CY1105795T1 - Σκευασματα για βελτιωση της βιοδιαθεσιμοτητας χορηγουμενων απο το στομα φαρμακων - Google Patents

Σκευασματα για βελτιωση της βιοδιαθεσιμοτητας χορηγουμενων απο το στομα φαρμακων

Info

Publication number
CY1105795T1
CY1105795T1 CY20061101680T CY061101680T CY1105795T1 CY 1105795 T1 CY1105795 T1 CY 1105795T1 CY 20061101680 T CY20061101680 T CY 20061101680T CY 061101680 T CY061101680 T CY 061101680T CY 1105795 T1 CY1105795 T1 CY 1105795T1
Authority
CY
Cyprus
Prior art keywords
orally administered
bioavailability
formulations
improving
administered drugs
Prior art date
Application number
CY20061101680T
Other languages
English (en)
Inventor
Johannes Henricus Matthias Schellens
Alfred Hermanus Schinkel
Original Assignee
Cancer Research Ventures Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Research Ventures Limited filed Critical Cancer Research Ventures Limited
Publication of CY1105795T1 publication Critical patent/CY1105795T1/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Μια μέθοδος αύξησης της συστηματικής έκθεσης κυττάρων που επιλέγονται από καρκινικά κύτταρα και φυσιολογικά κύτταρα σε μια χορηγούμενη από το στόμα φαρμακευτικώς δραστική ένωση, όπου ένας βιοενισχυτής που περιέχει έναν αναστολέα της προκαλούμενης από και/ή σχετιζόμενης με BCRP μεταφοράς φαρμάκων χορηγείται από το στόμα συγχρόνως με την αναφερόμενη χορηγούμενη από το στόμα φαρμακευτικώς δραστική ένωση, και στην οποία μέθοδο ο αναστολέας χορηγείται συγχρόνως με την φαρμακευτική ένωση.
CY20061101680T 1999-05-17 2006-11-16 Σκευασματα για βελτιωση της βιοδιαθεσιμοτητας χορηγουμενων απο το στομα φαρμακων CY1105795T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NL1012066 1999-05-17
NL1012481 1999-06-30
PCT/NL2000/000331 WO2000069390A2 (en) 1999-05-17 2000-05-17 Compositions for improving bioavailability of orally administered drugs

Publications (1)

Publication Number Publication Date
CY1105795T1 true CY1105795T1 (el) 2011-02-02

Family

ID=26642978

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101680T CY1105795T1 (el) 1999-05-17 2006-11-16 Σκευασματα για βελτιωση της βιοδιαθεσιμοτητας χορηγουμενων απο το στομα φαρμακων

Country Status (10)

Country Link
US (2) US7030132B2 (el)
EP (2) EP1749540B1 (el)
AT (2) ATE484295T1 (el)
AU (1) AU4955200A (el)
CY (1) CY1105795T1 (el)
DE (2) DE60030283T2 (el)
DK (1) DK1189637T3 (el)
ES (1) ES2270834T3 (el)
PT (1) PT1189637E (el)
WO (1) WO2000069390A2 (el)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9718903D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents
EP1749540B1 (en) * 1999-05-17 2010-10-13 Cancer Research Ventures Limited Compositions for improving bioavailability of orally administered drugs
HU0100947D0 (en) * 2001-03-02 2001-05-28 Solvo Kft Screening system based on expression of abcg2 half transporter protein in an expression system free of other abc-transporters, abcg2 homodimers
US7169763B2 (en) * 2002-02-22 2007-01-30 Oliver Yoa-Pu Hu Cytochrome P450 3A inhibitors and enhancers
RU2007103703A (ru) * 2004-07-01 2008-08-10 Дзе Недзеландз Кэнсе Инститьют (Nl) Комбинация, включающая ингибитор бррм (белка резистентности рака молочной железы) и 4-(4-метилпиперазин-1-илметил)-n-(4-метил-3-(4-пиридин-3-ил)пиримидин-2-иламино)фенил)-бензамид
CN101010114B (zh) 2004-08-27 2010-05-26 皇家飞利浦电子股份有限公司 电子遥控药丸和用于供应至少一种药物的***
JP2008521794A (ja) * 2004-11-29 2008-06-26 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ 少なくとも一の薬剤を輸送するための、少なくとも一のセンサを有する電子制御式の錠剤およびシステム
WO2006065125A1 (en) * 2004-12-16 2006-06-22 Het Nederlands Kanter Instituut Means and methods for determining and/or influencing transportation
WO2009083042A1 (en) * 2007-12-31 2009-07-09 Olaf Van Tellingen Methods and means for the treatment of cancer
CN101945613B (zh) * 2008-02-18 2014-08-13 皇家飞利浦电子股份有限公司 为患者用药
JP5681861B2 (ja) * 2008-03-31 2015-03-11 メディメトリクス ペルソナリズド ドルグ デリヴェリー ベー ヴェ センサを有する嚥下型カプセルを作成する方法
JP5627569B2 (ja) 2008-04-30 2014-11-19 シーメンス メディカル ソリューションズ ユーエスエー インコーポレイテッドＳｉｅｍｅｎｓ Ｍｅｄｉｃａｌ Ｓｏｌｕｔｉｏｎｓ ＵＳＡ，Ｉｎｃ． 新規基質に基づくｐｅｔ造影剤
CN102065930B (zh) * 2008-06-19 2013-05-22 皇家飞利浦电子股份有限公司 用于在潮湿环境下传递粉末状药物的装置
CN102076375B (zh) * 2008-06-25 2013-11-20 皇家飞利浦电子股份有限公司 包括多个药物储存器的电子药丸
US10046109B2 (en) 2009-08-12 2018-08-14 Progenity, Inc. Drug delivery device with compressible drug reservoir
CN106432490B (zh) * 2016-09-14 2020-01-07 北京大学 一种abcg2单克隆抗体及其用途

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ201084A (en) 1982-06-25 1985-10-11 New Zealand Dev Finance 4-carboxamidoacridine derivatives and pharmaceutical compositions containing such
CZ283038B6 (cs) 1991-01-11 1997-12-17 Laboratoires Glaxo Sa Akridinové deriváty, způsob výroby a farmaceutické prostředky s jejich obsahem
WO1994001408A1 (en) 1992-07-10 1994-01-20 Laboratoires Glaxo S.A. Anilide derivatives
US5567592A (en) 1994-02-02 1996-10-22 Regents Of The University Of California Screening method for the identification of bioenhancers through the inhibition of P-glycoprotein transport in the gut of a mammal
US5786344A (en) * 1994-07-05 1998-07-28 Arch Development Corporation Camptothecin drug combinations and methods with reduced side effects
BR9509251A (pt) 1994-10-05 1997-10-21 Glaxo Wellcome Inc Composição farmacêutica processo de reverte reduzir ou inibir a resistência a multidrogas ou de restaurar a sensibilidade de um tumor e artigo manufaturado
US5726181A (en) * 1995-06-05 1998-03-10 Bionumerik Pharmaceuticals, Inc. Formulations and compositions of poorly water soluble camptothecin derivatives
US6245805B1 (en) 1995-10-26 2001-06-12 Baker Norton Pharmaceuticals, Inc. Method, compositions and kits for increasing the oral bioavailability of pharmaceutical agents
GB9710612D0 (en) * 1997-05-23 1997-07-16 Glaxo Group Ltd Synthesis of acridine derivatives
BR9809694A (pt) 1997-05-27 2000-10-03 Baker Norton Pharma Processo e composição para administração de taxanos oralmente a pacientes humanos
GB9718903D0 (en) * 1997-09-05 1997-11-12 Glaxo Group Ltd Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents
DE69935782T3 (de) * 1998-02-05 2017-01-05 University Of Maryland, Baltimore Brustkrebsresistenzprotein (BCRP) und für dieses kodierende DNA
AU764370B2 (en) 1998-06-18 2003-08-14 George Washington University, The Methods of administering camptothecin compounds for the treatment of cancer with reduced side effects
DK1102594T3 (da) 1998-08-05 2002-08-26 Aventis Pharma Sa Anvendelse af natriumchlorid til nedsættelse af den gastrointestinale toxicitet af derivater af camptothecin
EP1749540B1 (en) * 1999-05-17 2010-10-13 Cancer Research Ventures Limited Compositions for improving bioavailability of orally administered drugs
US6521635B1 (en) * 2000-01-20 2003-02-18 The United States Of America As Represented By The Department Of Health And Human Services Inhibition of MXR transport by acridine derivatives

Also Published As

Publication number Publication date
DE60045114D1 (de) 2010-11-25
EP1749540A3 (en) 2007-05-30
EP1189637A2 (en) 2002-03-27
DE60030283D1 (de) 2006-10-05
ATE337016T1 (de) 2006-09-15
WO2000069390A3 (en) 2001-12-13
US7030132B2 (en) 2006-04-18
US20060128743A1 (en) 2006-06-15
AU4955200A (en) 2000-12-05
EP1749540A2 (en) 2007-02-07
EP1749540B1 (en) 2010-10-13
ATE484295T1 (de) 2010-10-15
DK1189637T3 (da) 2006-12-11
DE60030283T2 (de) 2007-09-20
EP1189637B1 (en) 2006-08-23
PT1189637E (pt) 2007-01-31
ES2270834T3 (es) 2007-04-16
WO2000069390A2 (en) 2000-11-23
US20020128282A1 (en) 2002-09-12

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