CY1109492T1 - Ανοσογονες συνθεσεις βασιζομενες σε βιοδιασπωμενα μικροσωματιδια που περιλαμβανουν ανατοξινη διφθεριτιδας και ανατοξινη τετανου - Google Patents
Ανοσογονες συνθεσεις βασιζομενες σε βιοδιασπωμενα μικροσωματιδια που περιλαμβανουν ανατοξινη διφθεριτιδας και ανατοξινη τετανουInfo
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- CY1109492T1 CY1109492T1 CY091101079T CY091101079T CY1109492T1 CY 1109492 T1 CY1109492 T1 CY 1109492T1 CY 091101079 T CY091101079 T CY 091101079T CY 091101079 T CY091101079 T CY 091101079T CY 1109492 T1 CY1109492 T1 CY 1109492T1
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- Prior art keywords
- antigen
- polysaccharide
- microparticles
- toxoid
- adsorbed
- Prior art date
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- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
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- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
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Abstract
Αποκαλύπτονται ανοσογόνες συνθέσεις που περιλαμβάνουν μικροσωματίδια με προσροφημένο αντιγόνο ανατοξίνης και/ή αντιγόνο που περιέχει πολυσακχαρίτη. Οι συνθέσεις ανοσογόνων μικροσωματιδίων περιλαμβάνουν (α) πολυμερές μικροσωματιδίων που περιλαμβάνουν ένα βιοδιασπώμενο πολυμερές, (β) ένα αντιγόνο προσροφημένο στα μικροσωματίδια που επιλέγεται από (i) ένα αντιγόνο ανατοξίνη , όπως μία ανατοξίνη τετάνου, μία ανατοξίνη διφθερίτιδας, ή έναν συνδυασμό αυτών, και/ή (ii) ένα αντιγόνο που περιέχει πολυσακχαρίτη, όπως ένα Hib πολυσακχαριτικό αντιγόνο, ένα Hib συνεζευγμένο αντιγόνο που περιλαμβάνει πολυσακχαριτική και πολυπεπτιδική περιοχή, ένα μηνιγκικοκκικό πολυσακχαριτικό αντιγόνο, ένα μηνιγκικοκκικό συνεζευγμένο αντιγόνο που περιλαμβάνει πολυσακχαριτική και πολυπεπτιδική περιοχή, ένα πνευμονοκοκκικό πολυσακχαριτικό αντιγόνο, ένα πνευμονοκοκκικό συνεζευγμένο αντιγόνο που περιλαμβάνει πολυσακχαριτική και πολυπεπτιδική περιοχή ή συνδυασμούς αυτών, και (γ) ένα φαρμακευτικά αποδεκτό έκδοχο. Το βιοδιασπώμενο πολυμερές μπορεί, για παράδειγμα , να είναι ένα πολυμερές που επιλέγεται από ένα πολυ(α-υδροξυ οξύ), ένα πολυυδροξυ βουτυρικό οξύ, μία πολυκαπρολακτόνη, έναν πολυορθοεστέρα, έναν πολυανυδρίτη και ένα πολυκυανοακρυλικό. Αποκαλύπτονται επίσης μέθοδοι ανοσοποίησης έναντι μόλυνσης από παθογόνους οργανισμούς και μέθοδοι διέγερσης ανοσολογικών αποκρίσεων οι οποίες περιλαμβάνουν χορήγηση αυτών των συνθέσεων σε ζώα ξενιστές. Μέθοδοι παραγωγής τέτοιων συνθέσεων μικροσωματιδίων αποκαλύπτονται επίσης οι οποίες περιλαμβάνουν σχηματισμό ενός γαλακτώματος νερού-σε-έλαιο-σε-νερό που περιλαμβάνει νερό, οργανικό διαλύτη και
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US47501003P | 2003-06-02 | 2003-06-02 | |
US51307403P | 2003-10-21 | 2003-10-21 | |
EP04776195.2A EP1631264B8 (en) | 2003-06-02 | 2004-06-02 | Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen |
Publications (1)
Publication Number | Publication Date |
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CY1109492T1 true CY1109492T1 (el) | 2014-08-13 |
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ID=34278342
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CY091101079T CY1109492T1 (el) | 2003-06-02 | 2009-10-15 | Ανοσογονες συνθεσεις βασιζομενες σε βιοδιασπωμενα μικροσωματιδια που περιλαμβανουν ανατοξινη διφθεριτιδας και ανατοξινη τετανου |
Country Status (13)
Country | Link |
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US (1) | US9107831B2 (el) |
EP (2) | EP1631264B8 (el) |
JP (3) | JP5557415B2 (el) |
CN (1) | CN1798548B (el) |
AT (1) | ATE437633T2 (el) |
CA (1) | CA2528007C (el) |
CY (1) | CY1109492T1 (el) |
DE (1) | DE602004022286D1 (el) |
ES (2) | ES2596553T3 (el) |
HK (1) | HK1087943A1 (el) |
PL (1) | PL1631264T5 (el) |
PT (1) | PT1631264E (el) |
WO (1) | WO2005020964A1 (el) |
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- 2004-06-02 EP EP04776195.2A patent/EP1631264B8/en not_active Expired - Lifetime
- 2004-06-02 AT AT04776195T patent/ATE437633T2/de active
- 2004-06-02 JP JP2006515040A patent/JP5557415B2/ja not_active Expired - Lifetime
- 2004-06-02 PT PT04776195T patent/PT1631264E/pt unknown
- 2004-06-02 WO PCT/US2004/017125 patent/WO2005020964A1/en active Application Filing
- 2004-06-02 ES ES09075251.0T patent/ES2596553T3/es not_active Expired - Lifetime
- 2004-06-02 EP EP09075251.0A patent/EP2179729B1/en not_active Expired - Lifetime
- 2004-06-02 ES ES04776195.2T patent/ES2328697T5/es not_active Expired - Lifetime
- 2004-06-02 US US10/858,858 patent/US9107831B2/en not_active Expired - Lifetime
- 2004-06-02 DE DE602004022286T patent/DE602004022286D1/de not_active Expired - Lifetime
- 2004-06-02 CN CN2004800152668A patent/CN1798548B/zh not_active Expired - Lifetime
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PL1631264T3 (pl) | 2010-01-29 |
ES2328697T5 (es) | 2017-07-25 |
EP1631264B2 (en) | 2017-03-08 |
CN1798548B (zh) | 2010-05-05 |
PT1631264E (pt) | 2009-11-03 |
ES2328697T3 (es) | 2009-11-17 |
EP1631264A1 (en) | 2006-03-08 |
EP2179729A1 (en) | 2010-04-28 |
DE602004022286D1 (de) | 2009-09-10 |
US20050118275A1 (en) | 2005-06-02 |
EP1631264B8 (en) | 2017-05-24 |
JP2006526649A (ja) | 2006-11-24 |
JP2012082228A (ja) | 2012-04-26 |
JP5557415B2 (ja) | 2014-07-23 |
PL1631264T5 (pl) | 2018-09-28 |
EP1631264B1 (en) | 2009-07-29 |
CN1798548A (zh) | 2006-07-05 |
EP2179729B1 (en) | 2016-07-20 |
ATE437633T2 (de) | 2009-08-15 |
CA2528007C (en) | 2012-03-27 |
ES2596553T3 (es) | 2017-01-10 |
US9107831B2 (en) | 2015-08-18 |
WO2005020964A1 (en) | 2005-03-10 |
HK1087943A1 (en) | 2006-10-27 |
JP2014111671A (ja) | 2014-06-19 |
CA2528007A1 (en) | 2005-03-10 |
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