CO6210740A2 - Un compuesto de [1,2,3]benzotriazinona sustituidos en la posicion 3 para mejorar las respuestas sinapticas glutamatergicas - Google Patents
Un compuesto de [1,2,3]benzotriazinona sustituidos en la posicion 3 para mejorar las respuestas sinapticas glutamatergicasInfo
- Publication number
- CO6210740A2 CO6210740A2 CO09072923A CO09072923A CO6210740A2 CO 6210740 A2 CO6210740 A2 CO 6210740A2 CO 09072923 A CO09072923 A CO 09072923A CO 09072923 A CO09072923 A CO 09072923A CO 6210740 A2 CO6210740 A2 CO 6210740A2
- Authority
- CO
- Colombia
- Prior art keywords
- alkyl
- substituted
- cycloalkyl
- alkoxy
- hydrogen
- Prior art date
Links
- 239000002131 composite material Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 10
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 210000004556 brain Anatomy 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 238000011282 treatment Methods 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000005518 carboxamido group Chemical group 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 2
- 229940124530 sulfonamide Drugs 0.000 abstract 2
- 150000003456 sulfonamides Chemical class 0.000 abstract 2
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000019022 Mood disease Diseases 0.000 abstract 1
- 208000018737 Parkinson disease Diseases 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000006399 behavior Effects 0.000 abstract 1
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 230000003930 cognitive ability Effects 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 206010027175 memory impairment Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000001537 neural effect Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 125000005415 substituted alkoxy group Chemical group 0.000 abstract 1
- 125000004426 substituted alkynyl group Chemical group 0.000 abstract 1
- 125000000446 sulfanediyl group Chemical group *S* 0.000 abstract 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
- 210000000225 synapse Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/08—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pain & Pain Management (AREA)
- Pest Control & Pesticides (AREA)
- Gynecology & Obstetrics (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Epidemiology (AREA)
- Agronomy & Crop Science (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Esta invención se refiere a la prevención y tratamiento de la insuficiencia cerebral incluyendo la mejoría en el funcionamiento de los receptores en sinápsis de redes cerebrales responsables por comportamientos de alto orden. Estas redes cerebrales participan en capacidades cognitivas relacionadas con el deterioro de la memoria, tal como las que se observan en una variedad de demencias y desequilibrios en la actividad neuronal entre diferentes regiones del cerebro, como se sugiere en trastornos del tipo de la enfermedad de Parkinson, la esquizofrenia y los trastornos afectivos. En forma particular, la presente invención se refiere a compuestos útiles para el tratamiento de dichas afecciones y a los métodos para el uso de esos compuestos en tales tratamientos. 1.- Un compuesto caracterizado porque comprende la fórmula:en la cual: R1 y R2 son independientemente hidrógeno, alquilo, alquilo sustituido, cicloalquilo, alquinilo, alquinilo sustituido, ciano, alcoxi, carboxamido, carboxamido sustituido, y si R1 y R2 son alquilo, R1 y R2 pueden unirse con un enlace o -(CH2)m- para dar un cicloalquilo. R3 y R4 son independientemente hidrógeno, alquilo, hidroxilo, alcoxi, ciano, fluoro y si R3 y R4 son alquilo, R3 y R4 pueden unirse con un enlace o -(CH2)m- para dar un cicloalquilo, Q puede no estar presente o ser hidrógeno, alquilo, cicloalquilo, cicloalquenilo, alcoxi, alcoxi sustituido, tio sustituido, ciano, tionitrilo, sulfonamida, sulfonamida sustituida, sulfonilo sustituido, aromático, aromático sustituido, heteroaromático, heteroaromático sustituido, o bicicloheteroaromático, R5 es hidrógeno, alquilo, cicloalquilo, o cuando R6 también es alquilo, junto con R6 puede formar un anillo heterocicloalquilo, R6 puede ser hidrógeno, alquilo, alquilo sustituido o -OR7, R7 es alquilo o, cuando R5 es alquilo, junto con R5 forma un anillo de 5, 6 o 7 miembros, L puede ser -O-, -S-, -N= o no estar, ...
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87862607P | 2007-01-03 | 2007-01-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6210740A2 true CO6210740A2 (es) | 2010-10-20 |
Family
ID=39608955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09072923A CO6210740A2 (es) | 2007-01-03 | 2009-07-14 | Un compuesto de [1,2,3]benzotriazinona sustituidos en la posicion 3 para mejorar las respuestas sinapticas glutamatergicas |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US20100041647A1 (es) |
| EP (1) | EP2114158B1 (es) |
| JP (1) | JP2010514837A (es) |
| KR (1) | KR20090098999A (es) |
| CN (1) | CN101626686A (es) |
| AP (1) | AP2009004915A0 (es) |
| AR (1) | AR064739A1 (es) |
| AU (1) | AU2007342364A1 (es) |
| BR (1) | BRPI0720323A2 (es) |
| CA (1) | CA2674321A1 (es) |
| CO (1) | CO6210740A2 (es) |
| CR (1) | CR10913A (es) |
| EA (1) | EA200900937A1 (es) |
| EC (1) | ECSP099538A (es) |
| IL (1) | IL199662A0 (es) |
| MA (1) | MA31159B1 (es) |
| MX (1) | MX2009007209A (es) |
| NZ (1) | NZ578290A (es) |
| TN (1) | TN2009000278A1 (es) |
| WO (1) | WO2008085505A1 (es) |
| ZA (1) | ZA200905065B (es) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL2144506T3 (pl) * | 2007-01-03 | 2012-04-30 | Servier Lab | 3-podstawiony-[1,2,3]-benzotriazynon jako związek do wzmacniania odpowiedzi glutaminianergicznych |
| KR101599661B1 (ko) * | 2007-05-17 | 2016-03-03 | 코텍스 파마슈티칼스, 인크. | 글루타메이트에 의한 시냅스 반응을 향상시키기 위한 이치환된 아미드 화합물 |
| US8119632B2 (en) | 2007-08-10 | 2012-02-21 | Cortex Pharmaceuticals, Inc. | Bicyclic amide derivatives for enhancing glutamatergic synaptic responses |
| BRPI0823262A2 (pt) * | 2007-08-10 | 2013-09-24 | Cortex Pharma Inc | mÉtodo de tratamento de depressço respiratària e uso de um composto na fabricaÇço de um medicamento para o tratamento de depressço respiratària |
| KR20100063087A (ko) * | 2007-09-20 | 2010-06-10 | 코텍스 파마슈티칼스, 인크. | 글루타메이트 시냅스 반응 향상을 위한 3-치환된 1,2,3-트리아진-4-온 및 3-치환된 1,3-피리미디논 |
| US20110257186A1 (en) * | 2010-04-15 | 2011-10-20 | Staubli Ursula V | Compositions and methods for treating visual disorders |
| EP3485882A1 (en) | 2013-01-25 | 2019-05-22 | Case Western Reserve University | Compositions for the treatment of pervasive development disorders |
| CN105418525B (zh) * | 2015-12-16 | 2017-12-15 | 郑州轻工业学院 | 一种n‑取代1,2,3‑苯并三嗪‑4‑酮的制备方法 |
| CN114716416B (zh) * | 2022-04-11 | 2023-06-16 | 湖北大学 | 3,4-二氢吡咯衍生物及其一锅法合成 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3723436A (en) * | 1971-02-25 | 1973-03-27 | Sun Oil Co | Process for aromatic lactams |
| FR2597103B1 (fr) * | 1986-04-15 | 1988-12-16 | Provesan Sa | Procede de preparation de derives d'oxazinobenzothiazine 6,6-dioxyde |
| GB9202915D0 (en) * | 1992-02-12 | 1992-03-25 | Wellcome Found | Chemical compounds |
| NZ255097A (en) * | 1992-07-24 | 2001-04-27 | Univ California | Heterocyclic derivatives (such as 1-(1,4-bgenzodioxan-5-ylcarbonyl)-1,2,3,6-tetrahydropyridine) and medicaments that enhance synaptic responses |
| US5962477A (en) * | 1994-04-12 | 1999-10-05 | Adolor Corporation | Screening methods for cytokine inhibitors |
| US5650409A (en) * | 1995-06-02 | 1997-07-22 | Cortex Pharmaceuticals, Inc. | Benzoyl piperidines/pyrrolidines for enhancing synaptic response |
| US5736543A (en) * | 1996-04-03 | 1998-04-07 | The Regents Of The University Of California | Benzoxazines for enhancing synaptic response |
| US6030968A (en) * | 1996-09-17 | 2000-02-29 | The Regents Of The University Of California | Positive AMPA receptor modulation to enhance brain neurotrophic factor expression |
| US6110935A (en) * | 1997-02-13 | 2000-08-29 | The Regents Of The University Of California | Benzofurazan compounds for enhancing glutamatergic synaptic responses |
| US5985871A (en) * | 1997-12-24 | 1999-11-16 | Cortex Pharmaceuticals, Inc. | Benzoxazine compounds for enhancing synaptic response |
| US6713474B2 (en) * | 1998-09-18 | 2004-03-30 | Abbott Gmbh & Co. Kg | Pyrrolopyrimidines as therapeutic agents |
| US6303542B1 (en) * | 2000-08-18 | 2001-10-16 | Rohm And Haas Company | Herbicidal 3-substituted-phenyl-1,2,3-benzotriazin-4-ones |
| MXPA04004815A (es) * | 2001-11-26 | 2005-02-17 | Cortex Pharma Inc | Compuestos de carbonilbenzoxazina para mejorar respuestas sinapticas, glutamatergicas. |
| AUPS255202A0 (en) * | 2002-05-27 | 2002-06-13 | Monash University | Agents and methods for the treatment of disorders associated with motor neuron degeneration |
| DE10238865A1 (de) * | 2002-08-24 | 2004-03-11 | Boehringer Ingelheim International Gmbh | Neue Carbonsäureamid-Verbindungen mit MCH-antagonistischer Wirkung, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung |
| GB0317482D0 (en) * | 2003-07-25 | 2003-08-27 | Pfizer Ltd | Nicotinamide derivatives useful as pde4 inhibitors |
| CN1897950A (zh) * | 2003-10-14 | 2007-01-17 | 惠氏公司 | 稠合芳基和杂芳基衍生物及其使用方法 |
| PL2144506T3 (pl) * | 2007-01-03 | 2012-04-30 | Servier Lab | 3-podstawiony-[1,2,3]-benzotriazynon jako związek do wzmacniania odpowiedzi glutaminianergicznych |
| KR101599661B1 (ko) * | 2007-05-17 | 2016-03-03 | 코텍스 파마슈티칼스, 인크. | 글루타메이트에 의한 시냅스 반응을 향상시키기 위한 이치환된 아미드 화합물 |
| KR20100063087A (ko) * | 2007-09-20 | 2010-06-10 | 코텍스 파마슈티칼스, 인크. | 글루타메이트 시냅스 반응 향상을 위한 3-치환된 1,2,3-트리아진-4-온 및 3-치환된 1,3-피리미디논 |
-
2007
- 2007-12-28 EA EA200900937A patent/EA200900937A1/ru unknown
- 2007-12-28 US US12/448,770 patent/US20100041647A1/en not_active Abandoned
- 2007-12-28 MX MX2009007209A patent/MX2009007209A/es not_active Application Discontinuation
- 2007-12-28 WO PCT/US2007/026415 patent/WO2008085505A1/en active Application Filing
- 2007-12-28 JP JP2009544856A patent/JP2010514837A/ja active Pending
- 2007-12-28 CA CA002674321A patent/CA2674321A1/en not_active Abandoned
- 2007-12-28 KR KR1020097015941A patent/KR20090098999A/ko not_active Application Discontinuation
- 2007-12-28 EP EP07868092A patent/EP2114158B1/en active Active
- 2007-12-28 AU AU2007342364A patent/AU2007342364A1/en not_active Abandoned
- 2007-12-28 CN CN200780051958A patent/CN101626686A/zh active Pending
- 2007-12-28 NZ NZ578290A patent/NZ578290A/en not_active IP Right Cessation
- 2007-12-28 AP AP2009004915A patent/AP2009004915A0/xx unknown
- 2007-12-28 BR BRPI0720323A patent/BRPI0720323A2/pt not_active IP Right Cessation
-
2008
- 2008-01-03 AR ARP080100021A patent/AR064739A1/es not_active Application Discontinuation
-
2009
- 2009-06-30 TN TNP2009000278A patent/TN2009000278A1/fr unknown
- 2009-07-02 IL IL199662A patent/IL199662A0/en unknown
- 2009-07-03 CR CR10913A patent/CR10913A/es not_active Application Discontinuation
- 2009-07-14 CO CO09072923A patent/CO6210740A2/es not_active Application Discontinuation
- 2009-07-20 ZA ZA200905065A patent/ZA200905065B/xx unknown
- 2009-07-23 EC EC2009009538A patent/ECSP099538A/es unknown
- 2009-07-31 MA MA32133A patent/MA31159B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP099538A (es) | 2009-12-28 |
| JP2010514837A (ja) | 2010-05-06 |
| IL199662A0 (en) | 2010-04-15 |
| EP2114158A1 (en) | 2009-11-11 |
| AU2007342364A1 (en) | 2008-07-17 |
| CR10913A (es) | 2009-09-21 |
| NZ578290A (en) | 2012-03-30 |
| TN2009000278A1 (en) | 2010-10-18 |
| MX2009007209A (es) | 2009-10-12 |
| MA31159B1 (fr) | 2010-02-01 |
| ZA200905065B (en) | 2010-04-28 |
| EA200900937A1 (ru) | 2009-12-30 |
| US20100041647A1 (en) | 2010-02-18 |
| KR20090098999A (ko) | 2009-09-18 |
| EP2114158B1 (en) | 2012-08-08 |
| AR064739A1 (es) | 2009-04-22 |
| CN101626686A (zh) | 2010-01-13 |
| BRPI0720323A2 (pt) | 2016-08-09 |
| CA2674321A1 (en) | 2008-07-17 |
| EP2114158A4 (en) | 2010-05-05 |
| WO2008085505A1 (en) | 2008-07-17 |
| AP2009004915A0 (en) | 2009-08-31 |
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