CO6331337A2 - Compuestos de isoindol 5-sustituidos - Google Patents

Compuestos de isoindol 5-sustituidos

Info

Publication number
CO6331337A2
CO6331337A2 CO10163294A CO10163294A CO6331337A2 CO 6331337 A2 CO6331337 A2 CO 6331337A2 CO 10163294 A CO10163294 A CO 10163294A CO 10163294 A CO10163294 A CO 10163294A CO 6331337 A2 CO6331337 A2 CO 6331337A2
Authority
CO
Colombia
Prior art keywords
alkyl
substituted
halogens
optionally substituted
isoindol
Prior art date
Application number
CO10163294A
Other languages
English (en)
Inventor
George W Muller
Roger Shen-Chu Chen
Alexander L Ruchelman
Original Assignee
Celgene Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celgene Corp filed Critical Celgene Corp
Publication of CO6331337A2 publication Critical patent/CO6331337A2/es

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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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Abstract

1.- Un compuesto de fórmula (III)o una sal, solvato, estereoisómero, o profármaco del mismo, aceptable farmacéuticamente, caracterizado porque:X es CH2 o C=O;Y es Q o S;R10 es:alquilo de (C1-C10) ; alcoxi de (C1-C10);alquilo de (C0-C10)-(heteroarilo o heterociclo de 5-10 miembros), dicho heteroarilo o heterociclo sustituido opcionalmente con uno o más de: alquilo de (C1-C6), sustituido a su vez con uno o más halógenos; halógeno; oxo; alcoxi de (C1-C6) sustituido a su vez con uno o más halógenos; o -Z-alquilo de (C1-C6), en donde Z es S o SO2 y en donde dicho alquilo de (C1-C6) puede estar sustituido opcionalmente con uno o más halógenos;alquilo de (C0-C10) - (arilo de 5 a 10 miembros) dicho arilo sustituido opcionalmente con uno o más de: halógeno; alcoxi de (C1-C6), sustituido a su vez con uno o más halógenos; alquilo de (C1-C6), sustituido a su vez con uno o más halógenos; o -Z-alquilo de (C1-C6), en donde Z es S o SO2, y en donde dicho alquilo de (C1-C6) puede estar sustituido opcionalmente con uno o más halógenos; o alquilo de (C1-C6)-C0-O-R12, en donde R12 es H, alquilo de (C1-C6); y R12 es H o alquilo de (C1-C6).
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