CY1110486T1 - 6-υποκατασταθεισες 2,3,4,5-τετραϋδρο-1η-βενζο[d]αζεπινες ως συναγωνιστες υποδοχεως 5-ηt2c - Google Patents

6-υποκατασταθεισες 2,3,4,5-τετραϋδρο-1η-βενζο[d]αζεπινες ως συναγωνιστες υποδοχεως 5-ηt2c

Info

Publication number
CY1110486T1
CY1110486T1 CY20091100923T CY091100923T CY1110486T1 CY 1110486 T1 CY1110486 T1 CY 1110486T1 CY 20091100923 T CY20091100923 T CY 20091100923T CY 091100923 T CY091100923 T CY 091100923T CY 1110486 T1 CY1110486 T1 CY 1110486T1
Authority
CY
Cyprus
Prior art keywords
sup
sub
substituted
benzo
tetrahydro
Prior art date
Application number
CY20091100923T
Other languages
English (en)
Inventor
John Gordon Allen
Karin Briner
Anne Marie Camp
Manuel Javier Cases-Thomas
Richard Charles Hoying
Maria Angeles Martines-Grau
Michael Philip Mazanetz
Natalia Pokrovskaia
Richard Edmund Rathmell
Roger Ryan Rothhaar
Selma Sapmaz
Andrew Caerwyn Williams
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of CY1110486T1 publication Critical patent/CY1110486T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Reproductive Health (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Child & Adolescent Psychology (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)

Abstract

Η παρούσα εφεύρεση παρέχει 6-υποκατασταθείσες 2,3,4,5-τετραϋδρο-1Η-βενζο[d] αζεπίνες Τύπου (Ι) ως επιλεκτικούς συναγωνιστές υποδοχέως 5-HT2C για την αγωγή σχετιζόμενων με τον 5-ΗΤ2C διαταραχών περιλαμβανόμενης της παχυσαρκίας, της ιδεοψυχαναγκαστικής διαταραχής, της καταθλίψεως και του άγχους: όπου το R6 είναι –C≡C-R10, -CH=CR11 R11’ ή -αλκυλ με C0-C8-Ar2 προαιρετικά υποκατασταθέν στη μονάδα αλκυλίου με 1 έως 6 υποκαταστάτες φθορίου και άλλους υποκαταστάτες όπως ορίζονται στην περιγραφή.
CY20091100923T 2005-09-01 2009-09-02 6-υποκατασταθεισες 2,3,4,5-τετραϋδρο-1η-βενζο[d]αζεπινες ως συναγωνιστες υποδοχεως 5-ηt2c CY1110486T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US71358405P 2005-09-01 2005-09-01
EP06802904A EP1926712B1 (en) 2005-09-01 2006-09-01 6-substituted 2,3,4,5-tetrahydro-1h-benzo[d]azepines as 5-ht2c receptor agonists

Publications (1)

Publication Number Publication Date
CY1110486T1 true CY1110486T1 (el) 2015-04-29

Family

ID=37499390

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091100923T CY1110486T1 (el) 2005-09-01 2009-09-02 6-υποκατασταθεισες 2,3,4,5-τετραϋδρο-1η-βενζο[d]αζεπινες ως συναγωνιστες υποδοχεως 5-ηt2c

Country Status (17)

Country Link
US (1) US8420631B2 (el)
EP (1) EP1926712B1 (el)
JP (1) JP5237810B2 (el)
CN (1) CN101253153A (el)
AT (1) ATE437859T1 (el)
AU (1) AU2006287160B2 (el)
BR (1) BRPI0615033A2 (el)
CA (1) CA2619287C (el)
CY (1) CY1110486T1 (el)
DE (1) DE602006008155D1 (el)
DK (1) DK1926712T3 (el)
ES (1) ES2328408T3 (el)
MX (1) MX2008002180A (el)
PL (1) PL1926712T3 (el)
PT (1) PT1926712E (el)
SI (1) SI1926712T1 (el)
WO (1) WO2007028131A1 (el)

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EP1924578B1 (en) * 2005-09-01 2013-11-06 Eli Lilly And Company 6-N-LINKED HETEROCYCLE-SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-BENZO[d]AZEPINES AS 5-HT2C RECEPTOR AGONISTS
ES2328520T3 (es) * 2005-09-01 2009-11-13 Eli Lilly And Company 2,3,4,5-tetrahidro-1h-benzo(d)azepinas 6-sustituidas como agonistas del receptor de 5-ht2c.
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WO2007140213A1 (en) 2006-05-26 2007-12-06 Forest Laboratories Holdings Limited Pyridoazepine derivatives
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EP3733204A4 (en) 2017-12-27 2021-09-15 Takeda Pharmaceutical Company Limited THERAPEUTIC FOR EXERCISE INCONTINENCE AND STAIR INCONTINENCE

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Also Published As

Publication number Publication date
AU2006287160A1 (en) 2007-03-08
EP1926712B1 (en) 2009-07-29
US8420631B2 (en) 2013-04-16
JP5237810B2 (ja) 2013-07-17
DE602006008155D1 (de) 2009-09-10
CA2619287A1 (en) 2007-03-08
AU2006287160B2 (en) 2012-04-05
PL1926712T3 (pl) 2009-12-31
CA2619287C (en) 2013-10-22
JP2009507037A (ja) 2009-02-19
ES2328408T3 (es) 2009-11-12
WO2007028131A1 (en) 2007-03-08
US20080207897A1 (en) 2008-08-28
CN101253153A (zh) 2008-08-27
MX2008002180A (es) 2008-04-22
SI1926712T1 (sl) 2010-01-29
ATE437859T1 (de) 2009-08-15
BRPI0615033A2 (pt) 2011-04-26
DK1926712T3 (da) 2009-11-09
PT1926712E (pt) 2009-10-06
EP1926712A1 (en) 2008-06-04

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