CO6650362A2 - Compuesto de piperdinilo como modulador de la actividad de receptor de quimiocinas - Google Patents
Compuesto de piperdinilo como modulador de la actividad de receptor de quimiocinasInfo
- Publication number
- CO6650362A2 CO6650362A2 CO13001893A CO13001893A CO6650362A2 CO 6650362 A2 CO6650362 A2 CO 6650362A2 CO 13001893 A CO13001893 A CO 13001893A CO 13001893 A CO13001893 A CO 13001893A CO 6650362 A2 CO6650362 A2 CO 6650362A2
- Authority
- CO
- Colombia
- Prior art keywords
- compound
- piperdinyl
- modulator
- chemokine receptor
- receptor activity
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/52—Oxygen atoms attached in position 4 having an aryl radical as the second substituent in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Communicable Diseases (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Transplantation (AREA)
- Gastroenterology & Hepatology (AREA)
Abstract
La presente solicitud describe el compuesto de Fórmula (I) o estereoisómeros o sales farmacéuticamente aceptables del mismo. Además, se describen métodos de tratar y prevenir enfermedades inflamatorias, tales como asma y enfermedades alérgicas, así como patologías autoinmunitarias, tales como artritis reumatoide y arterosclerosis, usando el compuesto de la invención.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US35522510P | 2010-06-16 | 2010-06-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO6650362A2 true CO6650362A2 (es) | 2013-04-15 |
Family
ID=44278764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO13001893A CO6650362A2 (es) | 2010-06-16 | 2013-01-04 | Compuesto de piperdinilo como modulador de la actividad de receptor de quimiocinas |
Country Status (20)
Country | Link |
---|---|
US (1) | US8642622B2 (es) |
EP (1) | EP2582670B1 (es) |
JP (1) | JP5795797B2 (es) |
KR (1) | KR20130032357A (es) |
CN (1) | CN103068800B (es) |
AR (1) | AR081943A1 (es) |
AU (1) | AU2011268373B2 (es) |
BR (1) | BR112012031768A2 (es) |
CL (1) | CL2012003521A1 (es) |
CO (1) | CO6650362A2 (es) |
EA (1) | EA022395B1 (es) |
IL (1) | IL223368A0 (es) |
MA (1) | MA34377B1 (es) |
MX (1) | MX2012014068A (es) |
NZ (1) | NZ605741A (es) |
SG (1) | SG186064A1 (es) |
TN (1) | TN2012000581A1 (es) |
TW (1) | TW201206435A (es) |
WO (1) | WO2011159852A1 (es) |
ZA (1) | ZA201300380B (es) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102648193A (zh) * | 2009-10-07 | 2012-08-22 | 百时美施贵宝公司 | 作为趋化因子受体活性调节剂的螺环化合物 |
SG186223A1 (en) | 2010-06-16 | 2013-01-30 | Takeda Pharmaceutical | Crystal of amide compound |
CN108135168B (zh) | 2015-05-21 | 2021-07-20 | 凯莫森特里克斯股份有限公司 | Ccr2调节剂 |
EP3375778A1 (en) | 2017-03-14 | 2018-09-19 | Artax Biopharma Inc. | Aryl-piperidine derivatives |
US11304952B2 (en) | 2017-09-25 | 2022-04-19 | Chemocentryx, Inc. | Combination therapy using a chemokine receptor 2 (CCR2) antagonist and a PD-1/PD-L1 inhibitor |
KR102037494B1 (ko) | 2017-12-11 | 2019-10-28 | 씨제이헬스케어 주식회사 | 광학활성을 갖는 피페리딘 유도체의 중간체 및 이의 제조방법 |
WO2019136368A2 (en) | 2018-01-08 | 2019-07-11 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
US20190269664A1 (en) | 2018-01-08 | 2019-09-05 | Chemocentryx, Inc. | Methods of treating solid tumors with ccr2 antagonists |
WO2024099908A1 (en) | 2022-11-09 | 2024-05-16 | Boehringer Ingelheim International Gmbh | Cyclic pyridine derivatives as cgas inhibitors |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9104656D0 (en) | 1991-03-05 | 1991-04-17 | Zambeletti Spa L | Pharmaceuticals |
DE4243858A1 (de) | 1992-12-23 | 1994-06-30 | Thomae Gmbh Dr K | Aminosäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
US5459151A (en) | 1993-04-30 | 1995-10-17 | American Home Products Corporation | N-acyl substituted phenyl piperidines as bronchodilators and antiinflammatory agents |
US5492920A (en) | 1993-12-10 | 1996-02-20 | Merck & Co., Inc. | Piperidine, pyrrolidine and hexahydro-1H-azepines promote release of growth hormone |
AU2695795A (en) | 1994-06-13 | 1996-01-05 | Merck & Co., Inc. | Piperazine compounds promote release of growth hormone |
CN1195343A (zh) | 1995-07-13 | 1998-10-07 | 千寿制药株式会社 | 哌啶衍生物及其用途 |
WO1997038665A2 (en) | 1996-04-03 | 1997-10-23 | Merck & Co., Inc. | Inhibitors of farnesyl-protein transferase |
ATE266673T1 (de) | 1996-09-10 | 2004-05-15 | Boehringer Ingelheim Pharma | Abgewandelte aminosäuren, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
WO1998017625A1 (fr) | 1996-10-22 | 1998-04-30 | Daiichi Pharmaceutical Co., Ltd. | Nouveaux remedes pour des maladies infectieuses |
US5847148A (en) | 1997-04-10 | 1998-12-08 | Pharmacia & Upjohn Company | Thiadiazole derivatives useful for the treatment of diseases related to connective tissue degradation |
ZA987385B (en) | 1997-08-19 | 2000-04-18 | Lilly Co Eli | Growth hormone secretagogues. |
ZA987383B (en) | 1997-08-19 | 2000-02-17 | Lilly Co Eli | Treatment of congestive heart failure with growth hormone secretagogues. |
EP1079825B1 (en) | 1998-04-16 | 2010-07-21 | Encysive Pharmaceuticals, Inc | Compounds that inhibit the binding of integrins to their receptors |
US6391865B1 (en) | 1999-05-04 | 2002-05-21 | Schering Corporation | Piperazine derivatives useful as CCR5 antagonists |
WO2000074679A1 (en) | 1999-06-04 | 2000-12-14 | Merck & Co., Inc. | Substituted piperidines as melanocortin-4 receptor agonists |
DE10041402A1 (de) | 2000-08-23 | 2002-03-14 | Morphochem Ag | Neue Verbindungen, die Faktor Xa-Aktivität inhibieren |
JP2001354657A (ja) | 2000-06-09 | 2001-12-25 | Sds Biotech:Kk | 置換ピペラジン誘導体及び農園芸用殺菌剤 |
AU2001268607A1 (en) | 2000-06-21 | 2002-01-02 | Bristol-Myers Squibb Company | Piperidine amides as modulators of chemokine receptor activity |
ES2247298T3 (es) | 2001-01-23 | 2006-03-01 | Eli Lilly And Company | Derivados de piperazina y piperidina como agonistas del receptor de melanocortina. |
JP2004532838A (ja) | 2001-03-02 | 2004-10-28 | ブリストル−マイヤーズ スクイブ カンパニー | メラノコルチン受容体のモデュレーターとして有用な化合物及びそれを含む製薬組成物 |
DE10124041A1 (de) | 2001-05-16 | 2002-11-21 | Graffinity Pharm Design Gmbh | Protease Inhibitoren |
WO2003007949A1 (en) | 2001-07-18 | 2003-01-30 | Merck & Co., Inc. | Bridged piperidine derivatives as melanocortin receptor agonists |
US6977264B2 (en) | 2001-07-25 | 2005-12-20 | Amgen Inc. | Substituted piperidines and methods of use |
AR036492A1 (es) | 2001-09-06 | 2004-09-15 | Schering Corp | Inhibidores de la 17beta-hidroxiesteroide deshidrogenasa tipo 3, composiciones farmaceuticas y el uso de dichos inhibidores para la elaboracion de un medicamento para el tratamiento de enfermedades androgeno dependientes |
CA2471059C (en) | 2001-12-20 | 2011-04-26 | Osi Pharmaceuticals, Inc. | Pyrimidine a2b selective antagonist compounds, their synthesis and use |
DE60236458D1 (de) | 2001-12-20 | 2010-07-01 | Osi Pharm Inc | Pyrrolopyrimidin a2b selektive antagonistische verbindungen, deren synthese und verwendung |
US7041681B2 (en) | 2002-04-29 | 2006-05-09 | Janssen Pharmaceutica N.V. | Compounds as opioid receptor modulators |
US20050256130A1 (en) | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
GB0224917D0 (en) | 2002-10-25 | 2002-12-04 | Novartis Ag | Organic compounds |
WO2004042351A2 (en) | 2002-10-30 | 2004-05-21 | Merck & Co., Inc. | Piperidinyl-alpha-aminoamide modulators of chemokine receptor activity |
WO2004076418A1 (en) | 2003-02-28 | 2004-09-10 | Galderma Research & Development, S.N.C. | Ligands that modulate lxr-type receptors |
US6846836B2 (en) | 2003-04-18 | 2005-01-25 | Bristol-Myers Squibb Company | N-substituted phenylurea inhibitors of mitochondrial F1F0 ATP hydrolase |
AU2004249698A1 (en) | 2003-06-13 | 2004-12-29 | Schering Aktiengesellschaft | Quinolyl amide derivatives as CCR-5 antagonists |
GB0315203D0 (en) | 2003-06-28 | 2003-08-06 | Celltech R&D Ltd | Chemical compounds |
DE10358539A1 (de) | 2003-12-15 | 2005-07-07 | Merck Patent Gmbh | Carbonsäureamidderivate |
WO2005084672A1 (de) | 2004-03-03 | 2005-09-15 | Boehringer Ingelheim International Gmbh | Ausgewählte cgrp-antagonisten, verfahren zu deren herstellung sowie deren verwendung als arzneimittel |
GB0412468D0 (en) | 2004-06-04 | 2004-07-07 | Astrazeneca Ab | Chemical compounds |
US7723360B2 (en) | 2004-08-06 | 2010-05-25 | Boehringer Ingelheim International Gmbh | Alkyl-and piperidine-substituted benzimidazole derivatives |
US7615556B2 (en) | 2006-01-27 | 2009-11-10 | Bristol-Myers Squibb Company | Piperazinyl derivatives as modulators of chemokine receptor activity |
US7601844B2 (en) * | 2006-01-27 | 2009-10-13 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
CN101600691A (zh) * | 2006-01-27 | 2009-12-09 | 百时美施贵宝公司 | 作为趋化因子受体活性调节剂的哌啶基衍生物 |
EP2173713B1 (en) | 2007-07-24 | 2016-02-17 | Bristol-Myers Squibb Company | Piperidinyl derivatives as modulators of chemokine receptor activity |
CN101808990B (zh) | 2007-07-24 | 2012-09-05 | 百时美施贵宝公司 | 作为趋化因子受体活性调节剂的哌啶衍生物 |
TWI433838B (zh) | 2008-06-25 | 2014-04-11 | 必治妥美雅史谷比公司 | 作為趨化因子受體活性調節劑之六氫吡啶衍生物 |
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2011
- 2011-06-15 US US13/160,944 patent/US8642622B2/en active Active
- 2011-06-16 BR BR112012031768A patent/BR112012031768A2/pt not_active IP Right Cessation
- 2011-06-16 WO PCT/US2011/040605 patent/WO2011159852A1/en active Application Filing
- 2011-06-16 EP EP11728134.5A patent/EP2582670B1/en not_active Not-in-force
- 2011-06-16 AU AU2011268373A patent/AU2011268373B2/en not_active Ceased
- 2011-06-16 KR KR1020137001026A patent/KR20130032357A/ko not_active Application Discontinuation
- 2011-06-16 MX MX2012014068A patent/MX2012014068A/es active IP Right Grant
- 2011-06-16 EA EA201270790A patent/EA022395B1/ru not_active IP Right Cessation
- 2011-06-16 TW TW100121094A patent/TW201206435A/zh unknown
- 2011-06-16 CN CN201180039590.3A patent/CN103068800B/zh not_active Expired - Fee Related
- 2011-06-16 JP JP2013515497A patent/JP5795797B2/ja not_active Expired - Fee Related
- 2011-06-16 AR ARP110102087A patent/AR081943A1/es unknown
- 2011-06-16 NZ NZ605741A patent/NZ605741A/en not_active IP Right Cessation
- 2011-06-16 SG SG2012085353A patent/SG186064A1/en unknown
- 2011-06-16 MA MA35558A patent/MA34377B1/fr unknown
-
2012
- 2012-11-29 IL IL223368A patent/IL223368A0/en unknown
- 2012-12-07 TN TNP2012000581A patent/TN2012000581A1/en unknown
- 2012-12-12 CL CL2012003521A patent/CL2012003521A1/es unknown
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2013
- 2013-01-04 CO CO13001893A patent/CO6650362A2/es active IP Right Grant
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Also Published As
Publication number | Publication date |
---|---|
EA022395B1 (ru) | 2015-12-30 |
US20120149733A1 (en) | 2012-06-14 |
WO2011159852A1 (en) | 2011-12-22 |
MA34377B1 (fr) | 2013-07-03 |
EA201270790A1 (ru) | 2013-04-30 |
EP2582670A1 (en) | 2013-04-24 |
TN2012000581A1 (en) | 2014-04-01 |
SG186064A1 (en) | 2013-01-30 |
AU2011268373A1 (en) | 2013-01-31 |
KR20130032357A (ko) | 2013-04-01 |
AU2011268373B2 (en) | 2014-05-22 |
AR081943A1 (es) | 2012-10-31 |
CN103068800B (zh) | 2014-10-29 |
CN103068800A (zh) | 2013-04-24 |
JP5795797B2 (ja) | 2015-10-14 |
ZA201300380B (en) | 2014-06-25 |
MX2012014068A (es) | 2013-01-28 |
JP2013528656A (ja) | 2013-07-11 |
US8642622B2 (en) | 2014-02-04 |
NZ605741A (en) | 2014-08-29 |
IL223368A0 (en) | 2013-03-05 |
BR112012031768A2 (pt) | 2016-11-01 |
TW201206435A (en) | 2012-02-16 |
EP2582670B1 (en) | 2015-12-16 |
CL2012003521A1 (es) | 2013-02-15 |
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