CO5580824A2 - Derivados de fenil o heteroaril amino alcano como antagonis- tas del receptor ip - Google Patents

Derivados de fenil o heteroaril amino alcano como antagonis- tas del receptor ip

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Publication number
CO5580824A2
CO5580824A2 CO05055462A CO05055462A CO5580824A2 CO 5580824 A2 CO5580824 A2 CO 5580824A2 CO 05055462 A CO05055462 A CO 05055462A CO 05055462 A CO05055462 A CO 05055462A CO 5580824 A2 CO5580824 A2 CO 5580824A2
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Colombia
Prior art keywords
amino
optionally substituted
halogen
alkyl
nhc
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CO05055462A
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English (en)
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Murata Toshiki
Umeda Masaomi
Urbahns Klaus
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Bayer Healthcare Ag
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Publication of CO5580824A2 publication Critical patent/CO5580824A2/es

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Abstract

1.- Un derivado de fenil o heteroaril aminoalcano de la fórmula (I), su forma tautomérica o estereoisomérica, o una sal del mismo: en la que Ar representa fenileno o un heteroarilo de 5 ó 6 miembros que contiene 1-3 heteroátomos seleccionados entre el grupo compuesto por O, N y S, donde dicho fenilo o un heteroarilo de 5 ó 6 miembros tiene opcionalmente uno o más sustituyentes seleccionados entre el grupo compuesto por halógeno, hidroxi, ciano, nitro, amino, N-alquil (C1-6)amino, N,N-dialquil (C1-6)amino, formilo, alquiltio (C1-6), alcoxi (C1-6) y alquilo (C1-6) opcionalmente sustituido con hidroxi, o uno, dos o tres átomos de halógeno;Q1, Q2, Q3 y Q4 representan independientemente CH, CR10 o N;donde R10 representa halógeno, ciano, amino, nitro, formilo, hidroximetilo, metiltio, alquilo (C1-6) opcionalmente sustituido con uno, dos o tres átomos de halógeno, o alcoxi (C1-6) opcionalmente sustituido con fenilo;R1 representa -OR11, -CH2NHR11, -C(O)R11, -C(O)NHR11, -SR11, -SOR11, -SO2R11, -NHR11, -NHC(O)OR11, -NHC(O)NR11, -NHC(O)R11, -NHSO2R11, hidrógeno, hidroxi, halógeno, un anillo mono- o bicíclico de 3-10 miembros saturado o insaturado que tiene opcionalmente uno o dos heteroátomos seleccionados independientemente entre O o N, alquilo (C1-6) opcionalmente sustituido con ariloxiimino, alcoxi (C1-6) opcionalmente sustituido con arilo o heteroarilo, o un anillo mono- o bicíclico de 3-10 miembros saturado o insaturado que tiene opcionalmente uno o dos heteroátomos seleccionados independientemente entre O o N, ...
CO05055462A 2002-11-11 2005-06-08 Derivados de fenil o heteroaril amino alcano como antagonis- tas del receptor ip CO5580824A2 (es)

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EP02025024 2002-11-11
EP03011397 2003-05-20

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US (1) US20060089371A1 (es)
EP (1) EP1575919A1 (es)
JP (1) JP2006514110A (es)
KR (1) KR20050074571A (es)
AR (1) AR042023A1 (es)
AU (1) AU2003276201A1 (es)
BR (1) BR0316191A (es)
CA (1) CA2505361A1 (es)
CO (1) CO5580824A2 (es)
EC (1) ECSP055789A (es)
HN (1) HN2003000353A (es)
HR (1) HRP20050529A2 (es)
MA (1) MA27491A1 (es)
NO (1) NO20052797L (es)
PE (1) PE20040672A1 (es)
PL (1) PL376993A1 (es)
TW (1) TW200418799A (es)
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WO (1) WO2004043926A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2262567T3 (es) 2001-03-20 2006-12-01 Schwarz Pharma Ag Nuevo uso de una clase peptidica de compuesto para tratamiento del dolor inflamatorio no neuropatico.
DE60100055T2 (de) 2001-03-21 2003-07-24 Sanol Arznei Schwarz Gmbh Neue Verwendung einer Klasse von Peptidverbindungen zur Behandlung von Allodynie oder andere Arten von chronischen oder Phantomschmerzen
EP1689378B1 (en) 2003-12-02 2009-04-15 Schwarz Pharma Ag Novel use of peptide compounds for treating central neuropathic pain
NZ546057A (en) 2003-12-03 2010-04-30 Ym Bioscience Australia Pty Lt Tubulin inhibitors
EP1604655A1 (en) 2004-06-09 2005-12-14 Schwarz Pharma Ag Novel use of peptide compounds for treating pain in trigeminal neuralgia
CA2573125A1 (en) 2004-08-27 2006-03-02 Schwarz Pharma Ag Novel use of peptide compounds for treating bone cancer pain, chemotherapy-and nucleoside-induced pain
WO2006029735A1 (en) * 2004-09-15 2006-03-23 Bayer Healthcare Ag Diagnostics and therapeutics for diseases associated with prostaglandin 12 receptor (ptgir)
HN2005000795A (es) * 2004-10-15 2010-08-19 Aventis Pharma Inc Pirimidinas como antagonistas del receptor de prostaglandina d2
PE20070341A1 (es) * 2005-07-29 2007-04-13 Wyeth Corp Derivados de pirrol como moduladores del receptor de progesterona
PE20070182A1 (es) 2005-07-29 2007-03-06 Wyeth Corp Derivados cianopirrol-fenil amida como moduladores del receptor de progesterona
PE20070404A1 (es) * 2005-07-29 2007-05-10 Wyeth Corp Compuestos derivados de cianopirrol-sulfonamida como moduladores del receptor de progesterona
JP2009503103A (ja) 2005-08-02 2009-01-29 レキシコン・ファーマシューティカルズ・インコーポレーテッド アリールピリジン及びその使用方法
EA019757B1 (ru) 2006-06-15 2014-06-30 ЮСиБи ФАРМА ГМБХ Фармацевтическая композиция с синергетическим противосудорожным эффектом
US20080242694A1 (en) * 2006-09-18 2008-10-02 D Sidocky Neil R Amino-substituted heterocycles, compositions thereof, and methods of treatment therewith
JO3598B1 (ar) * 2006-10-10 2020-07-05 Infinity Discovery Inc الاحماض والاسترات البورونية كمثبطات اميد هيدروليز الحامض الدهني
WO2009132310A1 (en) * 2008-04-25 2009-10-29 Wisconsin Alumni Research Foundation Inhibitors of udp-galactopyranose mutase thwart mycobacterial growth
US20100060985A1 (en) 2008-09-09 2010-03-11 Fujifilm Corporation Method for producing polarizing plate, and automobile's windshield
PE20110843A1 (es) 2008-09-22 2011-12-08 Cayman Chem Co Derivados de 5-(1h-imidazol-5-il)-2-fenilpirimidina, como inhibidores de prostaglandina d sintasa hematopoyetica
US9133123B2 (en) 2010-04-23 2015-09-15 Cytokinetics, Inc. Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use
AR081331A1 (es) 2010-04-23 2012-08-08 Cytokinetics Inc Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos
AR081626A1 (es) 2010-04-23 2012-10-10 Cytokinetics Inc Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos
US8759380B2 (en) 2011-04-22 2014-06-24 Cytokinetics, Inc. Certain heterocycles, compositions thereof, and methods for their use
EP2961746B1 (en) 2013-02-28 2018-01-03 Bristol-Myers Squibb Company Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors
TW201444798A (zh) 2013-02-28 2014-12-01 必治妥美雅史谷比公司 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物
ES2948192T3 (es) 2013-06-27 2023-09-01 Pfizer Compuestos heteroaromáticos y su uso como ligandos de dopamina D1
WO2015013322A1 (en) * 2013-07-22 2015-01-29 The Regents Of The University Of Colorado, A Body Corporate Silylalkyloxyaryl compounds and methods for treating cancer
WO2016057338A1 (en) 2014-10-06 2016-04-14 Takeda Pharmaceutical Company Limited Heteroarylamide inhibitors of tbk1
US10080757B2 (en) 2016-03-11 2018-09-25 Wisconsin Alumni Research Foundation Inhibitors of UDP-galactopyranose mutase

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4259489A (en) * 1977-12-22 1981-03-31 Kyowa Gas Chemical Industry Co. Ltd. 2,3-Dicyanopyrazines
WO1996033972A1 (en) * 1995-04-28 1996-10-31 Glaxo Group Limited Methods for synthesizing diverse collections of pyridines, pyrimidines, 1,4-dihydro derivatives thereof, and piperidine derivatives
CN1171878C (zh) * 1996-12-23 2004-10-20 伊兰药品公司 化合物、其用途以及含有所述化合物的药物组合物
GB2323842A (en) * 1997-04-04 1998-10-07 Ferring Bv Pyridine derivatives
AU2623900A (en) * 1999-01-22 2000-08-07 American Home Products Corporation Compounds which inhibit leukocyte adhesion mediated by vla-4
US20020058606A1 (en) * 1999-05-10 2002-05-16 Gonzalez Maria Isabel Treatment of sexual dysfunction
RU2268258C2 (ru) * 2000-03-16 2006-01-20 Ф.Хоффманн-Ля Рош Аг Производные карбоновых кислот в качестве антагонистов ip
WO2002040008A2 (en) * 2000-11-17 2002-05-23 Warner-Lambert Company Llc Treatment of sexual dysfunction with non peptide bombesin receptor antagonists
PT1399468E (pt) * 2001-05-30 2006-05-31 Novartis Ag Derivados do acido 2-{[n-(2-amino-3-(heteroaril ou aril)propionil)-aminoacil]-amino}-alquilboronico

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