CY1109669T1 - Χρηση υποκατεστημενων παραγωγων της ινδολιζινης 1,2,3 για τη θεραπεια νοσων που σχετιζονται με μια παθολογικη χοριοειδη αγγειογενεση - Google Patents

Χρηση υποκατεστημενων παραγωγων της ινδολιζινης 1,2,3 για τη θεραπεια νοσων που σχετιζονται με μια παθολογικη χοριοειδη αγγειογενεση

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Publication number
CY1109669T1
CY1109669T1 CY20091101327T CY091101327T CY1109669T1 CY 1109669 T1 CY1109669 T1 CY 1109669T1 CY 20091101327 T CY20091101327 T CY 20091101327T CY 091101327 T CY091101327 T CY 091101327T CY 1109669 T1 CY1109669 T1 CY 1109669T1
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CY
Cyprus
Prior art keywords
alk
alkyl
alkoxy
coor
pathological
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Application number
CY20091101327T
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English (en)
Inventor
Alain Badorc
Françoise Bono
Marie-Françoise Bordes
Jean-Michel Foidart
Nathalie Guillo
Agnès Noel
Jean-Marie Rakic
Original Assignee
Sanofi-Aventis
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Publication date
Application filed by Sanofi-Aventis filed Critical Sanofi-Aventis
Publication of CY1109669T1 publication Critical patent/CY1109669T1/el

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Η παρούσα εφεύρεση αφορά στη χρήση υποκατεστημένων παραγώγων ινδολιζίνης 1, 2, 3, για την παρασκευή φαρμάκων χρήσιμων στη θεραπεία ασθενειών οι οποίες σχετίζονται με μια παθολογική χοριοειδή αγγειογένεση, τα οποία παράγωγα αντιστοιχούν στον ακόλουθο γενικό χημικό τύπο (I) : στον οποίο το R1 αντιπροσωπεύει -ΟΗ, αλκοξυ(C1-C5), καρβοξυ, αλκοξυκαρβονυλ(C2 - C6), -NR5R6, -NH-SΟ2-Alk, -NH-SO2Ph, -NH-CO-Ph, -N(Alk)-CO-Ph, -NH-CO-NH-Ph, -NH-CO-Alk, -NH-CΟ2-Alk, -O-(CH2)n-cAlk, -O-Alk-COOR7, -O-Alk-O-R8, -O-Alk-OH, -O-Alk-C(NH2):NOH, -O-Alk-NR5R6, -O-Alk-CN, -O-(CH2)n-Ph, -O-Alk-CO-NR5R6, -CO-NH-(CH2)m-COOR7, -CO-NH-Alk· το R2 αντιπροσωπεύει Η, αλκυλ(C1-C5), αλογονίδιο αλκυλίου (C1-C5), κυκλοαλκυλ (C3-C6) ή ενδεχομένως υποκατεστημένο φαινυλ· το Α αντιπροσωπεύει -CO-, -SO-, ή -SO2-, το R3 και το R4 ταυτόσημα ή διαφορετικά αντιπροσωπεύουν το καθένα ξεχωριστά Η, αλκοξυ(C1-C5), αμινο, καρβοξυ, αλκοξυκαρβονυλ(C2-C6), -ΟΗ, νιτρο, υδροξυαμινο, -Alk-COOR7, -NR5R6, -NH-Alk-COOR7, -NH-COO-Alk, -N(R11)-SO2-Alk-NR9R10, -N(R11)-SΟ2-Alk, -N(R11)-Alk-NR5R6, -N(R11)-CO-Alk-NR9R10, -N(R11)-CO-Alk, -N(R11)-CO-CF3, -NH-Alk-HetN, -O-Alk-NR9R10,-O-Alk-CO-NR5R6, -O-Alk-HetN, ή το R3 και το R4 σχηματίζουν μαζί έναν ακόρεστο ετερόκυκλο ο οποίος αποτελείται από 5 έως 6 αλυσίδες, ενδεχομένως υπό την μορφή ενός εκ των φαρμακευτικώς αποδεκτών τους αλάτων.
CY20091101327T 2004-02-05 2009-12-09 Χρηση υποκατεστημενων παραγωγων της ινδολιζινης 1,2,3 για τη θεραπεια νοσων που σχετιζονται με μια παθολογικη χοριοειδη αγγειογενεση CY1109669T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0401094A FR2865934B1 (fr) 2004-02-05 2004-02-05 Utilisation de derives d'indolizine 1,2,3 substitues, inhibiteurs des fgfs, pour la preparation de medicaments utiles pour le traitement de maladies liees a une angiogenese pathologique choroidienne
EP05717556A EP1713543B1 (fr) 2004-02-05 2005-02-04 Utilisation de derives d'indolizine 1,2,3 substitues pour le traitement de maladies liees a une angiogenese pathologique choroidienne

Publications (1)

Publication Number Publication Date
CY1109669T1 true CY1109669T1 (el) 2014-08-13

Family

ID=34778525

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20091101327T CY1109669T1 (el) 2004-02-05 2009-12-09 Χρηση υποκατεστημενων παραγωγων της ινδολιζινης 1,2,3 για τη θεραπεια νοσων που σχετιζονται με μια παθολογικη χοριοειδη αγγειογενεση

Country Status (21)

Country Link
US (1) US8034828B2 (el)
EP (1) EP1713543B1 (el)
JP (1) JP5268258B2 (el)
KR (1) KR101199730B1 (el)
CN (1) CN1917922B (el)
AT (1) ATE448003T1 (el)
AU (1) AU2005216671B2 (el)
BR (1) BRPI0507509A (el)
CA (1) CA2553895C (el)
CY (1) CY1109669T1 (el)
DE (1) DE602005017581D1 (el)
DK (1) DK1713543T3 (el)
ES (1) ES2335900T3 (el)
FR (1) FR2865934B1 (el)
HK (1) HK1101065A1 (el)
HR (1) HRP20100030T1 (el)
IL (1) IL177088A (el)
PL (1) PL1713543T3 (el)
PT (1) PT1713543E (el)
SI (1) SI1713543T1 (el)
WO (1) WO2005082457A2 (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
SG158147A1 (en) * 2006-10-09 2010-01-29 Takeda Pharmaceutical Kinase inhibitors
EP2223925A1 (en) * 2006-10-09 2010-09-01 Takeda Pharmaceutical Company Limited Kinase inhibitors
EP2270043A1 (en) 2009-07-03 2011-01-05 Sanofi-Aventis Extracellular allosteric inhibitor binding domain from a tyrosine kinase receptor
FR2962438B1 (fr) * 2010-07-06 2012-08-17 Sanofi Aventis Derives d'indolizines, procedes de preparation et application en therapeutique
FR2962437B1 (fr) 2010-07-06 2012-08-17 Sanofi Aventis Derives d'imidazopyridine, leur procede de preparation et leur application en therapeutique

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2838123B1 (fr) * 2002-04-04 2005-06-10 Sanofi Synthelabo Nouveaux derives d'indolozine-1,2,3 substituee, inhibiteurs selectifs du b-fgf

Also Published As

Publication number Publication date
ATE448003T1 (de) 2009-11-15
PL1713543T3 (pl) 2010-04-30
US8034828B2 (en) 2011-10-11
CN1917922A (zh) 2007-02-21
IL177088A (en) 2010-12-30
JP2007520534A (ja) 2007-07-26
HK1101065A1 (el) 2007-10-05
CA2553895A1 (fr) 2005-09-09
US20090030034A1 (en) 2009-01-29
IL177088A0 (en) 2006-12-10
FR2865934B1 (fr) 2006-05-05
FR2865934A1 (fr) 2005-08-12
DK1713543T3 (da) 2010-03-22
CA2553895C (fr) 2013-04-02
ES2335900T3 (es) 2010-04-06
SI1713543T1 (sl) 2010-03-31
EP1713543B1 (fr) 2009-11-11
PT1713543E (pt) 2009-12-15
DE602005017581D1 (de) 2009-12-24
EP1713543A2 (fr) 2006-10-25
WO2005082457A2 (fr) 2005-09-09
AU2005216671B2 (en) 2010-09-16
JP5268258B2 (ja) 2013-08-21
CN1917922B (zh) 2013-06-12
KR101199730B1 (ko) 2012-11-08
WO2005082457A3 (fr) 2005-11-10
BRPI0507509A (pt) 2007-06-26
KR20070034986A (ko) 2007-03-29
HRP20100030T1 (hr) 2010-03-31
AU2005216671A1 (en) 2005-09-09

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