CY1105197T1 - Μεθοδος παραγωγης σουλφοναμιδο-υποκατεστημενων ιμιδαζοτριαζινονων - Google Patents
Μεθοδος παραγωγης σουλφοναμιδο-υποκατεστημενων ιμιδαζοτριαζινονωνInfo
- Publication number
- CY1105197T1 CY1105197T1 CY20061101263T CY061101263T CY1105197T1 CY 1105197 T1 CY1105197 T1 CY 1105197T1 CY 20061101263 T CY20061101263 T CY 20061101263T CY 061101263 T CY061101263 T CY 061101263T CY 1105197 T1 CY1105197 T1 CY 1105197T1
- Authority
- CY
- Cyprus
- Prior art keywords
- sulfonamido
- production
- substituted imidazotriazinones
- reaction
- imidazotriazinones
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- IJYHVZICHKCLMQ-UHFFFAOYSA-N imidazo[4,5-d]triazin-4-one Chemical class O=C1N=NN=C2N=CN=C12 IJYHVZICHKCLMQ-UHFFFAOYSA-N 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Reproductive Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Cosmetics (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Η παρούσα εφεύρεση σχετίζεται με μέθοδο παραγωγής σουλφοναμιδο-υποκατεστημένων ιμιδαζοτριαζινονών του γενικού τύπου (I), χαρακτηριζόμενη από αντίδραση ενώσεων του τύπου (II) με θειικό οξύ και στη συνέχεια αντίδραση των λαμβανόμενων προϊόντων με θειονυλοχλωρίδιο και in situ εντός αδρανούς διαλύτη με κάποια αμίνη προς σχηματισμό των σύμφωνων με την εφεύρεση ενώσεων, καθώς και ενίοτε μετατροπή αυτών στα αντίστοιχα άλατα, ένυδρα παράγωγα ή Ν-οξείδια.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10063108A DE10063108A1 (de) | 2000-12-18 | 2000-12-18 | Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen |
PCT/EP2001/014239 WO2002050076A2 (de) | 2000-12-18 | 2001-12-05 | Verfahren zur herstellung von sulfonamid-substituierten imidazotriazinonen |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1105197T1 true CY1105197T1 (el) | 2010-03-03 |
Family
ID=7667666
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20061101263T CY1105197T1 (el) | 2000-12-18 | 2006-09-05 | Μεθοδος παραγωγης σουλφοναμιδο-υποκατεστημενων ιμιδαζοτριαζινονων |
Country Status (43)
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE10063108A1 (de) * | 2000-12-18 | 2002-06-20 | Bayer Ag | Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen |
DE10107639A1 (de) * | 2001-02-15 | 2002-08-22 | Bayer Ag | 2-Alkoxyphenyl-substituierte Imidazotriazinone |
DE10232113A1 (de) | 2002-07-16 | 2004-01-29 | Bayer Ag | Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel |
DE202004006552U1 (de) * | 2004-04-26 | 2004-07-08 | Knürr AG | Kühlungssystem für Geräte- und Netzwerkschränke |
DE102004023069A1 (de) | 2004-05-11 | 2005-12-08 | Bayer Healthcare Ag | Neue Darreichungsformen des PDE 5-Inhibitors Vardenafil |
US7977478B2 (en) * | 2006-03-13 | 2011-07-12 | Dr. Reddy's Laboratories Limited | Polymorphic forms of vardenafil |
WO2009030095A1 (en) * | 2007-09-06 | 2009-03-12 | Topharman Shanghai Co., Ltd. | Process for preparing vardenafil and its intermediates |
WO2009082845A1 (en) | 2007-12-28 | 2009-07-09 | Topharman Shanghai Co., Ltd. | N-{1-[3-(2-ethoxy-5-(4-ethylpiperazinyl)benzenesulfonyl)-4,5-dihydro-5-oxo-1,2,4-triazin-6-yl]ethyl}butyramide, the preparation method and use thereof |
US20120190849A1 (en) | 2009-08-07 | 2012-07-26 | Ranbaxy Laboratories Limited | Processes for the preparation of vardenafil |
PL390079A1 (pl) * | 2009-12-30 | 2011-07-04 | Zakłady Farmaceutyczne POLPHARMA Spółka Akcyjna | Sposób otrzymywania wardenafilu i jego izolacji jako soli z kwasem cytrynowym oraz krystaliczna postać tej soli |
CN102134242B (zh) | 2011-01-21 | 2013-08-28 | 浙江大德药业集团有限公司 | 一种用于治疗阳痿的快速长效的化合物 |
CZ2011767A3 (cs) | 2011-11-24 | 2013-06-05 | Zentiva, K.S. | Zpusob prípravy a izolace solí vardenafilu s kyselinami |
US20160317542A1 (en) | 2013-12-09 | 2016-11-03 | Respira Therapeutics, Inc. | Pde5 inhibitor powder formulations and methods relating thereto |
PL223869B1 (pl) | 2013-12-16 | 2016-11-30 | Starogardzkie Zakłady Farm Polpharma Spółka Akcyjna | Sposób otrzymywania wardenafilu i jego soli |
CN107383020A (zh) * | 2017-07-29 | 2017-11-24 | 合肥创新医药技术有限公司 | 一种伐地那非杂质的制备方法 |
JP2021506986A (ja) | 2017-12-20 | 2021-02-22 | クラリア・ファルマ・ホールディング・アクチボラグ | バルデナフィルを含むフィルム配合物、その調製法、およびその使用 |
CN115043757B (zh) * | 2022-07-27 | 2023-08-08 | 南京桦冠生物技术有限公司 | 一种连续化制备苄脒盐酸盐的方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9311920D0 (en) * | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
PT1049695E (pt) | 1997-11-12 | 2002-07-31 | Bayer Ag | Imidazotriazinonas 2-fenil substituidas enquanto inibidores de fosfodiesterase |
DE10063108A1 (de) * | 2000-12-18 | 2002-06-20 | Bayer Ag | Verfahren zur Herstellung von Sulfonamid-substituierten Imidazotriazinonen |
DE10107639A1 (de) * | 2001-02-15 | 2002-08-22 | Bayer Ag | 2-Alkoxyphenyl-substituierte Imidazotriazinone |
-
2000
- 2000-12-18 DE DE10063108A patent/DE10063108A1/de not_active Withdrawn
-
2001
- 2001-05-12 UA UA2003076744A patent/UA75109C2/uk unknown
- 2001-11-28 AR ARP010105546A patent/AR032775A1/es active IP Right Grant
- 2001-11-28 DO DO2001000295A patent/DOP2001000295A/es unknown
- 2001-12-05 CZ CZ20031692A patent/CZ297005B6/cs not_active IP Right Cessation
- 2001-12-05 KR KR1020037008063A patent/KR100787288B1/ko active IP Right Grant
- 2001-12-05 AT AT01271374T patent/ATE328885T1/de active
- 2001-12-05 NZ NZ526477A patent/NZ526477A/xx not_active IP Right Cessation
- 2001-12-05 DE DE50110080T patent/DE50110080D1/de not_active Expired - Lifetime
- 2001-12-05 DK DK01271374T patent/DK1345939T3/da active
- 2001-12-05 BR BRPI0116227A patent/BRPI0116227B8/pt not_active IP Right Cessation
- 2001-12-05 PT PT01271374T patent/PT1345939E/pt unknown
- 2001-12-05 AU AU2002217089A patent/AU2002217089B2/en not_active Expired
- 2001-12-05 CA CA002431933A patent/CA2431933C/en not_active Expired - Lifetime
- 2001-12-05 HU HU0302467A patent/HU229296B1/hu unknown
- 2001-12-05 SK SK750-2003A patent/SK286894B6/sk not_active IP Right Cessation
- 2001-12-05 CN CNB018208177A patent/CN1227253C/zh not_active Expired - Lifetime
- 2001-12-05 AU AU1708902A patent/AU1708902A/xx active Pending
- 2001-12-05 WO PCT/EP2001/014239 patent/WO2002050076A2/de active IP Right Grant
- 2001-12-05 EP EP01271374A patent/EP1345939B1/de not_active Expired - Lifetime
- 2001-12-05 JP JP2002551969A patent/JP4441175B2/ja not_active Expired - Lifetime
- 2001-12-05 PL PL365310A patent/PL207294B1/pl unknown
- 2001-12-05 EE EEP200300294A patent/EE05308B1/xx unknown
- 2001-12-05 ES ES01271374T patent/ES2266098T3/es not_active Expired - Lifetime
- 2001-12-05 MX MXPA03005429A patent/MXPA03005429A/es active IP Right Grant
- 2001-12-05 RU RU2003122192/04A patent/RU2299211C2/ru active
- 2001-12-05 SI SI200130606T patent/SI1345939T1/sl unknown
- 2001-12-13 MY MYPI20015689A patent/MY126689A/en unknown
- 2001-12-14 GT GT200100251A patent/GT200100251A/es unknown
- 2001-12-14 HN HN2001000278A patent/HN2001000278A/es unknown
- 2001-12-14 UY UY27070A patent/UY27070A1/es not_active IP Right Cessation
- 2001-12-15 IL IL15627801A patent/IL156278A0/xx unknown
- 2001-12-17 TW TW090131175A patent/TWI289562B/zh not_active IP Right Cessation
- 2001-12-17 US US10/022,954 patent/US6777551B2/en not_active Expired - Lifetime
- 2001-12-17 SV SV2001000766A patent/SV2003000766A/es active IP Right Grant
- 2001-12-17 PE PE2001001258A patent/PE20020590A1/es active IP Right Grant
-
2003
- 2003-06-03 IL IL156278A patent/IL156278A/en active IP Right Grant
- 2003-06-09 BG BG107892A patent/BG66142B1/bg unknown
- 2003-06-09 CU CU20030128A patent/CU23341B7/es unknown
- 2003-06-16 NO NO20032731A patent/NO325398B1/no not_active IP Right Cessation
- 2003-06-17 EC EC2003004657A patent/ECSP034657A/es unknown
- 2003-06-18 ZA ZA200304705A patent/ZA200304705B/en unknown
- 2003-06-18 MA MA27202A patent/MA25927A1/fr unknown
- 2003-07-17 HR HR20030583A patent/HRP20030583B1/xx not_active IP Right Cessation
-
2004
- 2004-07-02 US US10/884,686 patent/US20050014756A1/en not_active Abandoned
- 2004-09-03 HK HK04106667A patent/HK1063799A1/xx not_active IP Right Cessation
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2005
- 2005-05-05 US US11/124,452 patent/US6998483B2/en not_active Expired - Lifetime
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2006
- 2006-09-05 CY CY20061101263T patent/CY1105197T1/el unknown
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2008
- 2008-11-17 CU CUP2008000213A patent/CU23873B1/es active IP Right Grant
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2017
- 2017-03-28 UY UY0001037172A patent/UY37172A/es not_active Application Discontinuation
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