CO6801735A2 - Derivados de pirazolidin-3-ona - Google Patents

Derivados de pirazolidin-3-ona

Info

Publication number
CO6801735A2
CO6801735A2 CO13205224A CO13205224A CO6801735A2 CO 6801735 A2 CO6801735 A2 CO 6801735A2 CO 13205224 A CO13205224 A CO 13205224A CO 13205224 A CO13205224 A CO 13205224A CO 6801735 A2 CO6801735 A2 CO 6801735A2
Authority
CO
Colombia
Prior art keywords
lower alkyl
res
hydrogen
derivatives
formula
Prior art date
Application number
CO13205224A
Other languages
English (en)
Inventor
Georg Jaeschke
Synese Jolidon
Lothar Lindermann
Antonio Ricci
Daniel Rueher
Heinz Stadler
Eric Vieira
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45998366&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6801735(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of CO6801735A2 publication Critical patent/CO6801735A2/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

La presente invención se refiere a derivados de etinilo de la fórmula IX es N o CH;G es N o CH;con la condición de que como máximo uno de X y G pueda ser nitrógeno;Res fenilo o piridilo, que están opcionalmente sustituidos por halógeno, alquilo inferior o alcoxi inferior;Res hidrógeno, alquilo inferior o junto con Rpuede formar un cicloalquilo C-C;R/R/R/Rcon independencia entre sí son hidrógeno, alquilo inferior o CF; o a una sal de adición de ácido farmacéuticamente aceptable, a una mezcla racémica, o a sus enantiómeros y/o isómeros ópticos y/o estereoisómeros correspondientes.Ahora se ha encontrado de modo sorprendente que los compuestos de la fórmula general I son moduladores alostéricos positivos (PAM) del receptor del glutamato metabotrópico del subtipo 5 (mGluR5).
CO13205224A 2011-04-26 2013-08-29 Derivados de pirazolidin-3-ona CO6801735A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP11163708 2011-04-26

Publications (1)

Publication Number Publication Date
CO6801735A2 true CO6801735A2 (es) 2013-11-29

Family

ID=45998366

Family Applications (1)

Application Number Title Priority Date Filing Date
CO13205224A CO6801735A2 (es) 2011-04-26 2013-08-29 Derivados de pirazolidin-3-ona

Country Status (24)

Country Link
US (1) US8648088B2 (es)
EP (1) EP2702050B1 (es)
JP (1) JP5753626B2 (es)
KR (1) KR101576343B1 (es)
CN (1) CN103492374B (es)
AR (1) AR086037A1 (es)
CA (1) CA2829171C (es)
CL (1) CL2013003068A1 (es)
CO (1) CO6801735A2 (es)
CR (1) CR20130476A (es)
EA (1) EA023146B1 (es)
EC (1) ECSP13012990A (es)
ES (1) ES2580333T3 (es)
HK (1) HK1191329A1 (es)
IL (1) IL229005A (es)
MA (1) MA35134B1 (es)
MX (1) MX2013011107A (es)
MY (1) MY165141A (es)
PE (1) PE20141168A1 (es)
SG (1) SG194095A1 (es)
TW (1) TWI434840B (es)
UA (1) UA113625C2 (es)
WO (1) WO2012146552A1 (es)
ZA (1) ZA201307404B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA110862C2 (uk) * 2011-10-07 2016-02-25 Ф. Хоффманн-Ля Рош Аг Похідні етинілу як алостеричні модулятори метаботропного рецептора глутамату mglur 5
UA113223C2 (xx) * 2012-08-13 2016-12-26 Арилетинілпіримідини
UA116023C2 (uk) * 2013-07-08 2018-01-25 Ф. Хоффманн-Ля Рош Аг Етинільні похідні як антагоністи метаботропного глутаматного рецептора
UA120309C2 (uk) * 2015-06-03 2019-11-11 Ф. Хоффманн-Ля Рош Аг Етинільні похідні
RS58929B1 (sr) 2015-07-15 2019-08-30 Hoffmann La Roche Derivati etinila kao modulatori metabotropnih glutamatnih receptora
AR105556A1 (es) * 2015-08-03 2017-10-18 Hoffmann La Roche Derivados de etinilo

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0325956D0 (en) 2003-11-06 2003-12-10 Addex Pharmaceuticals Sa Novel compounds
AU2005336513B2 (en) * 2004-10-07 2012-08-09 Merck Sharp & Dohme Llc Thiazolyl mGluR5 antagonists and methods for their use
EP1809620B1 (en) 2004-11-04 2010-12-29 Addex Pharma SA Novel tetrazole derivatives as positive allosteric modulators of metabotropic glutamate receptors
GB0510139D0 (en) 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B1
US20100179161A1 (en) * 2005-08-19 2010-07-15 Astrazeneca Ab Pyrazoline derivatives for the treatment of turberculosis
MX2009013169A (es) 2007-06-03 2010-04-30 Univ Vanderbilt Moduladores alostericos positivos del mglur5 benzamida y metodos de elaboracion y uso de los mismos.
US8853392B2 (en) * 2007-06-03 2014-10-07 Vanderbilt University Benzamide mGluR5 positive allosteric modulators and methods of making and using same

Also Published As

Publication number Publication date
AU2012247654A1 (en) 2013-09-19
US8648088B2 (en) 2014-02-11
NZ614883A (en) 2015-09-25
EA023146B1 (ru) 2016-04-29
EP2702050A1 (en) 2014-03-05
CA2829171A1 (en) 2012-11-01
CR20130476A (es) 2013-11-11
ECSP13012990A (es) 2013-11-29
JP2014514315A (ja) 2014-06-19
AR086037A1 (es) 2013-11-13
IL229005A (en) 2016-02-29
MX2013011107A (es) 2013-10-17
UA113625C2 (xx) 2017-02-27
CN103492374B (zh) 2016-06-01
US20120277243A1 (en) 2012-11-01
JP5753626B2 (ja) 2015-07-22
TWI434840B (zh) 2014-04-21
KR20130143141A (ko) 2013-12-30
WO2012146552A1 (en) 2012-11-01
CA2829171C (en) 2019-02-26
PE20141168A1 (es) 2014-09-22
MA35134B1 (fr) 2014-05-02
SG194095A1 (en) 2013-11-29
EA201391538A1 (ru) 2014-04-30
CL2013003068A1 (es) 2014-05-09
EP2702050B1 (en) 2016-05-18
IL229005A0 (en) 2013-12-31
HK1191329A1 (zh) 2014-07-25
ES2580333T3 (es) 2016-08-23
ZA201307404B (en) 2014-06-25
MY165141A (en) 2018-02-28
KR101576343B1 (ko) 2015-12-09
TW201309669A (zh) 2013-03-01
CN103492374A (zh) 2014-01-01

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