CR20140047A - Dominios variables singulares anti-vgf fusionados con dominios de fc - Google Patents
Dominios variables singulares anti-vgf fusionados con dominios de fcInfo
- Publication number
- CR20140047A CR20140047A CR20140047A CR20140047A CR20140047A CR 20140047 A CR20140047 A CR 20140047A CR 20140047 A CR20140047 A CR 20140047A CR 20140047 A CR20140047 A CR 20140047A CR 20140047 A CR20140047 A CR 20140047A
- Authority
- CR
- Costa Rica
- Prior art keywords
- domains
- antigen binding
- vgf
- dimers
- fused
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Diabetes (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Obesity (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención está dirigida a construcciones de unión de antígeno que comprenden uno o dos dominios de unión de epítope separados por una región Fc de una sola cadena de un anticuerpo, en donde cada dominio de unión de epítope es capaz de unirse a VEGF; a dímeros que comprenden dos construcciones de unión de antígeno de la invención; composiciones farmacéuticas que comprenden dichos dímeros, y su uso en el tratamiento de enfermedades asociadas con la señalización de VEGF, tales como edema macular diabético (DME), degeneración macular húmeda asociada con la edad (AMD húmeda), retinopatía diabética, oclusión de la vena retinal (RVO) y neovascularización corneal; y secuencias de polinucleótido que codifican dichas construcciones de unión de antígeno.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161512138P | 2011-07-27 | 2011-07-27 |
Publications (1)
Publication Number | Publication Date |
---|---|
CR20140047A true CR20140047A (es) | 2014-03-24 |
Family
ID=46579044
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CR20140047A CR20140047A (es) | 2011-07-27 | 2014-01-28 | Dominios variables singulares anti-vgf fusionados con dominios de fc |
Country Status (18)
Country | Link |
---|---|
US (2) | US9499612B2 (es) |
EP (1) | EP2736925A2 (es) |
JP (1) | JP5987057B2 (es) |
KR (1) | KR101632620B1 (es) |
CN (1) | CN103842380A (es) |
AU (1) | AU2012288846B2 (es) |
BR (1) | BR112014001855A2 (es) |
CA (1) | CA2842099A1 (es) |
CL (1) | CL2014000204A1 (es) |
CO (1) | CO7020847A2 (es) |
CR (1) | CR20140047A (es) |
DO (1) | DOP2014000017A (es) |
EA (1) | EA028886B1 (es) |
HK (1) | HK1198446A1 (es) |
MA (1) | MA35352B1 (es) |
MX (1) | MX2014001019A (es) |
PE (1) | PE20141659A1 (es) |
WO (1) | WO2013014208A2 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US11644471B2 (en) | 2010-09-30 | 2023-05-09 | Ablynx N.V. | Techniques for predicting, detecting and reducing aspecific protein interference in assays involving immunoglobulin single variable domains |
EP2853542A1 (en) * | 2010-11-24 | 2015-04-01 | Glaxo Group Limited | Multispecific antigen binding proteins targeting HGF |
KR20220114104A (ko) | 2011-06-23 | 2022-08-17 | 아블린쓰 엔.브이. | 면역글로불린 단일 가변 도메인을 수반하는 어세이에서 비특이적 단백질 간섭을 예측하고 검출하고 감소시키는 기법 |
US9840553B2 (en) | 2014-06-28 | 2017-12-12 | Kodiak Sciences Inc. | Dual PDGF/VEGF antagonists |
EA201791029A1 (ru) * | 2014-11-10 | 2017-12-29 | Дженентек, Инк. | Антитела против интерлейкина-33 и их применение |
CN107428828A (zh) | 2015-03-11 | 2017-12-01 | 葛兰素史密斯克莱知识产权发展有限公司 | Tslp结合蛋白 |
BR112018013407A2 (pt) | 2015-12-30 | 2018-12-18 | Kodiak Sciences Inc | anticorpos e conjugados dos mesmos |
MX2018009389A (es) * | 2016-03-16 | 2018-11-21 | Univ California | Polipeptidos de union a la proteina a, anticuerpos anti-epha2 y metodos de uso de estos. |
US20190119387A1 (en) | 2016-04-05 | 2019-04-25 | Glaxosmithkline Intellectual Property Development Limited | Inhibition of tgfbeta in immunotherapy |
WO2018129397A1 (en) * | 2017-01-06 | 2018-07-12 | Momenta Pharmaceuticals, Inc. | Compositions and methods related to engineered fc-antigen binding domain constructs |
CN109021103B (zh) * | 2017-06-12 | 2022-08-23 | 上海睿智化学研究有限公司 | 抗人血管内皮生长因子的抗体及其制备方法和应用 |
AU2020364071A1 (en) | 2019-10-10 | 2022-05-26 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
JP2023517345A (ja) | 2020-03-13 | 2023-04-25 | ジェネンテック, インコーポレイテッド | 抗インターロイキン-33抗体及びその使用 |
EP4294839A1 (en) * | 2021-02-19 | 2023-12-27 | DotBio Pte. Ltd. | Vegfa-binding molecules |
WO2023014892A1 (en) * | 2021-08-04 | 2023-02-09 | Alpine Biotherapeutics Corporation | Sustainable ocular cell-mediated intraocular delivery of cellular therapeutics for treatment of ocular diseases or disorders |
WO2023016516A1 (zh) * | 2021-08-13 | 2023-02-16 | 信达生物制药(苏州)有限公司 | 抗vegf a和vegf c双特异性抗体及其用途 |
WO2024029876A1 (ko) * | 2022-08-02 | 2024-02-08 | 주식회사 파노로스바이오사이언스 | 변형된 융합 단백질 및 이의 용도 |
WO2024055995A1 (zh) * | 2022-09-14 | 2024-03-21 | 寻济生物科技(北京)有限公司 | 一种抗vegfa融合蛋白及其制备方法和应用 |
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US4666884A (en) | 1984-04-10 | 1987-05-19 | New England Deaconess Hospital | Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls |
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EP0640094A1 (en) | 1992-04-24 | 1995-03-01 | The Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
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MXPA04001072A (es) | 2001-08-03 | 2005-02-17 | Glycart Biotechnology Ag | Variantes de glicosilacion de anticuerpos que tienen citotoxicidad celulares dependiente de anticuerpos incrementada. |
US7696320B2 (en) * | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
CN101039959A (zh) * | 2004-06-30 | 2007-09-19 | 杜门蒂斯有限公司 | 用于治疗炎性疾病的组合物和方法 |
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UA94213C2 (ru) * | 2004-09-17 | 2011-04-26 | Домантис Лимитед | Применение полипептида одноцепочечного антитела, который подавляет активность cd40 или cd40l в приготовлении медикамента для лечения аутоиммунного заболевания |
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CA2753287A1 (en) * | 2009-02-24 | 2010-09-02 | Glaxo Group Limited | Antigen-binding constructs |
AU2010251966A1 (en) * | 2009-05-28 | 2011-12-22 | Glaxo Group Limited | Combination of a TNF-alpha antagonist and a VEGF antagonist for use in the treatment or prevention of diseases of the eye. |
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EP2504360B1 (en) * | 2009-11-23 | 2018-08-15 | Amgen Inc. | Monomeric antibody fc |
EP2853542A1 (en) * | 2010-11-24 | 2015-04-01 | Glaxo Group Limited | Multispecific antigen binding proteins targeting HGF |
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-
2012
- 2012-07-25 JP JP2014522089A patent/JP5987057B2/ja not_active Expired - Fee Related
- 2012-07-25 EP EP12738476.6A patent/EP2736925A2/en not_active Ceased
- 2012-07-25 BR BR112014001855A patent/BR112014001855A2/pt not_active IP Right Cessation
- 2012-07-25 PE PE2014000126A patent/PE20141659A1/es not_active Application Discontinuation
- 2012-07-25 WO PCT/EP2012/064632 patent/WO2013014208A2/en active Application Filing
- 2012-07-25 KR KR1020147005082A patent/KR101632620B1/ko active IP Right Grant
- 2012-07-25 US US14/235,330 patent/US9499612B2/en not_active Expired - Fee Related
- 2012-07-25 AU AU2012288846A patent/AU2012288846B2/en not_active Ceased
- 2012-07-25 MX MX2014001019A patent/MX2014001019A/es unknown
- 2012-07-25 EA EA201391812A patent/EA028886B1/ru not_active IP Right Cessation
- 2012-07-25 CN CN201280047197.3A patent/CN103842380A/zh active Pending
- 2012-07-25 CA CA2842099A patent/CA2842099A1/en not_active Abandoned
-
2014
- 2014-01-27 DO DO2014000017A patent/DOP2014000017A/es unknown
- 2014-01-27 CL CL2014000204A patent/CL2014000204A1/es unknown
- 2014-01-28 CR CR20140047A patent/CR20140047A/es unknown
- 2014-01-29 CO CO14018316A patent/CO7020847A2/es unknown
- 2014-02-18 MA MA36759A patent/MA35352B1/fr unknown
- 2014-11-26 HK HK14111941.1A patent/HK1198446A1/xx unknown
-
2016
- 2016-10-14 US US15/294,058 patent/US20170029494A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EA201391812A1 (ru) | 2014-06-30 |
WO2013014208A3 (en) | 2013-05-10 |
JP5987057B2 (ja) | 2016-09-06 |
WO2013014208A2 (en) | 2013-01-31 |
JP2014523746A (ja) | 2014-09-18 |
CN103842380A (zh) | 2014-06-04 |
AU2012288846B2 (en) | 2016-05-19 |
EA028886B1 (ru) | 2018-01-31 |
CO7020847A2 (es) | 2014-08-11 |
KR101632620B1 (ko) | 2016-06-23 |
CL2014000204A1 (es) | 2014-07-25 |
US9499612B2 (en) | 2016-11-22 |
AU2012288846A1 (en) | 2014-02-06 |
DOP2014000017A (es) | 2014-04-30 |
MX2014001019A (es) | 2014-05-13 |
US20140205604A1 (en) | 2014-07-24 |
US20170029494A1 (en) | 2017-02-02 |
MA35352B1 (fr) | 2014-08-01 |
BR112014001855A2 (pt) | 2017-02-21 |
KR20140041908A (ko) | 2014-04-04 |
HK1198446A1 (en) | 2015-04-24 |
EP2736925A2 (en) | 2014-06-04 |
PE20141659A1 (es) | 2014-11-21 |
CA2842099A1 (en) | 2013-01-31 |
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