CO6260022A2 - Proceso de preparacion de complejo soluble en agua conteniendo el compuesto resveratrol productos formando dicho complejo y usos del mismos - Google Patents

Proceso de preparacion de complejo soluble en agua conteniendo el compuesto resveratrol productos formando dicho complejo y usos del mismos

Info

Publication number
CO6260022A2
CO6260022A2 CO10021163A CO10021163A CO6260022A2 CO 6260022 A2 CO6260022 A2 CO 6260022A2 CO 10021163 A CO10021163 A CO 10021163A CO 10021163 A CO10021163 A CO 10021163A CO 6260022 A2 CO6260022 A2 CO 6260022A2
Authority
CO
Colombia
Prior art keywords
complex
resveratrol
water
cyclodextrin
compound
Prior art date
Application number
CO10021163A
Other languages
English (en)
Inventor
Arigony Souto Andre
Original Assignee
Uniao Brasileira De Educacao
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Uniao Brasileira De Educacao filed Critical Uniao Brasileira De Educacao
Publication of CO6260022A2 publication Critical patent/CO6260022A2/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
    • C08B37/0009—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid alpha-D-Glucans, e.g. polydextrose, alternan, glycogen; (alpha-1,4)(alpha-1,6)-D-Glucans; (alpha-1,3)(alpha-1,4)-D-Glucans, e.g. isolichenan or nigeran; (alpha-1,4)-D-Glucans; (alpha-1,3)-D-Glucans, e.g. pseudonigeran; Derivatives thereof
    • C08B37/0012—Cyclodextrin [CD], e.g. cycle with 6 units (alpha), with 7 units (beta) and with 8 units (gamma), large-ring cyclodextrin or cycloamylose with 9 units or more; Derivatives thereof
    • C08B37/0015—Inclusion compounds, i.e. host-guest compounds, e.g. polyrotaxanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/16—Cyclodextrin; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Nanotechnology (AREA)
  • Food Science & Technology (AREA)
  • Diabetes (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)

Abstract

Proceso para la preparación del complejo soluble en agua conteniendo el compuesto resveratrol; Productos que conforman dicho complexo y Usos de los mismos. 1.- Proceso para la obtención del complejo soluble de resveratrol y el compuesto ciclodextrina caracterizado por estar conformado de los siguientes pasos: a) ciclodextrina completamente homogenizada en agua, con calentamiento de 50 a 80°C. hasta que una concentración de ciclodextrina más baja o igual a 60 mM; b) agregar, a la solución resultante, un solvente orgánico fisiológicamente aceptable y miscible en agua, hasta una proporción de solvente orgánico-agua que oscile de 1:1 a 1:5; c) agregar, a la mezcla resultante del paso (b), una solución del compuesto resveratrol diluido en un solvente orgánico fisiológicamente aceptable y miscible en agua, y caliente la mezcla resultante a una temperatura que oscile entre 50 a 80°C; d) enfriar lentamente la solución resultante del paso (c) hasta precipitación de cristales del complejo de dicho compuesto resveratrol/ciclodextrina; y e) separar los cristales de dicho complejo del compuesto resveratrol/ciclodextrina.
CO10021163A 2007-07-23 2010-02-23 Proceso de preparacion de complejo soluble en agua conteniendo el compuesto resveratrol productos formando dicho complejo y usos del mismos CO6260022A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI0705319-3A BRPI0705319A2 (pt) 2007-07-23 2007-07-23 processo para obtenção de um complexo solúvel de resveratrol e/ou seus derivados; complexo de resveratrol e/ou seus derivados; composição nutracêutica

Publications (1)

Publication Number Publication Date
CO6260022A2 true CO6260022A2 (es) 2011-03-22

Family

ID=40280935

Family Applications (1)

Application Number Title Priority Date Filing Date
CO10021163A CO6260022A2 (es) 2007-07-23 2010-02-23 Proceso de preparacion de complejo soluble en agua conteniendo el compuesto resveratrol productos formando dicho complejo y usos del mismos

Country Status (7)

Country Link
US (1) US8476248B2 (es)
EP (1) EP2178525A4 (es)
BR (2) BRPI0705319A2 (es)
CA (1) CA2694343C (es)
CO (1) CO6260022A2 (es)
EC (1) ECSP109982A (es)
WO (1) WO2009012551A1 (es)

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AU2005207029B2 (en) 2004-01-20 2011-09-01 Brigham Young University Novel sirtuin activating compounds and methods for making the same
BRPI0806044A2 (pt) * 2008-10-17 2010-09-14 Ubea método e kit para determinação de agentes moduladores de sirtuìnas, processo para modulação de sirtuìnas, compostos moduladores de sirtuìnas e composições compreendendo os mesmos
CA2744407A1 (en) * 2008-11-24 2010-05-27 Giovanni Nicolao Berta New formulations with anti-neoplastic activity
BRPI0900400B1 (pt) * 2009-02-10 2017-12-19 União Brasileira De Educação E Assistência Composition understanding vegetable oil and resveratrol and process for producing them
WO2010102245A1 (en) * 2009-03-05 2010-09-10 Upsher-Smith Laboratories, Inc. Solid dispersion comprising resveratrol
US9737495B2 (en) * 2009-06-22 2017-08-22 Indus Biotech Private Limited Process for obtaining purified pterostilbene and methods of use thereof
RU2464042C1 (ru) * 2011-03-31 2012-10-20 Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" КЛАТРАТНЫЙ КОМПЛЕКС β-ЦИКЛОДЕКСТРИНА С ПРОИЗВОДНЫМ 5-ГИДРОКСИ-4-АМИНОМЕТИЛ-1-ЦИКЛОГЕКСИЛ(ИЛИ ЦИКЛОГЕПТИЛ)-3-АЛКОКСИКАРБОНИЛИНДОЛА, СПОСОБ ЕГО ПОЛУЧЕНИЯ (ВАРИАНТЫ), ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И ЛЕКАРСТВЕННОЕ СРЕДСТВО
CN103120310A (zh) * 2011-11-20 2013-05-29 重庆还少堂生物技术有限责任公司 白藜芦醇水溶性干粉的制配方法
CN103356476B (zh) * 2012-03-31 2016-02-17 昆药集团股份有限公司 溶解黄酮类化合物、碳苷类化合物或茋类化合物的方法及注射液或注射用粉针剂的制备方法
ITRM20120275A1 (it) * 2012-06-13 2013-12-14 Noos S R L Associazione di resveratrolo e carbossimetilglucano.
KR101480600B1 (ko) * 2013-01-22 2015-01-08 경북대학교 산학협력단 레스베라트롤 유도체의 피부미백 용도
RU2594281C2 (ru) * 2013-04-03 2016-08-10 Чайна Медикал Юнивёсити Стильбеноидные соединения в качестве ингибиторов плоскоклеточной карциномы и гепатомы и их применения
US9855223B2 (en) 2013-08-21 2018-01-02 Concordia University Compositions comprising a dendrimer-resveratrol complex and methods for making and using the same
JP6435158B2 (ja) * 2014-10-17 2018-12-05 森永製菓株式会社 精製スチルベン化合物の製造方法
US20180085392A1 (en) * 2015-04-17 2018-03-29 Sens Research Foundation, Inc. Cyclodextrin compounds for the prevention and treatment of aging
JP7138643B2 (ja) * 2017-01-09 2022-09-16 サイファーム ソシエテ ア レスポンサビリテ リミテ 水溶性フォルスコリンの新規製造法
CN108774290B (zh) * 2018-07-10 2020-09-04 宁夏蓝博思化学技术有限公司 白藜芦醇-羧烷基型环糊精衍生物及其制备方法
EP3826637A4 (en) * 2018-07-26 2022-05-04 The Regents of The University of California TREATMENT OF VASCULAR OCCLUSION BY ACTIVATION OF THE NOTCH SIGNALING PATHWAY
EP3603415B1 (fr) * 2018-07-30 2020-12-30 Universite D'Avignon et Des Pays Du Vaucluse Procede d'extraction de composes phenoliques
US10882012B2 (en) * 2018-08-03 2021-01-05 Wakamono Corporation Process for producing a nano resveratrol microemulsion system
TWI689304B (zh) * 2018-12-04 2020-04-01 高雄醫學大學 抗霧霾組合物
CN111001013B (zh) * 2019-12-12 2023-04-18 安徽工业大学 一种枇杷叶提取物纳米胶囊、制备方法及应用
CN111387393B (zh) * 2020-05-07 2022-09-20 北京维泰力特生物医药有限公司 一种含有小分子肽、白藜芦醇和花青素的饮料及其制备方法
CN114656645B (zh) * 2022-03-23 2023-02-24 齐鲁工业大学 一种在水相中稳定存在的环糊精金属有机框架的制备方法

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US6884885B2 (en) * 2000-12-21 2005-04-26 Cerestar Holding B.V. Production of cyclodextrin complexes
US20060292099A1 (en) * 2005-05-25 2006-12-28 Michael Milburn Treatment of eye disorders with sirtuin modulators
WO2006138418A2 (en) * 2005-06-14 2006-12-28 President And Fellows Of Harvard College Improvement of cognitive performance with sirtuin activators

Also Published As

Publication number Publication date
BRPI0705319A2 (pt) 2009-07-21
EP2178525A1 (en) 2010-04-28
EP2178525A4 (en) 2013-08-28
BRPI0814308B8 (pt) 2021-05-25
ECSP109982A (es) 2010-04-30
CA2694343A1 (en) 2009-01-29
WO2009012551A1 (en) 2009-01-29
CA2694343C (en) 2016-03-29
US8476248B2 (en) 2013-07-02
US20100204179A1 (en) 2010-08-12
WO2009012551A4 (en) 2009-03-12
BRPI0814308A2 (pt) 2015-02-03
BRPI0814308B1 (pt) 2020-10-27

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