CR20200251A - Expansión de til de aspirados con aguja fina y biopsias por punción - Google Patents
Expansión de til de aspirados con aguja fina y biopsias por punciónInfo
- Publication number
- CR20200251A CR20200251A CR20200251A CR20200251A CR20200251A CR 20200251 A CR20200251 A CR 20200251A CR 20200251 A CR20200251 A CR 20200251A CR 20200251 A CR20200251 A CR 20200251A CR 20200251 A CR20200251 A CR 20200251A
- Authority
- CR
- Costa Rica
- Prior art keywords
- fine needle
- needle aspirates
- small biopsies
- til expansion
- tils
- Prior art date
Links
- 238000001574 biopsy Methods 0.000 title abstract 2
- 210000003171 tumor-infiltrating lymphocyte Anatomy 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 230000010034 metabolic health Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/852—Pancreas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/86—Lung
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/876—Skin, melanoma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/80—Vaccine for a specifically defined cancer
- A61K2039/892—Reproductive system [uterus, ovaries, cervix, testes]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/54—Pancreas
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/55—Lung
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/57—Skin; melanoma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the cancer treated
- A61K2239/59—Reproductive system, e.g. uterus, ovaries, cervix or testes
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2302—Interleukin-2 (IL-2)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2321—Interleukin-21 (IL-21)
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/515—CD3, T-cell receptor complex
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- C—CHEMISTRY; METALLURGY
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/50—Cell markers; Cell surface determinants
- C12N2501/599—Cell markers; Cell surface determinants with CD designations not provided for elsewhere
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2502/00—Coculture with; Conditioned medium produced by
- C12N2502/11—Coculture with; Conditioned medium produced by blood or immune system cells
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Mycology (AREA)
- Hematology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente divulgación proporciona métodos para expandir poblaciones de TIL a partir de aspirados con aguja fina (FNA) o biopsias por punción que contienen números bajos de TIL, utilizando los métodos descritos en el presente documento, que incluyen un sistema cerrado que conduce a un fenotipo mejorado y a una mayor salud metabólica de los TIL en un período de tiempo más corto.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762588044P | 2017-11-17 | 2017-11-17 | |
US201862621515P | 2018-01-24 | 2018-01-24 | |
US201862756038P | 2018-11-05 | 2018-11-05 | |
PCT/US2018/061865 WO2019100023A1 (en) | 2017-11-17 | 2018-11-19 | Til expansion from fine needle aspirates and small biopsies |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20200251A true CR20200251A (es) | 2020-07-17 |
Family
ID=64901650
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20200251A CR20200251A (es) | 2017-11-17 | 2018-11-19 | Expansión de til de aspirados con aguja fina y biopsias por punción |
Country Status (15)
Country | Link |
---|---|
US (2) | US20200277573A1 (es) |
EP (1) | EP3710576A1 (es) |
JP (1) | JP2021503281A (es) |
KR (1) | KR20200100060A (es) |
CN (1) | CN111601883B (es) |
AU (1) | AU2018368786A1 (es) |
BR (1) | BR112020009663A2 (es) |
CA (1) | CA3082484A1 (es) |
CR (1) | CR20200251A (es) |
IL (1) | IL274584A (es) |
MX (1) | MX2020004967A (es) |
PH (1) | PH12020550642A1 (es) |
SG (1) | SG11202004457XA (es) |
TW (1) | TWI833719B (es) |
WO (1) | WO2019100023A1 (es) |
Families Citing this family (32)
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US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
US11713446B2 (en) * | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
BR112020018658A2 (pt) | 2018-03-15 | 2020-12-29 | KSQ Therapeutics, Inc. | Composições de regulação gênica e métodos para imu-noterapia aprimorada |
US20220249559A1 (en) * | 2019-05-13 | 2022-08-11 | Iovance Biotherapeutics, Inc. | Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy |
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US20210285054A1 (en) * | 2019-05-28 | 2021-09-16 | Xiling Shen | Precision drug screening for personalized cancer therapy |
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2018
- 2018-11-19 SG SG11202004457XA patent/SG11202004457XA/en unknown
- 2018-11-19 MX MX2020004967A patent/MX2020004967A/es unknown
- 2018-11-19 WO PCT/US2018/061865 patent/WO2019100023A1/en unknown
- 2018-11-19 KR KR1020207016961A patent/KR20200100060A/ko active Search and Examination
- 2018-11-19 CN CN201880086659.XA patent/CN111601883B/zh active Active
- 2018-11-19 JP JP2020526902A patent/JP2021503281A/ja active Pending
- 2018-11-19 US US16/764,385 patent/US20200277573A1/en not_active Abandoned
- 2018-11-19 AU AU2018368786A patent/AU2018368786A1/en active Pending
- 2018-11-19 CA CA3082484A patent/CA3082484A1/en active Pending
- 2018-11-19 CR CR20200251A patent/CR20200251A/es unknown
- 2018-11-19 EP EP18827296.7A patent/EP3710576A1/en active Pending
- 2018-11-19 BR BR112020009663-6A patent/BR112020009663A2/pt unknown
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TW201932594A (zh) | 2019-08-16 |
WO2019100023A1 (en) | 2019-05-23 |
PH12020550642A1 (en) | 2021-03-22 |
MX2020004967A (es) | 2020-08-27 |
TWI833719B (zh) | 2024-03-01 |
CA3082484A1 (en) | 2019-05-23 |
IL274584A (en) | 2020-06-30 |
CN111601883B (zh) | 2024-06-21 |
US20200277573A1 (en) | 2020-09-03 |
CN111601883A (zh) | 2020-08-28 |
EP3710576A1 (en) | 2020-09-23 |
SG11202004457XA (en) | 2020-06-29 |
BR112020009663A2 (pt) | 2020-11-10 |
KR20200100060A (ko) | 2020-08-25 |
US20210309968A1 (en) | 2021-10-07 |
AU2018368786A1 (en) | 2020-06-18 |
JP2021503281A (ja) | 2021-02-12 |
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