CY1109398T1 - Ανοσοδιεγερτικα ολιγονουκλεοτιδια συνδυαστικου μοτιβου με βελτιωμενη δραστικοτητα - Google Patents
Ανοσοδιεγερτικα ολιγονουκλεοτιδια συνδυαστικου μοτιβου με βελτιωμενη δραστικοτηταInfo
- Publication number
- CY1109398T1 CY1109398T1 CY20081101400T CY081101400T CY1109398T1 CY 1109398 T1 CY1109398 T1 CY 1109398T1 CY 20081101400 T CY20081101400 T CY 20081101400T CY 081101400 T CY081101400 T CY 081101400T CY 1109398 T1 CY1109398 T1 CY 1109398T1
- Authority
- CY
- Cyprus
- Prior art keywords
- nucleic acids
- oligonokleotides
- immunizable
- improved activity
- class
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6811—Selection methods for production or design of target specific oligonucleotides or binding molecules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Oncology (AREA)
- Analytical Chemistry (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
Παρέχεται τάξη ανοσοδιεγερτικών νουκλεϊκών οξέων που έχουν τουλάχιστον δύο λειτουργικά και δομικά καθορισμένες περιοχές. Αυτή η τάξη ανοσοδιεγερτικών νουκλεϊκών οξέων συνδυαστικού μοτίβου ενεργοποιεί ανοσοαπόκριση και είναι χρήσιμη για θεραπευτική αγωγή ποικιλίας ανοσιακών ανωμαλιών όπως καρκίνος, λοιμώδης ασθένεια, και αλλεργικές ανωμαλίες. Τα νουκλεϊκά οξέα επίσης διεγείρουν την ενεργοποίηση φυσικών κυττάρων-φονιάδων και την παραγωγή ιντερφερόνης τύπου 1.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31327301P | 2001-08-17 | 2001-08-17 | |
US39395202P | 2002-07-03 | 2002-07-03 | |
EP02768621A EP1446162B1 (en) | 2001-08-17 | 2002-08-19 | Combination motif immune stimulatory oligonucleotides with improved activity |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109398T1 true CY1109398T1 (el) | 2014-07-02 |
Family
ID=26978772
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081101400T CY1109398T1 (el) | 2001-08-17 | 2008-12-03 | Ανοσοδιεγερτικα ολιγονουκλεοτιδια συνδυαστικου μοτιβου με βελτιωμενη δραστικοτητα |
Country Status (23)
Country | Link |
---|---|
US (1) | US8834900B2 (el) |
EP (1) | EP1446162B1 (el) |
JP (2) | JP4383534B2 (el) |
KR (1) | KR100991644B1 (el) |
CN (1) | CN1604795B (el) |
AT (1) | ATE411054T1 (el) |
AU (1) | AU2002331643B2 (el) |
BR (1) | BR0211962A (el) |
CA (1) | CA2457485C (el) |
CY (1) | CY1109398T1 (el) |
DE (1) | DE60229422D1 (el) |
DK (1) | DK1446162T3 (el) |
EA (1) | EA007232B1 (el) |
ES (1) | ES2314099T3 (el) |
HK (1) | HK1067547A1 (el) |
IL (2) | IL160157A0 (el) |
MX (1) | MXPA04001458A (el) |
NZ (2) | NZ531194A (el) |
PT (1) | PT1446162E (el) |
SG (1) | SG177000A1 (el) |
SI (1) | SI1446162T1 (el) |
WO (1) | WO2003015711A2 (el) |
ZA (1) | ZA200401531B (el) |
Families Citing this family (104)
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US6406705B1 (en) | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
DE69935507T2 (de) * | 1998-04-03 | 2007-12-06 | University Of Iowa Research Foundation | Verfahren und produkte zur stimulierung des immunsystems mittels immunotherapeutischer oligonukleotide und zytokine |
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2002
- 2002-08-19 EP EP02768621A patent/EP1446162B1/en not_active Expired - Lifetime
- 2002-08-19 AT AT02768621T patent/ATE411054T1/de active
- 2002-08-19 DK DK02768621T patent/DK1446162T3/da active
- 2002-08-19 CN CN028182138A patent/CN1604795B/zh not_active Expired - Fee Related
- 2002-08-19 BR BR0211962-5A patent/BR0211962A/pt not_active Application Discontinuation
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- 2002-08-19 KR KR1020047002289A patent/KR100991644B1/ko active IP Right Grant
- 2002-08-19 MX MXPA04001458A patent/MXPA04001458A/es active IP Right Grant
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2004
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