CY1109387T1 - Εξασθενημενα sp12 μεταλλαγματα σαλμονελας σαν αντιγονικοι φορεις - Google Patents
Εξασθενημενα sp12 μεταλλαγματα σαλμονελας σαν αντιγονικοι φορειςInfo
- Publication number
- CY1109387T1 CY1109387T1 CY20081101270T CY081101270T CY1109387T1 CY 1109387 T1 CY1109387 T1 CY 1109387T1 CY 20081101270 T CY20081101270 T CY 20081101270T CY 081101270 T CY081101270 T CY 081101270T CY 1109387 T1 CY1109387 T1 CY 1109387T1
- Authority
- CY
- Cyprus
- Prior art keywords
- nucleic acid
- cell
- acid molecule
- faded
- inactivated
- Prior art date
Links
- 241000607142 Salmonella Species 0.000 title 1
- 230000000890 antigenic effect Effects 0.000 title 1
- 239000000969 carrier Substances 0.000 title 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 3
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 101000823106 Equus caballus Alpha-1-antiproteinase 2 Proteins 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 230000002238 attenuated effect Effects 0.000 abstract 2
- 210000005256 gram-negative cell Anatomy 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/255—Salmonella (G)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με εμβόλια, συγκεκριμένα, με ένα εξασθενημένο gram αρνητικό κύτταρο που περιέχει το γονιδιακό τόπο SPI2, όπου τουλάχιστον ένα γονίδιο του SPI2 τόπου είναι απενεργοποιημένο / αδρανοποιημένο, όπου η εν λόγω αδρανοποίηση έχει σαν αποτέλεσμα μια εξασθένηση / μείωση της μολυσματικότητας σε σύγκριση με τον άγριο τύπο του εν λόγω κυττάρου, και (σχετίζεται) με ένα φορέα για τη παρουσίαση ενός αντιγόνου σε ένα ξενιστή, ο οποίος φορέας είναι το εν λόγω εξασθενημένο gram αρνητικό κύτταρο, όπου το εν λόγω κύτταρο περιέχει τουλάχιστον ένα ετερόλογο μόριο νουκλεϊκού οξέος περιέχοντας μια αλληλουχία νουκλεϊκού οξέος που κωδικοποιεί για το εν λόγω αντιγόνο, όπου το εν λόγω κύτταρο είναι ικανό έκφρασης του εν λόγω μορίου νουκλεϊκού οξέος ή ικανό στο να προκαλέσει την έκφραση του εν λόγω μορίου νουκλεϊκού οξέος σε ένα κύτταρο στόχο.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98116827 | 1998-09-04 | ||
EP99946122A EP1108034B1 (en) | 1998-09-04 | 1999-09-03 | Attenuated salmonella spi2 mutants as antigen carriers |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109387T1 true CY1109387T1 (el) | 2014-07-02 |
Family
ID=8232583
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081101270T CY1109387T1 (el) | 1998-09-04 | 2008-11-06 | Εξασθενημενα sp12 μεταλλαγματα σαλμονελας σαν αντιγονικοι φορεις |
Country Status (13)
Country | Link |
---|---|
US (3) | US6936425B1 (el) |
EP (2) | EP1970449B1 (el) |
JP (1) | JP2002524077A (el) |
AT (2) | ATE486940T1 (el) |
AU (1) | AU5860599A (el) |
BR (1) | BR9914479A (el) |
CA (1) | CA2341349C (el) |
CY (1) | CY1109387T1 (el) |
DE (2) | DE69939264D1 (el) |
DK (1) | DK1108034T3 (el) |
ES (2) | ES2356863T3 (el) |
PT (1) | PT1108034E (el) |
WO (1) | WO2000014240A2 (el) |
Families Citing this family (58)
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WO1996017951A2 (en) * | 1994-12-09 | 1996-06-13 | Rpms Technology Limited | Identification of genes responsible for in vivo survival of microorganisms |
DK1108034T3 (da) * | 1998-09-04 | 2008-11-10 | Emergent Product Dev Uk Ltd | Svækkede salmonella SPI2-mutanter som antigenbærere |
GB9910812D0 (en) * | 1999-05-10 | 1999-07-07 | Microscience Ltd | Vaccine composition |
AU2003204710B2 (en) * | 1999-05-10 | 2006-08-03 | Microscience Limited | Attenuated microorganisms for the treatment of infection |
EP1640013A3 (en) * | 2000-03-17 | 2007-02-21 | Pharmacia & Upjohn Company LLC | Inactivated Salmonella vaccines |
ATE300949T1 (de) * | 2000-03-17 | 2005-08-15 | Pharmacia & Upjohn Co Llc | Ssa inaktivierte salmonella impfstoffe |
GB0105924D0 (en) * | 2001-03-09 | 2001-04-25 | Microscience Ltd | Promoter |
DE60216099D1 (de) * | 2001-05-17 | 2006-12-28 | Creatogen Ag | Methode zum auffinden von abgeschwächten oder virulent-defekten mikroben |
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JP2008509168A (ja) | 2004-08-13 | 2008-03-27 | マーシャル,バリー,ジェー. | 細菌デリバリシステム |
CN1276076C (zh) * | 2004-12-14 | 2006-09-20 | 华东理工大学 | 一种鳗弧菌野生毒株的无标记基因缺失减毒突变株及其应用 |
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US8604178B2 (en) | 2006-09-18 | 2013-12-10 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancing immune responses |
US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
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EP2150616A4 (en) | 2007-05-10 | 2011-07-27 | Univ Arizona | REGULATED ANTIGEN SYNTHESIS AND / OR REGULATED ATTENUATION FOR IMPROVING VACCINATE IMMUNOGENICITY AND / OR SAFETY |
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JP5746333B2 (ja) | 2010-06-09 | 2015-07-08 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | カンピロバクター感染を減少させるワクチン及び方法 |
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US10987432B2 (en) * | 2013-09-05 | 2021-04-27 | The University Of Hong Kong | Therapeutic delivery and expression system, methods and uses thereof |
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EP3452069A4 (en) | 2016-05-03 | 2020-02-12 | The Board of Trustees of the University of Arkansas | Yeast vaccine vector with immunostimulating and antigenic polypeptides and method for using them |
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US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
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-
1999
- 1999-09-03 DK DK99946122T patent/DK1108034T3/da active
- 1999-09-03 DE DE69939264T patent/DE69939264D1/de not_active Expired - Lifetime
- 1999-09-03 WO PCT/EP1999/006514 patent/WO2000014240A2/en active IP Right Grant
- 1999-09-03 AT AT08075560T patent/ATE486940T1/de not_active IP Right Cessation
- 1999-09-03 EP EP08075560A patent/EP1970449B1/en not_active Expired - Lifetime
- 1999-09-03 US US09/763,620 patent/US6936425B1/en not_active Expired - Fee Related
- 1999-09-03 ES ES08075560T patent/ES2356863T3/es not_active Expired - Lifetime
- 1999-09-03 AT AT99946122T patent/ATE403728T1/de active
- 1999-09-03 ES ES99946122T patent/ES2313792T3/es not_active Expired - Lifetime
- 1999-09-03 JP JP2000568983A patent/JP2002524077A/ja active Pending
- 1999-09-03 AU AU58605/99A patent/AU5860599A/en not_active Abandoned
- 1999-09-03 CA CA2341349A patent/CA2341349C/en not_active Expired - Fee Related
- 1999-09-03 BR BR9914479-4A patent/BR9914479A/pt not_active Application Discontinuation
- 1999-09-03 DE DE69942925T patent/DE69942925D1/de not_active Expired - Lifetime
- 1999-09-03 PT PT99946122T patent/PT1108034E/pt unknown
- 1999-09-03 EP EP99946122A patent/EP1108034B1/en not_active Expired - Lifetime
-
2004
- 2004-01-23 US US10/763,883 patent/US7700104B2/en not_active Expired - Lifetime
-
2007
- 2007-08-17 US US11/840,928 patent/US7955600B2/en not_active Expired - Fee Related
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2008
- 2008-11-06 CY CY20081101270T patent/CY1109387T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ATE486940T1 (de) | 2010-11-15 |
EP1970449A1 (en) | 2008-09-17 |
ATE403728T1 (de) | 2008-08-15 |
JP2002524077A (ja) | 2002-08-06 |
WO2000014240A2 (en) | 2000-03-16 |
ES2356863T3 (es) | 2011-04-13 |
EP1108034A2 (en) | 2001-06-20 |
WO2000014240A3 (en) | 2000-08-03 |
US7700104B2 (en) | 2010-04-20 |
ES2313792T3 (es) | 2009-03-01 |
US6936425B1 (en) | 2005-08-30 |
EP1108034B1 (en) | 2008-08-06 |
US7955600B2 (en) | 2011-06-07 |
AU5860599A (en) | 2000-03-27 |
PT1108034E (pt) | 2008-11-14 |
CA2341349A1 (en) | 2000-03-16 |
US20080075739A1 (en) | 2008-03-27 |
BR9914479A (pt) | 2001-06-26 |
DE69942925D1 (de) | 2010-12-16 |
DK1108034T3 (da) | 2008-11-10 |
CA2341349C (en) | 2013-12-10 |
US20040203039A1 (en) | 2004-10-14 |
DE69939264D1 (de) | 2008-09-18 |
EP1970449B1 (en) | 2010-11-03 |
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