CY1107862T1 - Φαρμακευτικες συνθεσεις που περιλαμβανουν παραγωγα οιστερολης για χρηση στη θεραπεια του καρκινου - Google Patents
Φαρμακευτικες συνθεσεις που περιλαμβανουν παραγωγα οιστερολης για χρηση στη θεραπεια του καρκινουInfo
- Publication number
- CY1107862T1 CY1107862T1 CY20081100080T CY081100080T CY1107862T1 CY 1107862 T1 CY1107862 T1 CY 1107862T1 CY 20081100080 T CY20081100080 T CY 20081100080T CY 081100080 T CY081100080 T CY 081100080T CY 1107862 T1 CY1107862 T1 CY 1107862T1
- Authority
- CY
- Cyprus
- Prior art keywords
- esterol
- producers
- pharmaceutical compositions
- compositions containing
- cancer treatment
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
Η παρούσα εφεύρεση αναφέρεται σε μία μέθοδο θεραπείας ή πρόληψης των οιστρογόνο-κατεσταλμένων όγκων σε ένα θηλαστικό, με την αναφερθείσα μέθοδο να περιλαμβάνει την χορήγηση μιας θεραπευτικά αποτελεσματικής ποσότητας ενός οιστρογονικού συστατικού στο αναφερθέν θηλαστικό, όπου το οιστρογονικό συστατικό έχει επιλεγεί από την ομάδα, η οποία αποτελείται από: ουσίες που αντιπροσωπεύονται από τον ακόλουθο χημικό τύπο (I), στον οποίο χημικό τύπο οι R1, R2, R3, R4, είναι ανεξάρτητα, ένα άτομο υδρογόνου, μία υδροξυλική ομάδα ή μία αλκόξυ ομάδα με 1-5 άτομα άνθρακα, πρόδρομα μόρια ικανά να απελευθερώνουν την ουσία σύμφωνα με τον χημικό τύπο που αναφέρθηκε πιο πάνω όταν χρησιμοποιηθούν στην παρούσα μέθοδο, και μίγματα μιας ή περισσότερων εκ των ουσιών και/ή πρόδρομων μορίων που αναφέρθηκαν πιο πάνω. Το οιστρογονικό συστατικό σύμφωνα με την εφεύρεση είναι ιδιαιτέρως χρήσιμο στην θεραπεία ή τη πρόληψη του ορθοκολικού και του καρκίνο του προστάτη και, αντίθετα με τα οιστρογόνα που χρησιμοποιούνται συνήθως, δεν ενισχύει ταυτόχρονα τον κίνδυνο εμφάνισης οιστρογόνο-διεγερμένων καρκίνων, όπως είναι για παράδειγμα ο καρκίνος του μαστού.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02079414 | 2002-10-23 | ||
| EP03759076A EP1556058B1 (en) | 2002-10-23 | 2003-10-23 | Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1107862T1 true CY1107862T1 (el) | 2013-06-19 |
Family
ID=32116285
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20081100080T CY1107862T1 (el) | 2002-10-23 | 2008-01-18 | Φαρμακευτικες συνθεσεις που περιλαμβανουν παραγωγα οιστερολης για χρηση στη θεραπεια του καρκινου |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8987240B2 (el) |
| EP (1) | EP1556058B1 (el) |
| CN (1) | CN100528167C (el) |
| AT (1) | ATE380552T1 (el) |
| AU (1) | AU2003274823A1 (el) |
| CA (1) | CA2503549C (el) |
| CY (1) | CY1107862T1 (el) |
| DE (1) | DE60318092T2 (el) |
| DK (1) | DK1556058T3 (el) |
| ES (1) | ES2298570T3 (el) |
| PT (1) | PT1556058E (el) |
| SI (1) | SI1556058T1 (el) |
| WO (1) | WO2004037269A1 (el) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1526856B1 (en) | 2002-07-12 | 2008-01-02 | Pantarhei Bioscience B.V. | Pharmaceutical composition comprising estetrol derivatives for use in cancer therapy |
| CA2503549C (en) | 2002-10-23 | 2012-07-10 | Pantarhei Bioscience B.V. | Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapy |
| AU2007287098C1 (en) * | 2006-08-25 | 2018-03-15 | Janssen Pharmaceutica Nv | Methods and compositions for treating cancer |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| WO2008156365A1 (en) * | 2007-06-21 | 2008-12-24 | Pantarhei Bioscience B.V. | Treatment of meconium aspiration syndrome with estrogens |
| US11053274B2 (en) | 2011-06-01 | 2021-07-06 | Estetra S.P.R.L. | Process for the production of estetrol intermediates |
| CA2835979C (en) | 2011-06-01 | 2018-05-01 | Estetra S.A. | Process for the production of estetrol intermediates |
| EP2383279A1 (en) | 2011-07-19 | 2011-11-02 | Pantarhei Bioscience B.V. | Process for the preparation of estetrol |
| US20130123222A1 (en) * | 2011-11-10 | 2013-05-16 | Sri International, Inc. | Synergistic Anti-Cancer Activity of SR16388 with Anti-Mitotic Drugs |
| JP6285866B2 (ja) | 2011-11-23 | 2018-02-28 | セラピューティックスエムディー インコーポレーテッドＴｈｅｒａｐｅｕｔｉｃｓｍｄ， Ｉｎｃ． | 天然複合ホルモン補充製剤および療法 |
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| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| KR20170005819A (ko) | 2014-05-22 | 2017-01-16 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 천연 복합 호르몬 대체 제형 및 요법 |
| WO2016162229A1 (en) | 2015-04-10 | 2016-10-13 | Capsugel Belgium N.V. | Abiraterone acetate lipid formulations |
| MA44205B1 (fr) | 2015-06-18 | 2021-04-30 | Estetra Sprl | Comprimé orodispersible comprenant estetrol |
| GEP20217308B (en) | 2015-06-18 | 2021-10-25 | Estetra Sprl | Orodispersible dosage unit containing an estetrol component |
| DK3310346T3 (da) * | 2015-06-18 | 2021-05-25 | Estetra Sprl | Orodispersibel tablet indeholdende estetrol |
| PL3310333T3 (pl) | 2015-06-18 | 2020-07-13 | Estetra Sprl | Ulegająca rozpadowi w jamie ustnej jednostka dawkowana zawierająca składnik estetrolowy |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
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| JOP20200260A1 (ar) | 2018-04-19 | 2019-10-19 | Estetra Sprl | مركبات واستخداماتها للتخفيف من الأعراض المصاحبة لانقطاع الطمث |
| TWI801561B (zh) | 2018-04-19 | 2023-05-11 | 比利時商依思特拉私人有限責任公司 | 化合物及其用於緩解絕經相關症狀的用途 |
| HU231240B1 (hu) | 2019-09-03 | 2022-04-28 | Richter Gedeon Nyrt. | Ipari eljárás nagytisztaságú ösztetrol hatóanyag előállítására |
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-
2003
- 2003-10-23 CA CA2503549A patent/CA2503549C/en not_active Expired - Lifetime
- 2003-10-23 EP EP03759076A patent/EP1556058B1/en not_active Expired - Lifetime
- 2003-10-23 US US10/532,320 patent/US8987240B2/en active Active
- 2003-10-23 ES ES03759076T patent/ES2298570T3/es not_active Expired - Lifetime
- 2003-10-23 AU AU2003274823A patent/AU2003274823A1/en not_active Abandoned
- 2003-10-23 DK DK03759076T patent/DK1556058T3/da active
- 2003-10-23 SI SI200331061T patent/SI1556058T1/sl unknown
- 2003-10-23 PT PT03759076T patent/PT1556058E/pt unknown
- 2003-10-23 CN CNB2003801074356A patent/CN100528167C/zh not_active Expired - Lifetime
- 2003-10-23 DE DE60318092T patent/DE60318092T2/de not_active Expired - Lifetime
- 2003-10-23 WO PCT/NL2003/000718 patent/WO2004037269A1/en active IP Right Grant
- 2003-10-23 AT AT03759076T patent/ATE380552T1/de active
-
2008
- 2008-01-18 CY CY20081100080T patent/CY1107862T1/el unknown
-
2015
- 2015-02-12 US US14/621,267 patent/US9561238B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1556058A1 (en) | 2005-07-27 |
| DE60318092T2 (de) | 2008-11-27 |
| DK1556058T3 (da) | 2008-03-03 |
| DE60318092D1 (de) | 2008-01-24 |
| PT1556058E (pt) | 2008-03-20 |
| AU2003274823A1 (en) | 2004-05-13 |
| US8987240B2 (en) | 2015-03-24 |
| CA2503549C (en) | 2012-07-10 |
| ES2298570T3 (es) | 2008-05-16 |
| US9561238B2 (en) | 2017-02-07 |
| CN1732007A (zh) | 2006-02-08 |
| US20150150887A1 (en) | 2015-06-04 |
| US20060247221A1 (en) | 2006-11-02 |
| CA2503549A1 (en) | 2004-05-06 |
| EP1556058B1 (en) | 2007-12-12 |
| CN100528167C (zh) | 2009-08-19 |
| ATE380552T1 (de) | 2007-12-15 |
| WO2004037269A1 (en) | 2004-05-06 |
| SI1556058T1 (sl) | 2008-02-29 |
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