CY1107431T1 - Σωματιδια για γoνιδιακη θεραπεια - Google Patents
Σωματιδια για γoνιδιακη θεραπειαInfo
- Publication number
- CY1107431T1 CY1107431T1 CY20081101145T CY081101145T CY1107431T1 CY 1107431 T1 CY1107431 T1 CY 1107431T1 CY 20081101145 T CY20081101145 T CY 20081101145T CY 081101145 T CY081101145 T CY 081101145T CY 1107431 T1 CY1107431 T1 CY 1107431T1
- Authority
- CY
- Cyprus
- Prior art keywords
- particles
- protein
- gonal
- treatment
- virus
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2730/00—Reverse transcribing DNA viruses
- C12N2730/00011—Details
- C12N2730/10011—Hepadnaviridae
- C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
- C12N2730/10141—Use of virus, viral particle or viral elements as a vector
- C12N2730/10143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/40—Vectors comprising a peptide as targeting moiety, e.g. a synthetic peptide, from undefined source
- C12N2810/405—Vectors comprising RGD peptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Η παρούσα εφεύρεση αφορά σωματίδια, τα οποία περιλαμβάνουν: (a) ένα πρωτεϊνικό κάλυμμα με μια πρωτεΐνη σύντηξης, η οποία περιλαμβάνει μια ιική πρωτεΐνη, ένα πεπτίδιο που διαμεσολαβεί την κυτταρική διαπερατότητα και μια ετερόλογη ειδική θέση πρόσδεσης, και (b) ένα νουκλεϊνικό οξύ που βρίσκεται στο πρωτεϊνικό κάλυμμα, το οποίο έχει αλληλουχίες για ένα ειδικό στον ιό σήμα συσκευασίας και ένα δομικό γονίδιο. Περαιτέρω η εφεύρεση αφορά μεθόδους για την παρασκευή τέτοιων σωματιδίων και κατάλληλα για το σκοπό αυτό μέσα, καθώς και τη χρήση των σωματιδίων για γονιδιακή θεραπεία.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19904800A DE19904800C1 (de) | 1999-02-05 | 1999-02-05 | Partikel zur Gentherapie |
EP00909000A EP1165797B1 (de) | 1999-02-05 | 2000-02-04 | Partikel zur gentherapie |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107431T1 true CY1107431T1 (el) | 2012-12-19 |
Family
ID=7896602
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081101145T CY1107431T1 (el) | 1999-02-05 | 2008-10-16 | Σωματιδια για γoνιδιακη θεραπεια |
Country Status (9)
Country | Link |
---|---|
US (1) | US7018826B1 (el) |
EP (1) | EP1165797B1 (el) |
AT (1) | ATE402261T1 (el) |
CY (1) | CY1107431T1 (el) |
DE (2) | DE19904800C1 (el) |
DK (1) | DK1165797T3 (el) |
ES (1) | ES2310988T3 (el) |
PT (1) | PT1165797E (el) |
WO (1) | WO2000046376A2 (el) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19850718C1 (de) | 1998-11-03 | 2000-05-18 | Hildt Eberhardt | Zellpermeabilität-vermittelndes Polypeptid |
JP2003286199A (ja) * | 2002-03-29 | 2003-10-07 | Japan Science & Technology Corp | タンパク質中空ナノ粒子を用いる肝臓疾患治療用薬剤 |
US8101189B2 (en) | 2002-07-05 | 2012-01-24 | Folia Biotech Inc. | Vaccines and immunopotentiating compositions and methods for making and using them |
KR20050044886A (ko) * | 2002-07-05 | 2005-05-13 | 데니스 르클레르 | 면역보조 바이러스 입자 |
DE10240894A1 (de) * | 2002-09-04 | 2004-03-11 | Procom Biotechnologische Produktions Gmbh | Verstärkung der Resorption von Subtanzen über die Haut und Schleimhaut |
KR101253261B1 (ko) * | 2011-05-11 | 2013-04-10 | 한국과학기술연구원 | siRNA 의 전달을 위한 재조합 단백질 및 이를 포함하는 조성물 |
CN108611395A (zh) * | 2016-12-12 | 2018-10-02 | 中山大学 | 一种抗人乙肝病毒药物的筛选方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0633943A4 (en) * | 1992-04-03 | 1997-05-02 | Alexander T Young | GENTHERAPY USING TARGETED VIRAL VECTORS. |
EP0880596A1 (en) * | 1995-12-28 | 1998-12-02 | Chiron Corporation | Receptor specific chimeric viral surface polypeptides for viral and particle incorporation and internalization in target cells |
DE19850718C1 (de) | 1998-11-03 | 2000-05-18 | Hildt Eberhardt | Zellpermeabilität-vermittelndes Polypeptid |
-
1999
- 1999-02-05 DE DE19904800A patent/DE19904800C1/de not_active Expired - Fee Related
-
2000
- 2000-02-04 ES ES00909000T patent/ES2310988T3/es not_active Expired - Lifetime
- 2000-02-04 US US09/890,752 patent/US7018826B1/en not_active Expired - Fee Related
- 2000-02-04 DE DE50015272T patent/DE50015272D1/de not_active Expired - Fee Related
- 2000-02-04 PT PT00909000T patent/PT1165797E/pt unknown
- 2000-02-04 AT AT00909000T patent/ATE402261T1/de not_active IP Right Cessation
- 2000-02-04 DK DK00909000T patent/DK1165797T3/da active
- 2000-02-04 WO PCT/DE2000/000363 patent/WO2000046376A2/de active IP Right Grant
- 2000-02-04 EP EP00909000A patent/EP1165797B1/de not_active Expired - Lifetime
-
2008
- 2008-10-16 CY CY20081101145T patent/CY1107431T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2310988T3 (es) | 2009-02-01 |
ATE402261T1 (de) | 2008-08-15 |
PT1165797E (pt) | 2008-10-30 |
WO2000046376A3 (de) | 2000-11-16 |
DE19904800C1 (de) | 2001-02-08 |
US7018826B1 (en) | 2006-03-28 |
EP1165797B1 (de) | 2008-07-23 |
DK1165797T3 (da) | 2008-11-24 |
EP1165797A2 (de) | 2002-01-02 |
WO2000046376A2 (de) | 2000-08-10 |
DE50015272D1 (de) | 2008-09-04 |
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