CY1111431T1 - Μεταλλαγμενες πρωτεϊνες πλακουντιου αυξητικου παραγοντα τυπου 1, μεθοδος παρασκευης και εφαρμογες αυτων - Google Patents
Μεταλλαγμενες πρωτεϊνες πλακουντιου αυξητικου παραγοντα τυπου 1, μεθοδος παρασκευης και εφαρμογες αυτωνInfo
- Publication number
- CY1111431T1 CY1111431T1 CY20111100200T CY111100200T CY1111431T1 CY 1111431 T1 CY1111431 T1 CY 1111431T1 CY 20111100200 T CY20111100200 T CY 20111100200T CY 111100200 T CY111100200 T CY 111100200T CY 1111431 T1 CY1111431 T1 CY 1111431T1
- Authority
- CY
- Cyprus
- Prior art keywords
- type
- preparation
- plumbing
- practical
- applications
- Prior art date
Links
- 238000000034 method Methods 0.000 title 2
- 239000003102 growth factor Substances 0.000 title 1
- 238000009428 plumbing Methods 0.000 title 1
- 101000595923 Homo sapiens Placenta growth factor Proteins 0.000 abstract 2
- 102100035194 Placenta growth factor Human genes 0.000 abstract 2
- 230000001613 neoplastic effect Effects 0.000 abstract 2
- 102000008300 Mutant Proteins Human genes 0.000 abstract 1
- 108010021466 Mutant Proteins Proteins 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 239000002537 cosmetic Substances 0.000 abstract 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
- 230000037430 deletion Effects 0.000 abstract 1
- 238000012217 deletion Methods 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001575 pathological effect Effects 0.000 abstract 1
- 235000018102 proteins Nutrition 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/515—Angiogenesic factors; Angiogenin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/16—Emollients or protectives, e.g. against radiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- General Engineering & Computer Science (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Mycology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με χημικά σταθερές μεταλλαγμένες πρωτεΐνες πλακούντιου αυξητικού παράγοντα τύπου 1 (PLGF-1: Type 1 Placental Growth Factor) που φέρουν την υποκατάσταση ή εξάλειψη υπολείμματος κυστεΐνης στην αλληλουχία αμινοξέων της πρωτεΐνης φυσικού τύπου, με την παρασκευή τους, τις θεραπευτικές και καλλυντικές χρήσεις τους, και με φαρμακευτικές και καλλυντικές συνθέσεις που περιέχουν αυτά τα παράγωγα. Η εφεύρεση σχετίζεται επί πλέον με την παραγωγή αντισωμάτων γι' αυτά τα παράγωγα και με την χρήση τους στην διάγνωση και θεραπευτική αγωγή νεοπλασματικών και μη νεοπλασματικών παθολογικών καταστάσεων.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT2002RM000277A ITRM20020277A1 (it) | 2002-05-17 | 2002-05-17 | Muteine del fattore di crescita placentare tipo 1, metodo di preparazione e loro applicazioni. |
EP03727958A EP1506295B1 (en) | 2002-05-17 | 2003-05-19 | Muteins of placental growth factor type 1, preparation method and application thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1111431T1 true CY1111431T1 (el) | 2015-08-05 |
Family
ID=11456311
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20111100200T CY1111431T1 (el) | 2002-05-17 | 2011-02-16 | Μεταλλαγμενες πρωτεϊνες πλακουντιου αυξητικου παραγοντα τυπου 1, μεθοδος παρασκευης και εφαρμογες αυτων |
Country Status (22)
Country | Link |
---|---|
US (1) | US7314734B2 (el) |
EP (1) | EP1506295B1 (el) |
JP (1) | JP4230450B2 (el) |
KR (1) | KR101022934B1 (el) |
CN (1) | CN1323167C (el) |
AT (1) | ATE488590T1 (el) |
AU (1) | AU2003234066B2 (el) |
BR (1) | BR0309966A (el) |
CA (1) | CA2485587C (el) |
CY (1) | CY1111431T1 (el) |
DE (1) | DE60334986D1 (el) |
DK (1) | DK1506295T3 (el) |
ES (1) | ES2356360T3 (el) |
HK (1) | HK1079549A1 (el) |
HR (1) | HRP20041178B1 (el) |
IT (1) | ITRM20020277A1 (el) |
MX (1) | MXPA04011405A (el) |
PL (1) | PL209955B1 (el) |
PT (1) | PT1506295E (el) |
RU (1) | RU2344172C2 (el) |
WO (1) | WO2003097688A2 (el) |
ZA (1) | ZA200409943B (el) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8409815B2 (en) | 2002-11-16 | 2013-04-02 | Siemens Healthcare Diagnostics Products Gmbh | sCD40L and placental growth factor (PLGF) used as a biochemical marker combination in cardiovascular diseases |
DE102005022047A1 (de) | 2005-05-09 | 2006-11-30 | Dade Behring Marburg Gmbh | Bindungspartner des Plazentalen Wachstumsfaktors insbesondere gegen den Plazentalen Wachstumsfaktor gerichtete Antikörper, ihre Herstellung und Verwendung |
JP2009100680A (ja) * | 2007-10-23 | 2009-05-14 | Univ Nagoya | ヒト全身性強皮症動物モデルの作製方法、ヒト全身性強皮症動物モデル及びその用途 |
CA2711517C (en) | 2008-01-07 | 2016-07-12 | Ortho-Clinical Diagnostics, Inc. | Calibrator/control for simultaneous assay of proteins capable of complexing with one another |
CN101918839A (zh) | 2008-01-07 | 2010-12-15 | 奥索临床诊断有限公司 | sFlt-1:血管生成因子络合物的测定 |
EP2295449A1 (en) * | 2009-09-09 | 2011-03-16 | Dompe PHA.R.MA S.p.A. | PLGF-1 in homodimeric form |
CN103087153B (zh) * | 2011-10-28 | 2015-05-06 | 上海市第一人民医院 | 一类新的抑制新生血管的小肽及其应用 |
CN105451758A (zh) | 2013-05-31 | 2016-03-30 | 科比欧尔斯公司 | 用于心力衰竭的预防或治疗的人plgf-2 |
CN109134650A (zh) * | 2018-09-10 | 2019-01-04 | 宁波奥丞生物科技有限公司 | 抗人plgf单克隆抗体的制备方法 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1242149B (it) * | 1990-09-27 | 1994-02-16 | Consiglio Nazionale Ricerche | Sequenza di nucleotidi codificante per una proteina umana con proprieta' regolative dell'angiogenesi |
DE69229454T2 (de) * | 1991-03-28 | 2000-01-05 | Merck & Co., Inc. | Untereinheit-C des vaskulären endothelialen Zellwachstumsfaktors |
SE9601245D0 (sv) * | 1996-03-29 | 1996-03-29 | Pharmacia Ab | Chimeric superantigens and their use |
DE19748734A1 (de) * | 1997-11-05 | 1999-05-06 | Biotechnolog Forschung Gmbh | Verfahren zur Gewinnung von biologisch aktiven Dimeren von rekombinanten humanen Wachstumsfaktoren aus der Cystein-Knoten-Familie sowie Verwendung der gewonnenen Dimere |
WO2000075163A1 (en) * | 1999-06-03 | 2000-12-14 | Human Genome Sciences, Inc. | Angiogenic proteins and uses thereof |
WO2001085796A2 (en) * | 2000-05-12 | 2001-11-15 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Use of inhibitors of placental growth factor for the treatment of pathological angiogenesis, pathological arteriogenesis, inflammation, tumour formation and/or vascular leakage |
-
2002
- 2002-05-17 IT IT2002RM000277A patent/ITRM20020277A1/it unknown
-
2003
- 2003-05-19 WO PCT/IT2003/000296 patent/WO2003097688A2/en active Application Filing
- 2003-05-19 CA CA2485587A patent/CA2485587C/en not_active Expired - Fee Related
- 2003-05-19 AT AT03727958T patent/ATE488590T1/de active
- 2003-05-19 BR BR0309966-0A patent/BR0309966A/pt not_active IP Right Cessation
- 2003-05-19 AU AU2003234066A patent/AU2003234066B2/en not_active Ceased
- 2003-05-19 US US10/514,707 patent/US7314734B2/en not_active Expired - Fee Related
- 2003-05-19 MX MXPA04011405A patent/MXPA04011405A/es active IP Right Grant
- 2003-05-19 PT PT03727958T patent/PT1506295E/pt unknown
- 2003-05-19 RU RU2004137000/13A patent/RU2344172C2/ru not_active IP Right Cessation
- 2003-05-19 DK DK03727958.5T patent/DK1506295T3/da active
- 2003-05-19 DE DE60334986T patent/DE60334986D1/de not_active Expired - Lifetime
- 2003-05-19 PL PL372492A patent/PL209955B1/pl unknown
- 2003-05-19 JP JP2004506360A patent/JP4230450B2/ja not_active Expired - Fee Related
- 2003-05-19 ES ES03727958T patent/ES2356360T3/es not_active Expired - Lifetime
- 2003-05-19 EP EP03727958A patent/EP1506295B1/en not_active Expired - Lifetime
- 2003-05-19 KR KR1020047018601A patent/KR101022934B1/ko not_active IP Right Cessation
- 2003-05-19 CN CNB038112043A patent/CN1323167C/zh not_active Expired - Fee Related
-
2004
- 2004-12-08 ZA ZA2004/09943A patent/ZA200409943B/en unknown
- 2004-12-10 HR HRP20041178AA patent/HRP20041178B1/hr not_active IP Right Cessation
-
2005
- 2005-12-19 HK HK05111674A patent/HK1079549A1/xx not_active IP Right Cessation
-
2011
- 2011-02-16 CY CY20111100200T patent/CY1111431T1/el unknown
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