CY1107580T1 - Ενδιαμεσα για συνθεση ανταγωνιστων lhrh, διαδικασια για τη παραγωγη τους, και διαδικασια για παραγωγη ανταγωνιστων lhrh - Google Patents

Ενδιαμεσα για συνθεση ανταγωνιστων lhrh, διαδικασια για τη παραγωγη τους, και διαδικασια για παραγωγη ανταγωνιστων lhrh

Info

Publication number
CY1107580T1
CY1107580T1 CY20071100070T CY071100070T CY1107580T1 CY 1107580 T1 CY1107580 T1 CY 1107580T1 CY 20071100070 T CY20071100070 T CY 20071100070T CY 071100070 T CY071100070 T CY 071100070T CY 1107580 T1 CY1107580 T1 CY 1107580T1
Authority
CY
Cyprus
Prior art keywords
procedure
production
boc
4clphe
lhrh
Prior art date
Application number
CY20071100070T
Other languages
English (en)
Inventor
Jon H Rasmussen
Palle H Rasmussen
Wolfgang O Wachs
Stefan Hansen
Jens Fomsgaard
Original Assignee
Polypeptide Laboratories A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Polypeptide Laboratories A/S filed Critical Polypeptide Laboratories A/S
Publication of CY1107580T1 publication Critical patent/CY1107580T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0827—Tripeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Τα καινούργια τριπεπτίδια Ac-D-2Nal-D-4ClPh-D-3PaI-OH και Boc-D-2Nal-D-4ClPhe-D-3Pal-OH είναι ενδιάμεσα χρήσιμα στη σύνθεση αναλόγων LHRH δια σύζευξης με κατάλληλα επταπεπτίδια, συγκεκριμένα με τα επταπεπτίδια P1-Ser(P2)-NMeTyr(P3)-D-Lys(Nic)-Leu-Lys(iPr,P4)-Pro-D-AlaNH2 και P1-Ser(P2)-NMeTyr(P3)-D-Asn-Leu-Lys(iPr, P4)-Pro-D-AlaNH2.
CY20071100070T 2001-12-29 2007-01-18 Ενδιαμεσα για συνθεση ανταγωνιστων lhrh, διαδικασια για τη παραγωγη τους, και διαδικασια για παραγωγη ανταγωνιστων lhrh CY1107580T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0104463A SE0104463D0 (sv) 2001-12-29 2001-12-29 Mellanprodukter för syntes af LHRH-antagonister, sätt att framställa dem och sätt för framställning av LHRH-antagonister
EP02781699A EP1465917B1 (en) 2001-12-29 2002-12-23 Intermediates for lhrh antagonist synthesis, process for their production, and process for lhrh antagonist production

Publications (1)

Publication Number Publication Date
CY1107580T1 true CY1107580T1 (el) 2013-03-13

Family

ID=20286557

Family Applications (2)

Application Number Title Priority Date Filing Date
CY20071100070T CY1107580T1 (el) 2001-12-29 2007-01-18 Ενδιαμεσα για συνθεση ανταγωνιστων lhrh, διαδικασια για τη παραγωγη τους, και διαδικασια για παραγωγη ανταγωνιστων lhrh
CY20071101513T CY1107025T1 (el) 2001-12-29 2007-11-27 Ενδιαμεσα για συνθεση ανταγωνιστη lhrh, μεθοδος για την παρασκευη αυτου και μεθοδος για την παρασκευη ανταγωνιστη lhrh

Family Applications After (1)

Application Number Title Priority Date Filing Date
CY20071101513T CY1107025T1 (el) 2001-12-29 2007-11-27 Ενδιαμεσα για συνθεση ανταγωνιστη lhrh, μεθοδος για την παρασκευη αυτου και μεθοδος για την παρασκευη ανταγωνιστη lhrh

Country Status (22)

Country Link
US (2) US20050124788A1 (el)
EP (2) EP1630169B1 (el)
JP (1) JP4272529B2 (el)
KR (1) KR100844520B1 (el)
CN (1) CN1304417C (el)
AT (2) ATE342913T1 (el)
AU (1) AU2002348749B2 (el)
CA (1) CA2471723C (el)
CY (2) CY1107580T1 (el)
DE (2) DE60222189T2 (el)
DK (2) DK1630169T3 (el)
ES (2) ES2296050T3 (el)
HK (1) HK1075052A1 (el)
IL (2) IL162788A0 (el)
NO (1) NO330129B1 (el)
NZ (1) NZ534245A (el)
PT (2) PT1465917E (el)
RU (1) RU2307125C2 (el)
SE (1) SE0104463D0 (el)
SI (1) SI1630169T1 (el)
WO (1) WO2003055902A1 (el)
ZA (1) ZA200405136B (el)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4407322B2 (ja) * 2004-03-09 2010-02-03 味の素株式会社 ペプチドの製造方法
CN101037472B (zh) * 2006-03-14 2013-03-27 中国人民解放军军事医学科学院毒物药物研究所 具有低组胺释放作用的促***释放激素拮抗剂
TWI442932B (zh) 2008-02-11 2014-07-01 Ferring Int Ct Sa 以ＧｎＲＨ拮抗劑治療攝護腺癌的方法
PL2632934T3 (pl) * 2010-10-27 2017-06-30 Ferring B.V. Sposób wytwarzania degareliksu i jego związków pośrednich
EP2447276A1 (en) 2010-10-27 2012-05-02 Ferring B.V. Process for the manufacture of Degarelix and its intermediates
AR092840A1 (es) 2012-06-01 2015-05-06 Ferring Bv Elaboracion de degarelix

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4098777A (en) * 1977-03-14 1978-07-04 Merck & Co., Inc. Process for the preparation of pyroglutamyl-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn
US5225598A (en) * 1990-03-30 1993-07-06 Union Carbide Chemicals & Plastics Technology Corporation Selective production of linear pentaethylenehexamine and hydroxyethyldiethylenetriamine
JPH05508859A (ja) * 1990-07-24 1993-12-09 イーストマン コダック カンパニー ペプチド合成方法
US5710246A (en) * 1996-03-19 1998-01-20 Abbott Laboratories Process for intermediates for the synthesis of LHRH antagonists
US6235734B1 (en) * 1996-10-30 2001-05-22 Pfizer Inc Pyridone-fused azabicyclic- or cytisine derivatives, their preparation and their use in addiction therapy
US5968895A (en) * 1996-12-11 1999-10-19 Praecis Pharmaceuticals, Inc. Pharmaceutical formulations for sustained drug delivery
DE19941248A1 (de) 1998-09-01 2000-03-02 Asta Medica Ag Peptide mit N-substituierten Glycingruppen sowie diese enthaltende Arzneimittel zur Behandlung hormonabhängiger Tumore

Also Published As

Publication number Publication date
EP1465917A1 (en) 2004-10-13
WO2003055902A1 (en) 2003-07-10
EP1630169B1 (en) 2007-08-29
DK1465917T3 (da) 2007-02-19
NO330129B1 (no) 2011-02-21
ES2296050T3 (es) 2008-04-16
IL162788A (en) 2010-12-30
RU2307125C2 (ru) 2007-09-27
CA2471723C (en) 2011-02-15
RU2004119964A (ru) 2006-01-10
EP1630169A2 (en) 2006-03-01
JP4272529B2 (ja) 2009-06-03
CY1107025T1 (el) 2012-09-26
US20080306242A1 (en) 2008-12-11
IL162788A0 (en) 2005-11-20
ZA200405136B (en) 2005-07-27
DE60215544T2 (de) 2007-08-30
ATE342913T1 (de) 2006-11-15
CN1622954A (zh) 2005-06-01
US20050124788A1 (en) 2005-06-09
AU2002348749A1 (en) 2003-07-15
SE0104463D0 (sv) 2001-12-29
CN1304417C (zh) 2007-03-14
AU2002348749B2 (en) 2008-09-04
DE60215544D1 (de) 2006-11-30
EP1465917B1 (en) 2006-10-18
DE60222189D1 (de) 2007-10-11
KR20040090965A (ko) 2004-10-27
JP2005516962A (ja) 2005-06-09
NZ534245A (en) 2007-05-31
ES2275012T3 (es) 2007-06-01
DK1630169T3 (da) 2008-01-02
US8173770B2 (en) 2012-05-08
SI1630169T1 (sl) 2008-04-30
EP1630169A3 (en) 2006-03-15
DE60222189T2 (de) 2008-06-19
CA2471723A1 (en) 2003-07-10
NO20043047L (no) 2004-08-30
HK1075052A1 (en) 2005-12-02
PT1630169E (pt) 2007-12-06
ATE371666T1 (de) 2007-09-15
PT1465917E (pt) 2007-01-31
KR100844520B1 (ko) 2008-07-08

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