CY1108742T1 - Κρυσταλλικη μορφη της μηλεϊνικης ασεναπινης - Google Patents

Κρυσταλλικη μορφη της μηλεϊνικης ασεναπινης

Info

Publication number
CY1108742T1
CY1108742T1 CY20091100111T CY091100111T CY1108742T1 CY 1108742 T1 CY1108742 T1 CY 1108742T1 CY 20091100111 T CY20091100111 T CY 20091100111T CY 091100111 T CY091100111 T CY 091100111T CY 1108742 T1 CY1108742 T1 CY 1108742T1
Authority
CY
Cyprus
Prior art keywords
asenapin
malenic
crystal form
crystalline form
orthorhombic
Prior art date
Application number
CY20091100111T
Other languages
English (en)
Inventor
Gerhardus Johannes Heeres
Original Assignee
N.V. Organon
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36617328&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1108742(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by N.V. Organon filed Critical N.V. Organon
Publication of CY1108742T1 publication Critical patent/CY1108742T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Abstract

Η εφεύρεση αφορά σε μια ορθορομβική κρυσταλλική μορφή της ένωσης trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1H-dibenz [2,3:6,7] oxepino [4,5-c] pyrrole (Z)-2-butenedioate, σε μεθόδους παρασκευής αυτής της κρυσταλλικής μορφής και σε φαρμακευτικές συνθέσεις που περιέχουν μια ορθορομβική κρυσταλλική μορφή.
CY20091100111T 2005-04-07 2009-01-30 Κρυσταλλικη μορφη της μηλεϊνικης ασεναπινης CY1108742T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05102742 2005-04-07
EP05102969 2005-04-14
EP06725622A EP1917267B1 (en) 2005-04-07 2006-04-06 Crystal form of asenapine maleate

Publications (1)

Publication Number Publication Date
CY1108742T1 true CY1108742T1 (el) 2014-04-09

Family

ID=36617328

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20071101258T CY1106902T1 (el) 2005-04-07 2007-10-02 Κρυσταλλικη μορφη μηλεϊνικης ασεναπινης
CY20091100111T CY1108742T1 (el) 2005-04-07 2009-01-30 Κρυσταλλικη μορφη της μηλεϊνικης ασεναπινης

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CY20071101258T CY1106902T1 (el) 2005-04-07 2007-10-02 Κρυσταλλικη μορφη μηλεϊνικης ασεναπινης

Country Status (31)

Country Link
EP (2) EP1917267B1 (el)
JP (1) JP5058151B2 (el)
KR (1) KR101422843B1 (el)
AR (1) AR056306A1 (el)
AT (2) ATE418556T1 (el)
AU (1) AU2006231617B2 (el)
BR (1) BRPI0609741A8 (el)
CA (1) CA2603509C (el)
CY (2) CY1106902T1 (el)
DE (2) DE602006004463D1 (el)
DK (2) DK1710245T3 (el)
DO (1) DOP2006000082A (el)
ES (2) ES2293626T3 (el)
GT (1) GT200600135A (el)
HN (1) HN2006014095A (el)
HR (1) HRP20070429T3 (el)
IL (1) IL186355A (el)
MX (1) MX2007012445A (el)
MY (1) MY137969A (el)
NO (1) NO340520B1 (el)
NZ (1) NZ562124A (el)
PE (1) PE20061311A1 (el)
PL (2) PL1917267T3 (el)
PT (2) PT1710245E (el)
RS (1) RS50532B (el)
RU (1) RU2405786C2 (el)
SI (2) SI1710245T1 (el)
SV (1) SV2006002473A (el)
TW (1) TWI364423B (el)
UY (1) UY29459A1 (el)
WO (1) WO2006106135A1 (el)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CL2007002891A1 (es) * 2006-10-06 2008-04-18 Organon Nv Trans-5-cloro-2-metil-2,3,3a,12b-tetrahidro-1h-dibenz-[2,3:6,7]oxepino[4,5-c]pirrol 50% amorfo en base al peso total del compuesto; procedimiento de preparacion; composicion farmaceutica; y uso para el tratamiento de un trastorno seleccionado entre e
AU2010264670A1 (en) * 2009-06-24 2012-01-19 Merck Sharp & Dohme B.V. Injectable formulations containing asenapine and method of treatment using same
WO2011159903A2 (en) 2010-06-18 2011-12-22 Dr. Reddy's Laboratories Ltd. Asenapine maleate
WO2012066565A2 (en) * 2010-11-16 2012-05-24 Cadila Healthcare Limited Asenapine maleate amorphous and crystalline form and process for preparation thereof
EP2468750A1 (en) 2010-12-13 2012-06-27 Chemo Ibérica, S.A. Polymorphic forms of asenapine maleate and processes for their preparation
WO2012123325A1 (en) 2011-03-11 2012-09-20 Medichem S.A. NEW CRYSTAL FORMS OF THE SALT OF TRANS-5-CHLORO-2-METHYL-2,3,3A,12b-TETRAHYDRO-1H-DIBENZO[2,3:6,7]OXEPINO[4,5-c]PYRROLE WITH MALEIC ACID
ITMI20110734A1 (it) * 2011-05-02 2012-11-03 Olon Spa Sali cristallini di asenapina
EP2524920A1 (en) 2011-05-17 2012-11-21 Sandoz AG Novel Crystalline Asenapine Hydrochloride Salt Forms
EP2524919A1 (en) 2011-05-17 2012-11-21 Sandoz AG Novel crystalline salts of Asenapine with organic Di-acids and Tri-acids
EP2524921A1 (en) 2011-05-17 2012-11-21 Sandoz AG Novel Crystalline Salts of Asenapine
WO2012156676A1 (en) * 2011-05-18 2012-11-22 Laboratorios Lesvi S.L. Monoclinic crystalline form of asenapine maleate with a specific particle size distribution
US9505771B2 (en) 2011-05-18 2016-11-29 Laboratories Lesvi S.L. Stable micronised monoclin form of asenapine maleate and its synthesis
EP2572703A1 (en) 2011-09-21 2013-03-27 Hexal AG Compressed oral dosage form for asenapine maleate
WO2013041604A1 (en) 2011-09-21 2013-03-28 Sandoz Ag Crystal form of asenapine maleate
ES2632946T3 (es) * 2012-07-26 2017-09-18 Hisamitsu Pharmaceutical Co., Inc. Parche
ITMI20121810A1 (it) 2012-10-24 2014-04-25 Chemo Iberica Sa Poliformi di maleato di asenapina e processo per la loro preparazione
US9597291B2 (en) 2012-12-11 2017-03-21 Alfred E. Tiefenbacher (Gmbh & Co. Kg) Orally disintegrating tablet containing asenapine
WO2014127786A1 (en) 2013-02-22 2014-08-28 Zentiva, K.S. Orally disintegrating pharmaceutical composition comprising asenapine
EP3350194A4 (en) 2015-09-02 2019-04-24 Eloxx Pharmaceuticals Ltd. AMINO-LIKES DERIVATIVES AND USES THEREOF FOR THE TREATMENT OF GENETIC DISEASES
CN110087641B (zh) 2016-12-20 2024-03-12 罗曼治疗***股份公司 含有阿塞那平和聚硅氧烷或聚异丁烯的透皮治疗***
MX2019007391A (es) 2016-12-20 2019-08-16 Lts Lohmann Therapie Systeme Ag Sistema terapeutico transdermico que contiene asenapina.
CN110799180A (zh) 2017-06-26 2020-02-14 罗曼治疗***股份公司 含阿塞那平和硅氧烷丙烯酸杂化聚合物的经皮治疗***
WO2019243452A1 (en) 2018-06-20 2019-12-26 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system containing asenapine

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL7605526A (nl) * 1976-05-24 1977-11-28 Akzo Nv Nieuwe tetracyclische derivaten.
CZ284633B6 (cs) * 1994-03-02 1999-01-13 Akzo Nobel N. V. Farmaceutický prostředek a použití trans-5-chloro-2-methyl-2,3,3a,12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrolu pro výrobu farmaceutického prostředku
AU2418499A (en) * 1997-12-19 1999-07-12 Akzo Nobel N.V. Org-5222 in the treatment of depression
TWI327915B (en) * 2003-06-12 2010-08-01 Organon Nv Pharmaceutical composition comprising antipsychotic agent and use of the antipsychotic agent for treating patients with overweight

Also Published As

Publication number Publication date
CA2603509C (en) 2013-12-03
NO20075142L (no) 2007-11-05
RU2405786C2 (ru) 2010-12-10
DK1710245T3 (da) 2007-12-03
HRP20070429T3 (en) 2007-11-30
DOP2006000082A (es) 2006-11-30
EP1917267A1 (en) 2008-05-07
DK1917267T3 (da) 2009-04-14
CA2603509A1 (en) 2006-10-12
ATE370954T1 (de) 2007-09-15
KR101422843B1 (ko) 2014-07-24
SV2006002473A (es) 2009-11-24
UY29459A1 (es) 2006-11-30
ES2293626T3 (es) 2008-03-16
EP1710245B1 (en) 2007-08-22
HN2006014095A (es) 2010-08-19
DE602006000080T2 (de) 2008-05-15
GT200600135A (es) 2006-11-07
NZ562124A (en) 2010-07-30
RU2007141198A (ru) 2009-05-20
PL1917267T3 (pl) 2009-06-30
JP2008534656A (ja) 2008-08-28
AU2006231617B2 (en) 2010-06-03
SI1710245T1 (sl) 2007-12-31
RS50532B (sr) 2010-05-07
BRPI0609741A2 (pt) 2010-04-27
BRPI0609741A8 (pt) 2018-03-13
AU2006231617A1 (en) 2006-10-12
DE602006004463D1 (de) 2009-02-05
PT1917267E (pt) 2009-02-04
AR056306A1 (es) 2007-10-03
CY1106902T1 (el) 2012-09-26
PL1710245T3 (pl) 2008-01-31
TWI364423B (en) 2012-05-21
IL186355A (en) 2016-05-31
IL186355A0 (en) 2008-01-20
WO2006106135A1 (en) 2006-10-12
MY137969A (en) 2009-04-30
JP5058151B2 (ja) 2012-10-24
EP1917267B1 (en) 2008-12-24
ES2318742T3 (es) 2009-05-01
ATE418556T1 (de) 2009-01-15
PT1710245E (pt) 2007-10-03
NO340520B1 (no) 2017-05-02
DE602006000080D1 (de) 2007-10-04
TW200722428A (en) 2007-06-16
KR20080005253A (ko) 2008-01-10
EP1710245A1 (en) 2006-10-11
PE20061311A1 (es) 2007-02-09
MX2007012445A (es) 2007-11-07
SI1917267T1 (sl) 2009-04-30

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