ATE486940T1 - Abgeschwächte salmonella sp12 mutante als antigen-träger. - Google Patents
Abgeschwächte salmonella sp12 mutante als antigen-träger.Info
- Publication number
- ATE486940T1 ATE486940T1 AT08075560T AT08075560T ATE486940T1 AT E486940 T1 ATE486940 T1 AT E486940T1 AT 08075560 T AT08075560 T AT 08075560T AT 08075560 T AT08075560 T AT 08075560T AT E486940 T1 ATE486940 T1 AT E486940T1
- Authority
- AT
- Austria
- Prior art keywords
- cell
- nucleic acid
- acid molecule
- antigen
- carrier
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 3
- 108091007433 antigens Proteins 0.000 title abstract 3
- 102000036639 antigens Human genes 0.000 title abstract 3
- 241000607142 Salmonella Species 0.000 title 1
- 210000004027 cell Anatomy 0.000 abstract 4
- 150000007523 nucleic acids Chemical class 0.000 abstract 4
- 108020004707 nucleic acids Proteins 0.000 abstract 3
- 102000039446 nucleic acids Human genes 0.000 abstract 3
- 101000823106 Equus caballus Alpha-1-antiproteinase 2 Proteins 0.000 abstract 2
- 230000002238 attenuated effect Effects 0.000 abstract 2
- 210000005256 gram-negative cell Anatomy 0.000 abstract 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
- 230000001018 virulence Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/79—Transferrins, e.g. lactoferrins, ovotransferrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/255—Salmonella (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K2035/11—Medicinal preparations comprising living procariotic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Toxicology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98116827 | 1998-09-04 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE486940T1 true ATE486940T1 (de) | 2010-11-15 |
Family
ID=8232583
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08075560T ATE486940T1 (de) | 1998-09-04 | 1999-09-03 | Abgeschwächte salmonella sp12 mutante als antigen-träger. |
AT99946122T ATE403728T1 (de) | 1998-09-04 | 1999-09-03 | Attenuierte salmonella spi2 mutante als antigen- träger |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT99946122T ATE403728T1 (de) | 1998-09-04 | 1999-09-03 | Attenuierte salmonella spi2 mutante als antigen- träger |
Country Status (13)
Country | Link |
---|---|
US (3) | US6936425B1 (de) |
EP (2) | EP1970449B1 (de) |
JP (1) | JP2002524077A (de) |
AT (2) | ATE486940T1 (de) |
AU (1) | AU5860599A (de) |
BR (1) | BR9914479A (de) |
CA (1) | CA2341349C (de) |
CY (1) | CY1109387T1 (de) |
DE (2) | DE69939264D1 (de) |
DK (1) | DK1108034T3 (de) |
ES (2) | ES2356863T3 (de) |
PT (1) | PT1108034E (de) |
WO (1) | WO2000014240A2 (de) |
Families Citing this family (58)
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WO1996017951A2 (en) * | 1994-12-09 | 1996-06-13 | Rpms Technology Limited | Identification of genes responsible for in vivo survival of microorganisms |
DK1108034T3 (da) * | 1998-09-04 | 2008-11-10 | Emergent Product Dev Uk Ltd | Svækkede salmonella SPI2-mutanter som antigenbærere |
GB9910812D0 (en) * | 1999-05-10 | 1999-07-07 | Microscience Ltd | Vaccine composition |
AU2003204710B2 (en) * | 1999-05-10 | 2006-08-03 | Microscience Limited | Attenuated microorganisms for the treatment of infection |
EP1640013A3 (de) * | 2000-03-17 | 2007-02-21 | Pharmacia & Upjohn Company LLC | Inaktivierte Salmonella Impfstoffe |
ATE300949T1 (de) * | 2000-03-17 | 2005-08-15 | Pharmacia & Upjohn Co Llc | Ssa inaktivierte salmonella impfstoffe |
GB0105924D0 (en) * | 2001-03-09 | 2001-04-25 | Microscience Ltd | Promoter |
DE60216099D1 (de) * | 2001-05-17 | 2006-12-28 | Creatogen Ag | Methode zum auffinden von abgeschwächten oder virulent-defekten mikroben |
US8029777B2 (en) | 2004-08-13 | 2011-10-04 | Marshall Barry J | Helicobacter system and uses thereof |
JP2008509168A (ja) | 2004-08-13 | 2008-03-27 | マーシャル,バリー,ジェー. | 細菌デリバリシステム |
CN1276076C (zh) * | 2004-12-14 | 2006-09-20 | 华东理工大学 | 一种鳗弧菌野生毒株的无标记基因缺失减毒突变株及其应用 |
US20070134814A1 (en) * | 2005-12-09 | 2007-06-14 | Kajander E O | Methods and compositions for the detection of calcifying nano-particles, identification and quantification of associated proteins thereon, and correlation to disease |
US8604178B2 (en) | 2006-09-18 | 2013-12-10 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancing immune responses |
US20080124355A1 (en) | 2006-09-22 | 2008-05-29 | David Gordon Bermudes | Live bacterial vaccines for viral infection prophylaxis or treatment |
EP2152883A4 (de) * | 2007-05-10 | 2010-10-27 | Univ Arizona | Rekombinante bakterien mit vektoren zur expression von nukleinsäuresequenzencodierenden antigenen |
EP2150616A4 (de) | 2007-05-10 | 2011-07-27 | Univ Arizona | Geregelte antigensynthese und/oder geregelte attenuation zur verbesserung der impfstoff immunogenität und/oder -sicherheit |
WO2008153772A2 (en) * | 2007-05-25 | 2008-12-18 | Emergent Product Development Gaithersburg Inc. | Chlamydia vaccine comprising htra polypeptides |
WO2009046451A1 (en) * | 2007-10-05 | 2009-04-09 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium capable of eliciting a protective immune response against c. perfringens |
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DK2214701T3 (en) | 2007-11-01 | 2016-12-12 | Univ Arkansas | CONFIGURATIONS AND METHODS FOR IMPROVING THE IMMUNE RESPONSES TO Eimeria |
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WO2010048322A1 (en) * | 2008-10-21 | 2010-04-29 | Emergent Product Development United Kingdom | Use of e. coli surface antigen 3 sequences for the export of heterologous antigens |
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US9045742B2 (en) * | 2009-05-29 | 2015-06-02 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant Edwardsiella bacterium |
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WO2011150421A2 (en) | 2010-05-28 | 2011-12-01 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Recombinant bacterium to decrease tumor growth |
JP5746333B2 (ja) | 2010-06-09 | 2015-07-08 | ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー | カンピロバクター感染を減少させるワクチン及び方法 |
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RU2496518C1 (ru) * | 2012-05-03 | 2013-10-27 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Кубанский государственный аграрный университет" | Способ изготовления вакцины ассоциированной против сальмонеллеза, эшерихиоза и вирусной геморрагической болезни кроликов |
US9303264B2 (en) | 2012-05-18 | 2016-04-05 | The Arizona Board Of Regents For And On Behalf Of Arizona State University | Photosynthetic microorganisms expressing thermostable lipase |
EP2852405B1 (de) * | 2012-05-23 | 2019-03-13 | The United States of America, as represented by The Secretary, Department of Health and Human Services | Salmonella typhi ty21a zur expression eines yersinia pestis f1-v-fusionsproteins und verwendungen davon |
ES2752190T3 (es) | 2012-09-14 | 2020-04-03 | Us Health | Proteína Brachyury, vectores adenovirales que codifican proteína Brachyury y su uso |
PT2956165T (pt) | 2013-02-14 | 2019-11-29 | Texas A & M Univ Sys | Composições e métodos de potenciação das respostas imunitárias frente a eimeria ou limitação de uma infeção por eimeria |
WO2014144965A1 (en) * | 2013-03-15 | 2014-09-18 | Husseiny Elsayed Mohamed I | Attenuated salmonella bacteria and methods of using |
US10376571B2 (en) | 2013-03-15 | 2019-08-13 | The Board Of Trustees Of The University Of Arkansas | Compositions and methods of enhancing immune responses to enteric pathogens |
US9580718B2 (en) | 2013-06-17 | 2017-02-28 | Arizona Board Of Regents On Behalf Of Arizona State University | Attenuated live bacteria with increased acid resistance and methods of use thereof |
US10987432B2 (en) * | 2013-09-05 | 2021-04-27 | The University Of Hong Kong | Therapeutic delivery and expression system, methods and uses thereof |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
EP3452069A4 (de) | 2016-05-03 | 2020-02-12 | The Board of Trustees of the University of Arkansas | Hefeimpfstoffvektor mit immunstimulierenden und antigenen polypeptiden und verfahren zur verwendung davon |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
US11471497B1 (en) | 2019-03-13 | 2022-10-18 | David Gordon Bermudes | Copper chelation therapeutics |
EP4045672A4 (de) * | 2019-10-18 | 2023-11-22 | University of Virginia Patent Foundation | Zusammensetzungen und verfahren für die erzeugung verbesserter immunantworten und schnelle antikörperproduktion |
US10973908B1 (en) | 2020-05-14 | 2021-04-13 | David Gordon Bermudes | Expression of SARS-CoV-2 spike protein receptor binding domain in attenuated salmonella as a vaccine |
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CN114292339B (zh) * | 2022-01-05 | 2022-08-09 | 武汉科前生物股份有限公司 | 鞭毛素突变体与非洲猪瘟抗原的融合蛋白及其应用 |
CN114703214A (zh) * | 2022-03-03 | 2022-07-05 | 南京吉芮康生物科技研究院有限公司 | 一种抗丢失时空可控表达的新型质粒及其应用 |
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DK1108034T3 (da) | 1998-09-04 | 2008-11-10 | Emergent Product Dev Uk Ltd | Svækkede salmonella SPI2-mutanter som antigenbærere |
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-
1999
- 1999-09-03 DK DK99946122T patent/DK1108034T3/da active
- 1999-09-03 DE DE69939264T patent/DE69939264D1/de not_active Expired - Lifetime
- 1999-09-03 WO PCT/EP1999/006514 patent/WO2000014240A2/en active IP Right Grant
- 1999-09-03 AT AT08075560T patent/ATE486940T1/de not_active IP Right Cessation
- 1999-09-03 EP EP08075560A patent/EP1970449B1/de not_active Expired - Lifetime
- 1999-09-03 US US09/763,620 patent/US6936425B1/en not_active Expired - Fee Related
- 1999-09-03 ES ES08075560T patent/ES2356863T3/es not_active Expired - Lifetime
- 1999-09-03 AT AT99946122T patent/ATE403728T1/de active
- 1999-09-03 ES ES99946122T patent/ES2313792T3/es not_active Expired - Lifetime
- 1999-09-03 JP JP2000568983A patent/JP2002524077A/ja active Pending
- 1999-09-03 AU AU58605/99A patent/AU5860599A/en not_active Abandoned
- 1999-09-03 CA CA2341349A patent/CA2341349C/en not_active Expired - Fee Related
- 1999-09-03 BR BR9914479-4A patent/BR9914479A/pt not_active Application Discontinuation
- 1999-09-03 DE DE69942925T patent/DE69942925D1/de not_active Expired - Lifetime
- 1999-09-03 PT PT99946122T patent/PT1108034E/pt unknown
- 1999-09-03 EP EP99946122A patent/EP1108034B1/de not_active Expired - Lifetime
-
2004
- 2004-01-23 US US10/763,883 patent/US7700104B2/en not_active Expired - Lifetime
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2007
- 2007-08-17 US US11/840,928 patent/US7955600B2/en not_active Expired - Fee Related
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2008
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Also Published As
Publication number | Publication date |
---|---|
EP1970449A1 (de) | 2008-09-17 |
ATE403728T1 (de) | 2008-08-15 |
JP2002524077A (ja) | 2002-08-06 |
WO2000014240A2 (en) | 2000-03-16 |
ES2356863T3 (es) | 2011-04-13 |
EP1108034A2 (de) | 2001-06-20 |
WO2000014240A3 (en) | 2000-08-03 |
CY1109387T1 (el) | 2014-07-02 |
US7700104B2 (en) | 2010-04-20 |
ES2313792T3 (es) | 2009-03-01 |
US6936425B1 (en) | 2005-08-30 |
EP1108034B1 (de) | 2008-08-06 |
US7955600B2 (en) | 2011-06-07 |
AU5860599A (en) | 2000-03-27 |
PT1108034E (pt) | 2008-11-14 |
CA2341349A1 (en) | 2000-03-16 |
US20080075739A1 (en) | 2008-03-27 |
BR9914479A (pt) | 2001-06-26 |
DE69942925D1 (de) | 2010-12-16 |
DK1108034T3 (da) | 2008-11-10 |
CA2341349C (en) | 2013-12-10 |
US20040203039A1 (en) | 2004-10-14 |
DE69939264D1 (de) | 2008-09-18 |
EP1970449B1 (de) | 2010-11-03 |
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