CR20190331A - UNA FORMA CRISTALINA A DE UN MODULADOR DEL RECEPTOR ANDROGÉNICO (Divisional 2014-0549) - Google Patents

UNA FORMA CRISTALINA A DE UN MODULADOR DEL RECEPTOR ANDROGÉNICO (Divisional 2014-0549)

Info

Publication number
CR20190331A
CR20190331A CR20190331A CR20190331A CR20190331A CR 20190331 A CR20190331 A CR 20190331A CR 20190331 A CR20190331 A CR 20190331A CR 20190331 A CR20190331 A CR 20190331A CR 20190331 A CR20190331 A CR 20190331A
Authority
CR
Costa Rica
Prior art keywords
del
androgénico
androgen receptor
receptor
modulador
Prior art date
Application number
CR20190331A
Other languages
English (en)
Inventor
Nicholas D Smith
Mark R Herbert
Ouathek Ouerfelli
Anna Dilhas
Original Assignee
Aragon Pharmaceuticals Inc
Sloan Kettering Inst Cancer Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=49712550&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CR20190331(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aragon Pharmaceuticals Inc, Sloan Kettering Inst Cancer Res filed Critical Aragon Pharmaceuticals Inc
Publication of CR20190331A publication Critical patent/CR20190331A/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/41641,3-Diazoles
    • A61K31/41841,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28Antiandrogens
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CR20190331A 2012-06-07 2013-06-04 UNA FORMA CRISTALINA A DE UN MODULADOR DEL RECEPTOR ANDROGÉNICO (Divisional 2014-0549) CR20190331A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261656888P 2012-06-07 2012-06-07
PCT/US2013/044116 WO2013184681A1 (en) 2012-06-07 2013-06-04 Crystalline forms of an androgen receptor modulator

Publications (1)

Publication Number Publication Date
CR20190331A true CR20190331A (es) 2019-11-12

Family

ID=49712550

Family Applications (2)

Application Number Title Priority Date Filing Date
CR20190331A CR20190331A (es) 2012-06-07 2013-06-04 UNA FORMA CRISTALINA A DE UN MODULADOR DEL RECEPTOR ANDROGÉNICO (Divisional 2014-0549)
CR20140549A CR20140549A (es) 2012-06-07 2014-12-01 Formas cristalinas de un modulador del receptor androgénico

Family Applications After (1)

Application Number Title Priority Date Filing Date
CR20140549A CR20140549A (es) 2012-06-07 2014-12-01 Formas cristalinas de un modulador del receptor androgénico

Country Status (42)

Country Link
US (8) US9481663B2 (es)
EP (4) EP2858985B1 (es)
JP (3) JP6182209B2 (es)
KR (2) KR102062024B1 (es)
CN (3) CN104619692A (es)
AU (3) AU2013271751B2 (es)
BR (1) BR112014030678A2 (es)
CA (4) CA3114726A1 (es)
CL (1) CL2014003331A1 (es)
CO (1) CO7240407A2 (es)
CR (2) CR20190331A (es)
CY (3) CY1120393T1 (es)
DK (3) DK2858985T3 (es)
EA (3) EA033956B1 (es)
EC (1) ECSP14030098A (es)
ES (3) ES2809738T3 (es)
FR (1) FR21C1050I2 (es)
GT (1) GT201400283A (es)
HK (2) HK1210175A1 (es)
HR (3) HRP20180902T1 (es)
HU (4) HUE050357T2 (es)
IL (4) IL236055A0 (es)
IN (1) IN2014DN10084A (es)
LT (4) LT3533792T (es)
ME (2) ME03815B (es)
MX (1) MX356754B (es)
MY (1) MY187500A (es)
NI (1) NI201400142A (es)
NO (1) NO2021046I1 (es)
NZ (2) NZ702203A (es)
PE (2) PE20150631A1 (es)
PH (2) PH12014502714B1 (es)
PL (3) PL3533792T3 (es)
PT (3) PT3533792T (es)
RS (3) RS57370B1 (es)
SG (3) SG11201408140QA (es)
SI (3) SI2858985T1 (es)
TR (1) TR201808939T4 (es)
TW (1) TWI532732B (es)
UA (2) UA123142C2 (es)
WO (1) WO2013184681A1 (es)
ZA (1) ZA201500076B (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8461343B2 (en) 2007-03-27 2013-06-11 Sloan-Kettering Institute For Cancer Research Synthesis of thiohydantoins
EP2385960B1 (en) 2009-01-12 2020-03-11 University Of Massachusetts Lowell Polyisobutylene-based polyurethanes
CA2857061A1 (en) 2011-12-16 2013-06-20 Olema Pharmaceuticals, Inc. Novel benzopyran compounds, compositions and uses thereof
EP2858985B1 (en) 2012-06-07 2018-04-18 Aragon Pharmaceuticals, Inc. Crystalline forms of an androgen receptor modulator
RS62676B1 (sr) 2012-09-11 2021-12-31 Medivation Prostate Therapeutics Llc Formulacije enzalutamida
EA202190820A1 (ru) 2012-09-26 2021-10-29 Арагон Фармасьютикалз, Инк. Антиандрогены для лечения неметастатического кастрационно-резистентного рака простаты
US9926399B2 (en) 2012-11-21 2018-03-27 University Of Massachusetts High strength polyisobutylene polyurethanes
JOP20200097A1 (ar) * 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
EP3186247B1 (en) * 2014-08-26 2021-03-03 Astar Biotech LLC Protein kinase inhibitors
MA41107A (fr) 2014-12-05 2017-10-10 Aragon Pharmaceuticals Inc Compositions anti-cancéreuses
SI3226843T1 (sl) 2014-12-05 2021-11-30 Aragon Pharmaceuticals, Inc. Protirakavi sestavki
LT3226842T (lt) 2014-12-05 2021-03-25 Aragon Pharmaceuticals, Inc. Priešvėžinės kompozicijos
WO2016100905A1 (en) 2014-12-19 2016-06-23 Lutron Electronics Co., Inc. Multi-channel lighting fixture having multiple light-emitting diode drivers
CN109219437A (zh) 2016-06-03 2019-01-15 阿拉贡药品公司 抗癌组合物
EP3555061B1 (en) 2016-12-13 2023-06-07 Watson Laboratories Inc. Solid state forms of apalutamide
EP3592786B1 (en) 2017-03-07 2023-05-10 Cardiac Pacemakers, Inc. Hydroboration/oxidation of allyl-terminated polyisobutylene
US10835638B2 (en) 2017-08-17 2020-11-17 Cardiac Pacemakers, Inc. Photocrosslinked polymers for enhanced durability
WO2019078920A1 (en) 2017-10-16 2019-04-25 Aragon Pharmaceuticals, Inc. ANTI-ANDROGENS FOR THE TREATMENT OF NON-METASTATIC RESISTANT PROSTATE CANCER
WO2019135254A1 (en) 2018-01-02 2019-07-11 Mylan Laboratories Limited Apalutamide polymorphs and their preparation thereof
EP3740253B1 (en) 2018-01-17 2023-08-16 Cardiac Pacemakers, Inc. End-capped polyisobutylene polyurethane
US20200270226A1 (en) * 2018-06-20 2020-08-27 Crystal Pharmaceutical (Suzhou) Co., Ltd. Crystalline forms of arn-509, preparation method and use thereof
WO2020049598A2 (en) 2018-09-08 2020-03-12 Cipla Limited Apalutamide polymorphs
IT201900003839A1 (it) 2019-03-15 2020-09-15 Olon Spa Sintesi di apalutamide amorfa stabile
WO2020234817A1 (en) * 2019-05-21 2020-11-26 Laurus Labs Limited Polymorphic forms of apalutamide and its preparation thereof
IT201900010593A1 (it) 2019-07-01 2021-01-01 Dipharma Francis Srl Forma cristallina di un inibitore di recettori degli androgeni
WO2021033098A1 (en) * 2019-08-22 2021-02-25 Dr. Reddy’S Laboratories Limited Process for the preparation of apalutamide
IT201900015974A1 (it) 2019-09-10 2021-03-10 Olon Spa Apalutamide cristallina stabile in forma pura e processo per la sua preparazione
CN110590740A (zh) * 2019-09-20 2019-12-20 武汉大学 一种阿帕鲁胺化合物及其药物制剂
US20230312507A1 (en) 2020-09-04 2023-10-05 Synthon B.V. Improved process for preparation of apalutamide
WO2023143090A1 (zh) * 2022-01-25 2023-08-03 成都苑东生物制药股份有限公司 一种阿帕他胺溶剂化物新晶型及其制备方法

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5323907A (en) 1992-06-23 1994-06-28 Multi-Comp, Inc. Child resistant package assembly for dispensing pharmaceutical medications
US7709517B2 (en) 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
CN101032483B (zh) 2006-03-09 2011-05-04 陈德桂 调节雄激素受体活性的乙内酰脲衍生物及其应用
DK2656842T3 (en) * 2006-03-27 2016-11-07 Univ California Androgen receptor MODULATOR FOR THE TREATMENT OF PROSTATE CANCER AND androgen receptor-ASSOCIATED DISEASES
SG10201408699TA (en) * 2006-03-29 2015-02-27 Univ California Diarylthiohydantoin compounds
US8461343B2 (en) 2007-03-27 2013-06-11 Sloan-Kettering Institute For Cancer Research Synthesis of thiohydantoins
MX355915B (es) * 2010-02-16 2018-05-04 Aragon Pharmaceuticals Inc Moduladores del receptor de androgenos y usos de los mismos.
EP2858985B1 (en) 2012-06-07 2018-04-18 Aragon Pharmaceuticals, Inc. Crystalline forms of an androgen receptor modulator
US20200270226A1 (en) 2018-06-20 2020-08-27 Crystal Pharmaceutical (Suzhou) Co., Ltd. Crystalline forms of arn-509, preparation method and use thereof

Also Published As

Publication number Publication date
HUE038082T2 (hu) 2018-09-28
IL275413A (en) 2020-07-30
EP3533792A1 (en) 2019-09-04
KR102062024B1 (ko) 2020-01-03
UA123142C2 (uk) 2021-02-24
HUE054595T2 (hu) 2021-09-28
EP3348553A1 (en) 2018-07-18
PT3533792T (pt) 2021-06-07
NZ717683A (en) 2018-04-27
EP3922629A1 (en) 2021-12-15
LT3348553T (lt) 2020-09-25
US20180258067A1 (en) 2018-09-13
PL2858985T3 (pl) 2018-09-28
JP6345821B2 (ja) 2018-06-20
US10526310B2 (en) 2020-01-07
US9481663B2 (en) 2016-11-01
DK3533792T3 (da) 2021-06-28
CN105693692A (zh) 2016-06-22
ECSP14030098A (es) 2016-01-29
IN2014DN10084A (es) 2015-08-21
CY1123427T1 (el) 2021-12-31
SG11201408140QA (en) 2015-01-29
DK2858985T3 (en) 2018-05-28
ES2875932T3 (es) 2021-11-11
LT3533792T (lt) 2021-07-26
PH12014502714A1 (en) 2015-02-02
MY187500A (en) 2021-09-24
HRP20201387T1 (hr) 2020-11-27
HRP20210909T1 (hr) 2021-09-03
PH12014502714B1 (en) 2015-02-02
JP6182209B2 (ja) 2017-08-16
PL3533792T3 (pl) 2021-11-29
LTPA2021525I1 (es) 2021-11-25
SG10201610248SA (en) 2017-02-27
AU2013271751A1 (en) 2014-12-18
HK1210175A1 (en) 2016-04-15
MX356754B (es) 2018-06-11
IL259738B (en) 2021-06-30
NI201400142A (es) 2016-12-02
US10934271B2 (en) 2021-03-02
EP3533792B1 (en) 2021-05-05
DK3348553T3 (da) 2020-07-27
US20170001977A1 (en) 2017-01-05
PE20200725A1 (es) 2020-07-21
CA3055660A1 (en) 2013-12-12
FR21C1050I2 (fr) 2024-05-24
SI3533792T1 (sl) 2021-11-30
CA3008345A1 (en) 2013-12-12
CA3008345C (en) 2019-10-22
ME03815B (me) 2021-04-20
US20190241539A1 (en) 2019-08-08
US10308630B2 (en) 2019-06-04
TR201808939T4 (tr) 2018-07-23
JP2017178923A (ja) 2017-10-05
KR20190132543A (ko) 2019-11-27
AU2017200298A1 (en) 2017-02-02
BR112014030678A2 (pt) 2017-06-27
CA2875767A1 (en) 2013-12-12
EP2858985A1 (en) 2015-04-15
PT2858985T (pt) 2018-07-10
HUE050357T2 (hu) 2020-11-30
CL2014003331A1 (es) 2016-03-04
NZ702203A (en) 2016-09-30
ME03081B (me) 2019-01-20
US20190330182A1 (en) 2019-10-31
ZA201500076B (en) 2016-10-26
PE20150631A1 (es) 2015-05-11
AU2017200298B2 (en) 2017-09-28
ES2670683T3 (es) 2018-05-31
HK1226066A1 (zh) 2017-09-22
UA115665C2 (uk) 2017-12-11
CY1124831T1 (el) 2022-03-24
RS61988B1 (sr) 2021-07-30
SI2858985T1 (sl) 2018-12-31
AU2013271751B2 (en) 2017-02-23
LT2858985T (lt) 2018-09-25
US20210163441A1 (en) 2021-06-03
CA2875767C (en) 2018-08-14
HRP20180902T1 (hr) 2018-08-24
CO7240407A2 (es) 2015-04-17
SG10201610249TA (en) 2017-02-27
KR102195916B1 (ko) 2020-12-30
JP2015518890A (ja) 2015-07-06
US10556882B2 (en) 2020-02-11
IL267608A (en) 2019-08-29
EP3348553B1 (en) 2020-07-08
PH12016501470A1 (en) 2017-07-10
TW201402561A (zh) 2014-01-16
EA201992010A1 (ru) 2020-01-24
CY1120393T1 (el) 2019-07-10
TWI532732B (zh) 2016-05-11
SI3348553T1 (sl) 2020-11-30
CR20140549A (es) 2015-04-06
PT3348553T (pt) 2020-09-28
EA028791B1 (ru) 2017-12-29
EA201791592A1 (ru) 2018-01-31
US20200115361A1 (en) 2020-04-16
KR20150021993A (ko) 2015-03-03
ES2809738T3 (es) 2021-03-05
RS57370B1 (sr) 2018-08-31
EP2858985A4 (en) 2016-05-25
AU2017279807A1 (en) 2018-01-25
GT201400283A (es) 2017-07-03
JP2018141009A (ja) 2018-09-13
PL3348553T3 (pl) 2021-02-08
US20200354335A1 (en) 2020-11-12
CN104619692A (zh) 2015-05-13
IL259738A (en) 2018-07-31
MX2014015005A (es) 2015-09-04
US20150133481A1 (en) 2015-05-14
AU2017279807B2 (en) 2018-11-08
HUS2100047I1 (hu) 2021-11-29
RS60617B1 (sr) 2020-09-30
EA033956B1 (ru) 2019-12-13
EP2858985B1 (en) 2018-04-18
CA3114726A1 (en) 2013-12-12
PH12016501470B1 (en) 2017-07-10
US9994545B2 (en) 2018-06-12
CN113135892A (zh) 2021-07-20
IL236055A0 (en) 2015-02-01
WO2013184681A1 (en) 2013-12-12
EA201492272A1 (ru) 2015-05-29
FR21C1050I1 (fr) 2021-12-10
NO2021046I1 (no) 2021-11-02
US10766875B2 (en) 2020-09-08

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