CR20220334A - Anticuerpos específicos de apolipoproteína l1 y métodos de uso - Google Patents

Anticuerpos específicos de apolipoproteína l1 y métodos de uso

Info

Publication number
CR20220334A
CR20220334A CR20220334A CR20220334A CR20220334A CR 20220334 A CR20220334 A CR 20220334A CR 20220334 A CR20220334 A CR 20220334A CR 20220334 A CR20220334 A CR 20220334A CR 20220334 A CR20220334 A CR 20220334A
Authority
CR
Costa Rica
Prior art keywords
apol1
apolipoprotein
methods
specific antibodies
differentiate
Prior art date
Application number
CR20220334A
Other languages
English (en)
Inventor
Suzanna Jane Scales
Nidhi Gupta
Andrew Scott Peterson
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CR20220334A publication Critical patent/CR20220334A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/775—Apolipopeptides

Abstract

La presente divulgación proporciona anticuerpos anti-apolipoproteína L1 (APOL1), que incluyen anticuerpos anti-APOL1 que diferencian las formas de G0 y G1 de la forma de G2 de APOL1, diferencian APOL1 encontrada en podocitos en lugar de la encontrada en partículas de HDL en suero y diferencian APOL1 de apolipoproteínas L2, L3, L4 y L6 (APOL2, APOL3, APOL4 y APOL6), y los métodos para su uso.
CR20220334A 2019-12-23 2020-12-21 Anticuerpos específicos de apolipoproteína l1 y métodos de uso CR20220334A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962953097P 2019-12-23 2019-12-23
PCT/US2020/066377 WO2021133723A2 (en) 2019-12-23 2020-12-21 Apolipoprotein l1-specific antibodies and methods of use

Publications (1)

Publication Number Publication Date
CR20220334A true CR20220334A (es) 2022-08-26

Family

ID=74191928

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20220334A CR20220334A (es) 2019-12-23 2020-12-21 Anticuerpos específicos de apolipoproteína l1 y métodos de uso

Country Status (15)

Country Link
US (1) US20230071609A1 (es)
EP (1) EP4081294A2 (es)
JP (1) JP2023509390A (es)
KR (1) KR20220118527A (es)
CN (1) CN115515678A (es)
AU (1) AU2020412609A1 (es)
BR (1) BR112022012439A2 (es)
CA (1) CA3165504A1 (es)
CL (1) CL2022001714A1 (es)
CO (1) CO2022010235A2 (es)
CR (1) CR20220334A (es)
IL (1) IL294131A (es)
MX (1) MX2022007746A (es)
PE (1) PE20221186A1 (es)
WO (1) WO2021133723A2 (es)

Families Citing this family (3)

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WO2023086901A1 (en) * 2021-11-12 2023-05-19 Virginia Tech Intellectual Properties, Inc. Borrelia burgdorferi peptidoglycan detection methods
WO2023178208A2 (en) * 2022-03-16 2023-09-21 Stcube & Co., Inc. Btn1a1 binding proteins and methods of use thereof
WO2024050524A1 (en) * 2022-09-01 2024-03-07 University Of Georgia Research Foundation, Inc. Compositions and methods for directing apolipoprotein l1 to induce mammalian cell death

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Also Published As

Publication number Publication date
EP4081294A2 (en) 2022-11-02
US20230071609A1 (en) 2023-03-09
CL2022001714A1 (es) 2023-03-03
KR20220118527A (ko) 2022-08-25
BR112022012439A2 (pt) 2022-09-06
WO2021133723A3 (en) 2021-08-05
CO2022010235A2 (es) 2022-08-09
AU2020412609A1 (en) 2022-06-16
CA3165504A1 (en) 2021-07-01
WO2021133723A2 (en) 2021-07-01
JP2023509390A (ja) 2023-03-08
IL294131A (en) 2022-08-01
CN115515678A (zh) 2022-12-23
MX2022007746A (es) 2022-10-07
PE20221186A1 (es) 2022-08-05

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