CO6351686A2 - Agentes antifúngicos - Google Patents

Agentes antifúngicos

Info

Publication number
CO6351686A2
CO6351686A2 CO11016262A CO11016262A CO6351686A2 CO 6351686 A2 CO6351686 A2 CO 6351686A2 CO 11016262 A CO11016262 A CO 11016262A CO 11016262 A CO11016262 A CO 11016262A CO 6351686 A2 CO6351686 A2 CO 6351686A2
Authority
CO
Colombia
Prior art keywords
ring
cycloalkyl
alkyl
nitrogen
heteroaryl group
Prior art date
Application number
CO11016262A
Other languages
English (en)
Inventor
Mark L Greenlee
Robert R Wilkening
Jr Dann L Parker
Dongfang Meng
Kenneth James Wildonger
James Apgar
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41669132&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CO6351686(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of CO6351686A2 publication Critical patent/CO6351686A2/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
    • A01N43/647—Triazoles; Hydrogenated triazoles
    • A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J63/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by expansion of only one ring by one or two atoms
    • C07J63/008—Expansion of ring D by one atom, e.g. D homo steroids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Environmental Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto de la Fórmula (I):o una sal farmacéuticamente aceptable del mismo, caracterizado porque:X es O o H, H;Re es C(O)NRfRg o un grupo de heteroarilo anular de 6 miembros que contiene 1 o 2 átomos de nitrógeno, en donde el grupo heteroarilo es, opcionalmente, mono-substituido en un carbono del anillo con fluor o o cloro o en un nitrógeno del anillo con oxígeno;Rf, Rg, R6 y R7 son cada uno, independientemente, hidrógeno o alquilo C1-C3;R8 es alquilo C1-C4, cicloalquilo C3-C4 o cicloalquilo-alquilo C4-C5;R9 es metilo o etilo; yR8 y R9, opcionalmente, son tomados juntos para formar un anillo saturado de 6 miembros que contiene 1 átomo de oxígeno.
CO11016262A 2008-08-12 2011-02-11 Agentes antifúngicos CO6351686A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US13610608P 2008-08-12 2008-08-12

Publications (1)

Publication Number Publication Date
CO6351686A2 true CO6351686A2 (es) 2011-12-20

Family

ID=41669132

Family Applications (1)

Application Number Title Priority Date Filing Date
CO11016262A CO6351686A2 (es) 2008-08-12 2011-02-11 Agentes antifúngicos

Country Status (31)

Country Link
EP (1) EP2326172B1 (es)
KR (1) KR101686075B1 (es)
AR (1) AR073037A1 (es)
BR (1) BRPI0912074B1 (es)
CL (1) CL2011000292A1 (es)
CO (1) CO6351686A2 (es)
CR (1) CR20110075A (es)
DK (1) DK2326172T3 (es)
DO (1) DOP2011000053A (es)
EA (1) EA018337B1 (es)
ES (1) ES2526652T3 (es)
GT (1) GT201100039A (es)
HK (1) HK1158017A1 (es)
HN (1) HN2011000404A (es)
HR (1) HRP20150009T1 (es)
IL (2) IL210975A (es)
MA (1) MA32628B1 (es)
MX (1) MX2011001656A (es)
MY (1) MY156955A (es)
NI (1) NI201100035A (es)
NZ (1) NZ590914A (es)
PE (1) PE20110676A1 (es)
PL (1) PL2326172T3 (es)
PT (1) PT2326172E (es)
RS (1) RS53731B1 (es)
SI (1) SI2326172T1 (es)
SV (1) SV2011003839A (es)
TW (1) TWI439458B (es)
UA (1) UA105639C2 (es)
WO (1) WO2010019203A1 (es)
ZA (1) ZA201100788B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA036874B1 (ru) * 2015-01-19 2020-12-30 Скайнексис, Инк. Новые соли и полиморфы scy-078
US11110102B2 (en) * 2017-04-10 2021-09-07 Scynexis, Inc. Antifungal agents used in combination
WO2019028034A1 (en) * 2017-08-04 2019-02-07 Scynexis, Inc. ANTIFUNGAL AGENTS WITH IMPROVED PH ACID ACTIVITY
JP2022519500A (ja) * 2019-01-30 2022-03-24 サイネクシス，インコーポレーテッド 真菌性骨－関節感染症を治療するためのトリテルペノイド系抗真菌薬
WO2020232037A1 (en) * 2019-05-16 2020-11-19 Scynexis, Inc. Antifungal agents, like ibrexafungerp for candida auris decolonization
EP4157356A1 (en) 2020-05-29 2023-04-05 Centre National de la Recherche Scientifique Antifungal prodrugs

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE230268T1 (de) * 1996-01-31 2003-01-15 Merck & Co Inc Fungizid
US5756472A (en) 1996-01-31 1998-05-26 Merck & Co., Inc. Antifungal agent obtained from hormonema
EP1497281A4 (en) * 2002-04-17 2005-11-02 Ranbaxy Lab Ltd AZOLE DERIVATIVES AS ANTIFUNGAL AGENTS
DK2007396T3 (da) * 2006-04-03 2013-03-18 Merck Sharp & Dohme Enfumafungin-derivat som antimykotika

Also Published As

Publication number Publication date
DOP2011000053A (es) 2011-04-30
KR101686075B1 (ko) 2016-12-13
PL2326172T3 (pl) 2015-03-31
PE20110676A1 (es) 2011-09-23
TW201011004A (en) 2010-03-16
EP2326172A4 (en) 2012-06-06
EP2326172B1 (en) 2014-10-22
MX2011001656A (es) 2011-05-25
HK1158017A1 (en) 2012-07-13
CR20110075A (es) 2011-06-03
MY156955A (en) 2016-04-15
TWI439458B (zh) 2014-06-01
AR073037A1 (es) 2010-10-06
GT201100039A (es) 2013-08-21
WO2010019203A1 (en) 2010-02-18
HRP20150009T1 (hr) 2015-02-27
IL242031A0 (en) 2015-11-30
SV2011003839A (es) 2011-07-06
PT2326172E (pt) 2015-02-04
ES2526652T3 (es) 2015-01-14
BRPI0912074A2 (pt) 2018-10-02
WO2010019203A8 (en) 2011-03-17
NI201100035A (es) 2011-09-20
NZ590914A (en) 2011-11-25
MA32628B1 (fr) 2011-09-01
EA201100350A1 (ru) 2011-08-30
RS53731B1 (en) 2015-06-30
DK2326172T3 (da) 2015-01-26
BRPI0912074B1 (pt) 2021-08-03
EP2326172A1 (en) 2011-06-01
UA105639C2 (uk) 2014-06-10
IL210975A (en) 2015-10-29
EA018337B1 (ru) 2013-07-30
HN2011000404A (es) 2013-09-23
IL210975A0 (en) 2011-04-28
SI2326172T1 (sl) 2015-02-27
KR20110045054A (ko) 2011-05-03
CL2011000292A1 (es) 2011-11-04
ZA201100788B (en) 2012-05-01

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