CY1107118T1 - Βελτιωμενη μεθοδος κατεργασιας με οξινο θειωδες αλας - Google Patents
Βελτιωμενη μεθοδος κατεργασιας με οξινο θειωδες αλαςInfo
- Publication number
- CY1107118T1 CY1107118T1 CY20081100002T CY081100002T CY1107118T1 CY 1107118 T1 CY1107118 T1 CY 1107118T1 CY 20081100002 T CY20081100002 T CY 20081100002T CY 081100002 T CY081100002 T CY 081100002T CY 1107118 T1 CY1107118 T1 CY 1107118T1
- Authority
- CY
- Cyprus
- Prior art keywords
- solid phase
- glass
- nucleic acid
- treatment
- improved method
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Compounds Of Iron (AREA)
- Saccharide Compounds (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Abstract
Η παρούσα δήλωση αναφέρεται σε μια μέθοδο διεξαγωγής μιας αντίδρασης όξινου θειώδους άλατος για τον καθορισμό των θέσεων μεθυλίωσης σε ένα νουκλεϊκό οξύ, ήτοι μεθυλιωμένες και μη μεθυλιωμένες κυτοσίνες, κατά την οποία το νουκλεϊκό οξύ είναι συνδεδεμένο με μια στερεά φάση κατά τη διάρκεια της βαθμίδας απαμίνωσης ή/και αποσουλφόνωσης της αντίδρασης όξινου θειώδους άλατος. Η στερεά φάση είναι κατά προτίμηση ένα υλικό που περιέχει ύαλο ή πυριτία, προτιμότερα μαλλί υάλου, υάλινη μεμβράνη ή μαγνητικό υάλινο σωμάτιο. Περαιτέρω, αποκαλύπτεται η χρήση μιας στερεάς φάσης για σύνδεση ενός νουκλεϊκού οξέος κατά τη διάρκεια της βαθμίδας απαμίνωσης ή/και αποσουλφόνωσης της αντίδρασης όξινου θειώδους άλατος και ένα κυτίο συνέργων (κιτ) που περιέχει ένα αντιδραστήριο όξινου θειώδους άλατος και μια στερεά φάση.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02019097A EP1394172A1 (en) | 2002-08-29 | 2002-08-29 | Improved method for bisulfite treatment |
EP02028114 | 2002-12-18 | ||
EP03019321A EP1394173B9 (en) | 2002-08-29 | 2003-08-27 | Improved method for bisulfite treatment |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1107118T1 true CY1107118T1 (el) | 2012-10-24 |
Family
ID=32071078
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20081100002T CY1107118T1 (el) | 2002-08-29 | 2008-01-02 | Βελτιωμενη μεθοδος κατεργασιας με οξινο θειωδες αλας |
Country Status (15)
Country | Link |
---|---|
US (2) | US9394332B2 (el) |
EP (2) | EP1829886B1 (el) |
JP (2) | JP5153048B2 (el) |
CN (1) | CN1271081C (el) |
AT (1) | ATE374782T1 (el) |
AU (1) | AU2003236461B2 (el) |
CA (1) | CA2438327C (el) |
CY (1) | CY1107118T1 (el) |
DE (1) | DE60316642T2 (el) |
DK (2) | DK1829886T3 (el) |
ES (2) | ES2545577T3 (el) |
HK (1) | HK1062688A1 (el) |
HU (1) | HUE027240T2 (el) |
PT (1) | PT1394173E (el) |
SI (2) | SI1829886T1 (el) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
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DE10154317B4 (de) * | 2001-10-26 | 2005-06-09 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungen in immobilisierten DNA Proben |
US9394332B2 (en) * | 2002-08-29 | 2016-07-19 | Epigenomics Ag | Method for bisulfite treatment |
US7371526B2 (en) * | 2003-08-29 | 2008-05-13 | Applera Corporation | Method and materials for bisulfite conversion of cytosine to uracil |
US7262013B2 (en) * | 2003-08-29 | 2007-08-28 | Applera Corporation | Bisulfite method |
US7534873B2 (en) * | 2003-08-29 | 2009-05-19 | Applied Biosystems, Llc | Method and materials for quaternary amine catalyzed bisulfite conversion of cytosine to uracil |
US7368239B2 (en) * | 2003-08-29 | 2008-05-06 | Applera Corporation | Method and materials for polyamine catalyzed bisulfite conversion of cytosine to uracil |
AU2004282342B2 (en) | 2003-10-09 | 2009-05-14 | Epigenomics Ag | Improved bisulfite conversion of DNA |
US20080070240A2 (en) * | 2004-04-08 | 2008-03-20 | Toyo Boseki Kabushiki Kaisha | Composition for deaminating dna and method of detecting methylated dna |
EP1632578A1 (en) | 2004-09-03 | 2006-03-08 | Roche Diagnostics GmbH | DNA decontamination method |
WO2006034264A2 (en) * | 2004-09-21 | 2006-03-30 | Applera Corporation | Methods of using sulfur nucleophiles as improved alternatives to sodium bisulfite for methylated dna analysis |
US7658288B2 (en) | 2004-11-08 | 2010-02-09 | Applied Biosystems, Llc | Bisulfite conversion reagent |
WO2006103111A2 (en) | 2005-04-01 | 2006-10-05 | Epigenomics Ag | Improved bisulfite conversion of dna |
JP5374679B2 (ja) * | 2005-12-14 | 2013-12-25 | エピゲノミクス アーゲー | 重亜硫酸処理のための新規方法 |
US7820385B2 (en) * | 2006-03-22 | 2010-10-26 | The United States Of America As Represented By The Department Of Health And Human Services, Centers For Disease Control And Prevention | Method for retaining methylation pattern in globally amplified DNA |
US20080213870A1 (en) * | 2007-03-01 | 2008-09-04 | Sean Wuxiong Cao | Methods for obtaining modified DNA from a biological specimen |
US20110165565A1 (en) * | 2008-01-03 | 2011-07-07 | The Johns Hopkins University | Compositions and methods for polynucleotide extraction and methylation detection |
US9115386B2 (en) | 2008-09-26 | 2015-08-25 | Children's Medical Center Corporation | Selective oxidation of 5-methylcytosine by TET-family proteins |
FR2940805B1 (fr) | 2009-01-05 | 2015-10-16 | Biomerieux Sa | Procede d'amplification et/ou de detection d'acides nucleiques, kits et utilisations de ce procede |
CN107254539A (zh) | 2011-07-29 | 2017-10-17 | 剑桥表现遗传学有限公司 | 用于检测核苷酸修饰的方法 |
WO2014083118A1 (en) | 2012-11-30 | 2014-06-05 | Cambridge Epigenetix Limited | Oxidising agent for modified nucleotides |
US10533210B2 (en) * | 2015-06-10 | 2020-01-14 | Biocartis Nv | Detection of methylated DNA |
AU2016277943B2 (en) | 2015-06-15 | 2022-09-01 | Cepheid | Integrated purification and measurement of DNA methylation and co-measurement of mutations and/or mRNA expression levels in an automated reaction cartridge |
CN110267744A (zh) | 2016-12-12 | 2019-09-20 | 塞弗德公司 | 在自动化反应盒中DNA甲基化的整合的纯化和测量以及突变和/或mRNA表达水平的共同测量 |
AU2019234843A1 (en) | 2018-03-13 | 2020-09-24 | Grail, Llc | Anomalous fragment detection and classification |
CN108265050A (zh) * | 2018-03-13 | 2018-07-10 | 普迈德(北京)科技有限公司 | 一种血浆直接亚硫酸氢盐转化的方法及其应用 |
WO2019195268A2 (en) | 2018-04-02 | 2019-10-10 | Grail, Inc. | Methylation markers and targeted methylation probe panels |
CA3111887A1 (en) | 2018-09-27 | 2020-04-02 | Grail, Inc. | Methylation markers and targeted methylation probe panel |
DE102019118332B4 (de) | 2019-07-07 | 2022-04-07 | Ist Innuscreen Gmbh | Verfahren und testkit zur bisulfitmodifizierung von dna |
US12007397B2 (en) | 2021-09-13 | 2024-06-11 | PrognomIQ, Inc. | Enhanced detection and quantitation of biomolecules |
CN114317761A (zh) * | 2022-02-23 | 2022-04-12 | 厦门飞朔生物技术有限公司 | 一种***相关基因甲基化检测方法 |
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JP4201337B2 (ja) * | 2001-07-31 | 2008-12-24 | ニューヨーク・インスティテュート・オブ・テクノロジー | 固相上で分子を固定するための方法とその利用法 |
DE10154317B4 (de) * | 2001-10-26 | 2005-06-09 | Epigenomics Ag | Verfahren zum Nachweis von Cytosin-Methylierungen in immobilisierten DNA Proben |
EP1394172A1 (en) | 2002-08-29 | 2004-03-03 | Boehringer Mannheim Gmbh | Improved method for bisulfite treatment |
US9394332B2 (en) * | 2002-08-29 | 2016-07-19 | Epigenomics Ag | Method for bisulfite treatment |
JP4435174B2 (ja) * | 2003-12-02 | 2010-03-17 | エフ.ホフマン−ラ ロシュ アーゲー | 重亜硫酸塩処理の改良された方法 |
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-
2003
- 2003-08-25 US US10/647,720 patent/US9394332B2/en active Active
- 2003-08-25 AU AU2003236461A patent/AU2003236461B2/en not_active Ceased
- 2003-08-27 ES ES07012188.4T patent/ES2545577T3/es not_active Expired - Lifetime
- 2003-08-27 DK DK07012188.4T patent/DK1829886T3/en active
- 2003-08-27 PT PT03019321T patent/PT1394173E/pt unknown
- 2003-08-27 DE DE60316642T patent/DE60316642T2/de not_active Expired - Lifetime
- 2003-08-27 AT AT03019321T patent/ATE374782T1/de active
- 2003-08-27 EP EP07012188.4A patent/EP1829886B1/en not_active Revoked
- 2003-08-27 EP EP03019321A patent/EP1394173B9/en not_active Expired - Lifetime
- 2003-08-27 HU HUE07012188A patent/HUE027240T2/en unknown
- 2003-08-27 SI SI200332443T patent/SI1829886T1/sl unknown
- 2003-08-27 SI SI200331015T patent/SI1394173T1/sl unknown
- 2003-08-27 ES ES03019321T patent/ES2294231T3/es not_active Expired - Lifetime
- 2003-08-27 DK DK03019321T patent/DK1394173T3/da active
- 2003-08-28 CN CNB031602835A patent/CN1271081C/zh not_active Expired - Fee Related
- 2003-08-28 CA CA002438327A patent/CA2438327C/en not_active Expired - Fee Related
- 2003-08-29 JP JP2003306141A patent/JP5153048B2/ja not_active Expired - Lifetime
-
2004
- 2004-07-28 HK HK04105593A patent/HK1062688A1/xx not_active IP Right Cessation
-
2008
- 2008-01-02 CY CY20081100002T patent/CY1107118T1/el unknown
-
2009
- 2009-02-13 JP JP2009031400A patent/JP5310059B2/ja not_active Expired - Lifetime
-
2015
- 2015-08-24 US US14/833,738 patent/US9868756B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US9868756B2 (en) | 2018-01-16 |
EP1829886B1 (en) | 2015-07-29 |
CA2438327A1 (en) | 2004-02-29 |
HUE027240T2 (en) | 2016-10-28 |
SI1394173T1 (sl) | 2008-02-29 |
DK1829886T3 (en) | 2015-08-17 |
JP5153048B2 (ja) | 2013-02-27 |
EP1394173A1 (en) | 2004-03-03 |
EP1829886A3 (en) | 2008-10-15 |
AU2003236461A1 (en) | 2004-03-18 |
ES2545577T3 (es) | 2015-09-14 |
CN1271081C (zh) | 2006-08-23 |
JP5310059B2 (ja) | 2013-10-09 |
JP2004089195A (ja) | 2004-03-25 |
DK1394173T3 (da) | 2008-02-04 |
PT1394173E (pt) | 2007-11-28 |
JP2009106304A (ja) | 2009-05-21 |
CN1495192A (zh) | 2004-05-12 |
US20160068888A1 (en) | 2016-03-10 |
CA2438327C (en) | 2008-04-15 |
EP1394173B1 (en) | 2007-10-03 |
EP1829886A2 (en) | 2007-09-05 |
DE60316642D1 (de) | 2007-11-15 |
EP1394173B9 (en) | 2008-10-15 |
AU2003236461B2 (en) | 2009-05-28 |
US9394332B2 (en) | 2016-07-19 |
ATE374782T1 (de) | 2007-10-15 |
HK1062688A1 (en) | 2004-11-19 |
SI1829886T1 (sl) | 2015-12-31 |
ES2294231T3 (es) | 2008-04-01 |
US20040241704A1 (en) | 2004-12-02 |
DE60316642T2 (de) | 2008-01-31 |
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