CY1106287T1 - Απepιοριστα βλαστικα σωματικα κυτταρα που λαμβανονται απο αιμα ανθρωπινου ομφαλιου λωρου - Google Patents
Απepιοριστα βλαστικα σωματικα κυτταρα που λαμβανονται απο αιμα ανθρωπινου ομφαλιου λωρουInfo
- Publication number
- CY1106287T1 CY1106287T1 CY20061101781T CY061101781T CY1106287T1 CY 1106287 T1 CY1106287 T1 CY 1106287T1 CY 20061101781 T CY20061101781 T CY 20061101781T CY 061101781 T CY061101781 T CY 061101781T CY 1106287 T1 CY1106287 T1 CY 1106287T1
- Authority
- CY
- Cyprus
- Prior art keywords
- cord blood
- umbilical cord
- human umbilical
- depiorized
- cells derived
- Prior art date
Links
- 210000004700 fetal blood Anatomy 0.000 title abstract 3
- 230000000392 somatic effect Effects 0.000 title 1
- 239000003814 drug Substances 0.000 abstract 2
- 230000001172 regenerating effect Effects 0.000 abstract 2
- 210000000988 bone and bone Anatomy 0.000 abstract 1
- 210000000845 cartilage Anatomy 0.000 abstract 1
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000004069 differentiation Effects 0.000 abstract 1
- 230000003511 endothelial effect Effects 0.000 abstract 1
- 230000003394 haemopoietic effect Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
- 230000000977 initiatory effect Effects 0.000 abstract 1
- 238000012423 maintenance Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 210000002826 placenta Anatomy 0.000 abstract 1
- 210000001988 somatic stem cell Anatomy 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/51—Umbilical cord; Umbilical cord blood; Umbilical stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Reproductive Health (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Hematology (AREA)
- Neurology (AREA)
- Diabetes (AREA)
- Wood Science & Technology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Microbiology (AREA)
- Pregnancy & Childbirth (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Emergency Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
Abstract
Περιγράφεται εδώ σύνθεση σε αίμα ανθρώπινου ομφάλιου λώρου και πλακούντος, που περιλαμβάνει απεριόριστα σωματικά βλαστικά κύτταρα, η οποία μπορεί να ενισχύεται in vitro προς μεγάλες ποσότητες επαρκείς για ιατρικές εφαρμογές σαν αναγεννητικά φάρμακα. Περιγράφεται έναρξη και συντήρηση, καθώς επίσης πρωτόκολλα ex vivo επέκτασης τέτοιων βλαστοκυττάρων από αίμα ομφάλιου λώρου. Περαιτέρω, δεικνύεται ότι από αυτά τα κύτταρα, χρησιμοποιώντας διάφορα πρωτόκολλα διέγερσης διαφοροποίησης διακριτής γράμμωσης, απόγονοι για αιματοποίηση και ενδοθήλιο, καθώς επίσης μεσεγχυματικοί απόγονοι για μη οστό, χόνδρο και λίπος, καθώς επίσης ουδέτεροι απόγονοι μπορεί να καλλιεργηθούν και να επεκταθούν για χρήση στην επαναδημιουργική ιατρική.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US24516800P | 2000-11-03 | 2000-11-03 | |
PCT/EP2001/012768 WO2002036751A2 (en) | 2000-11-03 | 2001-11-03 | Human cord blood derived unrestricted somatic stem cells (ussc) |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1106287T1 true CY1106287T1 (el) | 2011-10-12 |
Family
ID=22925565
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101781T CY1106287T1 (el) | 2000-11-03 | 2006-12-11 | Απepιοριστα βλαστικα σωματικα κυτταρα που λαμβανονται απο αιμα ανθρωπινου ομφαλιου λωρου |
Country Status (25)
Country | Link |
---|---|
US (3) | US7560280B2 (el) |
EP (1) | EP1404815B1 (el) |
JP (2) | JP4799804B2 (el) |
CN (1) | CN100480375C (el) |
AT (1) | ATE340255T1 (el) |
AU (2) | AU2953302A (el) |
BG (1) | BG107770A (el) |
CA (1) | CA2426987C (el) |
CY (1) | CY1106287T1 (el) |
CZ (1) | CZ20031165A3 (el) |
DE (1) | DE60123293T2 (el) |
DK (1) | DK1404815T3 (el) |
EA (1) | EA008619B1 (el) |
EE (1) | EE200300205A (el) |
ES (1) | ES2272563T3 (el) |
HK (1) | HK1071771A1 (el) |
HU (1) | HUP0301600A3 (el) |
IL (2) | IL155608A0 (el) |
MX (1) | MXPA03003844A (el) |
NO (1) | NO20031999L (el) |
PL (1) | PL362293A1 (el) |
PT (1) | PT1404815E (el) |
SK (1) | SK5242003A3 (el) |
UA (1) | UA81390C2 (el) |
WO (1) | WO2002036751A2 (el) |
Families Citing this family (102)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE69924615T3 (de) * | 1998-07-30 | 2011-05-05 | The Government Of The United States Of America, Represented By The Department Of Health & Human Services, National Institute Of Health, Office Of Technology Transfer | Thymosin beta 4 stimuliert wundheilung |
US7927587B2 (en) * | 1999-08-05 | 2011-04-19 | Regents Of The University Of Minnesota | MAPC administration for the treatment of lysosomal storage disorders |
US8609412B2 (en) * | 1999-08-05 | 2013-12-17 | Regents Of The University Of Minnesota | Mapc generation of lung tissue |
US10638734B2 (en) | 2004-01-05 | 2020-05-05 | Abt Holding Company | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
US8252280B1 (en) | 1999-08-05 | 2012-08-28 | Regents Of The University Of Minnesota | MAPC generation of muscle |
US7015037B1 (en) * | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
EP1226233B1 (en) * | 1999-08-05 | 2011-06-29 | ABT Holding Company | Multipotent adult stem cells and methods for isolation |
US8075881B2 (en) | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
EP1491093B1 (en) | 2001-02-14 | 2013-07-31 | ABT Holding Company | Multipotent adult stem cells, sources thereof, methods of obtaining and maintaining same, methods of differentiation thereof, methods of use thereof and cells derived thereof |
MXPA04001942A (es) * | 2001-08-29 | 2004-07-23 | Regenerx Biopharmaceuticals | Composiciones farmaceuticas a base de timosina ??4(t??4), analogos, isorformas y otros derivados para curar o prevenir la inflamacion, el dano y otros cambios que ocurren antes, despues de, durante o inmediatamente despues de un evento micardico. |
DE10144326B4 (de) * | 2001-09-10 | 2005-09-22 | Siemens Ag | Verfahren und System zur Überwachung eines Reifenluftdrucks |
DE10158680B4 (de) * | 2001-11-30 | 2004-04-08 | Universitätsklinikum Hamburg-Eppendorf | Verfahren zur ex vivo-Expansion und -Differenzierung von multipotenten Stammzellen |
CA2473749C (en) * | 2002-01-23 | 2012-05-22 | University Of Utah Research Foundation | Pure populations of astrocyte restricted precursor cells and methods for isolation and use thereof |
KR100489248B1 (ko) * | 2002-02-19 | 2005-05-11 | 메디포스트(주) | 제대혈 유래 간엽줄기세포ㆍ전구세포의 분리배양방법 및간엽조직으로의 분화유도방법 |
BR0316695A (pt) | 2002-11-26 | 2005-10-18 | Anthrogenesis Corp | Unidade citoterapêutica, kit para tratamento, método de tratamento de uma enfermidade, biblioteca de unidades citoterapêuticas e método de tratamento de um paciente |
US20060228798A1 (en) | 2002-11-27 | 2006-10-12 | Catherine Verfaillie | Homologous recombination in multipotent adult progenitor cells |
WO2004052177A2 (en) * | 2002-12-05 | 2004-06-24 | Case Western Reserve University | Cell-based therapies for ischemia |
US7470538B2 (en) * | 2002-12-05 | 2008-12-30 | Case Western Reserve University | Cell-based therapies for ischemia |
JP3762975B2 (ja) * | 2003-03-18 | 2006-04-05 | 学校法人慶應義塾 | 単球由来多能性細胞momc |
US20040203142A1 (en) * | 2003-04-14 | 2004-10-14 | Reliance Life Sciences Pvt. Ltd. | Growth of neural precursor cells using umbilical cord blood serum and a process for the preparation thereof for therapeutic purposes |
AU2003304250A1 (en) | 2003-06-27 | 2005-01-13 | Universite Laval | Method of isolating cells from umbilical cord |
US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
JP4950659B2 (ja) | 2003-06-27 | 2012-06-13 | エチコン、インコーポレイテッド | 胎盤組織から由来最多分娩後細胞、及びそれらを作成し使用する方法。 |
EP1677594B1 (en) * | 2003-10-09 | 2011-01-12 | Core Dynamics Limited | Method for freezing, thawing and transplantation of viable cartilage |
JP2007513188A (ja) | 2003-12-04 | 2007-05-24 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | リソソーム蓄積症の処置のための組成物および方法 |
CA2550326A1 (en) * | 2003-12-19 | 2005-07-14 | Viacell, Inc. | Use of human cord blood-derived pluripotent cells for the treatment of disease |
EP1544290A1 (en) * | 2003-12-19 | 2005-06-22 | Yu-Show Fu | A cell system for generating somatic cells |
GB0329449D0 (en) * | 2003-12-19 | 2004-01-28 | Omnicyte Ltd | Stem cells |
JP4777908B2 (ja) * | 2004-02-02 | 2011-09-21 | コア・ダイナミクス・リミテッド | 生物学的材料ならびに生物学的材料の保存のための方法および溶液 |
EP1711214A1 (en) * | 2004-02-02 | 2006-10-18 | Interface Multigrad Technology (IMT) Ltd. | Device for directional cooling of biological matter |
WO2005083061A1 (en) * | 2004-02-11 | 2005-09-09 | Aldagen, Inc. | Stem cell populations and methods of use |
US7622108B2 (en) | 2004-04-23 | 2009-11-24 | Bioe, Inc. | Multi-lineage progenitor cells |
CA2563518C (en) | 2004-04-23 | 2014-09-02 | Bioe, Inc. | Multi-lineage progenitor cells |
US20070298015A1 (en) * | 2004-04-28 | 2007-12-27 | Viacell, Inc. | Treatment of Muscular Dystrophy with Mobilized Peripheral Blood Pluripotent Cells |
WO2005113749A2 (en) | 2004-05-14 | 2005-12-01 | Becton, Dickinson And Company | Stem cell populations and methods of use |
JP5096148B2 (ja) * | 2004-06-07 | 2012-12-12 | コア・ダイナミクス・リミテッド | 生物学的試料の殺菌方法 |
EP1778007A1 (en) * | 2004-08-12 | 2007-05-02 | I.M.T. Interface Multigrad Technology Ltd. | Method and apparatus for freezing or thawing of a biological material |
WO2006074308A2 (en) * | 2005-01-07 | 2006-07-13 | Wake Forest University Health Sciences | Regeneration of pancreatic islets by amniotic fluid stem cell therapy |
US20090104159A1 (en) * | 2005-02-10 | 2009-04-23 | Felipe Prosper | Vascular/Lymphatic Endothelial Cells |
US20080160496A1 (en) * | 2005-02-22 | 2008-07-03 | Victor Rzepakovsky | Preserved Viable Cartilage, Method for Its Preservation, and System and Devices Used Therefor |
CN101575590B (zh) * | 2005-02-28 | 2012-05-23 | 中国医学科学院血液学研究所泰达生命科学技术研究中心 | 人脐带间充质干细胞的制备方法 |
US20100034793A1 (en) * | 2005-04-19 | 2010-02-11 | The John Hopkins University | Method of using stroma cells from cord blood to expand and engraft nucleated cells from cord blood |
AU2005331534B2 (en) * | 2005-05-05 | 2011-12-08 | Regents Of The University Of Minnesota | Use of MAPC or progeny therefrom to populate lymphohematopoietic tissues |
US20080317740A1 (en) * | 2005-05-05 | 2008-12-25 | Bruce Blazar | Use of Nk Cell Inhibition to Facilitate Persistence of Engrafted Mhc-I-Negative Cells |
EP1888741B1 (en) * | 2005-05-27 | 2013-04-17 | Viacell, Inc. | Treatment of ischemia using stem cells |
US20080194024A1 (en) * | 2005-07-29 | 2008-08-14 | Mays Robert W | Culture of Non-Embryonic Cells at High Cell Density |
US8198085B2 (en) * | 2005-08-03 | 2012-06-12 | Core Dynamics Limited | Somatic cells for use in cell therapy |
ATE449165T1 (de) * | 2005-08-26 | 2009-12-15 | Seoul Nat Univ Ind Foundation | Multipotente blutstammzellen aus der nabelschnur und zellbehandlungsmittel damit zur behandlung der ischämischen krankheit |
WO2007047509A2 (en) | 2005-10-14 | 2007-04-26 | Regents Of The University Of Minnesota | Differentiation of non-embryonic stem cells to cells having a pancreatic phenotype |
AU2006325710B2 (en) | 2005-12-16 | 2012-05-17 | Ethicon, Inc. | Compositions and methods for inhibiting adverse immune response in histocompatibility-mismatched transplantation |
US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
NZ569562A (en) | 2005-12-29 | 2012-04-27 | Anthrogenesis Corp | Placental stem cell populations, CD200 |
US7727763B2 (en) | 2006-04-17 | 2010-06-01 | Bioe, Llc | Differentiation of multi-lineage progenitor cells to respiratory epithelial cells |
US7875453B2 (en) * | 2006-06-14 | 2011-01-25 | Bioe Llc | Differentiation of multi-lineage progenitor cells to hepatocytes |
CN101611139B (zh) * | 2006-11-13 | 2012-07-04 | 伊西康公司 | 利用微载体的产后来源的细胞的体外扩增 |
WO2008085229A2 (en) * | 2006-11-15 | 2008-07-17 | Arteriocyte Inc. | Cell-based therapies for treating liver disease |
CA2670497A1 (en) * | 2006-11-24 | 2008-05-29 | Regents Of The University Of Minnesota | Endodermal progenitor cells |
CA2669304C (en) | 2006-11-30 | 2016-10-25 | Medipost Co., Ltd. | Use of a composition contaning human umbilical cord blood-derived mesenchymal stem cell for inducing differentiation and proliferation of neural precursor cells or neural stem cells to neural cells |
EP2192908A4 (en) * | 2007-07-25 | 2010-09-01 | Bioe Inc | DIFFERENTIATION OF PRECURSOR CELLS OF MULTIPLE ABSTRACTS AGAINST CHONDROCYTES |
TW200936148A (en) * | 2007-10-31 | 2009-09-01 | Cryo Cell Int | Methods for co-culturing cord blood derived cells with menstrual stem cells |
US20120156134A1 (en) | 2007-12-20 | 2012-06-21 | Shayne Squires | Compositions and methods for detecting or eliminating senescent cells to diagnose or treat disease |
WO2009092092A1 (en) | 2008-01-18 | 2009-07-23 | Regents Of The University Of Minnesota | Stem cell aggregates and methods for making and using |
US20090202978A1 (en) * | 2008-02-13 | 2009-08-13 | Ginadi Shaham | Method and apparatus for freezing of a biological material |
US20090233993A1 (en) * | 2008-03-06 | 2009-09-17 | Burnham Institute For Medical Research | Compositions and methods for inhibiting gsk3 activity and uses thereof |
CN101543644B (zh) * | 2008-03-27 | 2012-07-25 | 中国人民解放军总医院 | 无支架工程软骨组织的构建方法及其产品 |
EP2294187A2 (en) * | 2008-05-21 | 2011-03-16 | BioE LLC | Differentiation of multi-lineage progenitor cells to pancreatic cells |
CN102176919A (zh) | 2008-08-22 | 2011-09-07 | 人类起源公司 | 用胎盘细胞群治疗骨缺损的方法和组合物 |
DK3006459T3 (da) | 2008-08-26 | 2021-12-06 | Hope City | Fremgangsmåde og sammensætninger til forbedring af t-cellers antitumoreffektorfunktion |
GB0818725D0 (en) | 2008-10-13 | 2008-11-19 | Habib Nagy A | Pharmaceutical composition |
EP2182055A1 (en) | 2008-10-14 | 2010-05-05 | Heinrich-Heine-Universität Düsseldorf | Human cord blood derived unrestricted somatic stem cells (USSC) |
WO2010049752A1 (en) | 2008-10-31 | 2010-05-06 | Katholieke Universiteit Leuven | Optimized methods for differentiation of cells into cells with hepatocyte and hepatocyte progenitor phenotypes, cells produced by the methods, and methods for using the cells |
KR20100054711A (ko) | 2008-11-14 | 2010-05-25 | 메디포스트(주) | 간엽 줄기세포 또는 이의 배양액을 포함하는 신경질환의 예방 또는 치료용 조성물 |
US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
WO2011011477A1 (en) | 2009-07-21 | 2011-01-27 | Abt Holding Company | Use of stem cells to reduce leukocyte extravasation |
BR112012001329B1 (pt) | 2009-07-21 | 2021-04-13 | Abt Holding Company | Uso de células progenitoras adultas multipotentes (mapcs), e, métodos para obter células progenitoras adultas multipotentes (mapcs) com uma potência desejada e para aumentar a potência de células progenitoras adultas multipotentes (mapcs) |
WO2011069091A1 (en) | 2009-12-04 | 2011-06-09 | Boston Biomedical Research Institute, Inc. | Method for cloning pluripotent stem cells |
WO2011069093A1 (en) | 2009-12-04 | 2011-06-09 | Boston Biomedical Research Institute, Inc. | Detecting and counting tissue-specific stem cells and uses thereof |
WO2011106476A1 (en) * | 2010-02-25 | 2011-09-01 | Abt Holding Company | Modulation of microglia activation |
US20110206647A1 (en) * | 2010-02-25 | 2011-08-25 | Abt Holding Company | Modulation of Angiogenesis |
IL282662B2 (en) | 2010-02-25 | 2024-01-01 | Univ Case Western Reserve | Modulation of macrophage activation |
JP2013523823A (ja) | 2010-04-08 | 2013-06-17 | アントフロゲネシス コーポレーション | 胎盤幹細胞を用いるサルコイドーシスの治療 |
SG10201913920PA (en) | 2010-05-12 | 2020-03-30 | Abt Holding Co | Modulation of splenocytes in cell therapy |
WO2011158125A2 (en) | 2010-06-17 | 2011-12-22 | Katholieke Universiteit Leuven | Methods for differentiating cells into hepatic stellate cells and hepatic sinusoidal endothelial cells, cells produced by the methods, and methods for using the cells |
US9057734B2 (en) | 2010-08-23 | 2015-06-16 | President And Fellows Of Harvard College | Optogenetic probes for measuring membrane potential |
AU2011293440B2 (en) | 2010-08-24 | 2016-05-05 | Katholieke Universiteit Leuven | Non-static suspension culture of cell aggregates |
WO2012048275A2 (en) | 2010-10-08 | 2012-04-12 | Caridianbct, Inc. | Configurable methods and systems of growing and harvesting cells in a hollow fiber bioreactor system |
AU2011352036A1 (en) | 2010-12-31 | 2013-07-18 | Anthrogenesis Corporation | Enhancement of placental stem cell potency using modulatory RNA molecules |
EP2697360A1 (en) * | 2011-04-11 | 2014-02-19 | Jaffar Ali Bin M. Abdullah | Protein-free culture media products |
CN102776150A (zh) * | 2011-05-13 | 2012-11-14 | 上海交通大学医学院附属第九人民医院 | 一种诱导脐带间充质干细胞分化为内皮细胞的方法 |
WO2012166844A2 (en) | 2011-06-01 | 2012-12-06 | Anthrogenesis Corporation | Treatment of pain using placental stem cells |
ES2763331T3 (es) | 2011-06-06 | 2020-05-28 | ReGenesys BVBA | Expansión de células madre en biorreactores de fibra hueca |
GB201119335D0 (en) | 2011-11-09 | 2011-12-21 | Univ Leuven Kath | Hepatitis virus infectable stem cells |
SG11201508403XA (en) | 2013-04-12 | 2015-11-27 | Saverio Lafrancesca | Improving organs for transplantation |
EP2992088B1 (en) | 2013-04-30 | 2019-08-21 | Katholieke Universiteit Leuven | Cell therapy for myelodysplastic syndromes |
WO2015073913A1 (en) | 2013-11-16 | 2015-05-21 | Terumo Bct, Inc. | Expanding cells in a bioreactor |
EP2952578A1 (de) | 2014-06-03 | 2015-12-09 | Peter Wernet | Epigenetische Reprogrammierung von fötalen Stammzellen |
BR112017005631A2 (pt) | 2014-09-19 | 2018-06-26 | City Of Hope | células t com receptor de antígeno coestimulador quimérico direcionadas à il13ra2 |
TW201613622A (en) * | 2014-10-14 | 2016-04-16 | Bionet Corp | Composition for skincare and pharmaceutical composition and preparation method thereof |
NZ745530A (en) | 2016-01-21 | 2023-03-31 | Abt Holding Co | Stem cells for wound healing |
CN106377547B (zh) * | 2016-09-30 | 2019-05-31 | 孔五一 | 脐带血再生粒子的提取方法及其用途 |
CN113637633B (zh) * | 2021-08-16 | 2023-11-03 | 浙江大学 | 一种促进间充质干细胞向成骨细胞分化的方法 |
EP4405375A1 (en) | 2021-09-23 | 2024-07-31 | President and Fellows of Harvard College | Genetically encoded voltage indicators and uses thereof |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3639949A1 (de) | 1986-11-22 | 1988-06-09 | Diagen Inst Molekularbio | Verfahren zur trennung von langkettigen nukleinsaeuren |
US5192553A (en) * | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
US5486359A (en) * | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
US5851832A (en) * | 1991-07-08 | 1998-12-22 | Neurospheres, Ltd. | In vitro growth and proliferation of multipotent neural stem cells and their progeny |
US5672346A (en) * | 1992-07-27 | 1997-09-30 | Indiana University Foundation | Human stem cell compositions and methods |
US6482231B1 (en) * | 1995-11-20 | 2002-11-19 | Giovanni Abatangelo | Biological material for the repair of connective tissue defects comprising mesenchymal stem cells and hyaluronic acid derivative |
US5842477A (en) * | 1996-02-21 | 1998-12-01 | Advanced Tissue Sciences, Inc. | Method for repairing cartilage |
AU2730497A (en) * | 1996-04-17 | 1997-11-07 | Case Western Reserve University | Cryopreservation and extensive subculturing of human mesenchymal stem cells |
US5843633A (en) * | 1996-04-26 | 1998-12-01 | Amcell Corporation | Characterization of a human hematopoietic progenitor cell antigen |
JPH10295369A (ja) | 1997-02-26 | 1998-11-10 | Japan Tobacco Inc | 造血幹細胞の製造方法 |
JPH10306027A (ja) | 1997-03-07 | 1998-11-17 | Otsuka Pharmaceut Co Ltd | 免疫寛容誘導剤 |
JP4562816B2 (ja) * | 1997-07-14 | 2010-10-13 | オシリス セラピューティクス,インコーポレイテッド | 心筋再生のための間葉幹細胞の使用法および組成物 |
DE19833476B4 (de) | 1998-07-24 | 2005-08-25 | Huss, Ralf, Dr. | Genetisch modifizierte CD34-Negative, adhärent wachsende hämatopoetische Stammzellen und deren Verwendung in der Gentherapie |
CA2371017A1 (en) | 1999-04-27 | 2000-11-02 | Layton Bioscience, Inc. | Cell therapy for chronic stroke |
US20020142457A1 (en) * | 1999-12-28 | 2002-10-03 | Akihiro Umezawa | Cell having the potentiality of differentiation into cardiomyocytes |
KR100489248B1 (ko) * | 2002-02-19 | 2005-05-11 | 메디포스트(주) | 제대혈 유래 간엽줄기세포ㆍ전구세포의 분리배양방법 및간엽조직으로의 분화유도방법 |
US20040197310A1 (en) * | 2003-02-12 | 2004-10-07 | Sanberg Paul R. | Compositions and methods for using umbilical cord progenitor cells in the treatment of myocardial infarction |
-
2001
- 2001-11-02 US US09/985,335 patent/US7560280B2/en not_active Expired - Fee Related
- 2001-11-03 CA CA2426987A patent/CA2426987C/en not_active Expired - Lifetime
- 2001-11-03 EE EEP200300205A patent/EE200300205A/xx unknown
- 2001-11-03 EA EA200300536A patent/EA008619B1/ru not_active IP Right Cessation
- 2001-11-03 AU AU2953302A patent/AU2953302A/xx active Pending
- 2001-11-03 AU AU2002229533A patent/AU2002229533B2/en not_active Expired
- 2001-11-03 CZ CZ20031165A patent/CZ20031165A3/cs unknown
- 2001-11-03 JP JP2002539497A patent/JP4799804B2/ja not_active Expired - Lifetime
- 2001-11-03 PL PL36229301A patent/PL362293A1/xx unknown
- 2001-11-03 SK SK524-2003A patent/SK5242003A3/sk not_active Application Discontinuation
- 2001-11-03 UA UA2003044039A patent/UA81390C2/xx unknown
- 2001-11-03 DK DK01990388T patent/DK1404815T3/da active
- 2001-11-03 AT AT01990388T patent/ATE340255T1/de active
- 2001-11-03 DE DE60123293T patent/DE60123293T2/de not_active Expired - Lifetime
- 2001-11-03 CN CNB018217028A patent/CN100480375C/zh not_active Expired - Lifetime
- 2001-11-03 EP EP01990388A patent/EP1404815B1/en not_active Expired - Lifetime
- 2001-11-03 HU HU0301600A patent/HUP0301600A3/hu unknown
- 2001-11-03 WO PCT/EP2001/012768 patent/WO2002036751A2/en active IP Right Grant
- 2001-11-03 PT PT01990388T patent/PT1404815E/pt unknown
- 2001-11-03 IL IL15560801A patent/IL155608A0/xx unknown
- 2001-11-03 ES ES01990388T patent/ES2272563T3/es not_active Expired - Lifetime
- 2001-11-03 MX MXPA03003844A patent/MXPA03003844A/es active IP Right Grant
-
2003
- 2003-04-28 IL IL155608A patent/IL155608A/en not_active IP Right Cessation
- 2003-04-30 BG BG107770A patent/BG107770A/bg unknown
- 2003-05-02 NO NO20031999A patent/NO20031999L/no not_active Application Discontinuation
-
2004
- 2004-01-15 US US10/758,644 patent/US7556801B2/en not_active Expired - Fee Related
-
2005
- 2005-05-31 HK HK05104566.1A patent/HK1071771A1/xx not_active IP Right Cessation
-
2006
- 2006-12-11 CY CY20061101781T patent/CY1106287T1/el unknown
-
2008
- 2008-01-28 JP JP2008016859A patent/JP4805960B2/ja not_active Expired - Lifetime
-
2009
- 2009-04-02 US US12/417,294 patent/US20090238803A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CY1106287T1 (el) | Απepιοριστα βλαστικα σωματικα κυτταρα που λαμβανονται απο αιμα ανθρωπινου ομφαλιου λωρου | |
CY1117464T1 (el) | Μεθοδος για την in vitro παραγωγη τρισδιαστατου ζωτικου χονδρινου ή οστικου ιστου | |
HK1065074A1 (en) | Methods for genetic modification of hematopoietic progenitor cells and uses of the modified cells | |
DE60229848D1 (de) | - und organtransplantationen und unterdrückt apoptose | |
BR0214029A (pt) | Métodos e composições para o uso de células estromais para suportar células tronco embriÈnicas e adultas | |
ATE312615T1 (de) | Zusammensetzung zur behandlung von schäden des gelenkknorpels | |
CY1106821T1 (el) | Μεθοδος για την καλλιεργεια υποκαταστατου χονδρου και βιολογικη μητρα, παραγομενη συμφωνα με τη μεθοδο αυτη | |
WO2004047747A3 (en) | Compositions and methods for cell dedifferentiation and tissue regeneration | |
DE60141964D1 (de) | Bandscheibe | |
CY1118230T1 (el) | Μεθοδος παραγωγης μοσχευματων κυτταρων μεσοσπονδυλιων δισκων και η χρηση τους ως υλικο μεταμοσχευσης | |
WO2003046161A3 (de) | Verfahren zur ex vivo-expansion und -differenzierung von multipotenten stammzellen | |
ES2184901T3 (es) | Anticuerpos anti-idiotipicos del factor de crecimiento endotelial vascular y su utilizacion como medicamentos. | |
SG162750A1 (en) | Semi-solid osteoblast composition containing fibrin for bone union and method preparing the same | |
MX2022006547A (es) | Métodos para la expansión de poblaciones de células t gamma delta con agentes multivalentes y composiciones de estas. | |
NO20016184D0 (no) | Frakoblingsoverflate | |
DK1124577T3 (da) | Anvendelse af et enterobakterielt OmpA-protein til specifik måling til antigenpræsenterende celler | |
MX2023010287A (es) | Composiciones para el cuidado de organos ex vivo. | |
PL361732A1 (en) | Use of a biological material containing three-dimensional scaffolds of hyaluronic acid derivatives for the preparation of implants in arthroscopy and kit for instruments for implanting said biological material by arthroscopy | |
MD2856F1 (en) | Material for osteoplasty (variants) | |
ATE377427T1 (de) | Verwendung des hepatozyten-wachstumsfaktors zur förderung der induktion der vaskulären differenzierung | |
CY1108543T1 (el) | Εμβολια dna που κωδικοποιουν βοηθητικες πρωτεϊνες του hiv | |
UA36811A (uk) | Спосіб визначення антитоксичної здатності замінників шкіри | |
MY136958A (en) | Semi-solid osteoblast composition containing fibrin for bone union and method preparing the same | |
UA39557A (uk) | Спосіб відновлювальної пластики артеріальних стовбурів | |
IT1320141B1 (it) | Uso di materiale biologico comprendente matrici tridimensionali diderivati di acido ialuronico per la preparazione di impianti in |