30 | 2018-08-06 | Лео Фарма А/С | Способ ингибирования экспрессии ил-22 активированными т-клетками |
JP6785666B2 (ja) * | 2014-06-23 | 2020-11-18 | レオ ファーマ アクティーゼルスカブ | 1,3−ベンゾジオキソール複素環化合物の調製方法 |
EP3310777B1 (en) | 2015-06-19 | 2019-10-09 | Bristol-Myers Squibb Company | Diamide macrocycles as factor xia inhibitors |
CA3007432A1 (en) * | 2015-12-18 | 2017-06-22 | Leo Pharma A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
US10793580B2 (en) | 2016-12-12 | 2020-10-06 | Leo Pharma A/S | Substituted pyrazoloazepin-8-ones and their use as phosphodiesterase inhibitors |
EP3551633B1 (en) * | 2016-12-12 | 2021-03-31 | Leo Pharma A/S | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors |
EP3551632A1 (en) * | 2016-12-12 | 2019-10-16 | Leo Pharma A/S | Substituted pyrazoloazepin-4-ones and their use as phosphodiesterase inhibitors |
AU2018286964B2 (en) * | 2017-06-20 | 2022-04-14 | UNION therapeutics A/S | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
TW201919682A (zh) | 2017-08-08 | 2019-06-01 | 西班牙商阿爾米雷爾有限公司 | 活化Nrf2路徑的新穎化合物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9507297D0 (en) | 1995-04-07 | 1995-05-31 | Rh Ne Poulenc Rorer Limited | New composition of matter |
JP4172817B2 (ja) * | 1995-05-19 | 2008-10-29 | 協和醗酵工業株式会社 | 含酸素複素環化合物 |
US6514996B2 (en) | 1995-05-19 | 2003-02-04 | Kyowa Hakko Kogyo Co., Ltd. | Derivatives of benzofuran or benzodioxole |
NZ332340A (en) | 1996-05-20 | 2000-04-28 | Darwin Discovery Ltd | 4-(aryl or heteroaryl) substituted benzofurancarboxamide derivatives and medicaments |
ATE272062T1 (de) * | 1996-08-28 | 2004-08-15 | Procter & Gamble | Spirocyclisch metalloprotease inhibitoren |
EP0943613A4 (en) * | 1996-11-19 | 2002-07-10 | Kyowa Hakko Kogyo Kk | HETEROCYCLIC COMPOUNDS CONTAINING OXYGEN |
JP4219554B2 (ja) * | 1997-10-01 | 2009-02-04 | 協和発酵キリン株式会社 | ベンゾフラン誘導体 |
DE19907038C2 (de) | 1999-02-19 | 2003-04-10 | Schott Glas | Transluzente oder opake Glaskeramik mit Hochquarz-Mischkristallen als vorherrschender Kristallphase und deren Verwendung |
-
2008
- 2008-02-26 ES ES08706922.5T patent/ES2478670T3/es active Active
- 2008-02-26 CA CA2676933A patent/CA2676933C/en active Active
- 2008-02-26 WO PCT/DK2008/000080 patent/WO2008104175A2/en active Application Filing
- 2008-02-26 PT PT87069225T patent/PT2114951E/pt unknown
- 2008-02-26 BR BRPI0807749A patent/BRPI0807749B8/pt active IP Right Grant
- 2008-02-26 AU AU2008221121A patent/AU2008221121B2/en active Active
- 2008-02-26 KR KR1020097018073A patent/KR101571654B1/ko active IP Right Grant
- 2008-02-26 PL PL08706922T patent/PL2114951T3/pl unknown
- 2008-02-26 US US12/528,649 patent/US8338431B2/en active Active
- 2008-02-26 MY MYPI20093168A patent/MY150075A/en unknown
- 2008-02-26 RU RU2009135810/04A patent/RU2495043C2/ru active
- 2008-02-26 RS RS20140365A patent/RS53407B/en unknown
- 2008-02-26 SI SI200831224T patent/SI2114951T1/sl unknown
- 2008-02-26 EP EP08706922.5A patent/EP2114951B9/en active Active
- 2008-02-26 DK DK08706922.5T patent/DK2114951T3/da active
- 2008-02-26 MX MX2009009238A patent/MX2009009238A/es active IP Right Grant
- 2008-02-26 NZ NZ578804A patent/NZ578804A/en unknown
- 2008-02-26 JP JP2009551915A patent/JP5501770B2/ja active Active
-
2009
- 2009-07-30 IL IL200153A patent/IL200153A/en active IP Right Grant
-
2010
- 2010-04-07 HK HK10103418.6A patent/HK1138262A1/xx unknown
-
2014
- 2014-06-17 CY CY20141100437T patent/CY1115227T1/el unknown
- 2014-06-23 HR HRP20140585AT patent/HRP20140585T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
CA2676933C (en) | 2015-09-29 |
US8338431B2 (en) | 2012-12-25 |
MY150075A (en) | 2013-11-29 |
HRP20140585T1 (hr) | 2014-09-12 |
BRPI0807749B8 (pt) | 2022-09-06 |
EP2114951B1 (en) | 2014-04-09 |
US20100099688A1 (en) | 2010-04-22 |
KR20090126252A (ko) | 2009-12-08 |
JP2010519332A (ja) | 2010-06-03 |
PT2114951E (pt) | 2014-07-17 |
RU2009135810A (ru) | 2011-04-10 |
WO2008104175A2 (en) | 2008-09-04 |
WO2008104175A3 (en) | 2009-01-29 |
IL200153A0 (en) | 2010-04-15 |
CA2676933A1 (en) | 2008-09-04 |
MX2009009238A (es) | 2009-09-08 |
RU2495043C2 (ru) | 2013-10-10 |
DK2114951T3 (da) | 2014-06-23 |
NZ578804A (en) | 2012-04-27 |
IL200153A (en) | 2016-11-30 |
BRPI0807749B1 (pt) | 2021-01-05 |
EP2114951B9 (en) | 2015-09-02 |
RS53407B (en) | 2014-10-31 |
KR101571654B1 (ko) | 2015-11-25 |
EP2114951A2 (en) | 2009-11-11 |
JP5501770B2 (ja) | 2014-05-28 |
AU2008221121B2 (en) | 2013-10-03 |
BRPI0807749A2 (pt) | 2014-06-17 |
AU2008221121A1 (en) | 2008-09-04 |
SI2114951T1 (sl) | 2014-08-29 |
HK1138262A1 (en) | 2010-08-20 |
ES2478670T3 (es) | 2014-07-22 |
PL2114951T3 (pl) | 2014-10-31 |
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