CO6361930A2 - Nuevas combinaciones de compuestos heterociclicos nitrogenados antibacterianos con otros compuestos antibacterianos y su utilizacion como medicamentos - Google Patents
Nuevas combinaciones de compuestos heterociclicos nitrogenados antibacterianos con otros compuestos antibacterianos y su utilizacion como medicamentosInfo
- Publication number
- CO6361930A2 CO6361930A2 CO11043791A CO11043791A CO6361930A2 CO 6361930 A2 CO6361930 A2 CO 6361930A2 CO 11043791 A CO11043791 A CO 11043791A CO 11043791 A CO11043791 A CO 11043791A CO 6361930 A2 CO6361930 A2 CO 6361930A2
- Authority
- CO
- Colombia
- Prior art keywords
- antibacterial
- compounds
- nitrogen
- beta
- chosen
- Prior art date
Links
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 title abstract 4
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 4
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 229910052757 nitrogen Inorganic materials 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- -1 nitrogen heterocyclic compounds Chemical class 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- IZXIZTKNFFYFOF-UHFFFAOYSA-N 2-Oxazolidone Chemical class O=C1NCCO1 IZXIZTKNFFYFOF-UHFFFAOYSA-N 0.000 abstract 1
- 241000588921 Enterobacteriaceae Species 0.000 abstract 1
- 108010015899 Glycopeptides Proteins 0.000 abstract 1
- 102000002068 Glycopeptides Human genes 0.000 abstract 1
- 108010028921 Lipopeptides Proteins 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- 108010034396 Streptogramins Proteins 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229940126575 aminoglycoside Drugs 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 239000003781 beta lactamase inhibitor Substances 0.000 abstract 1
- 229940126813 beta-lactamase inhibitor Drugs 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 1
- 229940041028 lincosamides Drugs 0.000 abstract 1
- 239000003120 macrolide antibiotic agent Substances 0.000 abstract 1
- 229940041033 macrolides Drugs 0.000 abstract 1
- 239000011707 mineral Substances 0.000 abstract 1
- 229940041009 monobactams Drugs 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 230000002611 ovarian Effects 0.000 abstract 1
- 150000007660 quinolones Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940041030 streptogramins Drugs 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 229940040944 tetracyclines Drugs 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 150000003952 β-lactams Chemical class 0.000 abstract 1
- 229940126085 β‑Lactamase Inhibitor Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
- A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La invención se refiere a la combinación de compuestos heterocíclicos nitrogenados antibacterianos de fórmula (I) con otros compuestos antibacterianos y su utilización como medicamentos.Los compuestos heterocíclicos nitrogenados responden a la fórmula general (I)en la que R1 representa un radical (CH2)n-NH2 o (CH2)n-NHR, siendo R un alquilo (C1-C6) y siendo n igual a 1 ó 2;R2 representa un átomo de hidrógeno;R3 y R4 forman juntos un heterociclo nitrogenado de carácter aromático con 5 vértices que contienen 1, 2 ó 3átomos de nitrógeno eventualmente sustituido por uno ovarios agrupamientos R', siendo R' elegido del grupo constituido por un átomo de hidrógeno y los radicales alquilo contienen de 1 a 6 átomos de carbono, en forma libre, de zwitteriones, y en forma de sales con las bases y los ácidos minerales u orgánicos farmacéuticamente aceptables.Los demás agentes antibacterianos se eligen del grupo constituido por los betalactámicos, los monobactamos, las penicilinas, llegado el caso combinados con un inhibidor de betalactamasas, los aminoglucósidos, las glicilciclinas, las tetraciclinas, las quinolonas, los glucopéptidos, los lipopéptidos, los macrólidos, los quetólidos, las lincosamidas, las estreptograminas, las oxazolidinonas, las polimixinas y los demás compuestos conocidos dotados de una actividad terapéutica sobre Pseudomonas aeruginosa y Enterobacteriaceae.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0805618A FR2936951B1 (fr) | 2008-10-10 | 2008-10-10 | Nouvelles combinaisons de composes heterocycliques azotes antibacteriens avec d'autres composes antibacteriens et leur utilisation comme medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6361930A2 true CO6361930A2 (es) | 2012-01-20 |
Family
ID=40591054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO11043791A CO6361930A2 (es) | 2008-10-10 | 2011-04-08 | Nuevas combinaciones de compuestos heterociclicos nitrogenados antibacterianos con otros compuestos antibacterianos y su utilizacion como medicamentos |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20100092443A1 (es) |
| EP (1) | EP2344500A1 (es) |
| JP (1) | JP2012505196A (es) |
| KR (1) | KR20110067148A (es) |
| CN (1) | CN102216301B (es) |
| AR (1) | AR073771A1 (es) |
| AU (1) | AU2009302153A1 (es) |
| BR (1) | BRPI0919812A8 (es) |
| CA (1) | CA2740035A1 (es) |
| CL (1) | CL2011000783A1 (es) |
| CO (1) | CO6361930A2 (es) |
| EA (1) | EA201170532A1 (es) |
| EC (1) | ECSP11010973A (es) |
| FR (1) | FR2936951B1 (es) |
| IL (1) | IL212180A0 (es) |
| MX (1) | MX2011003812A (es) |
| NZ (1) | NZ592165A (es) |
| PA (1) | PA8845401A1 (es) |
| PE (1) | PE20110392A1 (es) |
| TW (1) | TW201026697A (es) |
| UY (1) | UY32168A (es) |
| WO (1) | WO2010041112A1 (es) |
| ZA (1) | ZA201102498B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107260729B (zh) | 2010-11-25 | 2020-03-31 | 阿莱克拉治疗有限公司 | β-内酰胺化合物及其用途 |
| US9505761B2 (en) | 2011-12-02 | 2016-11-29 | Fedora Pharmaceuticals Inc. | Bicyclic compounds and their use as antibacterial agents and beta-lactamase inhibitors |
| US8796257B2 (en) | 2011-12-02 | 2014-08-05 | Naeja Pharmaceutical Inc. | Bicyclic compounds and their use as antibacterial agents and β-lactamase inhibitors |
| AR090539A1 (es) | 2012-04-02 | 2014-11-19 | Astrazeneca Ab | COMPUESTOS INHIBIDORES DE b LACTAMASA |
| UA111925C2 (uk) | 2012-12-11 | 2016-06-24 | Федора Фармасьютікалз Інк. | БІЦИКЛІЧНІ СПОЛУКИ ТА ЇХ ВИКОРИСТАННЯ ЯК АНТИБАКТЕРІАЛЬНИХ АГЕНТІВ ТА ІНГІБІТОРІВ β-ЛАКТАМАЗИ |
| GB201305277D0 (en) * | 2013-03-22 | 2013-05-01 | Helperby Therapeutics Ltd | Novel combination and use |
| AU2014333436A1 (en) | 2013-10-11 | 2016-05-05 | Wockhardt Limited | Nitrogen containing compounds and their use |
| DK3221313T3 (en) * | 2014-11-17 | 2019-04-08 | Entasis Therapeutics Ltd | COMBINATION THERAPY FOR TREATING INFECTIONS WITH RESISTANT BACTERIA |
| LT3512851T (lt) | 2016-09-16 | 2022-10-25 | Entasis Therapeutics Limited | Beta-laktamazės inhibitorių junginiai |
| JOP20190061A1 (ar) | 2016-09-28 | 2019-03-26 | Novartis Ag | مثبطات بيتا-لاكتاماز |
| US11046694B2 (en) | 2017-05-08 | 2021-06-29 | Entasis Therapeutics, Inc. | Compounds and methods for treating bacterial infections |
| GB202213753D0 (en) * | 2022-09-20 | 2022-11-02 | Helperby Therapeutics Ltd | Antimicrobial combinations |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL339408A1 (en) * | 1997-09-15 | 2000-12-18 | Procter & Gamble | Antimicrobial quinolones, agents containing them and their applications |
| US6387928B1 (en) * | 1997-09-15 | 2002-05-14 | The Procter & Gamble Co. | Antimicrobial quinolones, their compositions and uses |
| JP5219323B2 (ja) * | 2000-04-12 | 2013-06-26 | ファルマ・マール・ソシエダード・アノニマ | 抗腫瘍性エクチナサイジン誘導体 |
| NZ525570A (en) * | 2000-12-14 | 2005-04-29 | Procter & Gamble | Antimicrobial 2-pyridones, their compositions and uses |
| AU3089102A (en) * | 2000-12-14 | 2002-06-24 | Procter & Gamble | Antimicrobial quinolones |
| FR2833596B1 (fr) * | 2001-12-14 | 2005-02-18 | Aventis Pharma Sa | Procede de preparation de derives d'echinocandine |
| FR2835186B1 (fr) * | 2002-01-28 | 2006-10-20 | Aventis Pharma Sa | Nouveaux composes heterocycliques, actifs comme inhibiteurs de beta-lactamases |
| US6900224B2 (en) * | 2002-07-31 | 2005-05-31 | The Procter & Gamble Company | Antimicrobial quinolones, their compositions and uses |
| FR2844268B1 (fr) * | 2002-09-11 | 2004-10-22 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leurs procedes et intermediaires de preparation et les compositions qui les contiennent |
| FR2844270B1 (fr) * | 2002-09-11 | 2006-05-19 | Aventis Pharma Sa | Derives de la quinolyl propyl piperidine, leur procede et intermediaires de preparation et les compositions qui les contiennent |
| FR2848210B1 (fr) * | 2002-12-06 | 2007-10-19 | Aventis Pharma Sa | Nouveaux composes heterocycliques, leur preparation et leur utilisation comme medicaments, notamment comme anti-bacteriens et inhibiteurs de beta-lactamases |
| US7439253B2 (en) * | 2002-12-06 | 2008-10-21 | Novexel | Heterocyclic compounds, their preparation and their use as medicaments, in particular as antibacterials and beta-lactamase inhibitors |
| US7232833B2 (en) * | 2003-03-28 | 2007-06-19 | Novexel | 4-substituted quinoline derivatives, method and intermediates for their preparation and pharmaceutical compositions containing them |
| EP1635812A2 (en) * | 2003-06-10 | 2006-03-22 | Fulcrum Pharmaceuticals, Inc. | Beta-lactamase inhibitors and methods of use thereof |
| US7449481B2 (en) * | 2004-04-13 | 2008-11-11 | Cephalon, Inc. | Thio-substituted biaryl-methanesulfinyl derivatives |
| CN101129383B (zh) * | 2006-08-25 | 2014-04-02 | 天津和美生物技术有限公司 | 含氨基糖苷类抗生素的抗生素复方 |
| EP1958630A1 (en) * | 2007-02-13 | 2008-08-20 | LEK Pharmaceuticals d.d. | Antibacterial combination of a tricyclic carbapenem and an antibiotic |
-
2008
- 2008-10-10 FR FR0805618A patent/FR2936951B1/fr not_active Expired - Fee Related
-
2009
- 2009-08-05 US US12/535,865 patent/US20100092443A1/en not_active Abandoned
- 2009-09-29 PE PE2011000865A patent/PE20110392A1/es not_active Application Discontinuation
- 2009-09-29 EP EP09786281A patent/EP2344500A1/fr not_active Withdrawn
- 2009-09-29 CA CA2740035A patent/CA2740035A1/fr not_active Abandoned
- 2009-09-29 AU AU2009302153A patent/AU2009302153A1/en not_active Abandoned
- 2009-09-29 EA EA201170532A patent/EA201170532A1/ru unknown
- 2009-09-29 JP JP2011530584A patent/JP2012505196A/ja not_active Ceased
- 2009-09-29 MX MX2011003812A patent/MX2011003812A/es active IP Right Grant
- 2009-09-29 NZ NZ592165A patent/NZ592165A/xx not_active IP Right Cessation
- 2009-09-29 BR BRPI0919812A patent/BRPI0919812A8/pt not_active IP Right Cessation
- 2009-09-29 KR KR1020117010169A patent/KR20110067148A/ko not_active Application Discontinuation
- 2009-09-29 CN CN200980146340.2A patent/CN102216301B/zh not_active Expired - Fee Related
- 2009-09-29 WO PCT/IB2009/006992 patent/WO2010041112A1/fr active Application Filing
- 2009-10-05 AR ARP090103834A patent/AR073771A1/es not_active Application Discontinuation
- 2009-10-07 TW TW098133951A patent/TW201026697A/zh unknown
- 2009-10-08 UY UY0001032168A patent/UY32168A/es not_active Application Discontinuation
- 2009-10-09 PA PA20098845401A patent/PA8845401A1/es unknown
-
2011
- 2011-04-05 ZA ZA2011/02498A patent/ZA201102498B/en unknown
- 2011-04-06 IL IL212180A patent/IL212180A0/en unknown
- 2011-04-08 CL CL2011000783A patent/CL2011000783A1/es unknown
- 2011-04-08 CO CO11043791A patent/CO6361930A2/es not_active Application Discontinuation
- 2011-04-11 EC EC2011010973A patent/ECSP11010973A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20100092443A1 (en) | 2010-04-15 |
| PA8845401A1 (es) | 2010-05-26 |
| CA2740035A1 (fr) | 2010-04-15 |
| PE20110392A1 (es) | 2011-06-11 |
| EA201170532A1 (ru) | 2011-12-30 |
| AR073771A1 (es) | 2010-12-01 |
| CL2011000783A1 (es) | 2012-07-06 |
| UY32168A (es) | 2010-04-30 |
| BRPI0919812A8 (pt) | 2016-11-01 |
| FR2936951A1 (fr) | 2010-04-16 |
| ECSP11010973A (es) | 2011-06-30 |
| WO2010041112A1 (fr) | 2010-04-15 |
| TW201026697A (en) | 2010-07-16 |
| KR20110067148A (ko) | 2011-06-21 |
| JP2012505196A (ja) | 2012-03-01 |
| CN102216301A (zh) | 2011-10-12 |
| BRPI0919812A2 (pt) | 2015-12-22 |
| NZ592165A (en) | 2012-12-21 |
| IL212180A0 (en) | 2011-06-30 |
| CN102216301B (zh) | 2014-12-10 |
| MX2011003812A (es) | 2011-07-29 |
| ZA201102498B (en) | 2013-07-25 |
| EP2344500A1 (fr) | 2011-07-20 |
| FR2936951B1 (fr) | 2010-12-03 |
| AU2009302153A1 (en) | 2010-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Application refused |