CY1111102T1 - 2-(4-κυανοφαινυλ)-6-υδροξυλαμινοπυριμιδινες που αναστελλουν τον hiv - Google Patents

2-(4-κυανοφαινυλ)-6-υδροξυλαμινοπυριμιδινες που αναστελλουν τον hiv

Info

Publication number
CY1111102T1
CY1111102T1 CY20101100890T CY101100890T CY1111102T1 CY 1111102 T1 CY1111102 T1 CY 1111102T1 CY 20101100890 T CY20101100890 T CY 20101100890T CY 101100890 T CY101100890 T CY 101100890T CY 1111102 T1 CY1111102 T1 CY 1111102T1
Authority
CY
Cyprus
Prior art keywords
hydroxylaminopyrimidines
cyanophenyl
inhibit hiv
compounds
6alkyl
Prior art date
Application number
CY20101100890T
Other languages
English (en)
Inventor
Kock Herman Augustinus De
Piet Piet Tom Bert Paul Wigerinck
Original Assignee
Tibotec Pharmaceuticals
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharmaceuticals filed Critical Tibotec Pharmaceuticals
Publication of CY1111102T1 publication Critical patent/CY1111102T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

HIV αναστολείς αντιγραφής του τύπου (I) φαρμακευτικώς αποδεκτά άλατα προσθήκης, ή στερεοχημικώς ισομερείς μορφές αυτών, όπου το R1 είναι αλογόνο, τα R2 και R3 είναι το καθένα ανεξαρτήτως C1-6 αλκυλ, φαρμακευτικές συνθέσεις που περιέχουν τις ενώσεις αυτές ως δραστικό συστατικό και διεργασίες για την παρασκευή αυτών των ενώσεων και συνθέσεων.
CY20101100890T 2005-03-04 2010-10-06 2-(4-κυανοφαινυλ)-6-υδροξυλαμινοπυριμιδινες που αναστελλουν τον hiv CY1111102T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP05101707 2005-03-04
EP06708609A EP1858861B1 (en) 2005-03-04 2006-03-02 Hiv inhibiting 2-(4-cyanophenyl)-6-hydroxylaminopyrimidines

Publications (1)

Publication Number Publication Date
CY1111102T1 true CY1111102T1 (el) 2015-06-11

Family

ID=34938904

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100890T CY1111102T1 (el) 2005-03-04 2010-10-06 2-(4-κυανοφαινυλ)-6-υδροξυλαμινοπυριμιδινες που αναστελλουν τον hiv

Country Status (20)

Country Link
US (2) US20080214588A1 (el)
EP (1) EP1858861B1 (el)
JP (1) JP5118978B2 (el)
CN (1) CN101133038B (el)
AT (1) ATE473212T1 (el)
AU (1) AU2006222057B2 (el)
BR (1) BRPI0609291B1 (el)
CY (1) CY1111102T1 (el)
DE (1) DE602006015291D1 (el)
DK (1) DK1858861T3 (el)
ES (1) ES2347815T3 (el)
HR (1) HRP20100504T1 (el)
ME (1) ME01229B (el)
MX (1) MX2007010744A (el)
PL (1) PL1858861T3 (el)
PT (1) PT1858861E (el)
RS (1) RS51435B (el)
RU (1) RU2401261C2 (el)
SI (1) SI1858861T1 (el)
WO (1) WO2006094930A1 (el)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0607811B8 (pt) * 2005-02-18 2021-05-25 Janssen R & D Ireland derivados de óxido de pirimidina de 2-(4-cianofenilamino) inibidores de hiv, composição farmacêutica compreendendo os mesmos, processo para preparar a referida composição e uso
CA2671478C (en) 2006-12-13 2015-02-17 F. Hoffmann-La Roche Ag Non-nucleoside reverse transcriptase inhibitors
EP2342186B1 (en) * 2009-06-22 2014-09-17 Emcure Pharmaceuticals Limited Process for synthesis of etravirine
US8153790B2 (en) 2009-07-27 2012-04-10 Krizmanic Irena Process for the preparation and purification of etravirine and intermediates thereof
CN101993419B (zh) * 2009-08-20 2013-01-16 浙江九洲药业股份有限公司 一种4-［（5-溴-4，6-二氯-2-嘧啶基）氨基］苯甲腈的制备方法
GR1007010B (el) 2009-10-08 2010-10-07 Χημικα Και Βιοφαρμακευτικα Εργαστηρια Πατρων Αε (Cbl-Patras), Ινσουλινοειδη πεπτιδια
WO2011135578A1 (en) 2010-04-28 2011-11-03 Chetan Balar Composition comprising chitin and tinosporin for use in the treatment of viral diseases
WO2013059572A1 (en) 2011-10-19 2013-04-25 Assia Chemical Industries Ltd. Process for the preparation of etravirine and intermediates in the synthesis thereof
KR20220129043A (ko) 2020-02-19 2022-09-22 조인트 스톡 컴퍼니 “파르마신세즈” Hiv 감염의 치료 및 예방을 위한 항바이러스제로서 피리미딘계 바이사이클

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3459731A (en) * 1966-12-16 1969-08-05 Corn Products Co Cyclodextrin polyethers and their production
CZ154398A3 (cs) 1995-11-23 1998-08-12 Janssen Pharmaceutica N.V. Pevné směsi cyklodextrinů připravené vytlačováním taveniny
BRPI9915552B8 (pt) * 1998-11-10 2021-05-25 Janssen Pharmaceutica Nv pirimidinas inibidoras da reprodução do hiv
SK285240B6 (sk) * 1999-09-24 2006-09-07 Janssen Pharmaceutica N. V. Antivírusové prostriedky
DK1282607T3 (en) * 2000-05-08 2016-02-01 Janssen Pharmaceutica Nv Prodrugs of HIV replication inhibiting pyrimidines

Also Published As

Publication number Publication date
AU2006222057B2 (en) 2012-10-04
ATE473212T1 (de) 2010-07-15
DK1858861T3 (da) 2010-11-08
BRPI0609291A2 (pt) 2010-03-09
RU2401261C2 (ru) 2010-10-10
CN101133038B (zh) 2012-06-27
MX2007010744A (es) 2007-09-12
EP1858861A1 (en) 2007-11-28
RS51435B (en) 2011-04-30
JP2008531658A (ja) 2008-08-14
US20080214588A1 (en) 2008-09-04
BRPI0609291B1 (pt) 2022-02-08
AU2006222057A1 (en) 2006-09-14
HRP20100504T1 (hr) 2010-10-31
PL1858861T3 (pl) 2010-12-31
WO2006094930A1 (en) 2006-09-14
US20100121060A1 (en) 2010-05-13
SI1858861T1 (sl) 2010-10-29
EP1858861B1 (en) 2010-07-07
RU2007136782A (ru) 2009-04-10
CN101133038A (zh) 2008-02-27
US8119801B2 (en) 2012-02-21
JP5118978B2 (ja) 2013-01-16
DE602006015291D1 (de) 2010-08-19
ME01229B (me) 2013-06-20
ES2347815T3 (es) 2010-11-04
PT1858861E (pt) 2010-09-16

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