SG10201407538WA - Intravenous formulations of neurokinin-1 antagonists - Google Patents
Intravenous formulations of neurokinin-1 antagonistsInfo
- Publication number
- SG10201407538WA SG10201407538WA SG10201407538WA SG10201407538WA SG10201407538WA SG 10201407538W A SG10201407538W A SG 10201407538WA SG 10201407538W A SG10201407538W A SG 10201407538WA SG 10201407538W A SG10201407538W A SG 10201407538WA SG 10201407538W A SG10201407538W A SG 10201407538WA
- Authority
- SG
- Singapore
- Prior art keywords
- neurokinin
- antagonists
- intravenous formulations
- pharmaceutical compositions
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
- A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
- A01N43/42—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings condensed with carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
Abstract
Pharmaceutical compositions for intravenous administration comprising the compound of Formula I, or pharmaceutically acceptable salts, hydrates or prodrugs thereof are described herein. Methods of preparing the pharmaceutical compositions and methods for treating nausea and/or emesis with the pharmaceutical compositions are also described herein. FIGURE 4. 72
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US23412909P | 2009-08-14 | 2009-08-14 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201407538WA true SG10201407538WA (en) | 2015-01-29 |
Family
ID=43586486
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG10201407538WA SG10201407538WA (en) | 2009-08-14 | 2010-08-12 | Intravenous formulations of neurokinin-1 antagonists |
SG2012010146A SG178403A1 (en) | 2009-08-14 | 2010-08-12 | Intravenous formulations of neurokinin-1 antagonists |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG2012010146A SG178403A1 (en) | 2009-08-14 | 2010-08-12 | Intravenous formulations of neurokinin-1 antagonists |
Country Status (15)
Country | Link |
---|---|
US (2) | US9101615B2 (en) |
EP (2) | EP3143996A1 (en) |
JP (2) | JP5860399B2 (en) |
KR (1) | KR101834577B1 (en) |
CN (2) | CN105503870A (en) |
AU (1) | AU2010282483B2 (en) |
BR (1) | BR112012003263A2 (en) |
CA (1) | CA2770403C (en) |
ES (1) | ES2609640T3 (en) |
IL (1) | IL217942A0 (en) |
MX (1) | MX336071B (en) |
RU (2) | RU2017145628A (en) |
SG (2) | SG10201407538WA (en) |
TW (2) | TW201604195A (en) |
WO (1) | WO2011019911A1 (en) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102276606B (en) | 2006-04-05 | 2013-06-12 | 欧科生医股份有限公司 | Tosylate crystalline salts of 8-[{1-(3,5-bis-(trifluoromethyl) phenyl) -ethoxy}-methyl] -8-phenyl-1,7-diaza-spiro[4.5] decan-2-one and preparation process therefor |
AR060303A1 (en) | 2006-04-05 | 2008-06-04 | Schering Corp | SALM PHARMACEUTICAL FORMULATIONS OF 8- [1- (3,5 -BIS- (TRIFLUOROMETIL) PHENYL) -ETOXIMETILE] -8-PHENYL-1,7 -DIAZA-ESPIRO [4.5] DECAN -2- ONA AND TREATMENT METHODS USING SAME |
AR066191A1 (en) | 2007-03-22 | 2009-08-05 | Schering Corp | PROCESS AND INTERMEDIARIES FOR THE SYNTHESIS OF COMPOUNDS 8- [(1- (3,5- BIS- (TRIFLUOROMETIL) PHENYL) - ETOXI) - METAL] - 8 PHENYL - 1,7- DIAZA - ESPIRO (4, 5) DECAN - 2 ONA |
CN102203062B (en) | 2008-09-05 | 2014-12-17 | 欧科生医股份有限公司 | Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds |
RU2017145628A (en) | 2009-08-14 | 2019-02-19 | ОПКО Хельс, Инк. | COMPOSITIONS OF NEUROKININ-1 ANTAGONISTS FOR INTRAVENOUS INTRODUCTION |
TW201605852A (en) * | 2013-09-26 | 2016-02-16 | 美國禮來大藥廠 | Novel compounds and use for preparation of tau imaging agents and tau imaging formulations |
KR102424837B1 (en) | 2014-09-19 | 2022-07-25 | 헤론 테라퓨틱스 인코포레이티드 | Emulsion formulations of aprepitant |
WO2017044693A1 (en) | 2015-09-11 | 2017-03-16 | Chase Pharmaceuticals Corporation | Muscarinic combination and its use for combating hypocholinergic disorders of the central nervous system |
US9974742B2 (en) | 2016-02-01 | 2018-05-22 | Heron Therapeutics, Inc. | Emulsion formulations of an NK-1 receptor antagonist and uses thereof |
CA3013288A1 (en) * | 2016-02-01 | 2017-08-10 | Heron Therapeutics, Inc. | Emulsion comprising an nk-1 receptor antagonist |
US20190175702A1 (en) * | 2016-08-03 | 2019-06-13 | Zhuhai Beihai Biotech Co., Ltd. | Formulations of fosaprepitant and aprepitant |
WO2018094394A1 (en) * | 2016-11-21 | 2018-05-24 | Zhuhai Beihai Biotech Co., Ltd. | Formulations of rolapitant |
IL269875B1 (en) | 2017-04-10 | 2024-02-01 | Chase Therapeutics Corp | Nk1-antagonist combination and method for treating synucleinopathies |
CN110996911B (en) * | 2017-06-26 | 2023-01-17 | 福多兹制药公司 | Aprepitant nano-microcapsule preparation as well as method and application thereof |
WO2019006050A1 (en) | 2017-06-30 | 2019-01-03 | Chase Therapeutics Corporation | Nk-1 antagonist compositions and methods for use in treating depression |
CN109200018A (en) * | 2017-07-04 | 2019-01-15 | 南京诺瑞特医药科技有限公司 | Containing how the smooth microemulsion formulation of appropriate pyrrole |
CN108703950B (en) * | 2018-08-27 | 2021-04-20 | 辅必成(上海)医药科技有限公司 | Emulsion injection of Lapiaptan |
CN109453115A (en) * | 2018-12-25 | 2019-03-12 | 广州白云山汉方现代药业有限公司 | A kind of smooth intravenous injection emulsion of roller and its preparation method and application |
CN109394693A (en) * | 2018-12-25 | 2019-03-01 | 广州白云山汉方现代药业有限公司 | A kind of smooth emulsion of roller and its preparation method and application |
US20220380393A1 (en) | 2019-06-28 | 2022-12-01 | Shanghai Shengdi Pharmaceutical Co., Ltd | Neurokinin-1 antagonist |
WO2021198255A1 (en) | 2020-04-03 | 2021-10-07 | Nerre Therapeutics Limited | An nk-1 receptor antagonist for treating a disease selecting from sepsis, septic shock,, acute respiratory distress syndrome (ards) or multiple organ dysfunction syndrome (mods) |
CA3177477A1 (en) | 2020-06-02 | 2021-12-09 | Nerre Therapeutics Limited | Neurokinin (nk)-1 receptor antagonists for use in the treatment of pulmonary fibrosis conditions promoted by mechanical injury to the lungs |
JP2024501994A (en) | 2020-12-25 | 2024-01-17 | 上海盛迪医▲葯▼有限公司 | Combination use of NK1 antagonist prodrug compound and 5-HT3 receptor antagonist |
WO2023134725A1 (en) * | 2022-01-12 | 2023-07-20 | 江苏恒瑞医药股份有限公司 | Pharmaceutical composition comprising neurokinin-1 antagonist prodrug compound |
WO2023134723A1 (en) * | 2022-01-12 | 2023-07-20 | 江苏恒瑞医药股份有限公司 | Crystal form of neurokinin-1 antagonist prodrug compound |
Family Cites Families (43)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0338372A3 (en) * | 1988-04-22 | 1991-10-09 | American Cyanamid Company | Solubilized pro-drugs |
DE69034035T2 (en) * | 1989-07-07 | 2004-01-22 | Endorecherche Inc., Ste-Foy | METHOD FOR TREATING ANDROGEN DISEASES |
US5610140A (en) * | 1991-04-01 | 1997-03-11 | Cortech, Inc. | Bradykinin receptor antagonists with neurokinin receptor blocking activity |
AU678409B2 (en) | 1992-10-28 | 1997-05-29 | Merck Sharp & Dohme Limited | 4-arylmethyloxymethyl piperidines as tachykinin antagonists |
AU682838B2 (en) | 1992-12-14 | 1997-10-23 | Merck Sharp & Dohme Limited | 4-aminomethyl/thiomethyl/sulfonylmethyl-4-phenylpiperidines as tachykinin receptor antagonists |
GB9305718D0 (en) * | 1993-03-19 | 1993-05-05 | Glaxo Group Ltd | Medicaments |
ATE170174T1 (en) | 1994-01-13 | 1998-09-15 | Merck Sharp & Dohme | GEM-BIS-SUBSTITUTED AZAZYCLIC TACHYKININ ANTAGONISTS |
KR100405116B1 (en) | 1995-02-28 | 2004-02-05 | 아벤티스 파마슈티칼스 인크. | Pharmaceutical compositions for piperidino alkanol compounds |
SE9503143D0 (en) * | 1995-09-12 | 1995-09-12 | Astra Ab | New preparation |
GB9601680D0 (en) | 1996-01-27 | 1996-03-27 | Pfizer Ltd | Therapeutic agents |
ATE265209T1 (en) | 1996-07-17 | 2004-05-15 | Merck & Co Inc | ALTERING THE CIRCADIC RHYTHM WITH NON-PEPTID NEUROKININ-1 RECEPTOR ANTAGONISTS |
WO1998047514A1 (en) | 1997-04-24 | 1998-10-29 | Merck Sharp & Dohme Limited | Use of an nk-1 receptor antagonist and an ssri for treating obesity |
JP3571511B2 (en) * | 1997-11-11 | 2004-09-29 | トーアエイヨー株式会社 | Transdermal formulation |
EP1140074A1 (en) * | 1998-12-23 | 2001-10-10 | NPS Allelix Corp. | Indole and indolizidine derivatives for the treatment of migraine |
EP1185301A1 (en) | 1999-05-24 | 2002-03-13 | Sonus Pharmaceuticals, Inc. | Emulsion vehicle for poorly soluble drugs |
CA2393672A1 (en) | 1999-12-17 | 2001-06-21 | Schering Corporation | Selective neurokinin antagonists |
US6436928B1 (en) | 1999-12-17 | 2002-08-20 | Schering Corporation | Selective neurokinin antagonists |
US6499984B1 (en) | 2000-05-22 | 2002-12-31 | Warner-Lambert Company | Continuous production of pharmaceutical granulation |
MY128450A (en) * | 2000-05-24 | 2007-02-28 | Upjohn Co | 1-(pyrrolidin-1-ylmethyl)-3-(pyrrol-2-ylmethylidene)-2-indolinone derivatives |
EP1368322A4 (en) * | 2001-02-12 | 2004-03-17 | Teva Pharma | New crystal forms of oxcarbazepine and processes for their preparation |
AR038002A1 (en) | 2001-11-13 | 2004-12-22 | Schering Corp | ANTAGONISTS OF THE RECEIVER OF NEUROQUININA-1, PHARMACEUTICAL COMPOSITIONS AND THE USE OF SUCH ANTAGONISTS FOR THE PREPARATION OF A MEDICINAL PRODUCT |
PE20030762A1 (en) * | 2001-12-18 | 2003-09-05 | Schering Corp | HETEROCYCLIC COMPOUNDS AS NK1 ANTAGONISTS |
AU2003277299B2 (en) | 2002-04-10 | 2009-12-10 | Conforma Therapeutics Corporation | Drug formulations having long and medium chain triglycerides |
ATE358482T1 (en) * | 2002-07-03 | 2007-04-15 | Schering Corp | 1-AMIDO-4-PHENYL-4-BENZYLOXYMETHYL-PIPERIDINE DERIVATIVES AND RELATED COMPOUNDS AS NEUROKININ-1 (NK-1) ANTAGONISTS FOR THE TREATMENT OF VOMITING, DEPRESSION, ANXIETY AND COUGH |
US7534913B2 (en) * | 2002-07-18 | 2009-05-19 | Teva Pharmaceutica Industries Ltd. | Crystalline form of nateglinide |
EP1575962A1 (en) * | 2002-12-24 | 2005-09-21 | Teva Pharmaceutical Industries Limited | Novel crystal forms of olanzapine, methods for their preparation and method for the preparation of known olanzapine crystal forms |
GB0321256D0 (en) * | 2003-09-11 | 2003-10-08 | Generics Uk Ltd | Novel crystalline compounds |
EA009941B1 (en) | 2003-10-03 | 2008-04-28 | Пфайзер Инк. | Imidazopyridine substituted tropane derivatives with ccr5 receptor antagonist activity for the treatment of hiv and inflammation |
US20050153999A1 (en) * | 2003-12-22 | 2005-07-14 | Schering Corporation | Pharmaceutical compositions |
CN101006074B (en) * | 2004-07-01 | 2012-02-15 | 欧科生医股份有限公司 | Piperidine derivatives as NK1 antagonists |
US7871632B2 (en) | 2004-07-12 | 2011-01-18 | Adventrx Pharmaceuticals, Inc. | Compositions for delivering highly water soluble drugs |
CA2588052A1 (en) * | 2004-11-30 | 2006-06-08 | Myriad Genetics, Inc. | Therapeutic formulations |
CN100367951C (en) | 2005-12-16 | 2008-02-13 | 石药集团恩必普药业有限公司 | Butyl benzene phthalein vein emulsion and its application |
TW200800180A (en) * | 2006-03-06 | 2008-01-01 | Wyeth Corp | Liquid and semi-solid pharmaceutical formulations and processes |
AR060303A1 (en) * | 2006-04-05 | 2008-06-04 | Schering Corp | SALM PHARMACEUTICAL FORMULATIONS OF 8- [1- (3,5 -BIS- (TRIFLUOROMETIL) PHENYL) -ETOXIMETILE] -8-PHENYL-1,7 -DIAZA-ESPIRO [4.5] DECAN -2- ONA AND TREATMENT METHODS USING SAME |
CN102276606B (en) | 2006-04-05 | 2013-06-12 | 欧科生医股份有限公司 | Tosylate crystalline salts of 8-[{1-(3,5-bis-(trifluoromethyl) phenyl) -ethoxy}-methyl] -8-phenyl-1,7-diaza-spiro[4.5] decan-2-one and preparation process therefor |
CN101110758A (en) | 2006-07-21 | 2008-01-23 | 华为技术有限公司 | Method and system for establishing emergency conversation and proxy function of controlling call conversation |
EP2650291B1 (en) * | 2006-08-07 | 2017-10-04 | Palau Pharma, S.A. | Crystalline Antifungal Compounds |
US8263613B2 (en) * | 2007-02-16 | 2012-09-11 | Affinium Pharmaceuticals, Inc. | Salts, prodrugs and polymorphs of fab I inhibitors |
AR066191A1 (en) * | 2007-03-22 | 2009-08-05 | Schering Corp | PROCESS AND INTERMEDIARIES FOR THE SYNTHESIS OF COMPOUNDS 8- [(1- (3,5- BIS- (TRIFLUOROMETIL) PHENYL) - ETOXI) - METAL] - 8 PHENYL - 1,7- DIAZA - ESPIRO (4, 5) DECAN - 2 ONA |
AR065802A1 (en) | 2007-03-22 | 2009-07-01 | Schering Corp | FORMULATIONS OF TABLETS CONTAINING SALTS OF 8- [(1- (3,5- BIS- (TRIFLUOROMETIL) FENIL) -ETOXI) - METHYL) -8- PHENYL -1, 7- DIAZA- SPIRO [4,5] DECAN - 2- ONA AND TABLETS PREPARED FROM THESE |
CN102203062B (en) | 2008-09-05 | 2014-12-17 | 欧科生医股份有限公司 | Process and intermediates for the synthesis of 8-[{1-(3,5-bis-(trifluoromethyl)phenyl)-ethoxy}-methyl]-8-phenyl-1,7-diaza-spiro[4.5]decan-2-one compounds |
RU2017145628A (en) | 2009-08-14 | 2019-02-19 | ОПКО Хельс, Инк. | COMPOSITIONS OF NEUROKININ-1 ANTAGONISTS FOR INTRAVENOUS INTRODUCTION |
-
2010
- 2010-08-12 RU RU2017145628A patent/RU2017145628A/en not_active Application Discontinuation
- 2010-08-12 ES ES10808756.0T patent/ES2609640T3/en active Active
- 2010-08-12 WO PCT/US2010/045317 patent/WO2011019911A1/en active Application Filing
- 2010-08-12 CN CN201510830177.9A patent/CN105503870A/en active Pending
- 2010-08-12 SG SG10201407538WA patent/SG10201407538WA/en unknown
- 2010-08-12 EP EP16181864.6A patent/EP3143996A1/en not_active Withdrawn
- 2010-08-12 CN CN201080046905.2A patent/CN102573475B/en not_active Expired - Fee Related
- 2010-08-12 EP EP10808756.0A patent/EP2464230B1/en not_active Not-in-force
- 2010-08-12 SG SG2012010146A patent/SG178403A1/en unknown
- 2010-08-12 RU RU2012109405A patent/RU2642234C2/en not_active IP Right Cessation
- 2010-08-12 MX MX2012001872A patent/MX336071B/en unknown
- 2010-08-12 AU AU2010282483A patent/AU2010282483B2/en not_active Ceased
- 2010-08-12 KR KR1020127006576A patent/KR101834577B1/en active IP Right Grant
- 2010-08-12 BR BR112012003263A patent/BR112012003263A2/en not_active Application Discontinuation
- 2010-08-12 JP JP2012524868A patent/JP5860399B2/en not_active Expired - Fee Related
- 2010-08-12 CA CA2770403A patent/CA2770403C/en active Active
- 2010-08-13 US US12/855,889 patent/US9101615B2/en active Active
- 2010-08-13 TW TW104121014A patent/TW201604195A/en unknown
- 2010-08-13 TW TW099127158A patent/TWI498329B/en not_active IP Right Cessation
-
2012
- 2012-02-05 IL IL217942A patent/IL217942A0/en unknown
-
2015
- 2015-07-28 US US14/811,342 patent/US20160024092A1/en not_active Abandoned
- 2015-11-04 JP JP2015216374A patent/JP6308991B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EP2464230A1 (en) | 2012-06-20 |
IL217942A0 (en) | 2012-03-29 |
EP2464230B1 (en) | 2016-10-05 |
AU2010282483B2 (en) | 2014-09-04 |
US9101615B2 (en) | 2015-08-11 |
CN105503870A (en) | 2016-04-20 |
KR20120060215A (en) | 2012-06-11 |
ES2609640T3 (en) | 2017-04-21 |
JP2016041734A (en) | 2016-03-31 |
WO2011019911A1 (en) | 2011-02-17 |
KR101834577B1 (en) | 2018-03-05 |
EP3143996A1 (en) | 2017-03-22 |
JP2013501806A (en) | 2013-01-17 |
RU2017145628A (en) | 2019-02-19 |
MX336071B (en) | 2016-01-06 |
RU2012109405A (en) | 2013-09-20 |
SG178403A1 (en) | 2012-03-29 |
TW201111382A (en) | 2011-04-01 |
JP5860399B2 (en) | 2016-02-16 |
US20110038925A1 (en) | 2011-02-17 |
AU2010282483A1 (en) | 2012-03-01 |
BR112012003263A2 (en) | 2015-09-22 |
RU2642234C2 (en) | 2018-01-24 |
CA2770403C (en) | 2020-09-01 |
CA2770403A1 (en) | 2011-02-17 |
MX2012001872A (en) | 2012-04-11 |
TWI498329B (en) | 2015-09-01 |
CN102573475B (en) | 2016-01-20 |
TW201604195A (en) | 2016-02-01 |
US20160024092A1 (en) | 2016-01-28 |
EP2464230A4 (en) | 2013-01-02 |
CN102573475A (en) | 2012-07-11 |
JP6308991B2 (en) | 2018-04-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SG10201407538WA (en) | Intravenous formulations of neurokinin-1 antagonists | |
MX2021008356A (en) | Jak2 and alk2 inhibitors and methods for their use. | |
MX2018011831A (en) | SOLUBLE C5aR ANTAGONISTS. | |
MX2020010151A (en) | 1,4-disubstituted pyridazine analogs and methods for treating smn-deficiency-related conditions. | |
MX2013003019A (en) | Azabenzothiazole compounds, compositions and methods of use. | |
MX2016001400A (en) | 1,4-disubstituted pyridazine derivatives and their use for treating smn-deficiency-related conditions. | |
IN2012DN03337A (en) | ||
MX2011013771A (en) | 1, 3-disubstituted imidazolidin-2-one derivatives as inhibitors of cyp 17. | |
UA109868C2 (en) | N -alkyltriazole compounds asr | |
HK1149258A1 (en) | Compounds | |
UA105229C2 (en) | Pharmaceutical formulation | |
GEP20186880B (en) | 2-amino-3, 5, 5-trifluoro-3, 4, 5, 6-tetrahydropyridines as bace1 inhibitors for treatment of alzheimer's disease | |
MX2009009238A (en) | Novel phosphodi esterase inhibitors. | |
TN2009000287A1 (en) | Cyclized derivatives as eg-5inhibitors | |
MX2013000474A (en) | Novel arylamide derivatives having antiandrogenic properties. | |
MX2010002584A (en) | Piperidine derivatives as agonists of muscarinic receptors. | |
IN2012DN01232A (en) | ||
IN2012DN04868A (en) | ||
WO2014062838A3 (en) | Pkm2 modulators and methods for their use | |
MX2010009756A (en) | Muscarinic receptor agonists, compositions, methods of treatment thereof, and processes for preparation thereof. | |
MX2010009395A (en) | Muscarinic receptor agonists, compositions, methods of treatment thereof, and processes for preparation thereof 177. | |
TN2014000060A1 (en) | Benzothiazolone compound | |
WO2015002755A3 (en) | Compounds for the treatment of malaria | |
MY156955A (en) | Antifungal agents | |
IN2012DN01234A (en) |