CR20220541A - Moléculas de unión al antígeno multiespecíficas dirigidas a ligando de tipo delta 3 (dll3) y sus usos - Google Patents
Moléculas de unión al antígeno multiespecíficas dirigidas a ligando de tipo delta 3 (dll3) y sus usosInfo
- Publication number
- CR20220541A CR20220541A CR20220541A CR20220541A CR20220541A CR 20220541 A CR20220541 A CR 20220541A CR 20220541 A CR20220541 A CR 20220541A CR 20220541 A CR20220541 A CR 20220541A CR 20220541 A CR20220541 A CR 20220541A
- Authority
- CR
- Costa Rica
- Prior art keywords
- binding
- antigen
- dll3
- binding molecules
- multispecific antigen
- Prior art date
Links
- 239000000427 antigen Substances 0.000 title abstract 8
- 102000036639 antigens Human genes 0.000 title abstract 8
- 108091007433 antigens Proteins 0.000 title abstract 8
- 101000928513 Homo sapiens Delta-like protein 3 Proteins 0.000 abstract 3
- 102100036466 Delta-like protein 3 Human genes 0.000 abstract 2
- 229940127276 delta-like ligand 3 Drugs 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 102000053255 human DLL3 Human genes 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000001988 toxicity Effects 0.000 abstract 1
- 231100000419 toxicity Toxicity 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
La divulgación proporciona moléculas de unión a antígenos multiespecíficas que comprenden una primera fracción de unión a antígenos y una segunda fracción de unión a antígenos, cada una de las cuales es capaz de unirse a CD3 y CD137, pero no se une a CD3 y CD137 al mismo tiempo; y una tercera fracción de unión a antígenos que es capaz de unirse a DLL3, preferiblemente DLL3 humana, que inducen la citotoxidad dependiente de células T de manera más eficiente al tiempo que evitan los problemas de toxicidad adversa o los efectos secundarios que pueden tener otras moléculas multiespecíficas de unión a antígenos. La presente invención proporciona moléculas multiespecíficas de unión a antígenos y composiciones farmacéuticas que pueden tratar diversos tipos de cáncer, especialmente los asociados con DLL3, al comprender la molécula de unión al antígeno como ingrediente activo.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2020062326 | 2020-03-31 | ||
PCT/JP2021/013460 WO2021200898A1 (en) | 2020-03-31 | 2021-03-30 | Dll3-targeting multispecific antigen-binding molecules and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20220541A true CR20220541A (es) | 2022-11-28 |
Family
ID=77855554
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20220541A CR20220541A (es) | 2020-03-31 | 2021-03-30 | Moléculas de unión al antígeno multiespecíficas dirigidas a ligando de tipo delta 3 (dll3) y sus usos |
Country Status (18)
Country | Link |
---|---|
US (3) | US11274151B2 (es) |
EP (1) | EP4126969A4 (es) |
JP (2) | JP7085666B2 (es) |
KR (2) | KR20230035138A (es) |
CN (1) | CN115397866A (es) |
AR (1) | AR121695A1 (es) |
AU (1) | AU2021250186A1 (es) |
BR (1) | BR112022019498A2 (es) |
CA (1) | CA3173587A1 (es) |
CL (1) | CL2022002624A1 (es) |
CO (1) | CO2022015305A2 (es) |
CR (1) | CR20220541A (es) |
IL (1) | IL296803A (es) |
MX (1) | MX2022012091A (es) |
PE (1) | PE20230077A1 (es) |
SG (1) | SG11202105302PA (es) |
TW (2) | TW202325741A (es) |
WO (1) | WO2021200898A1 (es) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI712421B (zh) | 2013-11-11 | 2020-12-11 | 日商中外製藥股份有限公司 | 含改變的抗體可變區之抗原結合分子 |
US11952422B2 (en) * | 2017-12-05 | 2024-04-09 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137 |
EP3732195A4 (en) * | 2017-12-28 | 2022-02-09 | Chugai Seiyaku Kabushiki Kaisha | CYTOTOXICITY-INDUCING THERAPEUTIC |
US20230121511A1 (en) * | 2020-03-31 | 2023-04-20 | Chugai Seiyaku Kabushiki Kaisha | Method for producing multispecific antigen-binding molecules |
JP7085666B2 (ja) | 2020-03-31 | 2022-06-16 | 中外製薬株式会社 | Dll3標的多重特異性抗原結合分子およびその使用 |
WO2023053272A1 (en) * | 2021-09-29 | 2023-04-06 | Chugai Seiyaku Kabushiki Kaisha | Uses of dll3-targeting multispecific antigen-binding molecules |
WO2023164474A1 (en) | 2022-02-23 | 2023-08-31 | Amgen Inc. | Cancer treatment targeting dll3 |
CN116813784B (zh) * | 2023-05-17 | 2024-03-01 | 星奕昂(上海)生物科技有限公司 | 靶向dll3的抗体及其应用 |
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KR20180030856A (ko) | 2015-07-10 | 2018-03-26 | 메뤼스 엔.페. | 인간 cd3 결합 항체 |
TW202346349A (zh) * | 2015-07-31 | 2023-12-01 | 德商安美基研究(慕尼黑)公司 | Dll3及cd3抗體構築體 |
UA123323C2 (uk) | 2016-05-02 | 2021-03-17 | Ф. Хоффманн-Ля Рош Аг | Димерний злитий поліпептид |
EP3494139B1 (en) | 2016-08-05 | 2022-01-12 | F. Hoffmann-La Roche AG | Multivalent and multiepitopic anitibodies having agonistic activity and methods of use |
WO2018114754A1 (en) | 2016-12-19 | 2018-06-28 | F. Hoffmann-La Roche Ag | Combination therapy with targeted 4-1bb (cd137) agonists |
BR112019007267A2 (pt) | 2016-12-20 | 2019-07-09 | Hoffmann La Roche | anticorpo biespecífico anti-cd20/anti-cd3, produto farmacêutico, composição farmacêutica que compreende um anticorpo biespecífico anti-cd20/anti-cd3, uso de combinação de anticorpo biespecífico anti-cd20/anti-cd3 e um agonista de 4-1bb e método de tratamento ou retardamento da progressão de câncer em pacientes |
CN110913904A (zh) | 2017-05-05 | 2020-03-24 | 美国安进公司 | 用于改善的储存和施用的包含双特异性抗体构建体的药物组合物 |
US11952422B2 (en) | 2017-12-05 | 2024-04-09 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule comprising altered antibody variable region binding CD3 and CD137 |
EP3732195A4 (en) * | 2017-12-28 | 2022-02-09 | Chugai Seiyaku Kabushiki Kaisha | CYTOTOXICITY-INDUCING THERAPEUTIC |
MX2020013348A (es) * | 2018-06-09 | 2021-03-09 | Boehringer Ingelheim Int | Anticuerpos biespecificos contra dll3-cd3. |
US20220195045A1 (en) | 2018-08-03 | 2022-06-23 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule containing two antigen-binding domains that are linked to each other |
SG11202102882YA (en) | 2018-09-28 | 2021-04-29 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule comprising altered antibody variable region |
AU2019347412A1 (en) | 2018-09-28 | 2021-05-27 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecules capable of binding CD3 and CD137 but not simultaneously |
TW202028245A (zh) * | 2018-10-11 | 2020-08-01 | 美商英伊布里克斯公司 | Dll3單域抗體及其治療性組合物 |
JP2023512390A (ja) | 2020-02-05 | 2023-03-27 | 中外製薬株式会社 | 組換え抗原結合分子を製造するおよび/または濃縮するための方法 |
JP7085666B2 (ja) | 2020-03-31 | 2022-06-16 | 中外製薬株式会社 | Dll3標的多重特異性抗原結合分子およびその使用 |
US20230121511A1 (en) | 2020-03-31 | 2023-04-20 | Chugai Seiyaku Kabushiki Kaisha | Method for producing multispecific antigen-binding molecules |
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2021
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- 2021-03-30 CN CN202180026335.9A patent/CN115397866A/zh active Pending
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US11274151B2 (en) | 2022-03-15 |
US20240010725A1 (en) | 2024-01-11 |
EP4126969A4 (en) | 2024-05-29 |
AU2021250186A1 (en) | 2022-12-01 |
TWI799824B (zh) | 2023-04-21 |
US11718672B2 (en) | 2023-08-08 |
MX2022012091A (es) | 2022-10-13 |
EP4126969A1 (en) | 2023-02-08 |
IL296803A (en) | 2022-11-01 |
TW202204409A (zh) | 2022-02-01 |
US20210301016A1 (en) | 2021-09-30 |
US20220251201A1 (en) | 2022-08-11 |
KR102505383B1 (ko) | 2023-03-02 |
JP7085666B2 (ja) | 2022-06-16 |
JP2022122972A (ja) | 2022-08-23 |
KR20230035138A (ko) | 2023-03-10 |
CA3173587A1 (en) | 2021-10-07 |
CN115397866A (zh) | 2022-11-25 |
SG11202105302PA (en) | 2021-11-29 |
WO2021200898A1 (en) | 2021-10-07 |
CL2022002624A1 (es) | 2023-06-02 |
AR121695A1 (es) | 2022-06-29 |
BR112022019498A2 (pt) | 2022-11-16 |
TW202325741A (zh) | 2023-07-01 |
CO2022015305A2 (es) | 2022-11-08 |
JP2021159081A (ja) | 2021-10-11 |
KR20220100520A (ko) | 2022-07-15 |
PE20230077A1 (es) | 2023-01-11 |
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