CY1113825T1 - Υδατικα εναιωρηματα ριλουζολης - Google Patents
Υδατικα εναιωρηματα ριλουζοληςInfo
- Publication number
- CY1113825T1 CY1113825T1 CY20131100136T CY131100136T CY1113825T1 CY 1113825 T1 CY1113825 T1 CY 1113825T1 CY 20131100136 T CY20131100136 T CY 20131100136T CY 131100136 T CY131100136 T CY 131100136T CY 1113825 T1 CY1113825 T1 CY 1113825T1
- Authority
- CY
- Cyprus
- Prior art keywords
- suspensions
- riluzole
- rusluzole
- aquatic
- aqueous
- Prior art date
Links
- 239000000725 suspension Substances 0.000 title abstract 3
- FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical compound C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 abstract 4
- 229960004181 riluzole Drugs 0.000 abstract 4
- 239000007900 aqueous suspension Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
- 239000000080 wetting agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/428—Thiazoles condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Φυσικά και χημικά σταθερά υδατικά εναιωρήματα ριλουζόλης αποκαλύπτονται μαζί με τις μεθόδους παρασκευής αυτών. Τέτοια υδατικά εναιωρήματα περιλαμβάνουν ριλουζόλη σε μορφή σωματιδίων και τουλάχιστον ένα μέσον ύγρανσης, κατά προτίμηση ένα επιφανειοδραστικό. Η ριλουζόλη απαντά σε ποσότητες από περίπου 0,1% έως περίπου 20% w/v και έχει ένα μέσο μέγεθος σωματιδίου μικρότερο από 200 μm, τέτοια εναιωρήματα είναι απαλλαγμένα από τις γνωστές τοπικές (στοματικές) επιδράσεις της ριλουζόλης.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09425101A EP2228054A1 (en) | 2009-03-13 | 2009-03-13 | Riluzole aqueous suspensions |
EP10706234A EP2405890B1 (en) | 2009-03-13 | 2010-03-02 | Riluzole aqueous suspensions |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1113825T1 true CY1113825T1 (el) | 2016-07-27 |
Family
ID=40810549
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20131100136T CY1113825T1 (el) | 2009-03-13 | 2013-02-14 | Υδατικα εναιωρηματα ριλουζολης |
Country Status (22)
Country | Link |
---|---|
US (1) | US8765150B2 (el) |
EP (2) | EP2228054A1 (el) |
JP (1) | JP5607083B2 (el) |
KR (1) | KR101680175B1 (el) |
CN (1) | CN102341091B (el) |
BR (1) | BRPI1006418A2 (el) |
CA (1) | CA2748856C (el) |
CL (1) | CL2011002217A1 (el) |
CO (1) | CO6410281A2 (el) |
CY (1) | CY1113825T1 (el) |
DK (1) | DK2405890T3 (el) |
ES (1) | ES2400349T3 (el) |
HK (1) | HK1161985A1 (el) |
HR (1) | HRP20130021T1 (el) |
MX (1) | MX2011008922A (el) |
PE (1) | PE20120649A1 (el) |
PL (1) | PL2405890T3 (el) |
PT (1) | PT2405890E (el) |
RU (1) | RU2498802C2 (el) |
SI (1) | SI2405890T1 (el) |
SM (1) | SMT201300022B (el) |
WO (1) | WO2010102923A2 (el) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013010015A2 (en) * | 2011-07-13 | 2013-01-17 | Cytokinetics, Inc. | Combination als therapy |
US10357497B2 (en) | 2012-06-23 | 2019-07-23 | Biohaven Pharmaceutical Holding Company Limited | Pro-drugs of riluzole and their method of use for the treatment of amyotrophic lateral sclerosis |
DK3023093T3 (da) * | 2014-11-20 | 2017-11-06 | S I I T S R L -Servizio Int Imballaggi Termosaldanti | Medicinsk præparat på basis af diosmectit |
DK3220891T3 (da) * | 2014-11-21 | 2019-11-04 | Biohaven Therapeutics Ltd | Sublingual formulering af riluzol |
CN107735077A (zh) * | 2014-11-21 | 2018-02-23 | 拜尔哈文制药股份有限公司 | 利鲁唑的舌下给药 |
US11911369B2 (en) * | 2015-03-03 | 2024-02-27 | Biohaven Therapeutics Ltd. | Prodrugs of riluzole and their method of use |
ITUB20155193A1 (it) * | 2015-11-03 | 2017-05-03 | Italfarmaco Spa | Sospensioni orali di Givinostat fisicamente e chimicamente stabili |
CN105726477B (zh) * | 2016-03-01 | 2018-10-12 | 山东司邦得制药有限公司 | 一种小儿多潘立酮混悬液及其制备方法 |
CN108721325B (zh) * | 2017-04-13 | 2020-03-06 | 辽宁大熊制药有限公司 | 蒙脱石混悬液及其制备方法 |
WO2019108594A1 (en) * | 2017-11-28 | 2019-06-06 | University Of Houston System | Liquid formulations of riluzole for oral and intravenous use |
CN111437256A (zh) * | 2019-01-17 | 2020-07-24 | 北京万全德众医药生物技术有限公司 | 一种利鲁唑缓释口服混悬液 |
CN115025056A (zh) * | 2022-06-27 | 2022-09-09 | 郑州大学第一附属医院 | 一种含有替加氟、吉莫斯特和奥替拉西钾的口腔崩解制剂 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SK282950B6 (sk) | 1990-04-24 | 2003-01-09 | Biota Scientific Management Pty Ltd | Deriváty alfa-D-neuramínovej kyseliny, spôsob ich prípravy, ich použitie a farmaceutické prípravky na ich báze |
FR2688138B1 (fr) | 1992-03-06 | 1995-05-05 | Rhone Poulenc Rorer Sa | Application de l'amino-2 trifluoromethoxy-6 benzothiazole pour obtenir un medicament destine au traitement de la sclerose laterale amyotrophique. |
AUPN605795A0 (en) * | 1995-10-19 | 1995-11-09 | F.H. Faulding & Co. Limited | Analgesic pharmaceutical composition |
FR2777781B1 (fr) * | 1998-04-24 | 2004-04-09 | Rhone Poulenc Rorer Sa | Associations riluzole et l-dopa pour le traitement de la maladie de parkinson |
US7374779B2 (en) * | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
ATE419851T1 (de) * | 1999-06-04 | 2009-01-15 | Vereniging Voor Christelijk Wetenschappelijk Onderwijs | Verwendung von riluzol zur behandlung multipler sklerose |
EA004251B1 (ru) * | 1999-08-12 | 2004-02-26 | Эли Лилли Энд Компани | Эктопаразитицидные водные суспензионные препараты спинозинов |
US20030180352A1 (en) * | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US6432992B1 (en) | 2000-06-05 | 2002-08-13 | Aventis Pharm Sa | Use of riluzole or its salts for the prevention and treatment of adrenoleukodystrophy |
US6613308B2 (en) * | 2000-09-19 | 2003-09-02 | Advanced Inhalation Research, Inc. | Pulmonary delivery in treating disorders of the central nervous system |
US6861413B2 (en) * | 2001-05-22 | 2005-03-01 | Pfizer Inc. | Stable non-dihydrate azithromycin oral suspensions |
EP1492511B3 (fr) | 2002-04-09 | 2012-05-02 | Flamel Technologies | Formulation pharmaceutique orale sous forme de suspension aqueuse de microcapsules permettant la liberation modifiee de principe(s) actif(s) |
US7396860B2 (en) | 2002-11-15 | 2008-07-08 | Teva Pharmaceutical Industries, Ltd. | Use of rasagiline with or without riluzole to treat amyotrophic lateral sclerosis |
DK1477166T3 (da) | 2003-04-28 | 2006-12-11 | Biofrontera Bioscience Gmbh | Anvendelse af riluzoler kombineret med egnede hjælpe- og tilsætningsstoffer til behandling af sygdomme, som er kendetegnet ved en hyperproliferation af keratinocytter, navnlig neurodermitis og psoriasis |
US20050266032A1 (en) | 2003-12-17 | 2005-12-01 | Sovereign Pharmaceuticals, Ltd. | Dosage form containing multiple drugs |
US9492541B2 (en) | 2004-09-14 | 2016-11-15 | Sovereign Pharmaceuticals, Llc | Phenylepherine containing dosage form |
CA2558380A1 (en) | 2004-03-03 | 2005-09-15 | Teva Pharmaceutical Industries, Ltd. | Combination therapy with glatiramer acetate and riluzole |
US7691368B2 (en) * | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
ITMI20061274A1 (it) * | 2006-06-30 | 2008-01-01 | Consiglio Nazionale Ricerche | Vettori nanoparticellari lipidici contenenti riluzolo e composizioni farmaceutiche che li contengono |
US9132071B2 (en) * | 2006-07-28 | 2015-09-15 | Santen Sas | Compositions containing quaternary ammonium compounds |
UA41879U (ru) * | 2009-02-03 | 2009-06-10 | Сергей Викторович Фурс | Инфракрасный обогревательный прибор |
-
2009
- 2009-03-13 EP EP09425101A patent/EP2228054A1/en not_active Withdrawn
-
2010
- 2010-03-02 ES ES10706234T patent/ES2400349T3/es active Active
- 2010-03-02 JP JP2011553390A patent/JP5607083B2/ja active Active
- 2010-03-02 CN CN2010800108923A patent/CN102341091B/zh active Active
- 2010-03-02 CA CA2748856A patent/CA2748856C/en active Active
- 2010-03-02 PL PL10706234T patent/PL2405890T3/pl unknown
- 2010-03-02 PT PT107062341T patent/PT2405890E/pt unknown
- 2010-03-02 RU RU2011141422/15A patent/RU2498802C2/ru active
- 2010-03-02 US US13/138,047 patent/US8765150B2/en active Active
- 2010-03-02 PE PE2011001558A patent/PE20120649A1/es active IP Right Grant
- 2010-03-02 SI SI201030130T patent/SI2405890T1/sl unknown
- 2010-03-02 MX MX2011008922A patent/MX2011008922A/es active IP Right Grant
- 2010-03-02 KR KR1020117020162A patent/KR101680175B1/ko active Protection Beyond IP Right Term
- 2010-03-02 DK DK10706234.1T patent/DK2405890T3/da active
- 2010-03-02 EP EP10706234A patent/EP2405890B1/en active Active
- 2010-03-02 BR BRPI1006418A patent/BRPI1006418A2/pt not_active Application Discontinuation
- 2010-03-02 WO PCT/EP2010/052598 patent/WO2010102923A2/en active Application Filing
-
2011
- 2011-08-24 CO CO11107620A patent/CO6410281A2/es not_active Application Discontinuation
- 2011-09-08 CL CL2011002217A patent/CL2011002217A1/es unknown
-
2012
- 2012-03-14 HK HK12102552.2A patent/HK1161985A1/xx unknown
-
2013
- 2013-01-14 HR HRP20130021AT patent/HRP20130021T1/hr unknown
- 2013-02-14 CY CY20131100136T patent/CY1113825T1/el unknown
- 2013-02-14 SM SM201300022T patent/SMT201300022B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
PT2405890E (pt) | 2013-02-20 |
RU2498802C2 (ru) | 2013-11-20 |
WO2010102923A2 (en) | 2010-09-16 |
EP2405890B1 (en) | 2012-11-28 |
WO2010102923A3 (en) | 2011-03-03 |
BRPI1006418A2 (pt) | 2016-11-29 |
US20120039953A1 (en) | 2012-02-16 |
KR101680175B1 (ko) | 2016-11-28 |
RU2011141422A (ru) | 2013-04-20 |
CA2748856A1 (en) | 2010-09-16 |
PL2405890T3 (pl) | 2013-04-30 |
CA2748856C (en) | 2017-01-03 |
CN102341091B (zh) | 2013-08-07 |
EP2405890A2 (en) | 2012-01-18 |
JP5607083B2 (ja) | 2014-10-15 |
MX2011008922A (es) | 2011-12-06 |
HRP20130021T1 (hr) | 2013-02-28 |
CL2011002217A1 (es) | 2012-03-09 |
HK1161985A1 (en) | 2012-08-17 |
US8765150B2 (en) | 2014-07-01 |
SMT201300022B (it) | 2013-03-08 |
KR20120003854A (ko) | 2012-01-11 |
CN102341091A (zh) | 2012-02-01 |
DK2405890T3 (da) | 2013-02-04 |
PE20120649A1 (es) | 2012-06-07 |
EP2228054A1 (en) | 2010-09-15 |
ES2400349T3 (es) | 2013-04-09 |
CO6410281A2 (es) | 2012-03-30 |
SI2405890T1 (sl) | 2013-02-28 |
JP2012520254A (ja) | 2012-09-06 |
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