CS228515B2 - Method for producing new derivates of 6a,10a-trans-9beta-subst.-amino-1hydroxyoktahydrobenzo/c/quinoline - Google Patents

Method for producing new derivates of 6a,10a-trans-9beta-subst.-amino-1hydroxyoktahydrobenzo/c/quinoline Download PDF

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Publication number
CS228515B2
CS228515B2 CS815647A CS564781A CS228515B2 CS 228515 B2 CS228515 B2 CS 228515B2 CS 815647 A CS815647 A CS 815647A CS 564781 A CS564781 A CS 564781A CS 228515 B2 CS228515 B2 CS 228515B2
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CS
Czechoslovakia
Prior art keywords
formula
carbon atoms
hydrogen
group
alkyl
Prior art date
Application number
CS815647A
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Czech (cs)
English (en)
Inventor
Michael R Johnson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Priority to CS824285A priority Critical patent/CS228543B2/cs
Publication of CS228515B2 publication Critical patent/CS228515B2/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/10—Aza-phenanthrenes
    • C07D221/12—Phenanthridines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
CS815647A 1980-07-28 1981-07-23 Method for producing new derivates of 6a,10a-trans-9beta-subst.-amino-1hydroxyoktahydrobenzo/c/quinoline CS228515B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CS824285A CS228543B2 (cs) 1980-07-28 1981-07-23 Způsob výroby nových trans-(6a,10a) diasteroomerních 9-amino-l- -acetoxyoktahydrobenzo[ c J chinolinových derivátů

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/173,207 US4309545A (en) 1980-07-28 1980-07-28 Oximino-1-hydroxyoctahydrobenzo[c]quinolines and derivatives thereof

Publications (1)

Publication Number Publication Date
CS228515B2 true CS228515B2 (en) 1984-05-14

Family

ID=22630983

Family Applications (1)

Application Number Title Priority Date Filing Date
CS815647A CS228515B2 (en) 1980-07-28 1981-07-23 Method for producing new derivates of 6a,10a-trans-9beta-subst.-amino-1hydroxyoktahydrobenzo/c/quinoline

Country Status (29)

Country Link
US (1) US4309545A (pt)
EP (1) EP0045171B1 (pt)
JP (1) JPS57112372A (pt)
KR (1) KR850000273B1 (pt)
AR (1) AR230988A1 (pt)
AT (1) ATE11775T1 (pt)
AU (1) AU525944B2 (pt)
CA (1) CA1178274A (pt)
CS (1) CS228515B2 (pt)
DD (1) DD202012A5 (pt)
DE (1) DE3168891D1 (pt)
DK (1) DK334581A (pt)
EG (1) EG15535A (pt)
ES (1) ES8301926A1 (pt)
FI (1) FI812338L (pt)
GR (1) GR75283B (pt)
GT (1) GT198170557A (pt)
HU (1) HU185133B (pt)
IE (1) IE51426B1 (pt)
IL (1) IL63423A0 (pt)
IN (1) IN158867B (pt)
NO (2) NO812557L (pt)
NZ (1) NZ197856A (pt)
PH (1) PH17281A (pt)
PL (1) PL133928B1 (pt)
PT (1) PT73440B (pt)
SU (1) SU1217254A3 (pt)
YU (1) YU185181A (pt)
ZA (1) ZA815128B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4920221A (en) * 1982-03-16 1990-04-24 Pfizer Inc. Substituted decahydro-1H-pyrido[1,2-f]phenanthridines and decahydropyrrolo[1,2-f]phenanthridines
US4642373A (en) * 1982-03-16 1987-02-10 Pfizer Inc. Substituted dodecahydrotripheylenes, and decahydropyrrolo[1,2-f]phenanthridines as CNS agents
US4473704A (en) * 1982-03-16 1984-09-25 Pfizer Inc. Substituted dodecahydrotriphenylenes, decahydro-1H-cyclopenta[1]phenanthrenes, decahydro-1H-pyrido[1,2-f]phenanthridines and decahydropyrrolo[1,2-f]phenanthridines as CNS agents
US5605906A (en) * 1995-03-24 1997-02-25 Merck Frosst Canada, Inc. Cannabinoid receptor agonists
US6191138B1 (en) * 1996-01-31 2001-02-20 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines
US6127378A (en) * 1996-03-26 2000-10-03 Byk Gulden Lomberg Chemische Fabrik Gmbh Phenanthridines substituted in the 6 position
DK0889886T5 (da) * 1996-03-26 2003-02-24 Altana Pharma Ag Hidtil ukendte, i 6-stilling substituerede phenanthridiner
US5776482A (en) * 1996-03-29 1998-07-07 University Of Iowa Research Foundation Tetrahydroquinoline analogues for use in glaucoma treatment
WO1999005113A1 (en) * 1997-07-25 1999-02-04 Byk Gulden Lomberg Chemische Fabrik Gmbh Substituted 6-phenylphenanthridines
DE69808099T2 (de) * 1997-07-25 2003-05-15 Altana Pharma Ag Substituierte 6-alkylphenanthridine
US6566560B2 (en) 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
IL145470A0 (en) 1999-03-22 2002-06-30 Immugen Pharmaceuticals Inc Compositions for the treatment of immune diseases
US20060084021A1 (en) * 2004-09-10 2006-04-20 Kubicek Chris A Wick holder
US6541510B2 (en) * 2000-09-28 2003-04-01 Immugen Pharmaceuticals, Inc. Antiviral methods and compounds
WO2002026224A2 (en) * 2000-09-28 2002-04-04 Immugen Pharmaceuticals, Inc. Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation
AU2003214226A1 (en) * 2002-03-18 2003-10-08 Immugen Pharmaceuticals, Inc. Topical formulations of resorcinols and cannibinoids and methods of use
US7678829B2 (en) * 2004-05-25 2010-03-16 Qlt Inc. Oculoselective drugs and prodrugs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3839441A (en) * 1969-10-27 1974-10-01 Hoffmann La Roche Intermediates for partially hydrogenated phenanthridines
US3878219A (en) * 1973-07-13 1975-04-15 Abbott Lab 5H-{8 1{9 benzopyrano{8 3,4-d{9 pyridines
US3928598A (en) * 1973-11-05 1975-12-23 Lilly Co Eli Hexahydro-dibenzo{8 b,d{9 pyran-9-ones as an anti-anxiety drug
US4087545A (en) * 1976-02-17 1978-05-02 Eli Lilly And Company Hexahydro-dibenzo[b,d]pyran-9-ones as antiemetic drugs
SE7704749L (sv) * 1976-05-17 1977-12-05 Pfizer Kinoliner och forfarande och mellanprodukter for framstellning derav
HU180916B (hu) 1976-05-17 1983-05-30 Pfizer Eljárás benzo[c]kinolin-származékok előállítására
US4152450A (en) * 1978-02-17 1979-05-01 Eli Lilly And Company 9-Amino-dibenzopyrans

Also Published As

Publication number Publication date
GT198170557A (es) 1983-01-12
IE811686L (en) 1982-01-28
ZA815128B (en) 1982-07-28
EP0045171B1 (en) 1985-02-13
IE51426B1 (en) 1986-12-24
GR75283B (pt) 1984-07-13
DD202012A5 (de) 1983-08-24
DK334581A (da) 1982-01-29
CA1178274A (en) 1984-11-20
IL63423A0 (en) 1981-10-30
PT73440A (en) 1981-08-01
PL133928B1 (en) 1985-07-31
IN158867B (pt) 1987-02-07
AR230988A1 (es) 1984-08-31
AU7343481A (en) 1982-05-06
SU1217254A3 (ru) 1986-03-07
JPS57112372A (en) 1982-07-13
EP0045171A3 (en) 1982-04-28
KR850000273B1 (ko) 1985-03-15
NZ197856A (en) 1984-10-19
NO854454L (no) 1985-01-29
PH17281A (en) 1984-07-06
EP0045171A2 (en) 1982-02-03
DE3168891D1 (en) 1985-03-28
HU185133B (en) 1984-12-28
ES504323A0 (es) 1982-12-16
ES8301926A1 (es) 1982-12-16
EG15535A (en) 1986-09-30
YU185181A (en) 1983-12-31
US4309545A (en) 1982-01-05
ATE11775T1 (de) 1985-02-15
PL232331A1 (en) 1983-09-26
AU525944B2 (en) 1982-12-09
PT73440B (en) 1983-06-20
FI812338L (fi) 1982-01-29
KR830006217A (ko) 1983-09-20
NO812557L (no) 1982-01-29

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