CY1112655T1 - Γλυκοζυλιωμενη ιl-7, παρασκευη και χρησεις - Google Patents
Γλυκοζυλιωμενη ιl-7, παρασκευη και χρησειςInfo
- Publication number
- CY1112655T1 CY1112655T1 CY20121100161T CY121100161T CY1112655T1 CY 1112655 T1 CY1112655 T1 CY 1112655T1 CY 20121100161 T CY20121100161 T CY 20121100161T CY 121100161 T CY121100161 T CY 121100161T CY 1112655 T1 CY1112655 T1 CY 1112655T1
- Authority
- CY
- Cyprus
- Prior art keywords
- polypeptides
- well
- relates
- preparation
- cells
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/54—Interleukins [IL]
- C07K14/5418—IL-7
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σε νέα και βελτιωμένα πολυπεπτίδια ιντερλευκίνης-7, καθώς επίσης συνθέσεις που περιλαμβάνουν αυτά, παρασκευή αυτών και χρήσεις αυτών. Η εφεύρεση ειδικότερα αφορά σε υπεργλυκοζυλιωμένα ΙL-7 πολυπεπτίδια που έχουν βελτιωμένες ιδιότητες, καθώς επίσης τη βιομηχανική κατασκευή αυτών και θεραπευτικές χρήσεις αυτών. Η εφεύρεση επίσης αποκαλύπτει νέα πολυπεπτίδια IL-7 που έχουν τροποποιημένες αλληλουχίες αμινοξέος που περιέχουν τεχνητώς δημιουργούμενη θέση(-εις) γλυκοζυλίωσης, καθώς επίσης αντίστοιχα μόρια νουκλεϊνικού οξέος, φορείς και ανασυνδυασμένα κύτταρα ξενιστές. Η εφεύρεση επίσης αφορά στη χρήση τέτοιων πολυπεπτιδίων, κυττάρων ή νουκλεϊνικών οξέων για θεραπευτική ή προληπτική θεραπεία υποκειμένων θηλαστικών, συμπεριλαμβανομένων ανθρώπινων υποκειμένων.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP05291556A EP1746161A1 (en) | 2005-07-20 | 2005-07-20 | Glycosylated IL-7, preparation and uses |
EP06795556A EP1904635B1 (en) | 2005-07-20 | 2006-07-19 | Glycosylated il-7, preparation and uses |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1112655T1 true CY1112655T1 (el) | 2016-02-10 |
Family
ID=35385570
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20121100161T CY1112655T1 (el) | 2005-07-20 | 2012-02-16 | Γλυκοζυλιωμενη ιl-7, παρασκευη και χρησεις |
Country Status (20)
Country | Link |
---|---|
US (3) | US7708985B2 (el) |
EP (2) | EP1746161A1 (el) |
JP (2) | JP5685363B2 (el) |
CN (2) | CN101228275B (el) |
AT (1) | ATE542901T1 (el) |
AU (1) | AU2006271315B2 (el) |
CA (2) | CA2859145C (el) |
CY (1) | CY1112655T1 (el) |
DK (1) | DK1904635T3 (el) |
EA (1) | EA012802B1 (el) |
ES (1) | ES2379732T3 (el) |
HK (1) | HK1115154A1 (el) |
IL (1) | IL188480A0 (el) |
NO (1) | NO344802B1 (el) |
NZ (1) | NZ564907A (el) |
PL (1) | PL1904635T3 (el) |
PT (1) | PT1904635E (el) |
SI (1) | SI1904635T1 (el) |
WO (1) | WO2007010401A2 (el) |
ZA (1) | ZA200800533B (el) |
Families Citing this family (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2367891T3 (es) | 2000-09-29 | 2011-11-10 | Schering Corporation | Interleucina-10 pegilada. |
EP1391513A1 (en) * | 2002-08-08 | 2004-02-25 | Cytheris | IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof |
EP2066336B1 (en) | 2006-09-28 | 2012-09-19 | Merck Sharp & Dohme Corp. | Use of pegylated il-10 to treat cancer |
AR063975A1 (es) * | 2006-11-28 | 2009-03-04 | Centelion | Fusiones fc con receptor para fgf soluble modificadas con actividad biologica mejorada |
CN101943688B (zh) * | 2009-07-10 | 2013-01-02 | 复旦大学 | 一种利用质谱靶板富集糖基化肽段的方法 |
US9169329B2 (en) | 2010-06-01 | 2015-10-27 | Ludwig Institute For Cancer Research | Antibodies directed to the receptor tyrosine kinase c-Met |
NZ605640A (en) * | 2010-07-19 | 2016-01-29 | Otago Innovation Ltd | Signal biomarkers |
SG10201407036YA (en) | 2010-11-05 | 2014-12-30 | Transbio Ltd | Markers of Endothelial Progenitor Cells and Uses Thereof |
CA2820956C (en) * | 2010-12-10 | 2016-05-03 | University Of Central Florida Research Foundation, Inc. | Methods and compositions comprising il-7 receptor ligands |
KR20140063657A (ko) | 2011-08-03 | 2014-05-27 | 사이세리스 | Hcv 면역요법 |
CN105209054A (zh) | 2013-04-18 | 2015-12-30 | 阿尔莫生物科技股份有限公司 | 使用白细胞介素-10治疗疾病和病症的方法 |
WO2014204816A2 (en) | 2013-06-17 | 2014-12-24 | Armo Biosciences, Inc. | Method for assessing protein identity and stability |
WO2015070060A1 (en) | 2013-11-11 | 2015-05-14 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
CN104725484B (zh) * | 2013-12-19 | 2018-03-13 | 中国科学院微生物研究所 | 一种糖基化多肽及其制备方法和其应用 |
US20180028593A1 (en) | 2014-03-21 | 2018-02-01 | Boreal Invest | Terminal nanofiltration of solubilized protein compositions for removal of immunogenic aggregates |
WO2015187295A2 (en) | 2014-06-02 | 2015-12-10 | Armo Biosciences, Inc. | Methods of lowering serum cholesterol |
EP3209320B1 (en) | 2014-10-22 | 2023-03-08 | Armo Biosciences, Inc. | Methods of using interleukin-10 for treating diseases and disorders |
CN104372021A (zh) * | 2014-11-05 | 2015-02-25 | 太仓思源生物医药有限公司 | 人白细胞介素-2蛋白质的制备方法 |
US10618970B2 (en) | 2015-02-03 | 2020-04-14 | Armo Biosciences, Inc. | Method of treating cancer with IL-10 and antibodies that induce ADCC |
CN107847583A (zh) | 2015-05-28 | 2018-03-27 | 阿尔莫生物科技股份有限公司 | 用于治疗癌症的聚乙二醇化白细胞介素‑10 |
KR101873201B1 (ko) | 2015-06-11 | 2018-07-02 | 주식회사 제넥신 | 변형된 인터루킨-7 단백질 및 이의 용도 |
JP6959229B2 (ja) * | 2015-10-23 | 2021-11-02 | アポジェニックス アーゲー | 一本鎖gitr受容体アゴニストタンパク質 |
KR102386735B1 (ko) | 2015-11-06 | 2022-04-14 | 주식회사 제넥신 | 변형된 인터루킨-7 융합 단백질의 제형 |
KR102604595B1 (ko) | 2015-12-04 | 2023-11-21 | 주식회사 제넥신 | 면역글로불린 Fc가 융합된 인터루킨-7 융합 단백질을 포함하는 인플루엔자 바이러스 감염의 예방 또는 치료용 약학적 조성물 |
KR20170066265A (ko) | 2015-12-04 | 2017-06-14 | 주식회사 제넥신 | 면역글로불린 Fc가 융합된 인터루킨-7 융합 단백질을 포함하는 사람 파필로마바이러스 유래 질환의 예방 또는 치료용 약학적 조성물 |
CN106317226B (zh) * | 2016-08-19 | 2017-09-05 | 安源医药科技(上海)有限公司 | 用于构建融合蛋白的连接肽 |
CA3082975A1 (en) | 2018-01-25 | 2019-08-19 | I-Mab Biopharma Us Limited | Anti-pd-l1 antibody and il-7 fusions |
KR20210093950A (ko) | 2018-11-16 | 2021-07-28 | 네오이뮨텍, 인코퍼레이티드 | Il-7 단백질 및 면역 관문 저해제의 조합으로 종양을 치료하는 방법 |
US20230071889A1 (en) | 2018-12-21 | 2023-03-09 | Ose Immunotherapeutics | Bifunctional anti-pd-1/il-7 molecule |
KR102402276B1 (ko) * | 2019-11-15 | 2022-05-26 | 주식회사 제넥신 | 변형된 인터루킨-7 및 tgf 베타 수용체 ii를 포함하는 융합단백질 및 이의 용도 |
CN114945409A (zh) | 2020-01-13 | 2022-08-26 | 新免疫技术有限公司 | 用il-7蛋白和双特异性抗体的组合***的方法 |
JP2023512657A (ja) | 2020-02-05 | 2023-03-28 | ワシントン・ユニバーシティ | Il-7タンパク質とcar保有免疫細胞の組み合わせで固形腫瘍を治療する方法 |
WO2022093718A1 (en) | 2020-10-26 | 2022-05-05 | Neoimmunetech, Inc. | Methods of inducing stem cell mobilization |
WO2022094475A1 (en) | 2020-11-02 | 2022-05-05 | Neoimmunetech, Inc. | Use of interleukin-7 for the treatment of coronavirus |
JP2023549112A (ja) | 2020-11-05 | 2023-11-22 | ネオイミューンテック, インコーポレイテッド | Il-7タンパク質とヌクレオチドワクチンの組み合わせで腫瘍を治療する方法 |
WO2022117569A1 (en) | 2020-12-02 | 2022-06-09 | Oncurious Nv | A ccr8 antagonist antibody in combination with a lymphotoxin beta receptor agonist antibody in therapy against cancer |
CN113817043B (zh) * | 2021-09-22 | 2023-07-25 | 清华大学 | 制备活性铁调节激素的方法 |
WO2023130081A1 (en) | 2021-12-30 | 2023-07-06 | Neoimmunetech, Inc. | Method of treating a tumor with a combination of il-7 protein and vegf antagonist |
WO2023133595A2 (en) | 2022-01-10 | 2023-07-13 | Sana Biotechnology, Inc. | Methods of ex vivo dosing and administration of lipid particles or viral vectors and related systems and uses |
WO2023193015A1 (en) | 2022-04-01 | 2023-10-05 | Sana Biotechnology, Inc. | Cytokine receptor agonist and viral vector combination therapies |
WO2024102722A1 (en) | 2022-11-07 | 2024-05-16 | Neoimmunetech, Inc. | Methods of treating a tumor with an unmethylated mgmt promoter |
WO2024150158A1 (en) | 2023-01-11 | 2024-07-18 | Bright Peak Therapeutics Ag | Il-7 polypeptides, immunocytokines comprising same, and uses thereof |
CN117050178B (zh) * | 2023-10-13 | 2024-01-12 | 北京百普赛斯生物科技股份有限公司 | 特异性检测il-7的抗体及应用 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5714585A (en) * | 1987-10-26 | 1998-02-03 | Sterling Winthrop, Inc. | Antibodies that are immunoreactive with interleukin-7 |
US4965195A (en) | 1987-10-26 | 1990-10-23 | Immunex Corp. | Interleukin-7 |
ZA887773B (en) | 1987-10-26 | 1989-07-26 | Immunex Corp | Interleukin-7 |
US5328988A (en) * | 1987-10-26 | 1994-07-12 | Immunex Corporation | Interleukin-7 |
US5153310A (en) * | 1989-02-28 | 1992-10-06 | Du Pont Merck Pharmaceutical Company | Il-2 analogs containing n-linked glycosylation sites |
EP1299535A2 (en) * | 2000-06-30 | 2003-04-09 | Maxygen Aps | Peptide extended glycosylated polypeptides |
EP1391513A1 (en) * | 2002-08-08 | 2004-02-25 | Cytheris | IL-7 drug substance, IL-7 comprising composition, preparation and uses thereof |
-
2005
- 2005-07-20 EP EP05291556A patent/EP1746161A1/en not_active Withdrawn
-
2006
- 2006-07-19 AT AT06795556T patent/ATE542901T1/de active
- 2006-07-19 EP EP06795556A patent/EP1904635B1/en active Active
- 2006-07-19 JP JP2008522097A patent/JP5685363B2/ja active Active
- 2006-07-19 CA CA2859145A patent/CA2859145C/en active Active
- 2006-07-19 PL PL06795556T patent/PL1904635T3/pl unknown
- 2006-07-19 SI SI200631263T patent/SI1904635T1/sl unknown
- 2006-07-19 WO PCT/IB2006/002663 patent/WO2007010401A2/en active Application Filing
- 2006-07-19 NZ NZ564907A patent/NZ564907A/en not_active IP Right Cessation
- 2006-07-19 AU AU2006271315A patent/AU2006271315B2/en active Active
- 2006-07-19 PT PT06795556T patent/PT1904635E/pt unknown
- 2006-07-19 CN CN200680026503.XA patent/CN101228275B/zh active Active
- 2006-07-19 ES ES06795556T patent/ES2379732T3/es active Active
- 2006-07-19 US US11/996,176 patent/US7708985B2/en active Active
- 2006-07-19 DK DK06795556.7T patent/DK1904635T3/da active
- 2006-07-19 CA CA2615562A patent/CA2615562C/en active Active
- 2006-07-19 CN CN201610038940.9A patent/CN105647939A/zh active Pending
- 2006-07-19 EA EA200800368A patent/EA012802B1/ru not_active IP Right Cessation
-
2007
- 2007-12-27 IL IL188480A patent/IL188480A0/en active IP Right Grant
-
2008
- 2008-01-03 NO NO20080045A patent/NO344802B1/no not_active IP Right Cessation
- 2008-01-18 ZA ZA200800533A patent/ZA200800533B/xx unknown
- 2008-04-30 HK HK08104792.4A patent/HK1115154A1/xx not_active IP Right Cessation
-
2010
- 2010-02-24 US US12/711,675 patent/US8034327B2/en active Active
-
2011
- 2011-08-24 US US13/216,331 patent/US8153114B2/en active Active
-
2012
- 2012-02-16 CY CY20121100161T patent/CY1112655T1/el unknown
-
2014
- 2014-10-01 JP JP2014202828A patent/JP2015057392A/ja active Pending
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