CY1105722T1 - Ανταγωνιστες παραγοντων προκλησης φλεγμονης - Google Patents
Ανταγωνιστες παραγοντων προκλησης φλεγμονηςInfo
- Publication number
- CY1105722T1 CY1105722T1 CY20061101520T CY061101520T CY1105722T1 CY 1105722 T1 CY1105722 T1 CY 1105722T1 CY 20061101520 T CY20061101520 T CY 20061101520T CY 061101520 T CY061101520 T CY 061101520T CY 1105722 T1 CY1105722 T1 CY 1105722T1
- Authority
- CY
- Cyprus
- Prior art keywords
- antagonists
- factors causing
- causing inflammation
- osm
- inflammatory
- Prior art date
Links
- 239000005557 antagonist Substances 0.000 title abstract 3
- 206010061218 Inflammation Diseases 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 208000036487 Arthropathies Diseases 0.000 abstract 1
- 208000012659 Joint disease Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003384 small molecules Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Microbiology (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Transplantation (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Psychiatry (AREA)
- Mycology (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με τη χρήση ενός ανταγωνιστή της OSM όπως ένα αντίσωμα ή μικρό μόριο για την παρασκευή ενός φαρμάκου για τη θεραπεία ή την πρόληψη μιας φλεγμονώδους αρθροπάθειας ή φλεγμονώδους διαταραχής, και με τη χρήση της OSM για την εξεύρεση τέτοιων ανταγωνιστών.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9806530.3A GB9806530D0 (en) | 1998-03-26 | 1998-03-26 | Inflammatory mediator |
PCT/GB1999/000943 WO1999048523A2 (en) | 1998-03-26 | 1999-03-25 | Antagonists of the inflammatory mediator oncostatin m (osm) |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105722T1 true CY1105722T1 (el) | 2010-12-22 |
Family
ID=10829337
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101520T CY1105722T1 (el) | 1998-03-26 | 2006-10-24 | Ανταγωνιστες παραγοντων προκλησης φλεγμονης |
Country Status (20)
Country | Link |
---|---|
US (5) | US6706266B1 (el) |
EP (2) | EP1071449B1 (el) |
JP (2) | JP3825255B2 (el) |
KR (1) | KR20010034672A (el) |
CN (1) | CN1295482A (el) |
AT (1) | ATE338565T1 (el) |
AU (1) | AU3046399A (el) |
BR (1) | BR9909077A (el) |
CA (1) | CA2325585A1 (el) |
CY (1) | CY1105722T1 (el) |
DE (1) | DE69933115T2 (el) |
DK (1) | DK1071449T3 (el) |
ES (1) | ES2272058T3 (el) |
GB (1) | GB9806530D0 (el) |
HU (1) | HUP0101690A2 (el) |
IL (1) | IL138604A0 (el) |
PL (1) | PL343431A1 (el) |
PT (1) | PT1071449E (el) |
WO (1) | WO1999048523A2 (el) |
ZA (1) | ZA200005076B (el) |
Families Citing this family (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9806530D0 (en) * | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Inflammatory mediator |
AU4878601A (en) * | 2000-04-20 | 2001-11-07 | Mitsubishi Corporation | Aromatic amide compounds |
UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
US20060067938A1 (en) * | 2001-10-26 | 2006-03-30 | Sherif Daouti | Methods for the treatment of osteoarthritis and compositions thereof |
US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
CA2503748A1 (en) * | 2002-11-08 | 2004-05-27 | Genentech, Inc. | Compositions and methods for the treatment of natural killer cell related diseases |
JP4803789B2 (ja) * | 2004-02-03 | 2011-10-26 | 独立行政法人科学技術振興機構 | 疼痛を処置するための薬学的組成物 |
RU2429245C2 (ru) * | 2004-03-30 | 2011-09-20 | Глаксо Груп Лимитед | Иммуноглобулины |
TWI307630B (en) | 2004-07-01 | 2009-03-21 | Glaxo Group Ltd | Immunoglobulins |
EP1795204A4 (en) * | 2004-09-29 | 2009-10-21 | Asama Kasei Kk | FUNCTIONAL COMPOSITION OR FOODS WITH MOLKEPROTEIN, FROM MILK-ORGANIC ANTIBODIES OR ANTIBODIES |
EP1671642A1 (en) * | 2004-12-15 | 2006-06-21 | Universite D'angers | Compositions comprising (ant)agonists of oncostatin M (OSM), IL-31 and IFN-gamma for modulating keratinocyte migration and functions via a receptor containing OSMRbeta as a subunit, and applications thereof. |
US10080779B2 (en) | 2004-12-15 | 2018-09-25 | Universite D'angers | Method for increasing the expression of anti-microbial peptides by keratinocytes comprising administering a composition comprising IL-17, TNF-alpha and OSM |
US20060276440A1 (en) * | 2005-01-03 | 2006-12-07 | An Wenqian F | Treatment of inflammatory disorders |
ATE524546T1 (de) * | 2005-03-25 | 2011-09-15 | Medtronic Inc | Verwendung von anti-tnf oder anti-il1-rnai zur unterdrückung der wirkung entzündungsfördernder cytokine zur lokalen schmerzbehandlung |
US20090075342A1 (en) * | 2005-04-26 | 2009-03-19 | Sharon Cload | Metabolic profile directed aptamer medicinal chemistry |
US8354501B2 (en) * | 2005-08-02 | 2013-01-15 | Trustees Of Tufts College | Methods for stepwise deposition of silk fibroin coatings |
JP2010532790A (ja) * | 2007-07-06 | 2010-10-14 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | 抗体処方 |
US8030290B2 (en) * | 2007-12-07 | 2011-10-04 | City Of Hope | Cell-type specific aptamer-siRNA delivery system for HIV-1 Therapy |
USRE48948E1 (en) | 2008-04-18 | 2022-03-01 | Warsaw Orthopedic, Inc. | Clonidine compounds in a biodegradable polymer |
TW201029662A (en) | 2008-12-19 | 2010-08-16 | Glaxo Group Ltd | Novel antigen binding proteins |
US8309688B2 (en) | 2008-12-30 | 2012-11-13 | Centocor Ortho Biotech Inc. | Monkey homolog of human oncostatin M and methods of use thereof |
US20110305693A1 (en) * | 2009-02-24 | 2011-12-15 | Glaxo Group Limited | Anitigen-binding constructs |
US20100239632A1 (en) | 2009-03-23 | 2010-09-23 | Warsaw Orthopedic, Inc. | Drug depots for treatment of pain and inflammation in sinus and nasal cavities or cardiac tissue |
WO2011080050A2 (en) | 2009-12-11 | 2011-07-07 | Novartis Ag | Binding molecules |
UA104663C2 (en) | 2010-01-28 | 2014-02-25 | Глаксо Груп Лимитед | Antibody binding to cd127 |
UA108227C2 (xx) | 2010-03-03 | 2015-04-10 | Антигензв'язуючий білок | |
AR081556A1 (es) | 2010-06-03 | 2012-10-03 | Glaxo Group Ltd | Proteinas de union al antigeno humanizadas |
MX347734B (es) | 2010-06-14 | 2017-05-11 | Lykera Biomed Sa | Anticuerpos anti-s100a4 y usos aplicaciones terapéuticas. |
WO2012051111A2 (en) * | 2010-10-13 | 2012-04-19 | Janssen Biotech, Inc. | Human oncostatin m antibodies and methods of use |
EP2787007A3 (en) | 2010-11-08 | 2015-03-11 | F. Hoffmann-La Roche AG | Subcutaneously administered ANTI-IL-6 receptor antibody |
KR101947356B1 (ko) | 2010-11-23 | 2019-02-12 | 글락소 그룹 리미티드 | 온코스타틴 m (osm)에 대한 항원 결합 단백질 |
WO2013168829A1 (en) | 2012-05-11 | 2013-11-14 | Wakayama Medical University | Anti oncostatin m receptor beta antibody |
BR112015029643B1 (pt) | 2013-05-30 | 2023-12-12 | Kiniksa Phamaceuticals, Ltd | Proteínas de ligação ao antígeno de receptor de oncostatina m, seu método de preparação e seu uso, composições farmacêuticas, ácido nucleico isolado, vetor de expressão e célula hospedeira procariótica recombinante |
US10307487B2 (en) * | 2013-07-09 | 2019-06-04 | President And Fellows Of Harvard College | Microvessel endothelial cell surface markers and uses thereof |
US9550828B2 (en) | 2013-09-05 | 2017-01-24 | Boise State University | Oncostatin M (OSM) antagonists for preventing cancer metastasis and IL-6 related disorders |
JP2014062100A (ja) * | 2013-11-05 | 2014-04-10 | Glaxosmithkline Llc | 抗体処方 |
WO2015069459A1 (en) | 2013-11-05 | 2015-05-14 | Novartis Ag | Organic compounds |
CN104096219A (zh) * | 2014-07-08 | 2014-10-15 | 武汉大学 | Ⅱ型抑瘤素m受体(osmr)在治疗脂肪肝和ⅱ型糖尿病中的功能和应用 |
EP2985294A1 (en) | 2014-08-14 | 2016-02-17 | Deutsches Krebsforschungszentrum | Recombinant antibody molecule and its use for target cell restricted T cell activation |
WO2016046738A1 (en) | 2014-09-24 | 2016-03-31 | Università Degli Studi Di Padova | Composition to induce bone marrow stem cell mobilization |
WO2016059602A2 (en) | 2014-10-16 | 2016-04-21 | Glaxo Group Limited | Methods of treating cancer and related compositions |
WO2016120625A1 (en) * | 2015-01-29 | 2016-08-04 | Isis Innovation Limited | Biomarker |
GB201614627D0 (en) * | 2016-08-30 | 2016-10-12 | Glaxosmithkline Ip Dev Ltd | Antigen binding proteins |
US11633457B2 (en) | 2019-04-11 | 2023-04-25 | Boise State University | Pharmaceutical compositions comprising oncostatin m (OSM) antagonist derivatives and methods of use |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US646727A (en) * | 1899-06-20 | 1900-04-03 | Columbia Motor And Mfg Company | Steam-generator. |
US5681930A (en) * | 1985-12-20 | 1997-10-28 | Bristol-Myers Squibb Company | Anti-oncostatin M monoclonal antibodies |
US5618715A (en) * | 1985-12-20 | 1997-04-08 | Oncogen Limited Partnership | Oncostatin M and novel compositions having anti-neoplastic activity |
JPS6463395A (en) | 1987-05-04 | 1989-03-09 | Oncogen | Oncostatin m and novel composition having antitumor activity |
US5814307A (en) | 1989-04-10 | 1998-09-29 | Bristol-Myers Squibb Company | Method for regulating cell growth, leukocyte differentiation and tumor cell growth using Oncostatin M to stimulate synthesis of IL-6 |
IL112767A (en) | 1989-04-10 | 1998-01-04 | Oncogen | Pharmaceutical compositions containing oncostatin m |
PT96134B (pt) | 1989-12-08 | 1998-04-30 | Oncogen | Processo de obtencao de mutantes da oncostatina m |
NO303226B1 (no) * | 1990-03-29 | 1998-06-15 | Bristol Myers Squibb Co | Monoklonalt antistoff mot Onkostatin M, samt DNA-molekyl, cellelinje og hybridom |
DE4011684A1 (de) | 1990-04-06 | 1991-10-10 | Schering Ag | Dtpa-monoamide, diese verbindungen enthaltende pharmazeutische mittel, ihre verwendung und verfahren zu deren herstellung |
CA2055122A1 (en) | 1990-11-13 | 1992-05-14 | Robert I. Grove | Methods for stimulating ldl uptake and ldl receptor expression |
ATE173763T1 (de) | 1991-08-30 | 1998-12-15 | Hutchinson Fred Cancer Res | Hybride cytokine |
US6171824B1 (en) | 1991-08-30 | 2001-01-09 | Fred Hutchinson Cancer Research Center | Hybrid cytokines |
US5262522A (en) * | 1991-11-22 | 1993-11-16 | Immunex Corporation | Receptor for oncostatin M and leukemia inhibitory factor |
JPH05304986A (ja) | 1992-04-28 | 1993-11-19 | Tosoh Corp | gp130蛋白質に対するモノクロ−ナル抗体 |
US5744442A (en) | 1992-08-26 | 1998-04-28 | Bristol Meyers Squibb Company | Regulation of cellular invasiveness |
US5460810A (en) | 1992-09-02 | 1995-10-24 | Genetics Institute, Inc. | Method for maintaining gut epithelial cells by treatment with a cytokine such as interleukin 11 |
IT1261787B (it) | 1993-06-23 | 1996-06-03 | Angeletti P Ist Richerche Bio | Metodologia per la selezione di superagonisti, antagonisti e super- antagonisti di ormoni del cui complesso recettoriale fa parte gp 130. |
FR2707882B1 (fr) * | 1993-07-23 | 1997-08-01 | Immunotech Sa | Nouveaux kits thérapeutiques anti-médiateurs protéiques, procédé de préparation et compositions pharmaceutiques les renfermant. |
US5451411A (en) * | 1993-10-15 | 1995-09-19 | University Of Washington | Methods and compositions for the oral delivery of therapeutic agents |
US5783672A (en) | 1994-05-26 | 1998-07-21 | Immunex Corporation | Receptor for oncostatin M |
GB9419021D0 (en) | 1994-09-21 | 1994-11-09 | Applied Research Systems | Therapeutic protein |
US5571513A (en) * | 1995-05-31 | 1996-11-05 | The Board Of Regents Of The University Of Oklahoma | Anti-gp130 monoclonal antibodies |
JPH09117288A (ja) | 1995-06-06 | 1997-05-06 | Bristol Myers Squibb Co | オンコスタチンm誘導造血 |
EP0871472A4 (en) | 1995-10-27 | 2001-05-30 | Amrad Operations Pty Ltd | CYTOKINES AND THEIR USE IN THE TREATMENT AND / OR PROPHYLAXIS OF BREAST CANCER |
AU4669097A (en) | 1996-10-25 | 1998-05-22 | Bristol-Myers Squibb Company | Oncostatin m for treating inflammation |
US5958442A (en) * | 1997-10-24 | 1999-09-28 | Bristol-Myers Squibb Company | Oncostatin M for treating inflammation |
GB9806530D0 (en) | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Inflammatory mediator |
-
1998
- 1998-03-26 GB GBGB9806530.3A patent/GB9806530D0/en not_active Ceased
-
1999
- 1999-03-25 WO PCT/GB1999/000943 patent/WO1999048523A2/en active IP Right Grant
- 1999-03-25 PL PL99343431A patent/PL343431A1/xx not_active Application Discontinuation
- 1999-03-25 KR KR1020007010639A patent/KR20010034672A/ko not_active Application Discontinuation
- 1999-03-25 AT AT99911954T patent/ATE338565T1/de active
- 1999-03-25 EP EP99911954A patent/EP1071449B1/en not_active Expired - Lifetime
- 1999-03-25 AU AU30463/99A patent/AU3046399A/en not_active Abandoned
- 1999-03-25 BR BR9909077-5A patent/BR9909077A/pt not_active Application Discontinuation
- 1999-03-25 PT PT99911954T patent/PT1071449E/pt unknown
- 1999-03-25 CN CN99804497A patent/CN1295482A/zh active Pending
- 1999-03-25 ES ES99911954T patent/ES2272058T3/es not_active Expired - Lifetime
- 1999-03-25 EP EP06119544.2A patent/EP1849478A3/en not_active Withdrawn
- 1999-03-25 CA CA002325585A patent/CA2325585A1/en not_active Abandoned
- 1999-03-25 JP JP2000537570A patent/JP3825255B2/ja not_active Expired - Lifetime
- 1999-03-25 DK DK99911954T patent/DK1071449T3/da active
- 1999-03-25 IL IL13860499A patent/IL138604A0/xx unknown
- 1999-03-25 DE DE69933115T patent/DE69933115T2/de not_active Expired - Lifetime
- 1999-03-25 HU HU0101690A patent/HUP0101690A2/hu unknown
- 1999-03-25 US US09/276,147 patent/US6706266B1/en not_active Expired - Lifetime
-
2000
- 2000-09-21 ZA ZA200005076A patent/ZA200005076B/en unknown
-
2003
- 2003-05-21 US US10/442,289 patent/US20040081650A1/en not_active Abandoned
-
2005
- 2005-10-27 US US11/260,844 patent/US7291332B2/en not_active Expired - Fee Related
-
2006
- 2006-05-08 JP JP2006129454A patent/JP2006290893A/ja not_active Withdrawn
- 2006-10-24 CY CY20061101520T patent/CY1105722T1/el unknown
-
2007
- 2007-05-09 US US11/746,090 patent/US8003101B2/en not_active Expired - Fee Related
- 2007-09-20 US US11/858,308 patent/US20080019967A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
CN1295482A (zh) | 2001-05-16 |
US20080044409A1 (en) | 2008-02-21 |
EP1849478A3 (en) | 2013-05-29 |
EP1071449A2 (en) | 2001-01-31 |
JP2002507580A (ja) | 2002-03-12 |
DE69933115D1 (de) | 2006-10-19 |
AU3046399A (en) | 1999-10-18 |
WO1999048523A2 (en) | 1999-09-30 |
WO1999048523A3 (en) | 1999-11-25 |
US20080019967A1 (en) | 2008-01-24 |
HUP0101690A2 (hu) | 2001-08-28 |
ATE338565T1 (de) | 2006-09-15 |
BR9909077A (pt) | 2000-12-05 |
CA2325585A1 (en) | 1999-09-30 |
JP2006290893A (ja) | 2006-10-26 |
EP1071449B1 (en) | 2006-09-06 |
ZA200005076B (en) | 2001-09-21 |
EP1849478A2 (en) | 2007-10-31 |
GB9806530D0 (en) | 1998-05-27 |
ES2272058T3 (es) | 2007-04-16 |
PT1071449E (pt) | 2006-12-29 |
US20060093602A1 (en) | 2006-05-04 |
US7291332B2 (en) | 2007-11-06 |
PL343431A1 (en) | 2001-08-13 |
KR20010034672A (ko) | 2001-04-25 |
US8003101B2 (en) | 2011-08-23 |
DK1071449T3 (da) | 2007-01-02 |
US20040081650A1 (en) | 2004-04-29 |
US6706266B1 (en) | 2004-03-16 |
DE69933115T2 (de) | 2007-04-05 |
IL138604A0 (en) | 2001-10-31 |
JP3825255B2 (ja) | 2006-09-27 |
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